메뉴 건너뛰기




Volumn 6, Issue 30, 2015, Pages 30006-30016

MiR-146b-5p mediates p16-dependent repression of IL-6 and suppresses paracrine procarcinogenic effects of breast stromal fibroblasts

Author keywords

Breast cancer; Cancer associated fibroblasts; IL 6; MiR 146b 5p; p16INK4A

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 6; MICRORNA; MICRORNA 146B 5P; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B; PROTEIN P16; UNCLASSIFIED DRUG; VIMENTIN; 3' UNTRANSLATED REGION; ANTINEOPLASTIC AGENT; CURCUMIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MIRN146 MICRORNA, HUMAN;

EID: 84945162098     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4933     Document Type: Article
Times cited : (40)

References (32)
  • 2
    • 84876721085 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts: Non-neoplastic tumour-promoting mesenchymal cells
    • Polanska UM, Orimo A. Carcinoma-associated fibroblasts: Non-neoplastic tumour-promoting mesenchymal cells. J Cell Physiol. 2013; 228:1651-1657.
    • (2013) J Cell Physiol , vol.228 , pp. 1651-1657
    • Polanska, U.M.1    Orimo, A.2
  • 3
    • 84877585372 scopus 로고    scopus 로고
    • p16(INK4A) Represses the paracrine tumor-promoting effects of breast stromal fibroblasts
    • Al-Ansari MM, Hendrayani SF, Shehata AI, Aboussekhra A. p16(INK4A) Represses the paracrine tumor-promoting effects of breast stromal fibroblasts. Oncogene. 2013; 32:2356-2364.
    • (2013) Oncogene , vol.32 , pp. 2356-2364
    • Al-Ansari, M.M.1    Hendrayani, S.F.2    Shehata, A.I.3    Aboussekhra, A.4
  • 4
    • 82555196948 scopus 로고    scopus 로고
    • Role of cancer-associated fibroblasts in breast cancer development and prognosis
    • Aboussekhra A. Role of cancer-associated fibroblasts in breast cancer development and prognosis. The International journal of developmental biology. 2011; 55:841-849.
    • (2011) The International journal of developmental biology , vol.55 , pp. 841-849
    • Aboussekhra, A.1
  • 5
    • 84909607972 scopus 로고    scopus 로고
    • The Cytokine IL-6 Reactivates Breast Stromal Fibroblasts through Transcription Factor STAT3-dependent Up-regulation of the RNA-binding Protein AUF1
    • Hendrayani SF, Al-Khalaf HH, Aboussekhra A. The Cytokine IL-6 Reactivates Breast Stromal Fibroblasts through Transcription Factor STAT3-dependent Up-regulation of the RNA-binding Protein AUF1. J Biol Chem. 2014; 289:30962-30976.
    • (2014) J Biol Chem , vol.289 , pp. 30962-30976
    • Hendrayani, S.F.1    Al-Khalaf, H.H.2    Aboussekhra, A.3
  • 6
    • 84877826703 scopus 로고    scopus 로고
    • The role of intratumoral and systemic IL-6 in breast cancer
    • Dethlefsen C, Hojfeldt G, Hojman P. The role of intratumoral and systemic IL-6 in breast cancer. Breast Cancer Res Treat. 2013; 138:657-664.
    • (2013) Breast Cancer Res Treat , vol.138 , pp. 657-664
    • Dethlefsen, C.1    Hojfeldt, G.2    Hojman, P.3
  • 8
    • 84880934991 scopus 로고    scopus 로고
    • Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors
    • Erez N, Glanz S, Raz Y, Avivi C, Barshack I. Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. Biochem Biophys Res Commun. 2013; 437:397-402.
    • (2013) Biochem Biophys Res Commun , vol.437 , pp. 397-402
    • Erez, N.1    Glanz, S.2    Raz, Y.3    Avivi, C.4    Barshack, I.5
  • 11
    • 0034468513 scopus 로고    scopus 로고
    • Post-transcriptional regulation of pro-inflammatory gene expression
    • Clark A. Post-transcriptional regulation of pro-inflammatory gene expression. Arthritis research. 2000; 2:172-174.
    • (2000) Arthritis research , vol.2 , pp. 172-174
    • Clark, A.1
  • 14
    • 84864300017 scopus 로고    scopus 로고
    • microRNA involvement in human cancer
    • Iorio MV, Croce CM. microRNA involvement in human cancer. Carcinogenesis. 2012; 33:1126-1133.
    • (2012) Carcinogenesis , vol.33 , pp. 1126-1133
    • Iorio, M.V.1    Croce, C.M.2
  • 16
    • 84890296289 scopus 로고    scopus 로고
    • The Cyclin-dependent Kinase Inhibitor p16INK4a Physically Interacts with Transcription Factor Sp1 and Cyclin-dependent Kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p Spontaneously and in Response to Ultraviolet Light-induced DNA Damage
    • Al-Khalaf HH, Mohideen P, Nallar SC, Kalvakolanu DV, Aboussekhra A. The Cyclin-dependent Kinase Inhibitor p16INK4a Physically Interacts with Transcription Factor Sp1 and Cyclin-dependent Kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p Spontaneously and in Response to Ultraviolet Light-induced DNA Damage. J Biol Chem. 2013; 288:35511-35525.
    • (2013) J Biol Chem , vol.288 , pp. 35511-35525
    • Al-Khalaf, H.H.1    Mohideen, P.2    Nallar, S.C.3    Kalvakolanu, D.V.4    Aboussekhra, A.5
  • 17
    • 52149102044 scopus 로고    scopus 로고
    • Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells
    • Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, Benz CC. Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene. 2008; 27:5643-5647.
    • (2008) Oncogene , vol.27 , pp. 5643-5647
    • Bhaumik, D.1    Scott, G.K.2    Schokrpur, S.3    Patil, C.K.4    Campisi, J.5    Benz, C.C.6
  • 18
    • 78649258023 scopus 로고    scopus 로고
    • MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma
    • Katakowski M, Zheng X, Jiang F, Rogers T, Szalad A, Chopp M. MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma. Cancer Invest. 2010; 28:1024-1030.
    • (2010) Cancer Invest , vol.28 , pp. 1024-1030
    • Katakowski, M.1    Zheng, X.2    Jiang, F.3    Rogers, T.4    Szalad, A.5    Chopp, M.6
  • 20
    • 60549090858 scopus 로고    scopus 로고
    • Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis
    • Hurst DR, Edmonds MD, Scott GK, Benz CC, Vaidya KS, Welch DR. Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. Cancer Res. 2009; 69:1279-1283.
    • (2009) Cancer Res , vol.69 , pp. 1279-1283
    • Hurst, D.R.1    Edmonds, M.D.2    Scott, G.K.3    Benz, C.C.4    Vaidya, K.S.5    Welch, D.R.6
  • 21
    • 33747608638 scopus 로고    scopus 로고
    • NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A. 2006; 103:12481-12486.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 22
    • 84878644283 scopus 로고    scopus 로고
    • Curcumin triggers p16-dependent senescence in active breast cancerassociated fibroblasts and suppresses their paracrine procarcinogenic effects
    • Hendrayani SF, Al-Khalaf HH, Aboussekhra A. Curcumin triggers p16-dependent senescence in active breast cancerassociated fibroblasts and suppresses their paracrine procarcinogenic effects. Neoplasia. 2013; 15:631-640.
    • (2013) Neoplasia , vol.15 , pp. 631-640
    • Hendrayani, S.F.1    Al-Khalaf, H.H.2    Aboussekhra, A.3
  • 23
    • 0032587245 scopus 로고    scopus 로고
    • Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis
    • Taniguchi K, Kohsaka H, Inoue N, Terada Y, Ito H, Hirokawa K, Miyasaka N. Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis. Nat Med. 1999; 5:760-767.
    • (1999) Nat Med , vol.5 , pp. 760-767
    • Taniguchi, K.1    Kohsaka, H.2    Inoue, N.3    Terada, Y.4    Ito, H.5    Hirokawa, K.6    Miyasaka, N.7
  • 24
    • 0034671571 scopus 로고    scopus 로고
    • Adenoviral transfer of cyclindependent kinase inhibitor genes suppresses collageninduced arthritis in mice
    • Nasu K, Kohsaka H, Nonomura Y, Terada Y, Ito H, Hirokawa K, Miyasaka N. Adenoviral transfer of cyclindependent kinase inhibitor genes suppresses collageninduced arthritis in mice. J Immunol. 2000; 165:7246-7252.
    • (2000) J Immunol , vol.165 , pp. 7246-7252
    • Nasu, K.1    Kohsaka, H.2    Nonomura, Y.3    Terada, Y.4    Ito, H.5    Hirokawa, K.6    Miyasaka, N.7
  • 25
    • 84868589822 scopus 로고    scopus 로고
    • p16(INK4a) exerts an anti-inflammatory effect through accelerated IRAK1 degradation in macrophages
    • Murakami Y, Mizoguchi F, Saito T, Miyasaka N, Kohsaka H. p16(INK4a) exerts an anti-inflammatory effect through accelerated IRAK1 degradation in macrophages. J Immunol. 2012; 189:5066-5072.
    • (2012) J Immunol , vol.189 , pp. 5066-5072
    • Murakami, Y.1    Mizoguchi, F.2    Saito, T.3    Miyasaka, N.4    Kohsaka, H.5
  • 28
    • 84865440355 scopus 로고    scopus 로고
    • MiRNA expression analysis of cancer-associated fibroblasts and normal fibroblasts in breast cancer
    • Zhao L, Sun Y, Hou Y, Peng Q, Wang L, Luo H, Tang X, Zeng Z, Liu M. MiRNA expression analysis of cancer-associated fibroblasts and normal fibroblasts in breast cancer. Int J Biochem Cell Biol. 2012; 44:2051-2059.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 2051-2059
    • Zhao, L.1    Sun, Y.2    Hou, Y.3    Peng, Q.4    Wang, L.5    Luo, H.6    Tang, X.7    Zeng, Z.8    Liu, M.9
  • 29
    • 84909953901 scopus 로고    scopus 로고
    • MicroRNA-141 and MicroRNA-146b-5p Inhibit the Prometastatic Mesenchymal Characteristics through the RNA-binding Protein AUF1 Targeting the Transcription Factor ZEB1 and the Protein Kinase AKT
    • Al-Khalaf HH, Aboussekhra A. MicroRNA-141 and MicroRNA-146b-5p Inhibit the Prometastatic Mesenchymal Characteristics through the RNA-binding Protein AUF1 Targeting the Transcription Factor ZEB1 and the Protein Kinase AKT. J Biol Chem. 2014; 289:31433-31447.
    • (2014) J Biol Chem , vol.289 , pp. 31433-31447
    • Al-Khalaf, H.H.1    Aboussekhra, A.2
  • 32
    • 33846657255 scopus 로고    scopus 로고
    • The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light
    • Al-Mohanna MA, Al-Khalaf HH, Al-Yousef N, Aboussekhra A. The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light. Nucleic Acids Res. 2007; 35:223-233.
    • (2007) Nucleic Acids Res , vol.35 , pp. 223-233
    • Al-Mohanna, M.A.1    Al-Khalaf, H.H.2    Al-Yousef, N.3    Aboussekhra, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.