-
1
-
-
0034748994
-
Comparison of the levels of enzymes involved in drug metabolism between transgenic or gene-knockout and the parental mice
-
COI: 1:CAS:528:DC%2BD3MXotl2ms70%3D, PID: 11695553
-
Ariyoshi N, Imaoka S, Nakayama K, Takahashi Y, Fujita K, Funae Y, Kamataki T (2001) Comparison of the levels of enzymes involved in drug metabolism between transgenic or gene-knockout and the parental mice. Toxicol Pathol 29(Suppl):161–172
-
(2001)
Toxicol Pathol
, vol.29
, pp. 161-172
-
-
Ariyoshi, N.1
Imaoka, S.2
Nakayama, K.3
Takahashi, Y.4
Fujita, K.5
Funae, Y.6
Kamataki, T.7
-
2
-
-
29144535822
-
3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence
-
COI: 1:CAS:528:DC%2BD2MXhtlagur7L, PID: 16199526
-
Arlt VM (2005) 3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence. Mutagenesis 20:399–410
-
(2005)
Mutagenesis
, vol.20
, pp. 399-410
-
-
Arlt, V.M.1
-
3
-
-
0035427209
-
DNA adduct formation by the ubiquitous environmental contaminant 3-nitrobenzanthrone in rats determined by (32)P-postlabeling
-
COI: 1:CAS:528:DC%2BD3MXlt12gtr8%3D, PID: 11433414
-
Arlt VM, Bieler CA, Mier W, Wiessler M, Schmeiser HH (2001) DNA adduct formation by the ubiquitous environmental contaminant 3-nitrobenzanthrone in rats determined by (32)P-postlabeling. Int J Cancer 93:450–454
-
(2001)
Int J Cancer
, vol.93
, pp. 450-454
-
-
Arlt, V.M.1
Bieler, C.A.2
Mier, W.3
Wiessler, M.4
Schmeiser, H.H.5
-
4
-
-
0036850037
-
Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase
-
COI: 1:CAS:528:DC%2BD38Xps1ehs7k%3D, PID: 12419844
-
Arlt VM, Glatt H, Muckel E, Pabel U, Sorg BL, Schmeiser HH, Phillips DH (2002) Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase. Carcinogenesis 23:1937–1945
-
(2002)
Carcinogenesis
, vol.23
, pp. 1937-1945
-
-
Arlt, V.M.1
Glatt, H.2
Muckel, E.3
Pabel, U.4
Sorg, B.L.5
Schmeiser, H.H.6
Phillips, D.H.7
-
5
-
-
0037939783
-
Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase
-
COI: 1:CAS:528:DC%2BD3sXkt1aju7s%3D, PID: 12782579
-
Arlt VM, Stiborova M, Hewer A, Schmeiser HH, Phillips DH (2003) Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase. Cancer Res 63:2752–2761
-
(2003)
Cancer Res
, vol.63
, pp. 2752-2761
-
-
Arlt, V.M.1
Stiborova, M.2
Hewer, A.3
Schmeiser, H.H.4
Phillips, D.H.5
-
6
-
-
20144388221
-
Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols
-
COI: 1:CAS:528:DC%2BD2MXjtVeqsLw%3D, PID: 15805261
-
Arlt VM, Stiborova M, Henderson CJ, Osborne MR, Bieler CA, Frei E, Martinek V, Sopko B, Wolf CR, Schmeiser HH, Phillips DH (2005) Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols. Cancer Res 65:2644–2652
-
(2005)
Cancer Res
, vol.65
, pp. 2644-2652
-
-
Arlt, V.M.1
Stiborova, M.2
Henderson, C.J.3
Osborne, M.R.4
Bieler, C.A.5
Frei, E.6
Martinek, V.7
Sopko, B.8
Wolf, C.R.9
Schmeiser, H.H.10
Phillips, D.H.11
-
7
-
-
33645659234
-
Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine
-
COI: 1:CAS:528:DC%2BD28XjsVCgtr4%3D, PID: 16331602
