Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts

Free Radical Biology and Medicine

Volumn 53, Issue 9, 2012, Pages 1760-1769

  Höhn, Annika ^a,b   Sittig, Anna ^b   Jung, Tobias ^a   Grimm, Stefanie ^a   Grune, Tilman ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

Aging; Lipofuscin; Lysosome; Macroautophagy; Oxidative stress; Stress induced premature senescence (SIPS)

Indexed keywords

AUTOPHAGY PROTEIN 5; BIOLOGICAL MARKER; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LIPOFUSCIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROTEIN ATG12; PROTEIN LC3I; PROTEIN LC3II; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BIOACCUMULATION; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; CYTOSOL; EMBRYO; HUMAN; HUMAN CELL; LYSOSOME; MACROAUTOPHAGY; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; SENESCENCE; SKIN FIBROBLAST; STRESS INDUCED PREMATURE SENESCENCE;

ANIMALS; AUTOPHAGY; CELL AGING; CELL LINE; FIBROBLASTS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIPOFUSCIN; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MICE; MICROTUBULE-ASSOCIATED PROTEINS; OXIDATIVE STRESS; PARAQUAT; PHAGOSOMES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84867347561     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.08.591     Document Type: Article

References (34)

1. A. Höhn, T. Jung, S. Grimm, B. Catalgol, D. Weber, and T. Grune Lipofuscin inhibits the proteasome by binding to surface motifs Free Radic. Biol. Med. 50 2011 585 591
2. N. Sitte, M. Huber, T. Grune, A. Ladhoff, W.D. Doecke, and Z.T. Von Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts FASEB J 14 2000 1490 1498
3. A. Overbye, M. Fengsrud, and P.O. Seglen Proteomic analysis of membrane-associated proteins from rat liver autophagosomes Autophagy 3 2007 300 322
4. N. Mizushima, A. Yamamoto, M. Hatano, Y. Kobayashi, Y. Kabeya, and K. Suzuki Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells J. Cell Biol 152 2001 657 668
5. Y. Kabeya, N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, and T. Noda LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J 19 2000 5720 5728
6. D.A. Wenger, S. Coppola, and S.L. Liu Insights into the diagnosis and treatment of lysosomal storage diseases Arch. Neurol 60 2003 322 328
7. A.M. Cuervo, and J.F. Dice When lysosomes get old Exp. Gerontol. 35 2000 119 131
8. G. Lynch, and X. Bi Lysosomes and brain aging in mammals Neurochem. Res 28 2003 1725 1734
9. E.E. O., Medrano, and Z.T. Von Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes Exp. Gerontol 35 2000 927 945
10. A. Kuma, M. Hatano, M. Matsui, A. Yamamoto, H. Nakaya, and T. Yoshimori The role of autophagy during the early neonatal starvation period Nature 432 2004 1032 1036
11. Höhn, A.; Jung, T.; Grimm, S.; Grune, T. Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells. Free Radic. Biol. Med. 2010.
12. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63
13. A. Biederbick, H.F. Kern, and H.P. Elsasser Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles Eur. J. Cell Biol 66 1995 3 14
14. T. Jung, A. Höhn, B. Catalgol, and T. Grune Age-related differences in oxidative protein-damage in young and senescent fibroblasts Arch. Biochem. Biophys 483 2009 127 135
15. I. Nishino Autophagic vacuolar myopathies Curr. Neurol. Neurosci. Rep. 3 2003 64 69
16. M.C. Malicdan, and I. Nishino Autophagy in lysosomal myopathies Brain Pathol. 22 2012 82 88
17. P. Anglade, S. Vyas, F. Javoy-Agid, M.T. Herrero, P.P. Michel, and J. Marquez Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease Histol. Histopathol 12 1997 25 31
18. A.M. Cataldo, D.J. Hamilton, J.L. Barnett, P.A. Paskevich, and R.A. Nixon Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease J. Neurosci 16 1996 186 199
19. K.B. Kegel, M. Kim, E. Sapp, C. McIntyre, J.G. Castano, and N. Aronin Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy J. Neurosci. 20 2000 7268 7278
20. W.F. Ward The relentless effects of the aging process on protein turnover Biogerontology 1 2000 195 199
21. A. Terman The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes Gerontology 41 2 1995 319 326
22. A.M. Cuervo, and J.F. Dice Age-related decline in chaperone-mediated autophagy J. Biol. Chem. 275 2000 31505 31513
23. S. Goto, R. Takahashi, A.A. Kumiyama, Z. Radak, T. Hayashi, and M. Takenouchi Implications of protein degradation in aging Ann. N. Y. Acad. Sci. 928 2001 54 64
24. T. Jung, N. Bader, and T. Grune Lipofuscin: formation, distribution, and metabolic consequences Ann. N. Y. Acad. Sci. 1119 2007 97 111
25. R.S. Sohal, and U.T. Brunk Mitochondrial production of pro-oxidants and cellular senescence Mutat. Res 275 1992 295 304
26. U.T. Brunk, and A. Terman Lipofuscin: mechanisms of age-related accumulation and influence on cell function Free Radic. Biol. Med 33 2002 611 619
27. G.P. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, and C. Roskelley A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc. Natl. Acad. Sci. USA 92 1995 9363 9367
28. 2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase Exp. Gerontol 39 2004 1379 1389
29. E. Levine, and E.M. Eagle H. Morphologic changes accompanying senescence of cultured human diploid cells J. Exp. Med 131 1970 1211 1222
30. U. Brunk Distribution and shifts of ingested marker particles in residual bodies and other lysosomes. Studies on in vitro cultivated human glia cells in phase II and 3 Exp. Eye Res 79 1973 15 27
31. N. Chondrogianni, F.L. Stratford, I.P. Trougakos, B. Friguet, A.J. Rivett, and E.S. Gonos Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation J. Biol. Chem 278 2003 28026 28037
32. A. Hinton, S.R. Sennoune, S. Bond, M. Fang, M. Reuveni, and G.G. Sahagian Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells J. Biol. Chem 284 2009 16400 16408
33. J.A. Sobota, N. Back, B.A. Eipper, and R.E. Mains Inhibitors of the V0 subunit of the vacuolar H-ATPase prevent segregation of lysosomal- and secretory-pathway proteins J. Cell Sci 122 2009 3542 3553
34. Y. Nishida, S. Arakawa, K. Fujitani, H. Yamaguchi, T. Mizuta, and T. Kanaseki Discovery of Atg5/Atg7-independent alternative macroautophagy Nature 461 2009 654 658