메뉴 건너뛰기




Volumn 526, Issue 7574, 2015, Pages 578-582

Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN; SHH PROTEIN, MOUSE;

EID: 84945275578     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14984     Document Type: Article
Times cited : (168)

References (29)
  • 1
    • 79957922264 scopus 로고    scopus 로고
    • The three R's of lung health and disease: Repair, remodeling, and regeneration
    • Beers, M. F. & Morrisey, E. E. The three R's of lung health and disease: repair, remodeling, and regeneration. J. Clin. Invest. 121, 2065-2073 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2065-2073
    • Beers, M.F.1    Morrisey, E.E.2
  • 2
    • 84892748994 scopus 로고    scopus 로고
    • Lung development: Orchestrating the generation and regeneration of a complex organ
    • Herriges,M.& Morrisey, E. E. Lung development: orchestrating the generation and regeneration of a complex organ. Development 141, 502-513 (2014).
    • (2014) Development , vol.141 , pp. 502-513
    • Herriges, M.1    Morrisey, E.E.2
  • 3
    • 84905869926 scopus 로고    scopus 로고
    • Repair and regeneration of the respiratory system: Complexity, plasticity, and mechanisms of lung stemcell function
    • Hogan, B. L. et al. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stemcell function. Cell Stem Cell 15, 123-138 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 123-138
    • Hogan, B.L.1
  • 4
    • 0014075968 scopus 로고
    • Proliferation of respiratory tract epithelium in the rat
    • Blenkinsopp, W. K. Proliferation of respiratory tract epithelium in the rat. Exp. Cell Res. 46, 144-154 (1967).
    • (1967) Exp. Cell Res. , vol.46 , pp. 144-154
    • Blenkinsopp, W.K.1
  • 6
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • McMahon, A. P., Ingham, P. W. & Tabin, C. J. Developmental roles and clinical significance of hedgehog signaling. Curr. Top. Dev. Biol. 53, 1-114 (2003).
    • (2003) Curr. Top. Dev. Biol. , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 7
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • Lum, L. & Beachy, P. A. The Hedgehog response network: sensors, switches, and routers. Science 304, 1755-1759 (2004).
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 8
    • 84883135927 scopus 로고    scopus 로고
    • Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor
    • Peng, T. et al. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature 500, 589-592 (2013).
    • (2013) Nature , vol.500 , pp. 589-592
    • Peng, T.1
  • 9
    • 4644328190 scopus 로고    scopus 로고
    • Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    • Harfe, B. D. et al. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118, 517-528 (2004).
    • (2004) Cell , vol.118 , pp. 517-528
    • Harfe, B.D.1
  • 10
    • 0036801765 scopus 로고    scopus 로고
    • Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    • Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D. & Joyner, A. L. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 129, 4753-4761 (2002).
    • (2002) Development , vol.129 , pp. 4753-4761
    • Bai, C.B.1    Auerbach, W.2    Lee, J.S.3    Stephen, D.4    Joyner, A.L.5
  • 11
    • 84880978616 scopus 로고    scopus 로고
    • Hedgehog signaling in neonatal and adult lung
    • Liu, L. et al. Hedgehog signaling in neonatal and adult lung. Am. J. Respir. Cell Mol. Biol. 48, 703-710 (2013).
    • (2013) Am. J. Respir. Cell Mol. Biol. , vol.48 , pp. 703-710
    • Liu, L.1
  • 12
    • 27144487469 scopus 로고    scopus 로고
    • In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
    • Ahn, S. & Joyner, A. L. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 437, 894-897 (2005).
    • (2005) Nature , vol.437 , pp. 894-897
    • Ahn, S.1    Joyner, A.L.2
  • 13
    • 47549116834 scopus 로고    scopus 로고
    • Cre-mediated recombination inmouse Clara cells
    • Li, H. et al. Cre-mediated recombination inmouse Clara cells.Genesis46, 300-307 (2008).
    • (2008) Genesis , vol.46 , pp. 300-307
    • Li, H.1
  • 14
    • 30344440869 scopus 로고    scopus 로고
    • Ephrin-B2 controls cell motility and adhesion during blood-vesselwall assembly
    • Foo, S. S. et al. Ephrin-B2 controls cell motility and adhesion during blood-vesselwall assembly. Cell 124, 161-173 (2006).
    • (2006) Cell , vol.124 , pp. 161-173
    • Foo, S.S.1
  • 15
    • 1942466507 scopus 로고    scopus 로고
    • Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
    • Jeong, J., Mao, J., Tenzen, T., Kottmann, A. H.&McMahon, A. P.Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 18, 937-951 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 937-951
    • Jeong, J.1    Mao, J.2    Tenzen, T.3    Kottmann, A.H.4    McMahon, A.P.5
  • 16
    • 59649093844 scopus 로고    scopus 로고