-
Arlt VM, Schmeiser HH, Osborne MR, Kawanishi M, Kanno T, Yagi T, Phillips DH, Takamura-Enya T (2006) Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine. Int J Cancer 118:2139–2146
-
(2006)
Int J Cancer
, vol.118
, pp. 2139-2146
-
-
Arlt, V.M.1
Schmeiser, H.H.2
Osborne, M.R.3
Kawanishi, M.4
Kanno, T.5
Yagi, T.6
Phillips, D.H.7
Takamura-Enya, T.8
-
8
-
-
40949083424
-
Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice
-
COI: 1:CAS:528:DC%2BD1cXjsVamsLw%3D, PID: 18204078
-
Arlt VM, Stiborova M, Henderson CJ, Thiemann M, Frei E, Aimova D, Singh R, Gamboa da Costa G, Schmitz OJ, Farmer PB, Wolf CR, Phillips DH (2008) Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice. Carcinogenesis 29:656–665
-
(2008)
Carcinogenesis
, vol.29
, pp. 656-665
-
-
Arlt, V.M.1
Stiborova, M.2
Henderson, C.J.3
Thiemann, M.4
Frei, E.5
Aimova, D.6
Singh, R.7
Gamboa da Costa, G.8
Schmitz, O.J.9
Farmer, P.B.10
Wolf, C.R.11
Phillips, D.H.12
-
9
-
-
84864487999
-
Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling
-
COI: 1:CAS:528:DC%2BC38Xht1SktbfE, PID: 22759596
-
Arlt VM, Poirier MC, Sykes SE, John K, Moserova M, Stiborova M, Wolf CR, Henderson CJ, Phillips DH (2012) Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling. Toxicol Lett 213:160–166
-
(2012)
Toxicol Lett
, vol.213
, pp. 160-166
-
-
Arlt, V.M.1
Poirier, M.C.2
Sykes, S.E.3
John, K.4
Moserova, M.5
Stiborova, M.6
Wolf, C.R.7
Henderson, C.J.8
Phillips, D.H.9
-
10
-
-
0028797624
-
Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes
-
COI: 1:CAS:528:DyaK2MXivVertr4%3D, PID: 7703357
-
Bauer E, Guo Z, Ueng YF, Bell LC, Zeldin D, Guengerich FP (1995) Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes. Chem Res Toxicol 8:136–142
-
(1995)
Chem Res Toxicol
, vol.8
, pp. 136-142
-
-
Bauer, E.1
Guo, Z.2
Ueng, Y.F.3
Bell, L.C.4
Zeldin, D.5
Guengerich, F.P.6
-
11
-
-
78650027929
-
Haplo-insufficiency: a driving force in cancer
-
COI: 1:CAS:528:DC%2BC3MXltlehsw%3D%3D, PID: 21125671
-
Berger AH, Pandolfi PP (2011) Haplo-insufficiency: a driving force in cancer. J Pathol 223(2):137–146
-
(2011)
J Pathol
, vol.223
, Issue.2
, pp. 137-146
-
-
Berger, A.H.1
Pandolfi, P.P.2
-
12
-
-
80051680291
-
A continuum model for tumour suppression
-
COI: 1:CAS:528:DC%2BC3MXhtVOku7zM, PID: 21833082
-
Berger AH, Knudson AG, Pandolfi PP (2011) A continuum model for tumour suppression. Nature 476:163–169
-
(2011)
Nature
, vol.476
, pp. 163-169
-
-
Berger, A.H.1
Knudson, A.G.2
Pandolfi, P.P.3
-
13
-
-
0034751259
-
Mechanisms of hormonal carcinogenesis in the p53 +/- hemizygous knockout mouse: studies with diethylstilbestrol
-
COI: 1:CAS:528:DC%2BD3MXotl2ms7w%3D, PID: 11695552
-
Carmichael PL, Mills JJ, Campbell M, Basu M, Caldwell J (2001) Mechanisms of hormonal carcinogenesis in the p53 +/- hemizygous knockout mouse: studies with diethylstilbestrol. Toxicol Pathol 29(Suppl):155–160
-
(2001)
Toxicol Pathol
