Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: Randomised clinical trial

British Journal of Psychiatry

Volumn 202, Issue 3, 2013, Pages 212-219

  Kessing, Lars Vedel ^a   Hansen, Hanne Vibe ^a   Hvenegaard, Anne ^b   Christensen, Ellen Margrethe ^a   Dam, Henrik ^a   Gluud, Christian ^a   Wetterslev, Jørn ^a  

^a Rigshospitalet   (Denmark)

^b not available   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; MOOD STABILIZER; NEUROLEPTIC AGENT;

ADULT; AGED; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; COST; GROUP THERAPY; HOSPITAL ADMISSION; HOSPITAL READMISSION; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MANIA; MOOD DISORDER; OUTPATIENT CARE; PSYCHOEDUCATION; PSYCHOTHERAPY; RANDOMIZED CONTROLLED TRIAL; SPECIALIZATION;

EID: 84874910622     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.112.113548     Document Type: Article

References (46)

1. Kessing LV, Hansen MG, Andersen PK. Course of illness in depressive and bipolar disorders. Naturalistic study, 1994-1999. Br J Psychiatry 2004; 185: 372-7. (Pubitemid 39482072)
2. Kessing LV, Hansen MG, Andersen PK, Angst J. The predictive effect of episodes on the risk of recurrence in depressive and bipolar disorders - a life-long perspective. Acta Psychiatr Scand 2004; 109: 339-44. (Pubitemid 38491280)
3. Tohen M, Hennen J, Zarate Jr CM, Baldessarini RJ, Strakowski SM, Stoll AL, et al. Two-year syndromal and functional recovery in 219 cases of firstepisode major affective disorder with psychotic features. Am J Psychiatry 2000; 157: 220-8. (Pubitemid 30080901)
4. Torres IJ, Boudreau VG, Yatham LN. Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis. Acta Psychiatr Scand Suppl 2007; 434: 17-26. (Pubitemid 47231065)
5. Kessing LV, Nilsson FM. Increased risk of developing dementia in patients with major affective disorders compared to patients with other medical illnesses. J Affect Disord 2003; 73: 261-9. (Pubitemid 36120737)
6. Geddes JR, Goodwin GM, Rendell J, Azorin JM, Cipriani A, Ostacher MJ, et al. Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial. Lancet 2010; 375: 385-95.
7. Colom F, Vieta E, Martinez-Aran A, Reinares M, Goikolea JM, Benabarre A, et al. A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remission. Arch Gen Psychiatry 2003; 60: 402-7. (Pubitemid 36403001)
8. Kessing LV, Sondergard L, Kvist K, Andersen PK. Adherence to lithium in naturalistic settings: results from a nationwide pharmacoepidemiological study. Bipolar Disord 2007; 9: 730-6. (Pubitemid 350042408)
9. Macneil CA, Hallam K, Conus P, Henry L, Kader L, Berk M. Are we missing opportunities for early intervention in bipolar disorder? Expert Rev Neurother 2012; 12: 5-7.
10. Macneil CA, Hasty MK, Berk M, Henry L, Evans M, Redlich C, et al. Psychological needs of adolescents in the early phase of bipolar disorder: implications for early intervention. Early Interv Psychiatry 2011; 5: 100-7.
11. Nierenberg AA, Ostacher MJ, Borrelli DJ, Iosifescu DV, Perlis RH, Desrosiers A, et al. The integration of measurement and management for the treatment of bipolar disorder: a STEP-BD model of collaborative care in psychiatry. J Clin Psychiatry 2006; 67 (suppl 11): 3-7. (Pubitemid 44439681)
12. Colom F, Berk L. Psychoeducation as a core element of psychological approaches for bipolar disorder. In Bipolar Disorder: Clinical and Neurobiological Foundations (eds LN Yatham, M Maj): 412-21. John Wiley & Sons, 2010.
13. Post RM, Leverich GS, Kupka RW, Keck Jr PE, McElroy SL, Altshuler LL, et al. Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood. J Clin Psychiatry 2010; 71: 864-72.
14. Rosa AR, Gonzalez-Ortega I, Gonzalez-Pinto A, Echeburúa E, Comes M, Martínez-Àran A, et al. One-year psychosocial functioning in patients in the early vs. late stage of bipolar disorder. Acta Psychiatr Scand 2012; 125: 335-41.
15. Rosa AR, Reinares M, Amann B, Popovic D, Franco C, Comes M, et al. Six-month functional outcome of a bipolar disorder cohort in the context of a specialized-care program. Bipolar Disord 2011; 13: 679-86.
16. Post RM, Fleming J, Kapczinski F. Neurobiological correlates of illness progression in the recurrent affective disorders. J Psychiatr Res 2012; 46: 561-73.
17. Kessing LV, Hellmund G, Andersen PK. Predictors of excellent response to lithium: results from a nationwide register-based study. Int Clin Psychopharmacol 2011; 26: 323-8.
18. Manji HK, Moore GJ, Chen G. Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness. Biol Psychiatry 2000; 48: 740-54.
19. Fountoulakis KN, Vieta E, Bouras C, Notaridis G, Giannakopoulos P, Kaprinis G, et al. A systematic review of existing data on long-term lithium therapy: neuroprotective or neurotoxic? Int J Neuropsychopharmacol 2008; 11: 269-87. (Pubitemid 351231818)
20. Berk M, Hallam K, Lucas N, Hasty M, McNeil CA, Conus P, et al. Early intervention in bipolar disorders: opportunities and pitfalls. Med J Aust 2007; 187: S11-4.
21. Macneil CA, Hasty M, Cotton S, Berk M, Hallam K, Kader L, et al. Can a targeted psychological intervention be effective for young people following a first manic episode? Results from an 18-month pilot study. Early Interv Psychiatry 2012; 6: 380-8.
22. Vieta E. Bipolar units and programmes: are they really needed? World Psychiatry 2011; 10: 152.
23. Zwarenstein M, Treweek S, Gagnier JJ, Altman DG, Tunis S, Haynes B, et al. Improving the reporting of pragmatic trials: an extension of the CONSORT statement. BMJ 2008; 337: a2390.
24. Kessing LV, Hansen HV, Christensen EM, Dam H, Gluud C, Wetterslev J. The effects of centralised and specialised combined pharmacological and psychological intervention compared with decentralised and non-specialised treatment in the early course of severe unipolar and bipolar affective disorders-design of two randomised clinical trials. Trials 2011; 12: 32.
25. World Health Organization. Klassifikation af sygdomme. Systematisk Del [International Statistical Classification of Diseases and Health Related Problems (10th rev, Danish edn)]. Munksgaard, 1993.
26. Goodwin GM. Evidence-based guidelines for treating bipolar disorder: revised second edition - recommendations from the British Association for Psychopharmacology. J Psychopharmacol 2009; 23: 346-88.
27. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978; 133: 429-35. (Pubitemid 9006756)
28. Hamilton M. Development of a rating scale for primary depressive illness. Br J Clin Psychol 1967; 6: 278-96.
29. Munk-Jorgensen P, Mortensen PB. The Danish Psychiatric Central Register. Dan Med Bull 1997; 44: 82-4. (Pubitemid 27110215)
30. Olsen LR, Jensen DV, Noerholm V, Martiny K, Bech P. The internal and external validity of the Major Depression Inventory in measuring severity of depressive states. Psychol Med 2003; 33: 351-6. (Pubitemid 36221467)
31. Hirschfeld RM, Williams JB, Spitzer RL, Calabrese JR, Flynn L, Keck Jr PE, et al. Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire. Am J Psychiatry 2000; 157: 1873-5.
32. Kessing LV, Hansen HV, Ruggeri M, Bech P. Satisfaction with treatment among patients with depressive and bipolar disorders. Soc Psychiatry Psychiatr Epidemiol 2006; 41: 148-55.
33. Kessing LV, Hansen HV, Hougaard E, Hvenegaard A, Albæk J. Preventive Outpatient Treatment in Affective Disorders. Results from a Health Tecnology Assessment (HTA). National Board of Health, Danish Centre for Evaluation and Health Tecnology Assessment, 2006.
34. Danish Ministry of Health. Rate Guidance 2012. Danish Ministry of Health, 2012 (http://www.sum.dk).
35. Kessing LV. Recurrence in affective disorder. II. Effect of age and gender. Br J Psychiatry 1998; 172: 29-34. (Pubitemid 28122523)
36. Munk-Jorgensen P, Mortensen PB. The Danish Psychiatric Central Register. Dan Med Bull 1997; 44: 82-4. (Pubitemid 27110215)
37. Danish National Board of Health (Sundhedsstyrelsen). Cause of Death in Denmark. Sundhedsstyrelsen, 1992.
38. Khalsa HM, Salvatore P, Hennen J, Baethge C, Tohen M, Baldessarini RJ. Suicidal events and accidents in 216 first-episode bipolar I disorder patients: predictive factors. J Affect Disord 2008; 106: 179-84.
39. Perugi G, Micheli C, Akiskal HS, Madaro D, Socci C, Quilici C, et al. Polarity of the first episode, clinical characteristics, and course of manic depressive illness: a systematic retrospective investigation of 320 bipolar I patients. Compr Psychiatry 2000; 41: 13-8. (Pubitemid 30051762)
40. Kessing LV. Diagnostic stability in bipolar disorder in clinical practise as according to ICD-10. J Affect Disord 2005; 85: 293-9. (Pubitemid 40386513)
41. Goodwin FK, Jamison KR. Manic Depressive Illness. Bipolar Disorder and Recurrent Depression (2nd edn). Oxford University Press, 2007.
42. Kessing LV. Validity of diagnoses and other register data in patients with affective disorder. Eur Psychiatry 1998; 13: 392-8.
43. Burns T. End of the road for treatment-as-usual studies? Br J Psychiatry 2009; 195: 5-6.
44. Gupta RD, Guest JF. Annual cost of bipolar disorder to UK society. Br J Psychiatry 2002; 180: 227-33.
45. Scott J, Colom F, Popova E, Benabarre A, Cruz N, Valenti M, et al. Long-term mental health resource utilization and cost of care following group psychoeducation or unstructured group support for bipolar disorders: a cost-benefit analysis. J Clin Psychiatry 2009; 70: 378-86.
46. Colom F, Vieta E, Sánchez-Moreno J, Palomino-Otiniano R, Reinares M, Goikolea JM, et al. Group psychoeducation for stabilised bipolar disorders: 5-year outcome of a randomised clinical trial. Br J Psychiatry 2009; 194: 260-5.