    • Increased PDGFRa activation disrupts connective tissue development and drives systemic fibrosis
    • Olson, L. E. & Soriano, P. Increased PDGFRa activation disrupts connective tissue development and drives systemic fibrosis. Dev. Cell 16, 303-313 (2009).
    • (2009) Dev. Cell , vol.16 , pp. 303-313
    • Olson, L.E.1    Soriano, P.2
  • 17
    • 79958239247 scopus 로고    scopus 로고
    • PDGFRb signaling regulates mural cell plasticity and inhibits fat development
    • Olson, L. E. & Soriano, P. PDGFRb signaling regulates mural cell plasticity and inhibits fat development. Dev. Cell 20, 815-826 (2011).
    • (2011) Dev. Cell , vol.20 , pp. 815-826
    • Olson, L.E.1    Soriano, P.2
  • 18
    • 0022498261 scopus 로고
    • Comparison of the arachidonic acid and NADPH-dependent microsomal metabolism of naphthalene and 2-methylnaphthalene and the effect of indomethacin on the bronchiolar necrosis
    • Buckpitt, A. R., Bahnson, L. S. & Franklin, R. B. Comparison of the arachidonic acid and NADPH-dependent microsomal metabolism of naphthalene and 2-methylnaphthalene and the effect of indomethacin on the bronchiolar necrosis. Biochem. Pharmacol. 35, 645-650 (1986).
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 645-650
    • Buckpitt, A.R.1    Bahnson, L.S.2    Franklin, R.B.3
  • 19
    • 84870951352 scopus 로고    scopus 로고
    • Role of Sonic Hedgehog in idiopathic pulmonary fibrosis
    • Bolaños, A. L. et al. Role of Sonic Hedgehog in idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 303, L978-L990 (2012).
    • (2012) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.303 , pp. L978-L990
    • Bolaños, A.L.1
  • 20
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signallingwithin airway epithelial progenitors and in small-cell lung cancer
    • Watkins,D.N. et al.Hedgehog signallingwithin airway epithelial progenitors and in small-cell lung cancer. Nature 422, 313-317 (2003).
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1
  • 21
    • 70349862613 scopus 로고    scopus 로고
    • B-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium
    • Zemke, A. C. et al. b-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. Am. J. Respir. Cell Mol. Biol. 41, 535-543 (2009).
    • (2009) Am. J. Respir. Cell Mol. Biol. , vol.41 , pp. 535-543
    • Zemke, A.C.1
  • 22
    • 84875344085 scopus 로고    scopus 로고
    • Development and regeneration of Sox21endodermprogenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway
    • Wang, Y. et al. Development and regeneration of Sox21endodermprogenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev. Cell 24, 345-358 (2013).
    • (2013) Dev. Cell , vol.24 , pp. 345-358
    • Wang, Y.1
  • 24
    • 77957223906 scopus 로고    scopus 로고
    • Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
    • Snippert, H. J. et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143, 134-144 (2010).
    • (2010) Cell , vol.143 , pp. 134-144
    • Snippert, H.J.1
  • 25
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long, F., Zhang, X. M., Karp, S., Yang, Y. & McMahon, A. P. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128, 5099-5108 (2001).
    • (2001) Development , vol.128 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3    Yang, Y.4    McMahon, A.P.5
  • 26
    • 0035368725 scopus 로고    scopus 로고
    • Cholesterol modification of sonic hedgehog is required for longrange signaling activity and effective modulation of signaling by Ptc1
    • Lewis, P. M. et al. Cholesterol modification of sonic hedgehog is required for longrange signaling activity and effective modulation of signaling by Ptc1. Cell 105, 599-612 (2001).
    • (2001) Cell , vol.105 , pp. 599-612
    • Lewis, P.M.1
  • 27
    • 35548932872 scopus 로고    scopus 로고
    • A global doublefluorescent Cre reporter mouse
    • Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. A global doublefluorescent Cre reporter mouse. Genesis 45, 593-605 (2007).
    • (2007) Genesis , vol.45 , pp. 593-605
    • Muzumdar, M.D.1    Tasic, B.2    Miyamichi, K.3    Li, L.4    Luo, L.5
  • 28
    • 34249885603 scopus 로고    scopus 로고
    • Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypesandstemcell loss
    • Ruzankina, Y. et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypesandstemcell loss. Cell StemCell 1,113-126 (2007).
    • (2007) Cell StemCell , vol.1 , pp. 113-126
    • Ruzankina, Y.1
  • 29
    • 80054995024 scopus 로고    scopus 로고
    • Scale: A chemical approach for fluorescence imaging and reconstruction of transparent mouse brain
    • Hama, H. et al. Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain. Nature Neurosci. 14, 1481-1488 (2011).
    • (2011) Nature Neurosci. , vol.14 , pp. 1481-1488
    • Hama, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.