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Volumn 90, Issue 4, 2016, Pages 839-851

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice

Author keywords

Benzo a pyrene; Carcinogen metabolism; Cytochrome P450; DNA adducts; Mouse models; Tumour suppressor p53

Indexed keywords

BENZO[A]PYRENE; CYTOCHROME P450 1A1; PROTEIN P53; BENZO(A)PYRENE-DNA ADDUCT; CARCINOGEN; DNA ADDUCT; NQO1 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

EID: 84960415148     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1531-8     Document Type: Article
Times cited : (41)

References (55)
  • 1
    • 0034748994 scopus 로고    scopus 로고
    • Comparison of the levels of enzymes involved in drug metabolism between transgenic or gene-knockout and the parental mice
    • COI: 1:CAS:528:DC%2BD3MXotl2ms70%3D, PID: 11695553
    • Ariyoshi N, Imaoka S, Nakayama K, Takahashi Y, Fujita K, Funae Y, Kamataki T (2001) Comparison of the levels of enzymes involved in drug metabolism between transgenic or gene-knockout and the parental mice. Toxicol Pathol 29(Suppl):161–172
    • (2001) Toxicol Pathol , vol.29 , pp. 161-172
    • Ariyoshi, N.1    Imaoka, S.2    Nakayama, K.3    Takahashi, Y.4    Fujita, K.5    Funae, Y.6    Kamataki, T.7
  • 2
    • 29144535822 scopus 로고    scopus 로고
    • 3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence
    • COI: 1:CAS:528:DC%2BD2MXhtlagur7L, PID: 16199526
    • Arlt VM (2005) 3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence. Mutagenesis 20:399–410
    • (2005) Mutagenesis , vol.20 , pp. 399-410
    • Arlt, V.M.1
  • 3
    • 0035427209 scopus 로고    scopus 로고
    • DNA adduct formation by the ubiquitous environmental contaminant 3-nitrobenzanthrone in rats determined by (32)P-postlabeling
    • COI: 1:CAS:528:DC%2BD3MXlt12gtr8%3D, PID: 11433414
    • Arlt VM, Bieler CA, Mier W, Wiessler M, Schmeiser HH (2001) DNA adduct formation by the ubiquitous environmental contaminant 3-nitrobenzanthrone in rats determined by (32)P-postlabeling. Int J Cancer 93:450–454
    • (2001) Int J Cancer , vol.93 , pp. 450-454
    • Arlt, V.M.1    Bieler, C.A.2    Mier, W.3    Wiessler, M.4    Schmeiser, H.H.5
  • 4
    • 0036850037 scopus 로고    scopus 로고
    • Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase
    • COI: 1:CAS:528:DC%2BD38Xps1ehs7k%3D, PID: 12419844
    • Arlt VM, Glatt H, Muckel E, Pabel U, