Multigenerational positive family history of psychiatric disorders is associated with a poor prognosis in bipolar disorder

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 27, Issue 4, 2015, Pages 304-310

  Post, Robert M ^a,b   Altshuler, Lori ^c,d   Kupka, Ralph ^e   McElroy, Susan L ^f,g   Frye, Mark A ^h   Rowe, Michael ^a   Grunze, Heinz ⁱ   Suppes, Trisha ^j,k   Keck, Paul E ^f,g   Leverich, Gabriele S ^a   Nolen, Willem A ^l  

^a Bipolar Collaborative Network   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f LINDNER CENTER OF HOPE   (United States)

^g UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^h MAYO CLINIC   (United States)

ⁱ NEWCASTLE UNIVERSITY   (United Kingdom)

^j STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^l UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL ABUSE; ALCOHOLISM; ANXIETY; ANXIETY DISORDER; ARTICLE; BIPOLAR DISORDER; COMORBIDITY; DEPRESSION; DISEASE ASSOCIATION; DRUG ABUSE; FAMILY HISTORY; HUMAN; MENTAL DISEASE; MENTAL PATIENT; MOOD DISORDER; ONSET AGE; PRIORITY JOURNAL; PROGNOSIS; SUBSTANCE ABUSE; SUICIDE ATTEMPT; UNITED STATES; ADULT; FAMILY; FEMALE; GENETICS; MALE; PSYCHOLOGY;

ADULT; BIPOLAR DISORDER; FAMILY; FEMALE; HUMANS; MALE; MENTAL DISORDERS; PROGNOSIS; SUICIDE, ATTEMPTED;

EID: 84944735117     PISSN: 08950172     EISSN: 15457222     Source Type: Journal    
DOI: 10.1176/appi.neuropsych.14080204     Document Type: Article

References (40)