, vol.29
, pp. 155-160
-
-
Carmichael, P.L.1
Mills, J.J.2
Campbell, M.3
Basu, M.4
Caldwell, J.5
-
14
-
-
84901235131
-
Insights into wild-type and mutant p53 functions provided by genetically engineered mice
-
COI: 1:CAS:528:DC%2BC2cXosVOnsbY%3D
-
Donehower LA (2014) Insights into wild-type and mutant p53 functions provided by genetically engineered mice. Human Mutat 35:715–727
-
(2014)
Human Mutat
, vol.35
, pp. 715-727
-
-
Donehower, L.A.1
-
15
-
-
24044506283
-
Regulation of DNA damage recognition and nucleotide excision repair: another role for p53
-
COI: 1:CAS:528:DC%2BD2MXosVehu7k%3D, PID: 15927209
-
Ford JM (2005) Regulation of DNA damage recognition and nucleotide excision repair: another role for p53. Mutat Res 577:195–202
-
(2005)
Mutat Res
, vol.577
, pp. 195-202
-
-
Ford, J.M.1
-
16
-
-
84872160824
-
Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53
-
COI: 1:CAS:528:DC%2BC3sXktV2qtw%3D%3D, PID: 23054612
-
Goldstein I, Rivlin N, Shoshana OY, Ezra O, Madar S, Goldfinger N, Rotter V (2013) Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53. Carcinogenesis 34:190–198
-
(2013)
Carcinogenesis
, vol.34
, pp. 190-198
-
-
Goldstein, I.1
Rivlin, N.2
Shoshana, O.Y.3
Ezra, O.4
Madar, S.5
Goldfinger, N.6
Rotter, V.7
-
17
-
-
73649118199
-
Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo
-
PID: 19917589
-
Güngör N, Haegens A, Knaapen AM, Godschalk RW, Chiu RK, Wouters EF, van Schooten FJ (2010) Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo. Mutagenesis 25:77–82
-
(2010)
Mutagenesis
, vol.25
, pp. 77-82
-
-
Güngör, N.1
Haegens, A.2
Knaapen, A.M.3
Godschalk, R.W.4
Chiu, R.K.5
Wouters, E.F.6
van Schooten, F.J.7
-
18
-
-
0032574332
-
Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta Mouse)
-
COI: 1:CAS:528:DyaK1cXitFKnt7k%3D, PID: 9626972
-
Hakura A, Tsutsui Y, Sonoda J, Kai J, Imade T, Shimada M, Sugihara Y, Mikami T (1998) Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta Mouse). Mutat Res 398:123–130
-
(1998)
Mutat Res
, vol.398
, pp. 123-130
-
-
Hakura, A.1
Tsutsui, Y.2
Sonoda, J.3
Kai, J.4
Imade, T.5
Shimada, M.6
Sugihara, Y.7
Mikami, T.8
-
19
-
-
33750595636
-
Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2
-
Hockley SL, Arlt VM, Brewer D, Giddings I, Phillips DH (2006) Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2. BMC Genom 7:260
-
(2006)
BMC Genom
, vol.7
, pp. 260
-
-
Hockley, S.L.1
Arlt, V.M.2
Brewer, D.3
Giddings, I.4
Phillips, D.H.5
-
20
-
-
38849094467
-
Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53
-
COI: 1:CAS:528:DC%2BD1cXhs1aitbs%3D, PID: 17942461
-
Hockley SL, Arlt VM, Jahnke G, Hartwig A, Giddings I, Phillips DH (2008) Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. Carcinogenesis 29:202–210
-
(2008)
Carcinogenesis
, vol.29
, pp. 202-210
-
-
Hockley, S.L.1
Arlt, V.M.2
Jahnke, G.3
Hartwig, A.4
Giddings, I.5
Phillips, D.H.6
-
21
-
-
0028118111
-
Tumor spectrum analysis in p53-mutant mice
-
COI: 1:CAS:528:DyaK2cXhvVygu7k%3D, PID: 7922305
-
Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA (1994) Tumor spectrum analysis in p53-mutant mice. Curr Biol 4:1–7
-
(1994)
Curr Biol
, vol.4
, pp. 1-7
-
-
Jacks, T.1
Remington, L.2
Williams, B.O.3
Schmitt, E.M.4
Halachmi, S.5
Bronson, R.T.6
Weinberg, R.A.7
-
22
-
-
77955354374
-
In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models
-
COI: 1:CAS:528:DC%2BC3cXpvFWqs7o%3D, PID: 20097732
-
Kenzelmann Broz D, Attardi LD (2010) In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis 31:1311–1318
-
(2010)
Carcinogenesis
, vol.31
, pp. 1311-1318
-
-
Kenzelmann Broz, D.1
Attardi, L.D.2
-
23
-
-
0031595916
-
Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1
-
COI: 1:CAS:528:DyaK1cXntVWmsb0%3D, PID: 9806168
-
Kim JH, Stansbury KH, Walker NJ, Trush MA, Strickland PT, Sutter TR (1998) Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1. Carcinogenesis 19:1847–1853
-
(1998)
Carcinogenesis
, vol.19
, pp. 1847-1853
-
-
Kim, J.H.1
Stansbury, K.H.2
Walker, N.J.3
Trush, M.A.4
Strickland, P.T.5
Sutter, T.R.6
-
24
-
-
0037211539
-
Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo
-
COI: 1:CAS:528:DC%2BD38Xptl2hsbs%3D, PID: 12455047
-
Kondraganti SR, Fernandez-Salguero P, Gonzalez FJ, Ramos KS, Jiang W, Moorthy B (2003) Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo. Int J Cancer 103:5–11
-
(2003)
Int J Cancer
, vol.103
, pp. 5-11
-
-
Kondraganti, S.R.1
Fernandez-Salguero, P.2
Gonzalez, F.J.3
Ramos, K.S.4
Jiang, W.5
Moorthy, B.6
-
25
-
-
77953219808
-
Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model
-
COI: 1:CAS:528:DC%2BC3cXnsFOqt7g%3D, PID: 20553493
-
Kucab JE, Phillips DH, Arlt VM (2010) Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model. FEBS J 277:2567–2583
-
(2010)
FEBS J
, vol.277
, pp. 2567-2583
-
-
Kucab, J.E.1
Phillips, D.H.2
Arlt, V.M.3
-
26
-
-
84922985390
-
TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts
-
COI: 1:CAS:528:DC%2BC2MXitl2rs7o%3D
-
Kucab JE, van Steeg H, Luiten M, Schmeiser HH, White PA, Phillips DH, Arlt VM (2015) TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts. Mutat Res, Fundam Mol Mech Mutagen 773:48–62
-
(2015)
Mutat Res, Fundam Mol Mech Mutagen
, vol.773
, pp. 48-62
-
-
Kucab, J.E.1
van Steeg, H.2
Luiten, M.3
Schmeiser, H.H.4
White, P.A.5
Phillips, D.H.6
Arlt, V.M.7
-
27
-
-
33645871837
-
Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair
-
COI: 1:CAS:528:DC%2BD28Xjtlals74%3D, PID: 16556641
-
Langie SA, Knaapen AM, Brauers KJ, van Berlo D, van Schooten FJ, Godschalk RW (2006) Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair. Mutagenesis 21:153–158
-
(2006)
Mutagenesis
, vol.21
, pp. 153-158
-
-
Langie, S.A.1
Knaapen, A.M.2
Brauers, K.J.3
van Berlo, D.4
van Schooten, F.J.5
Godschalk, R.W.6
-
28
-
-
77956069027
-
Mouse models of p53 functions
-
PID: 20452944
-
