Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Bashir, Mohamed Elfatih H ^a   Lui, Jan Hsi ^a   Palnivelu, Ravishankar ^a,b   Naclerio, Robert M ^a   Preuss, Daphne ^a,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c Chromatin Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANE DERIVATIVE; ARACHIDIC ACID; BEHENIC ACID; BIOLOGICAL MARKER; DICARBOXYLIC ACID DERIVATIVE; FATTY ACID; FATTY ALCOHOL; HEPTADECANOIC ACID; HEPTANOIC ACID DERIVATIVE; HEXACOSANOIC ACID; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; LAURIC ACID; LONG CHAIN FATTY ACID; MYELOID DIFFERENTIATION FACTOR 88; MYRISTIC ACID; NONADECANOIC ACID; NONANOIC ACID; PALMITIC ACID; PENTADECANOIC ACID; POLLEN ANTIGEN; STEARIC ACID; STEROL; TETRACOSANOICOLEIC ACID; TRICOSANOIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ALLERGY; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; INTRACELLULAR SIGNALING; LIPID ANALYSIS; LIPIDOMICS; MASS FRAGMENTOGRAPHY; MOUSE; NATURAL KILLER CELL; NONHUMAN; POLLEN; PROTEIN EXPRESSION; SPECIES DIFFERENCE; SPECIES DIVERSITY; UPREGULATION;

ALLERGENS; BIOLOGICAL MARKERS; FLOW CYTOMETRY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYPERSENSITIVITY; KILLER CELLS, NATURAL; LIPID METABOLISM; LYMPHOCYTE ACTIVATION; POLLEN; PRINCIPAL COMPONENT ANALYSIS;

EID: 84874565816     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057566     Document Type: Article

References (57)

1. Nathan RA, (2007) The burden of allergic rhinitis. Allergy Asthma Proc 28: 3-9.
2. Wolters-Arts M, Lush WM, Mariani C, (1998) Lipids are required for directional pollen-tube growth. Nature 392: 818-821.
3. Piffanelli P, Ross JH, Murphy DJ, (1997) Intra- and extracellular lipid composition and associated gene expression patterns during pollen development in Brassica napus. Plant J 11: 549-562.
4. Preuss D, Lemieux B, Yen G, Davis RW, (1993) A conditional sterile mutation eliminates surface components from Arabidopsis pollen and disrupts cell signaling during fertilization. Genes Dev 7: 974-985.
5. Dickinson H, (1993) Pollen dressed for success. Nature 364: 573-574.
6. Evans DE, Sang JP, Cominos X, Rothnie NE, Knox RB, (1990) A Study of Phospholipids and Galactolipids in Pollen of Two Lines of Brassica napus L. (Rapeseed) with Different Ratios of Linoleic to Linolenic Acid. Plant Physiol 93: 418-424.
7. Swoboda I, Grote M, Verdino P, Keller W, Singh MB, et al. (2004) Molecular characterization of polygalacturonases as grass pollen-specific marker allergens: expulsion from pollen via submicronic respirable particles. J Immunol 172: 6490-6500.
8. Engel E, Richter K, Obermeyer G, Briza P, Kungl AJ, et al. (1997) Immunological and biological properties of Bet v 4, a novel birch pollen allergen with two EF-hand calcium-binding domains. J Biol Chem 272: 28630-28637.
9. Fiebig A, Mayfield JA, Miley NL, Chau S, Fischer RL, et al. (2000) Alterations in CER6, a gene identical to CUT1, differentially affect long-chain lipid content on the surface of pollen and stems. Plant Cell 12: 2001-2008.
10. Rodriguez-Garcia MI, M'Rani-Alaoui M, Fernandez MC, (2003) Behavior of storage lipids during development and germination of olive (Olea europaea L.) pollen. Protoplasma 221: 237-244.
11. Hulskamp M, Schneitz K, Pruitt RE, (1995) Genetic Evidence for a Long-Range Activity That Directs Pollen Tube Guidance in Arabidopsis. Plant Cell 7: 57-64.
12. Johnson RA, Haer H, Kirkpatrick CH, Dawson CR, Khurana RG, (1972) Comparison of the contact allergenicity of the four pentadecylcatechols derived from poison ivy urushiol in human subjects. J Allergy Clin Immunol 49: 27-35.
13. Allen PL, (2006) Leaves of three, let them be: if it were only that easy! Dermatol Nurs. 18: 236-242.
14. Gafner F, Epstein W, Reynolds G, Rodriguez E, (1988) Human maximization test of falcarinol, the principal contact allergen of English ivy and Algerian ivy (Hedera helix, H. canariensis). Contact Dermatitis 19: 125-128.