1. Weissman MM, Wickramaratne P, Nomura Y, et al: Families at high and low risk for depression: a 3-generation study. Arch Gen Psychiatry 2005; 62:29-36
2. Post RM, Leverich GS, Kupka R, et al: Increased parental history of bipolar disorder in the United States: association with early age of onset. Acta Psychiatr Scand 2014; 129:375-382
3. Post RM, Altshuler L, Kupka R, et al: More pernicious course of bipolar disorder in the United States than in many European countries: implications for policy and treatment. J Affect Disord 2014; 160:27-33
4. Post RM, Leverich GS, Kupka R, et al: Increases in multiple psychiatric disorders in relatives of patients with bipolar disorder from the United States compared to the Netherlands and Germany. Acta Psychiatrica Scandinavica 2014; 129:375-382
5. Post RM, Nolen WA, Kupka RW, et al: The Stanley Foundation Bipolar Network. I. Rationale and methods. Br J Psychiatry Suppl 2001; 41:s169-s176
6. Post RM, Leverich GS, Kupka RW, et al: Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood. J Clin Psychiatry 2010; 71:864-872
7. Post RM, Leverich GS, Altshuler LL, et al: Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany. Int Clin Psychopharmacol 2011a; 26:96-106
8. Post RM, Altshuler L, Leverich GS, et al: The impact of verbal abuse on the course of bipolar disorder in patients from the United States. Bipolar Disord (Epub ahead of print, Oct 13, 2014)
9. Perlis RH, Miyahara S, Marangell LB, et al: STEP-BD Investigators: Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry 2004; 55:875-881
10. Post RM, Denicoff KD, Leverich GS, et al: Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method. J Clin Psychiatry 2003; 64:680-690, quiz 738-739
11. Perlis RH, Dennehy EB, Miklowitz DJ, et al: Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study. Bipolar Disord 2009; 11:391-400
12. Lapalme M, Hodgins S, LaRoche C: Children of parents with bipolar disorder: a metaanalysis of risk for mental disorders. Can J Psychiatry 1997; 42:623-631
13. Gottesman II, Laursen TM, Bertelsen A, et al: Severe mental disorders in offspring with 2 psychiatrically ill parents. Arch Gen Psychiatry 2010; 67:252-257
14. Pavuluri MN, Birmaher B, Naylor MW: Pediatric bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 2005; 44:846-871
15. Shonkoff JP, Garner AS; Committee on Psychosocial Aspects of Child and Family Health; Committee on Early Childhood, Adoption, and Dependent Care; Section on Developmental and Behavioral Pediatrics: The lifelong effects of early childhood adversity and toxic stress. Pediatrics 2012; 129:e232-e246
16. Post RM, Altshuler L, Leverich G, et al: More stressors prior to and during the course of bipolar illness in patients from the United States compared with the Netherlands and Germany. Psychiatry Res 2013; 210:880-886
17. Post RM, Altshuler LL, Leverich GS, et al: More medical comor-bidities in patients with bipolar disorder from the United States than from the Netherlands and Germany. J Nerv Ment Dis 2014; 202:265-270
18. Wickramaratne P, Gameroff MJ, Pilowsky DJ, et al: Children of depressed mothers 1 year after remission of maternal depression: findings from the STAR*D-Child study. Am J Psychiatry 2011; 168:593-602
19. Roth TL, Lubin FD, Funk AJ, et al: Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 2009; 65: 760-769
20. Nestler EJ: Epigenetic mechanisms of drug addiction. Neuro- pharmacology 2014; 76:259-268
21. Dias BG, Ressler KJ: Parental olfactory experience influences behavior and neural structure in subsequent generations. Nat Neu- rosci 2014; 17:89-96
22. Szutorisz H, DiNieri JA, Sweet E, Egervari G, Michaelides M, Carter JM, et al: Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation. Neuropsychopharmacology 2014; 39:1315-1323
23. Vassoler FM, Byrnes EM, Pierce RC: The impact of exposure to addictive drugs on future generations: Physiological and behavioral effects. Neuropharmacology 2014; 76:269-75.
24. Craddock N, Jones L, Jones IR, et al: Wellcome Trust Case Control Consortium (WTCCC). Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry 2010; 15:146-153
25. Comings DE: The gene bomb. Duarte, CA, Hope Press, 1996
26. Niculescu AB, Le-Niculescu H: Convergent functional genomics: what we have learned and can learn about genes, pathways, and mechanisms. Neuropsychopharmacology 2010; 35:355-356
27. Nurnberger JI Jr, Koller DL, Jung J, et al: Psychiatric Genomics Consortium Bipolar Group: Identification of pathways for bipolar disorder: a meta-analysis. JAMA Psychiatry 2014; 71:657-664
28. Miklowitz DJ, Schneck CD, Singh MK, et al: Early intervention for symptomatic youth at risk for bipolar disorder: a randomized trial of family-focused therapy. J Am Acad Child Adolesc Psychiatry 2013; 52:121-131
29. Gao K, Wu R, Kemp DE, et al: Efficacy and safety of quetiapine-XR as monotherapy or adjunctive therapy to a mood stabilizer in acute bipolar depression with generalized anxiety disorder and other comorbidities: a randomized, placebo-controlled trial. J Clin Psychiatry 2014; 75:1062-1068
30. Suominen K, Mantere O, Valtonen H, et al: Early age at onset of bipolar disorder is associated with more severe clinical features but delayed treatment seeking. Bipolar Disord 2007; 9:698-705
31. Etain B, Lajnef M, Bellivier F, et al: Clinical expression of bipolar disorder type I as a function of age and polarity at onset: convergent findings in samples from France and the United States. J Clin Psychiatry 2012; 73:e561-e566
32. Drancourt N, Etain B, Lajnef M, et al: Duration of untreated bipolar disorder: missed opportunities on the long road to optimal treatment. Acta Psychiatr Scand 2013; 127:136-144
33. Post RM, Altshuler LL, Leverich GS, et al: Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder. J Affect Disord 2013a; 147:288-294
34. Post RM, Kowatch RA: The health care crisis of childhood-onset bipolar illness: some recommendations for its amelioration. J Clin Psychiatry 2006; 67:115-125
35. Post RM: The perfect storm of childhood onset bipolar disorder. Psy Annals 2009; 39:879-886
36. Post RM, Chang K, Frye MA: Paradigm shift: preliminary clinical categorization of ultrahigh risk for childhood bipolar disorder to facilitate studies on prevention. J Clin Psychiatry 2013; 74:167-169
37. Kessing LV, Hansen HV, Hvenegaard A, et al: Early Intervention Affective Disorders (EIA) Trial Group: Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial. Br J Psychiatry 2013; 202:212-219
38. Kessing LV (ed): Plenary presentation. Seoul, Korea, International Society for Bipolar Disorders, 2014
39. Colton CW, Manderscheid RW: Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states. Prev Chronic Dis 2006; 3:A42
40. Newcomer JW, Hennekens CH: Severe mental illness and risk of cardiovascular disease. JAMA 2007; 298:1794-1796