Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology.

Free Radical Biology and Medicine

Volumn 89, Issue , 2015, Pages 786-792

  Just, Jesper ^a   Jung, Tobias ^b   Friis, Niels Anton ^a   Lykkemark, Simon ^a,c   Drasbek, Kim ^a   Siboska, Gunhild ^a   Grune, Tilman ^b   Kristensen, Peter ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c Sino Danish Centre for Education and Research   (Denmark)

Author keywords

4 hydroxynonenal(HNE); Lipid peroxidation; Oxidativestress; Phage display; Post translational modification; Proteasome; Recombinantantibodies; Unstablemodification

Indexed keywords

20S PROTEASOME SUBUNIT ALPHA7; 4 HYDROXYNONENAL; EPITOPE; PROTEASOME; RECOMBINANT ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; 4-HYDROXY-2-NONENAL; ALDEHYDE; IMMUNOGLOBULIN VARIABLE REGION; PSMA7 PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CELL METABOLISM; COVALENT BOND; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; MOLECULAR STABILITY; OXIDATIVE STRESS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN SUBUNIT; REGULATORY MECHANISM; TURNOVER TIME; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; METABOLISM; PHYSIOLOGY; WESTERN BLOTTING;

ALDEHYDES; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT PROTEINS;

EID: 84945177377     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.10.405     Document Type: Article

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