15. Kronenberg M, Rudensky A, (2005) Regulation of immunity by self-reactive T cells. Nature 435: 598-604.
16. Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, et al. (2005) Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med 202: 295-308.
17. Traidl-Hoffmann C, Kasche A, Jakob T, Huger M, Plotz S, et al. (2002) Lipid mediators from pollen act as chemoattractants and activators of polymorphonuclear granulocytes. J Allergy Clin Immunol 109: 831-838.
18. Traidl-Hoffmann C, Kasche A, Menzel A, Jakob T, Thiel M, et al. (2003) Impact of pollen on human health: more than allergen carriers? Int Arch Allergy Immunol 131: 1-13.
19. Traidl-Hoffmann C, Mariani V, Hochrein H, Karg K, Wagner H, et al. (2005) Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J Exp Med 201: 627-636.
20. Russano AM, Agea E, Corazzi L, Postle AD, De Libero G, et al. (2006) Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted gamma delta T cells. J Allergy Clin Immunol 117: 1178-1184.
21. Szatmari I, Gogolak P, Im JS, Dezso B, Rajnavolgyi E, et al. (2004) Activation of PPARgamma specifies a dendritic cell subtype capable of enhanced induction of iNKT cell expansion. Immunity 21: 95-106.
22. Wooten MW, Wrenn RW, (1988) Linoleic acid is a potent activator of protein kinase C type III-alpha isoform in pancreatic acinar cells; its role in amylase secretion. Biochem Biophys Res Commun 153: 67-73.
23. Lernhardt W, (1990) Fatty acid requirement of B lymphocytes activated in vitro. Biochem Biophys Res Commun 166: 879-885.
24. Wooten RM, Clem LW, Bly JE, (1993) The effects of temperature and oleic acid on murine memory and virgin T cell activation: interleukin-2 secretion and interleukin-2 receptor expression. Cell Immunol 152: 35-48.
25. Karsten S, Schafer G, Schauder P, (1994) Cytokine production and DNA synthesis by human peripheral lymphocytes in response to palmitic, stearic, oleic, and linoleic acid. J Cell Physiol 161: 15-22.
26. Satoh M, Kuroda Y, Yoshida H, Behney KM, Mizutani A, et al. (2003) Induction of lupus autoantibodies by adjuvants. J Autoimmun 21: 1-9.
27. Papa G, Quaratino D, Di Fonso M, Guiffreda F, Romano A, et al. (1996) Allergic respiratory diseases and environmental pollution: experience in the printing/paper-manufacturing industry. Allergy 51: 833-836.
28. Bashir MEH, Ward JM, Cummings M, Karrar EE, Root R, et al. (2013) Dual Function of Novel Pollen Coat (Surface) Proteins: IgE-binding Capacity and Proteolytic Activity Disrupting the Airway Epithelial Barrier. PLOS ONE.
29. Mayfield JA, Fiebig A, Johnstone SE, Preuss D, (2001) Gene families from the Arabidopsis thaliana pollen coat proteome. Science 292: 2482-2485.
30. Mayfield JA, Preuss D, (2000) Rapid initiation of Arabidopsis pollination requires the oleosin-domain protein GRP17. Nat Cell Biol 2: 128-130.
31. Bendelac A, (1995) Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes. J Exp Med 182: 2091-2096.
32. Lutz MB, Kukutsch N, Ogilvie AL, Rossner S, Koch F, et al. (1999) An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223: 77-92.
33. Ogren TL (2000) Allergy-Free Gardening: The Revolutionary Guide to Healthy Landscaping. Berkeley, CA: Ten Speed Pr.
34. Ritchie G, Still K, Rossi J 3rd, Bekkedal M, Bobb A, et al (2003) Biological and health effects of exposure to kerosene-based jet fuels and performance additives. J Toxicol Environ Health B Crit Rev 6: 357-451.
35. Beck JP, Heutelbeck A, Dunkelberg H, (2007) Volatile organic compounds in dwelling houses and stables of dairy and cattle farms in Northern Germany. Sci Total Environ 372: 440-454.
36. Cincinelli A, Bubba MD, Martellini T, Gambaro A, Lepri L, (2007) Gas-particle concentration and distribution of n-alkanes and polycyclic aromatic hydrocarbons in the atmosphere of Prato (Italy). Chemosphere 68: 472-478.
