Combination of correctors rescue AF508-CFTR by reducing its association with Hsp40 and Hsp27

Journal of Biological Chemistry

Volumn 290, Issue 42, 2015, Pages 25636-25645

  Lopes Pacheco, Miquéias ^a,b   Boinot, Clément ^a   Sabirzhanova, Inna ^a   Morales, Marcelo M ^b   Guggino, William B ^a   Cebotaru, Liudmila ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CELL CULTURE; CELL MEMBRANES; CELLS; CYTOLOGY; DISEASE CONTROL; SAWING;

AFTER-TREATMENT; CYCLOHEXIMIDES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATIONS; HEAT SHOCK PROTEIN; PHYSIOLOGICAL TEMPERATURE; SMALL MOLECULES;

PROTEINS;

CYCLOHEXIMIDE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 40; SMALL INTERFERING RNA; CFTR PROTEIN, HUMAN; PROTEIN BINDING;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; COS 7 CELL LINE; EMBRYO; GENE SILENCING; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN TRANSPORT; ANIMAL; CHLOROCEBUS AETHIOPS; COS CELL LINE; GENETICS; METABOLISM; MUTATION; TEMPERATURE;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HEK293 CELLS; HSP27 HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; MUTATION; PROTEIN BINDING; TEMPERATURE;

EID: 84945207194     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.671925     Document Type: Article

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