Post-transcriptional regulation of pro-inflammatory gene expression

Arthritis Research

Volumn 2, Issue 3, 2000, Pages 172-174

  Clark, A ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Adenosine uridine rich element; Dexamethasone; Inflammation; MRNA stability; Translation; Tumour necrosis factor

Indexed keywords

ADENOSINE DERIVATIVE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; CYTOKINE; DACTINOMYCIN; DEXAMETHASONE; GLUCOCORTICOID; GROWTH FACTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; POLYADENYLIC ACID; PROLINE DERIVATIVE; PROTEIN INHIBITOR; REGULATOR PROTEIN; RNA; RNA BINDING PROTEIN; SYNAPTOPHYSIN; TRANS ACTING FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNINDEXED DRUG; URIDINE DERIVATIVE; VASCULAR CELL ADHESION MOLECULE 1; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL FUNCTION; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GENETIC ANALYSIS; IMMUNE RESPONSE; INFLAMMATION; MEDIATOR RELEASE; MOUSE; NONHUMAN; NOTE; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; RNA STABILITY; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

HUMANS; RHEUMATIC DISEASES; RNA PROCESSING, POST-TRANSCRIPTIONAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034468513     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar83     Document Type: Note

References (24)

1. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
2. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators
3. AU-rich elements: Characterization and importance in mRNA degradation
4. Binding of neuronal ELAV-like proteins to the uridine-rich sequence in the 3′-untranslated region of tumor necrosis factor-alpha messenger RNA
5. Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA
6. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
7. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
8. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
9. Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay
10. Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha
11. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
12. Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level
13. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis
14. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
15. p38 mitogen-activated protein kinase inhibitors - Mechanisms and therapeutic potentials
16. Regulation of interleukin-1 beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
17. p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level
18. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
19. Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA
20. Clustered AU-rich elements are the target of IL-10-mediated mRNA destabilization in mouse macrophages
21. Differential regulation of the stability of cytokine mRNAs in lipopolysaccharide-activated blood monocytes in response to interleukin-10
22. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
23. Disease-modifying activity of SB 242235, a selective inhibitor or p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
24. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability