Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene

Archives of Toxicology

Volumn 90, Issue 9, 2016, Pages 2261-2273

  Shi, Q ^a   Haenen, G R ^a   Maas, L ^a   Arlt, V M ^b,c   Spina, D ^d   Vasquez, Y Riffo ^d   Moonen, E ^a   Veith, C ^a   Van Schooten, F J ^a   Godschalk, R W L ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Benzo a pyrene; Carcinogen metabolism; Cytochrome P450 1A1; DNA adducts; IGF2R; Inflammation; Glucuronidase

Indexed keywords

BENZO[A]PYRENE; BETA GLUCURONIDASE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; GLUCURONOSYLTRANSFERASE 1A6; LIPOPOLYSACCHARIDE; MANNOSE 6 PHOSPHATE; SACCHAROLACTONE; SOMATOMEDIN; SOMATOMEDIN RECEPTOR; AHR PROTEIN, HUMAN; AROMATIC HYDROCARBON RECEPTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BENZO(A)PYRENE-DNA ADDUCT; CARCINOGEN; CYP1A1 PROTEIN, HUMAN; CYP1B1 PROTEIN, HUMAN; DNA ADDUCT; SOMATOMEDIN B RECEPTOR;

A549 CELL LINE; ANIMAL TISSUE; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; CONTROLLED STUDY; DNA ADDUCT; ENZYME ACTIVITY; GENE EXPRESSION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LIMIT OF DETECTION; LIVER; LUNG PARENCHYMA; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; AGONISTS; ANIMAL; BIOTRANSFORMATION; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEP-G2 CELL LINE; LIVER CELL; LUNG; METABOLISM; PATHOLOGY; PNEUMONIA; SIGNAL TRANSDUCTION; TIME FACTOR;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BENZO(A)PYRENE; BIOTRANSFORMATION; CARCINOGENS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1B1; DISEASE MODELS, ANIMAL; DNA ADDUCTS; GLUCURONIDASE; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIPOPOLYSACCHARIDES; LUNG; PNEUMONIA; RECEPTOR, IGF TYPE 2; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84944575866     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1593-7     Document Type: Article

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