Lozano G (2010) Mouse models of p53 functions. Cold Spring Harb Perspect Biol 2:a001115
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
, pp. a001115
-
-
Lozano, G.1
-
30
-
-
79955751752
-
Metabolic regulation by p53
-
COI: 1:CAS:528:DC%2BC3MXitlaqt7w%3D, PID: 21340684
-
Maddocks OD, Vousden KH (2011) Metabolic regulation by p53. J Mol Med 89:237–245
-
(2011)
J Mol Med
, vol.89
, pp. 237-245
-
-
Maddocks, O.D.1
Vousden, K.H.2
-
31
-
-
79451472958
-
Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats
-
COI: 1:CAS:528:DC%2BC3MXhsFOnsrY%3D, PID: 21167309
-
Mizerovska J, Dracinska H, Frei E, Schmeiser HH, Arlt VM, Stiborova M (2011) Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats. Mutat Res 720:34–41
-
(2011)
Mutat Res
, vol.720
, pp. 34-41
-
-
Mizerovska, J.1
Dracinska, H.2
Frei, E.3
Schmeiser, H.H.4
Arlt, V.M.5
Stiborova, M.6
-
32
-
-
0034834264
-
Lack of change in the levels of liver and kidney cytochrome P-450 isozymes in p53 +/- knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine
-
COI: 1:CAS:528:DC%2BD3MXntFSqsbo%3D, PID: 11507236
-
Mori Y, Koide A, Fuwa K, Wanibuchi H, Fukushima S (2001) Lack of change in the levels of liver and kidney cytochrome P-450 isozymes in p53 +/- knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Mutagenesis 16:377–383
-
(2001)
Mutagenesis
, vol.16
, pp. 377-383
-
-
Mori, Y.1
Koide, A.2
Fuwa, K.3
Wanibuchi, H.4
Fukushima, S.5
-
33
-
-
33644827547
-
Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on “development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
-
COI: 1:CAS:528:DC%2BD28XhsVSjtbg%3D, PID: 16338979
-
Nebert DW (2006) Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on “development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes”. Am J Physiol Cell Physiol 290:C37–C41
-
(2006)
Am J Physiol Cell Physiol
, vol.290
, pp. C37-C41
-
-
Nebert, D.W.1
-
34
-
-
33845267470
-
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis
-
COI: 1:CAS:528:DC%2BD28Xht1ClsrrN
-
Nebert DW, Dalton TP (2006) The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev 6:947–960
-
(2006)
Nat Rev
, vol.6
, pp. 947-960
-
-
Nebert, D.W.1
Dalton, T.P.2
-
35
-
-
84883148290
-
Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences–Cyp1 knockout mouse lines as a paradigm
-
COI: 1:CAS:528:DC%2BC3sXhtlCmu7jE, PID: 23761301
-
Nebert DW, Shi Z, Galvez-Peralta M, Uno S, Dragin N (2013) Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences–Cyp1 knockout mouse lines as a paradigm. Mol Pharmacol 84:304–313
-
(2013)
Mol Pharmacol
, vol.84
, pp. 304-313
-
-
Nebert, D.W.1
Shi, Z.2
Galvez-Peralta, M.3
Uno, S.4
Dragin, N.5
-
36
-
-
77955363995
-
TP53 mutations in human cancers: origins, consequences, and clinical use
-
PID: 20182602
-
Olivier M, Hollstein M, Hainaut P (2010) TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol 2:a001008
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
, pp. a001008
-
-
Olivier, M.1
Hollstein, M.2
