Design and evaluation of an intravesical delivery system for superficial bladder cancer: Preparation of gemcitabine HCl-loaded chitosan-thioglycolic acid nanoparticles and comparison of chitosan/poloxamer gels as carriers

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 6493-6507

  Şenyiğit, Zeynep Ay ^a   Karavana, Sinem Yaprak ^a   İlem Özdemir, Derya I ^a   Caliskan C ^a   Waldner, Claudia ^b   Şen, Sait ^a   Bernkop Schnürch, Andreas ^c   Baloğlu, Esra ^a  

^a EGE UNIVERSITY   (Turkey)

^b Thiomatrix Forschungs und Beratungs GmbH   (Austria)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Chitosan; Chitosan TGA; Gemcitabine HCl; Intravesical administration; Nanoparticle; Poloxamer; Superficial bladder cancer

Indexed keywords

CHITOSAN; GEMCITABINE; NANOPARTICLE; POLOXAMER; THIOGLYCOLIC ACID DERIVATIVE; 2-MERCAPTOACETATE; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; DRUG CARRIER; GEL;

ARTICLE; BLADDER CANCER; CALIBRATION; CENTRIFUGATION; DILUTION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG RETENTION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TOLERABILITY; EMBOLIC PARTICLE; EX VIVO STUDY; FLOW KINETICS; GELATION; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; LIGHT SCATTERING; MEAN RESIDENCE TIME; MOLECULAR WEIGHT; MUSCLE INVASIVE BLADDER CANCER; NANOENCAPSULATION; NONHUMAN; OSCILLATION; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SUPERNATANT; VISCOELASTICITY; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; CHEMISTRY; GEL; INTRAVESICAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; TUMOR CELL CULTURE; URINARY BLADDER NEOPLASMS;

ADMINISTRATION, INTRAVESICAL; ANTIMETABOLITES, ANTINEOPLASTIC; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DEOXYCYTIDINE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; GELS; HUMANS; NANOPARTICLES; POLOXAMER; THIOGLYCOLATES; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 84945208420     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S93750     Document Type: Article

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