IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB

American Journal of Physiology - Endocrinology and Metabolism

Volumn 309, Issue 8, 2015, Pages E715-E726

  Burke, Susan J ^a   Stadler, Krisztian ^a   Lu, Danhong ^b   Gleason, Evanna ^c   Han, Anna ^d   Donohoe, Dallas R ^d   Rogers, Richard C ^a   Hermann, Gerlinda E ^a   Karlstad, Michael D ^e   Collier, J Jason ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF TENNESSEE   (United States)

^e UNIVERSITY OF TENNESSEE MEDICAL CENTER   (United States)

Author keywords

Chemokine; Inflammation; Insulin secretion; Interleukin 1; Nitric oxide

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; CCL2 PROTEIN, RAT; CCL20 PROTEIN, RAT; CHEMOKINE; HOMEODOMAIN PROTEIN; IL1B PROTEIN, RAT; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; MESSENGER RNA; NKX6A PROTEIN, RAT; NOS2 PROTEIN, RAT; RIBOSOMAL PROTEIN S9; RIBOSOME PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; INFLAMMATION; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; ANIMAL; ELECTRON SPIN RESONANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; INSULINOMA; METABOLISM; OXYGEN CONSUMPTION; PANCREAS TUMOR; PATCH CLAMP TECHNIQUE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); TUMOR CELL CULTURE; WISTAR RAT; ZUCKER RAT;

ANIMALS; CHEMOKINE CCL2; CHEMOKINE CCL20; CHEMOKINES; DIABETES MELLITUS; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; IMMUNOBLOTTING; INSULIN; INSULIN-SECRETING CELLS; INSULINOMA; INTERLEUKIN-1BETA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXYGEN CONSUMPTION; PANCREATIC NEOPLASMS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RATS, ZUCKER; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 84945242928     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00153.2015     Document Type: Article

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