Hainaut, P.3
-
37
-
-
39149106168
-
The 32P-postlabeling assay for DNA adducts
-
COI: 1:CAS:528:DC%2BD2sXhtlSlsr3L
-
Phillips DH, Arlt VM (2007) The 32P-postlabeling assay for DNA adducts. Nat Protocol 2:2772–2781
-
(2007)
Nat Protocol
, vol.2
, pp. 2772-2781
-
-
Phillips, D.H.1
Arlt, V.M.2
-
38
-
-
84908500203
-
(32)P-postlabeling analysis of DNA adducts
-
COI: 1:CAS:528:DC%2BC2MXnt1CktLw%3D
-
Phillips DH, Arlt VM (2014) (32)P-postlabeling analysis of DNA adducts. Meth Mol Biol 1105:127–138
-
(2014)
Meth Mol Biol
, vol.1105
, pp. 127-138
-
-
Phillips, D.H.1
Arlt, V.M.2
-
39
-
-
0037041278
-
The effect of pentachlorophenol on DNA adduct formation in p53 wild-type and knockout mice exposed to benzo[a]pyrene
-
COI: 1:CAS:528:DC%2BD38Xht1ahsbo%3D, PID: 11849736
-
Ress NB, Donnelly KC, George SE (2002) The effect of pentachlorophenol on DNA adduct formation in p53 wild-type and knockout mice exposed to benzo[a]pyrene. Cancer Lett 178:11–17
-
(2002)
Cancer Lett
, vol.178
, pp. 11-17
-
-
Ress, N.B.1
Donnelly, K.C.2
George, S.E.3
-
40
-
-
33751168745
-
Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice
-
COI: 1:CAS:528:DC%2BD28Xht1eqtrnN, PID: 17049425
-
Sagredo C, Ovrebo S, Haugen A, Fujii-Kuriyama Y, Baera R, Botnen IV, Mollerup S (2006) Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice. Toxicol Lett 167:173–182
-
(2006)
Toxicol Lett
, vol.167
, pp. 173-182
-
-
Sagredo, C.1
Ovrebo, S.2
Haugen, A.3
Fujii-Kuriyama, Y.4
Baera, R.5
Botnen, I.V.6
Mollerup, S.7
-
41
-
-
65949086997
-
Biotransformation of benzo[a]pyrene in Ahr knockout mice is dependent on time and route of exposure
-
COI: 1:CAS:528:DC%2BD1MXhvFGntrw%3D, PID: 19216581
-
Sagredo C, Mollerup S, Cole KJ, Phillips DH, Uppstad H, Ovrebo S (2009) Biotransformation of benzo[a]pyrene in Ahr knockout mice is dependent on time and route of exposure. Chem Res Toxicol 22:584–591
-
(2009)
Chem Res Toxicol
, vol.22
, pp. 584-591
-
-
Sagredo, C.1
Mollerup, S.2
Cole, K.J.3
Phillips, D.H.4
Uppstad, H.5
Ovrebo, S.6
-
42
-
-
0035030550
-
Comparative xenobiotic metabolism between Tg.AC and p53 +/- genetically altered mice and their respective wild types
-
COI: 1:CAS:528:DC%2BD3MXjtV2rs7w%3D, PID: 11294974
-
Sanders JM, Burka LT, Chanas B, Matthews HB (2001) Comparative xenobiotic metabolism between Tg.AC and p53 +/- genetically altered mice and their respective wild types. Toxicol Sci 61:54–61
-
(2001)
Toxicol Sci
, vol.61
, pp. 54-61
-
-
Sanders, J.M.1
Burka, L.T.2
Chanas, B.3
Matthews, H.B.4
-
43
-
-
11244344381
-
p53: traffic cop at the crossroads of DNA repair and recombination
-
COI: 1:CAS:528:DC%2BD2MXlvVWh, PID: 15688066
-
Sengupta S, Harris CC (2005) p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol 6:44–55
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 44-55
-
-
Sengupta, S.1
Harris, C.C.2
-
44
-
-
0034681182
-
Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor
-
