The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote TH17 cell-dependent emphysema

Nature Immunology

Volumn 16, Issue 11, 2015, Pages 1185-1194

  Lu, Wen ^a   You, Ran ^a   Yuan, Xiaoyi ^a   Yang, Tianshu ^a   Samuel, Errol L G ^b   Marcano, Daniela C ^b   Sikkema, William K A ^b   M Tour, James ^b   Rodriguez, Antony ^a,d   Kheradmand, Farrah ^a,c   Corry, David B ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b RICE UNIVERSITY   (United States)

^c Michael E Debakey VA Center for Translational Research on Inflammatory Diseases   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD86 ANTIGEN; COLLAGENASE 3; CRE RECOMBINASE; GELATINASE A; GELATINASE B; HISTONE DEACETYLASE 4; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23P19; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MICRORNA 22; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P100; PROTEIN P105; PROTEIN P50; PROTEIN P52; TRANSCRIPTION FACTOR AP 1; HDAC4 PROTEIN, HUMAN; HDAC5 PROTEIN, MOUSE; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; MIRN22 MICRORNA, HUMAN; MIRN22 MICRORNA, MOUSE; REPRESSOR PROTEIN; SOOT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVATION; CIGARETTE SMOKE-INDUCED EMPHYSEMA; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; LUNG EMPHYSEMA; MACROPHAGE; MOUSE; MYELOID DENDRITIC CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SMOKING; TH17 CELL; UPREGULATION; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DENDRITIC CELL; DISEASE MODEL; EMPHYSEMA; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; METABOLISM; PATHOLOGY; SOOT; TOXICITY;

ANIMALS; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; EMPHYSEMA; HISTONE DEACETYLASES; HUMANS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; NF-KAPPA B; REPRESSOR PROTEINS; SMOKING; SOOT; TH17 CELLS; TRANSCRIPTION FACTOR AP-1;

EID: 84944899556     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3292     Document Type: Article

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