37. Ting JT, Wu SS, Ratnayake C, Huang AH, (1998) Constituents of the tapetosomes and elaioplasts in Brassica campestris tapetum and their degradation and retention during microsporogenesis. Plant J 16: 541-551.
38. Ajuwon KM, Spurlock ME, (2005) Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. J Nutr 135: 1841-1846.
39. Joshi-Barve S, Barve SS, Amancherla K, Gobejishvili L, Hill D, et al. (2007) Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology.
40. Laine PS, Schwartz EA, Wang Y, Zhang WY, Karnik SK, et al. (2007) Palmitic acid induces IP-10 expression in human macrophages via NF-kappaB activation. Biochem Biophys Res Commun 358: 150-155.
41. Chang CC, Wright A, Punnonen J, (2000) Monocyte-derived CD1a+ and CD1a- dendritic cell subsets differ in their cytokine production profiles, susceptibilities to transfection, and capacities to direct Th cell differentiation. J Immunol 165: 3584-3591.
42. Jakobsen MA, Petersen RK, Kristiansen K, Lange M, Lillevang ST, (2006) Peroxisome proliferator-activated receptor alpha, delta, gamma1 and gamma2 expressions are present in human monocyte-derived dendritic cells and modulate dendritic cell maturation by addition of subtype-specific ligands. Scand J Immunol 63: 330-337.
43. Palmer CN, Doney AS, Ismail T, Lee SP, Murrie I, et al. (2007) PPARG locus haplotype variation and exacerbations in asthma. Clin Pharmacol Ther 81: 713-718.
44. Lee JY, Hwang DH, (2006) The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors. Mol Cells 21: 174-185.
45. Lee KS, Kim SR, Park SJ, Park HS, Min KH, et al. (2006) Peroxisome proliferator activated receptor-gamma modulates reactive oxygen species generation and activation of nuclear factor-kappaB and hypoxia-inducible factor 1alpha in allergic airway disease of mice. J Allergy Clin Immunol 118: 120-127.
46. Roth M, Black JL, (2006) Transcription factors in asthma: are transcription factors a new target for asthma therapy? Curr Drug Targets 7: 589-595.
47. August A, Mueller C, Weaver V, Polanco TA, Walsh ER, et al. (2006) Nutrients, nuclear receptors, inflammation, immunity lipids, PPAR, and allergic asthma. J Nutr 136: 695-699.
48. Kuroda Y, Nacionales DC, Akaogi J, Reeves WH, Satoh M, (2004) Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine. Biomed Pharmacother 58: 325-337.
49. Kuroda Y, Ono N, Akaogi J, Nacionales DC, Yamasaki Y, et al. (2006) Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice. Toxicology 218: 186-196.
50. Fukanoki SI, Matsumoto K, Mori H, Takeda R, (2000) Adjuvanticity and inflammatory response following administration of water-in-oil emulsions prepared with saturated hydrocarbons in chickens. J Vet Med Sci 62: 917-919.
51. Aceves M, Grimalt JO, Sunyer J, Anto JM, Reed CE, (1991) Identification of soybean dust as an epidemic asthma agent in urban areas by molecular marker and RAST analysis of aerosols. J Allergy Clin Immunol 88: 124-134.
52. Pont F, Gispert X, Canete C, Pinto E, Dot D, et al. (1997) [An epidemic of asthma caused by soybean in L'Hospitalet de Llobregat (Barcelona)]. Arch Bronconeumol 33: 453-456.
53. Kim JL, Elfman L, Mi Y, Wieslander G, Smedje G, et al. (2007) Indoor molds, bacteria, microbial volatile organic compounds and plasticizers in schools-associations with asthma and respiratory symptoms in pupils. Indoor Air 17: 153-163.
54. McEwan M, Macfarlane Smith WH, (1998) Identification of volatile organic compounds emitted in the field by oilseed rape (Brassica napus ssp. oleifera) over the growing season. Clin Exp Allergy 28: 332-338.
55. Taylor PE, Jacobson KW, House JM, Glovsky MM, (2007) Links between Pollen, Atopy and the Asthma Epidemic. Int Arch Allergy Immunol 144: 162-170.
56. Belvisi MG, Hele DJ, Birrell MA, (2004) New advances and potential therapies for the treatment of asthma. BioDrugs 18: 211-223.
57. D'Amato G, Bucchioni E, Oldani V, Canonica W, (2006) Treating Moderate-to-Severe Allergic Asthma with a Recombinant Humanized Anti-IgE Monoclonal Antibody (Omalizumab). Treat Respir Med 5: 393-398.