COI: 1:CAS:528:DC%2BD3cXot1answ%3D%3D, PID: 10639156
-
Shimizu Y, Nakatsuru Y, Ichinose M, Takahashi Y, Kume H, Mimura J, Fujii-Kuriyama Y, Ishikawa T (2000) Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc Natl Acad Sci USA 97:779–782
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 779-782
-
-
Shimizu, Y.1
Nakatsuru, Y.2
Ichinose, M.3
Takahashi, Y.4
Kume, H.5
Mimura, J.6
Fujii-Kuriyama, Y.7
Ishikawa, T.8
-
45
-
-
51549086000
-
Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53
-
COI: 1:CAS:528:DC%2BD1cXhtFCktLvP, PID: 18639569
-
Simoes ML, Hockley SL, Schwerdtle T, da Costa GG, Schmeiser HH, Phillips DH, Arlt VM (2008) Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53. Toxicol Appl Pharmacol 232:86–98
-
(2008)
Toxicol Appl Pharmacol
, vol.232
, pp. 86-98
-
-
Simoes, M.L.1
Hockley, S.L.2
Schwerdtle, T.3
da Costa, G.G.4
Schmeiser, H.H.5
Phillips, D.H.6
Arlt, V.M.7
-
46
-
-
33746075616
-
The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase
-
COI: 1:CAS:528:DC%2BD28Xnslarsrw%3D, PID: 16714372
-
Stiborova M, Dracinska H, Hajkova J, Kaderabkova P, Frei E, Schmeiser HH, Soucek P, Phillips DH, Arlt VM (2006) The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase. Drug Metab Dispos 34:1398–1405
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1398-1405
-
-
Stiborova, M.1
Dracinska, H.2
Hajkova, J.3
Kaderabkova, P.4
Frei, E.5
Schmeiser, H.H.6
Soucek, P.7
Phillips, D.H.8
Arlt, V.M.9
-
47
-
-
41249085471
-
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity
-
COI: 1:CAS:528:DC%2BD1cXksVagtrk%3D, PID: 18329153
-
Stiborova M, Dracinska H, Mizerovska J, Frei E, Schmeiser HH, Hudecek J, Hodek P, Phillips DH, Arlt VM (2008) The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity. Toxicology 247:11–22
-
(2008)
Toxicology
, vol.247
, pp. 11-22
-
-
Stiborova, M.1
Dracinska, H.2
Mizerovska, J.3
Frei, E.4
Schmeiser, H.H.5
Hudecek, J.6
Hodek, P.7
Phillips, D.H.8
Arlt, V.M.9
-
48
-
-
77955347746
-
Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone
-
COI: 1:CAS:528:DC%2BC3cXnsVans70%3D, PID: 20545351
-
Stiborova M, Martinek V, Svobodova M, Sístkova J, Dvorak Z, Ulrichova J, Simanek V, Frei E, Schmeiser HH, Phillips DH, Arlt VM (2010) Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone. Chem Res Toxicol 23:1192–1201
-
(2010)
Chem Res Toxicol
, vol.23
, pp. 1192-1201
-
-
Stiborova, M.1
Martinek, V.2
Svobodova, M.3
Sístkova, J.4
Dvorak, Z.5
Ulrichova, J.6
Simanek, V.7
Frei, E.8
Schmeiser, H.H.9
Phillips, D.H.10
Arlt, V.M.11
-
49
-
-
84896850394
-
Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions
-
COI: 1:CAS:528:DC%2BC2cXkslGksL4%3D, PID: 24530354
-
Stiborova M, Moserova M, Cerna V, Indra R, Dracinsky M, Sulc M, Henderson CJ, Wolf CR, Schmeiser HH, Phillips DH, Frei E, Arlt VM (2014) Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions. Toxicology 318:1–12
-
(2014)
Toxicology
, vol.318
, pp. 1-12
-
-
Stiborova, M.1
