Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

Thorax

Volumn 70, Issue 11, 2015, Pages 1022-1032

  Korfei, Martina ^a,b   Skwarna, Sylwia ^a,b   Henneke, Ingrid ^a,b   MacKenzie, BreAnne ^a,b   Klymenko, Oleksiy ^a,b   Saito, Shigeki ^c   Ruppert, Clemens ^a,b,d   Von Der Beck, Daniel ^a,b   Mahavadi, Poornima ^a,b   Klepetko, Walter ^e,k   Bellusci, Saverio ^a,b,d   Crestani, Bruno ^f,k   Pullamsetti, Soni Savai ^a,b,g   Fink, Ludger ^b,d,h   Seeger, Werner ^a,b,d   Krämer, Oliver Holger ⁱ   Guenther, Andreas ^a,b,d,j,k  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d Excellencecluster Cardio Pulmonary System   (Germany)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f BICHAT HOSPITAL   (France)

^g MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^h Institute of Pathology and Cytology   (Germany)

ⁱ UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^j Agaplesion Lung Clinic Waldh of Elgershausen   (Germany)

^k European IPF Network   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 5; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE 9; HISTONE DEACETYLASE INHIBITOR; PANOBINOSTAT; VALPROIC ACID; RNA;

ADULT; APOPTOSIS; ARTICLE; BASAL CELL; BRONCHIOLE; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INDUCTION; EPITHELIZATION; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; FIBROSING ALVEOLITIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG PARENCHYMA; MALE; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; BIOSYNTHESIS; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

CELLS, CULTURED; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE 2; HISTONE DEACETYLASES; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RNA;

EID: 84945195455     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2014-206411     Document Type: Article

References (43)

1. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 2000;161:646-64.
2. Vancheri C. Common pathways in idiopathic pulmonary fibrosis and cancer. Eur Respir Rev 2013;22:265-72.
3. Conte E, Gili E, Fruciano M, et al. PI3K p110gamma overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition. Lab Invest 2013;93:566-76.
4. Sisson TH, Maher TM, Ajayi IO, et al. Increased survivin expression contributes to apoptosis-resistance in IPF-fibroblasts. Adv Biosci Biotechnol 2012;3:657-64.
5. Lafon-Hughes L, Di Tomaso MV, Mendez-Acuna L, et al. Chromatin-remodelling mechanisms in cancer. Mutat Res 2008;658:191-214.
6. Backs J, Olson EN. Control of cardiac growth by histone acetylation/deacetylation. Circ Res 2006;98:15-24.
7. Ito K, Ito M, Elliott WM, et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. New Engl J Med 2005;352:1967-76.
8. Brandl A, Wagner T, Uhlig KM, et al. Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress. J Mol Cell Biol 2012;4:284-93.
9. Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: Molecular mechanisms of action. Oncogene 2007;26:5541-52.
10. Sundar IK, Yao H, Rahman I. Oxidative stress and chromatin remodelling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal 2013;18:1956-71.
11. Richon VM, Garcia-Vargas J, Hardwick JS. Development of vorinostat: current applications and future perspectives for cancer therapy. Cancer Lett 2009;280:201-10.
12. Anne M, Sammartino D, Barginear MF, et al. Profile of panobinostat and its potential for treatment in solid tumors: an update. Onco Targets Ther 2013;6:1613-24.
13. Coward WR, Watts K, Feghali-Bostwick CA, et al. Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis. Mol Cell Biol 2009;29:4325-39.
14. Guo W, Shan B, Klingsberg RC, et al. Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. Am J Physiol Lung Cell Mol Physiol 2009;297:L864-870.
15. Sanders YY, Hagood JS, Liu H, et al. Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice. Eur Respir J 2014;43:1448-58.
16. Krämer OH, Zhu P, Ostendorff HP, et al. The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J 2003;22:3411-20.
17. Waltregny D, Glenisson W, Tran SL, et al. Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. FASEB J 2005;19:966-8.
18. Lam HC, Cloonan SM, Bhashyam AR, et al. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest 2013;123:5212-30.
19. Hagood JS, Prabhakaran P, Kumbla P, et al. Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am J Pathol 2005;167:365-79.
20. Montalbano R, Waldegger P, Quint K, et al. Endoplasmic reticulum stress plays a pivotal role in cell death mediated by the pan-deacetylase inhibitor panobinostat in human hepatocellular cancer cells. Transl Cncol 2013;6:143-57.
21. Dokmanovic M, Perez G, Xu W, et al. Histone deacetylase inhibitors selectively suppress expression of HDAC7. Mol Cancer Ther 2007;6:2525-34.
22. Wilson AJ, Byun DS, Nasser S, et al. HDAC4 promotes growth of colon cancer cells via repression of p21. Mol Biol Cell 2008;19:4062-75.
23. Jin YH, Jeon EJ, Li QL, et al. Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J Biol Chem 2004;279:29409-17.
24. Ma C, D'Mello SR. Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. J Biol Chem 2011;286:4819-28.
25. Zhu C, Chen Q, Xie Z, et al. The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: Regulation on c-myc. J Mol Med 2011;89:279-89.
26. Chilosi M, Poletti V, Murer B, et al. Abnormal re-epithelialization and lung remodelling in idiopathic pulmonary fibrosis: the role of deltaN-p63. Lab Invest 2002;82:1335-45.
27. Wang Z, Qin G, Zhao TC. HDAC4: mechanism of regulation and biological functions. Epigenomics 2014;6:139-50.
28. Witt O, Deubzer HE, Milde T, et al. HDAC family: what are the cancer relevant targets? Cancer Lett 2009;277:8-21.
29. Eckle T, Brodsky K, Bonney M, et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol 2013;11:e1001665.
30. Saini Y, Harkema JR, LaPres JJ. HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. J Biol Chem 2008;283:33650-7.
31. Lawson WE, Crossno PF, Polosukhin VV, et al. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol 2008;294:L1119-26.
32. Korfei M, Ruppert C, Mahavadi P, et al. Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2008;178:838-46.
33. Cha SI, Ryerson CJ, Lee JS, et al. Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respir Res 2012;13:105.
34. Paroni G, Mizzau M, Henderson C, et al. Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis. Mol Biol Cell 2004;15:2804-18.
35. Scott FL, Fuchs GJ, Boyd SE, et al. Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem 2008;283:19499-510.
36. Parmigiani RB, Xu WS, Venta-Perez G, et al. HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci USA 2008;105:9633-8.
37. Lee JY, Koga H, Kawaguchi Y, et al. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO Journal 2010;29:969-80.
38. Hockly E, Richon VM, Woodman B, et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Proc Natl Acad Sci USA 2003;100:2041-6.
39. Petri S, Kiaei M, Kipiani K, et al. Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 2006;22:40-9.
40. Qiu L, Burgess A, Fairlie DP, et al. Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells. Mol Biol Cell 2000;11:2069-83.
41. Tao R, de Zoeten EF, Ozkaynak E, et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 2007;13:1299-307.
42. King TE Jr, Schwarz MI, Brown K, et al. Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med 2001;164:1025-32.
43. Pang M, Kothapally J, Mao H, et al. Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol 2009;297:F996-F1005.