Potent neutralizing anti-CD1d antibody reduces lung cytokine release in primate asthma model

mAbs

Volumn 7, Issue 3, 2015, Pages 638-650

  Nambiar, Jonathan ^a   Clarke, Adam W ^a   Shim, Doris ^a   Mabon, David ^a   Tian, Chen ^a   Windloch, Karolina ^a   Buhmann, Chris ^a   Corazon, Beau ^a   Lindgren, Matilda ^a   Pollard, Matthew ^a   Domagala, Teresa ^a   Poulton, Lynn ^a   Doyle, Anthony G ^a  

^a Teva Pharmaceuticals Australia Pty Ltd   (Australia)

Author keywords

Antibody; Asthma; CD1d; Cytokine; NKT cell

Indexed keywords

ANTI CD1D ANTIBODY; CD1D ANTIGEN; GAMMA INTERFERON; GLYCOLIPID; IMMUNOGLOBULIN G4; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 5; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; METHACHOLINE; NEUTRALIZING ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; MONOCLONAL ANTIBODY;

ANTIGEN BINDING; ARTICLE; ASCARIS SUUM; ASTHMA; BASOPHIL; BETA CHAIN; BLOOD ANALYSIS; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; DEUTERIUM HYDROGEN EXCHANGE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FLOW CYTOMETRY; HEK293E CELL LINE; HUMAN; HUMAN CELL; IC50; INFLAMMATION; LUNG LAVAGE; MACACA FASCICULARIS; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODEL; IMMUNOLOGY; LUNG; MACROPHAGE; PATHOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD1D; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; HUMANS; LUNG; MACACA FASCICULARIS; MACROPHAGES; NATURAL KILLER T-CELLS;

EID: 84945182801     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.1080/19420862.2015.1016693     Document Type: Article

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