Lipofuscin inhibits the proteasome by binding to surface motifs

Free Radical Biology and Medicine

Volumn 50, Issue 5, 2011, Pages 585-591

  Höhn, Annika ^a,b   Jung, Tobias ^a,b   Grimm, Stefanie ^a,b   Catalgol, Betül ^b   Weber, Daniela ^a,b   Grune, Tilman ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

Aging; Free radicals; Lipofuscin; Proteasome; Protein aggregates; Protein oxidation

Indexed keywords

LIPOFUSCIN; PROTEASOME;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MOTIF;

CELL AGING; CELLS, CULTURED; ENDOPEPTIDASE K; FIBROBLASTS; HUMANS; LIPOFUSCIN; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 79551492104     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.12.011     Document Type: Article

References (21)

1. J.M. Gutteridge Age pigments: role of iron and copper salts in the formation of fluorescent lipid complexes Mech. Ageing Dev. 25 1984 205 214
2. T. Jung, N. Bader, and T. Grune Lipofuscin: formation, distribution, and metabolic consequences Ann. NY Acad. Sci. 1119 2007 97 111
3. S.H. Benavides, A.J. Monserrat, S. Farina, and E.A. Porta Sequential histochemical studies of neuronal lipofuscin in human cerebral cortex from the first to the ninth decade of life Arch. Gerontol. Geriatr. 34 2002 219 231
4. T. Jung, A. Höhn, B. Catalgol, and T. Grune Age-related differences in oxidative protein-damage in young and senescent fibroblasts Arch. Biochem. Biophys. 483 2009 127 135
5. D. Yin Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores Free Radic. Biol. Med. 21 1996 871 888
6. A. Terman, T. Kurz, M. Navratil, E.A. Arriaga, and U.T. Brunk Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging Antioxid. Redox Signaling 12 2010 503 535
7. U.T. Brunk, and A. Terman The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis Eur. J. Biochem. 269 2002 1996 2002
8. A. Höhn, T. Jung, S. Grimm, and T. Grune Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells Free Radic. Biol. Med. 48 2010 1100 1108
9. T. Kurz, A. Terman, B. Gustafsson, and U.T. Brunk Lysosomes in iron metabolism, ageing and apoptosis Histochem. Cell Biol. 129 2008 389 406
10. N. Bader, T. Jung, and T. Grune The proteasome and its role in nuclear protein maintenance Exp. Gerontol. 42 2007 864 870
11. R. Shringarpure, T. Grune, N. Sitte, and K.J. Davies 4-Hydroxynonenal- modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimers disease Cell. Mol. Life Sci. 57 2000 1802 1809
12. J.A. Cohn, L. Tsai, B. Friguet, and L.I. Szweda Chemical characterization of a protein-4-hydroxy-2-nonenal cross-link: immunochemical detection in mitochondria exposed to oxidative stress Arch. Biochem. Biophys. 328 1996 158 164
13. R.E. Pacifici, Y. Kono, and K.J. Davies Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome J. Biol. Chem. 268 1993 15405 15411
14. R.L. Levine, J. Moskovitz, and E.R. Stadtman Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation IUBMB Life 50 2000 301 307
15. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63
16. A. Stolzing, A. Wengner, and T. Grune Degradation of oxidized extracellular proteins by microglia Arch. Biochem. Biophys. 400 2002 171 179
17. M. Demasi, and K.J. Davies Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism FEBS Lett. 542 2003 89 94
18. A. Terman Garbage catastrophe theory of aging: imperfect removal of oxidative damage? Redox Rep. 6 2001 15 26
19. A. Terman, and U.T. Brunk Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis Mech. Ageing Dev. 104 1998 277 291
20. N. Sitte, M. Huber, T. Grune, A. Ladhoff, W.D. Doecke, Z.T. Von, and K.J. Davies Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts FASEB J. 14 2000 1490 1498
21. S.R. Powell, P. Wang, A. Divald, S. Teichberg, V. Haridas, T.W. McCloskey, K.J. Davies, and H. Katzeff Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins Free Radic. Biol. Med. 38 2005 1093 1101