Development of metronidazole intravaginal gel for the treatment of bacterial vaginosis: Effect of mucoadhesive natural polymers on the release of metronidazole

International Journal of PharmTech Research

Volumn 2, Issue 3, 2010, Pages 1746-1750

  Yellanki, Shiva Kumar ^a   Nerella, Naveen Kumar ^a   Goranti, Sharada ^b   Deb, Sambit Kumar ^a  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b INSTITUTE OF PHARMACEUTICAL TECHNOLOGY   (India)

Author keywords

Intravaginal gel; Metronidazole; Polyvinyl pyrolidone K30; Prolonged release

Indexed keywords

CHITOSAN; GELATIN; METHYL PARABEN; METRONIDAZOLE; PROPYL PARABEN; XANTHAN;

ANTIBIOTIC SENSITIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED DRUG RELEASE; DISPERSION; DRUG EFFICACY; DRUG FORMULATION; DRUG SCREENING; NONHUMAN; PATIENT COMPLIANCE; PH; STAPHYLOCOCCUS AUREUS; TREATMENT INDICATION; VAGINITIS; VISCOSITY;

EID: 77957566454     PISSN: None     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. ACOG., ACOG technical bulletin: vaginitis, Int J Gynecol & Obstet., 1996, 53, 271- 280.
2. Sherrard J., European guidelines for the management of vaginal discharge, Int J STD AIDS., 2001, 12, 73-77.
3. Kukner S, Ergin T, Cicek N, Ugur M, Yesilyurt H, Gokmen O., Treatment of vaginitis, Int J Gynecol & Obstet., 1996, 52, 43-47.
4. Peppas Lb., Novel yaginal drug release applications, Adv Drug Deliv Rev., 1993, 11, 169-176.
5. Hussain A, Ahsan F., The vagina as a route for systemic drug delivery, J. Control. Release., 2005,103, 301-13.
6. Chien YW., Novel drug delivery systems, 2nd ed. New York: Marcel Dekker., 1992, p. 11-28.
7. Jack DS, Daron F, Jane S et al., Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis, American Journal of Obstet Gyneco., 2006, 194(5), 1283-1289.
8. Hope MJ, Kitson CN., Liposomes: a perspective for dermatologists, Dermatol. Clin., 1993, 11, 143-154.
9. Grewal MS., Metronidazole as direct acting amoebicide, Indian Practnr., 1966, 19, 40.
10. Hedges AR., In dustrial applications of cyclodextrins, Chem Rev., 1998, 98, 2035-2044.
11. Senel S, Ikinci G, Akincibay H, Kar S, Erics S, Wilson CG, et al., Effect of chitosan on periodontal pathogen porphyromonas gingivalis, Int J Pharm., 2002, 235, 121-127.
12. Choi HG, Jung JH, Ryu JM, Yoon SJ, Oh YK, Kim C K., Development of in situ gelling and mucoadhesive acetaminophen liquid suppository, Int J Pharm., 1998, 165, 33-44.
13. Nagaraja P, Sunitha KR, Vasantha RA, Yathirajan HS., Spectrophotometric determination of metronidazole and tinidazole in pharmaceutical preparations, Journal of Pharmaceutical and Biomedical Analysis., 2002, 28 (3-4), 527-535.
14. Jones DS, Woolfson AD, Brown AF, O'Neill MJ., Mucoadhesive syringeable drug delivery systems for controlled application of metronidazole to periodontal pocket: in vitro release kinetics, syringeability, mechanical and mucoadhesive properties, J Controlled Rel., 1997, 49 (1), 71-79.
15. Alam MA, Ahmad FJ, Khan ZI, Khar RK, Ali M., Development and Evaluation of Acid-buffering Bioadhesive Vaginal Tablet for Mixed Vaginal Infections, AAPS PharmSciTech., 2007, 8(4), Article 109.
16. Alka G, Garg S, Khar RK., Measurement of bioadhesive strength of mucoadhesive buccal tablet: Design of an in-vitro assembly, Indian Drugs., 1992, 30 (4), 152-155.
17. Bilensoy E, Rouf MA, Vural I, Şen M, Hi{dotless}ncal AA., Mucoadhesive, Thermosensitive, Prolonged-Release Vaginal Gel for Clotrimazole:β-Cyclodextrin Complex, AAPS PharmSciTech., 2006, 7(2), Article 38.
18. Golomb G, Friedman M, Soskolene A, Stabholz A, Sela MN., Sustained release device containing metronidazole for periodontal use, J Dent Res., 1984, 63 (9), 1149-1153.