Moserova, M.2
Cerna, V.3
Indra, R.4
Dracinsky, M.5
Sulc, M.6
Henderson, C.J.7
Wolf, C.R.8
Schmeiser, H.H.9
Phillips, D.H.10
Frei, E.11
Arlt, V.M.12
-
50
-
-
84860403811
-
Transgenic and knockout mice models to reveal the functions of tumor suppressor genes
-
COI: 1:CAS:528:DC%2BC3MXhtV2mtbbP, PID: 21836819
-
Taneja P, Zhu S, Maglic D, Fry EA, Kendig RD, Inoue K (2011) Transgenic and knockout mice models to reveal the functions of tumor suppressor genes. Clin Med Insights Oncol 5:235–257
-
(2011)
Clin Med Insights Oncol
, vol.5
, pp. 235-257
-
-
Taneja, P.1
Zhu, S.2
Maglic, D.3
Fry, E.A.4
Kendig, R.D.5
Inoue, K.6
-
51
-
-
84878839538
-
Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons
-
PID: 23052197
-
Van Kesteren PCE, Zwart PE, Schaap MM, Pronk TE, van Herwijnen MHM, Kleinjans JCS, Bokkers BGH, Godschalk RWL, Zeilmaker MJ, van Steeg H, Luijten M (2013) Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons. Arch Toxicol 87:505–515
-
(2013)
Arch Toxicol
, vol.87
, pp. 505-515
-
-
Van Kesteren, P.C.E.1
Zwart, P.E.2
Schaap, M.M.3
Pronk, T.E.4
van Herwijnen, M.H.M.5
Kleinjans, J.C.S.6
Bokkers, B.G.H.7
Godschalk, R.W.L.8
Zeilmaker, M.J.9
van Steeg, H.10
Luijten, M.11
-
52
-
-
79551475053
-
Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors
-
COI: 1:CAS:528:DC%2BC3MXht1els7k%3D, PID: 20521247
-
Wang T, Gavin HM, Arlt VM, Lawrence BP, Fenton SE, Medina D, Vorderstrasse BA (2011) Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors. Int J Cancer 128:1509–1523
-
(2011)
Int J Cancer
, vol.128
, pp. 1509-1523
-
-
Wang, T.1
Gavin, H.M.2
Arlt, V.M.3
Lawrence, B.P.4
Fenton, S.E.5
Medina, D.6
Vorderstrasse, B.A.7
-
53
-
-
58849120883
-
p53 polymorphisms: cancer implications
-
COI: 1:CAS:528:DC%2BD1MXpsVCntg%3D%3D
-
Whibley C, Pharoah PD, Hollstein M (2009) p53 polymorphisms: cancer implications. Nature Rev 9:95–107
-
(2009)
Nature Rev
, vol.9
, pp. 95-107
-
-
Whibley, C.1
Pharoah, P.D.2
Hollstein, M.3
-
54
-
-
0024289285
-
Investigation of the bicinchoninic acid protein assay: identification of the groups responsible for color formation
-
COI: 1:CAS:528:DyaL1MXjs1ensQ%3D%3D, PID: 3245570
-
Wiechelman KJ, Braun RD, Fitzpatrick JD (1988) Investigation of the bicinchoninic acid protein assay: identification of the groups responsible for color formation. Anal Biochem 175:231–237
-
(1988)
Anal Biochem
, vol.175
, pp. 231-237
-
-
Wiechelman, K.J.1
Braun, R.D.2
Fitzpatrick, J.D.3
-
55
-
-
84958124444
-
Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53 dependent mechanism. Arch Toxicol
-
Wohak LE, Krais AM, Kucab JE, Stertmann J, Ovrebo S, Seidel A, Phillips DH, Arlt VM (2014) Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53 dependent mechanism. Arch Toxicol, Nov 15 (Epub ahead of print)
-
(2014)
Nov
, vol.15
, Issue.Epub ahead of print
-
-
Wohak, L.E.1
Krais, A.M.2
Kucab, J.E.3
Stertmann, J.4
Ovrebo, S.5
Seidel, A.6
Phillips, D.H.7
Arlt, V.M.8
|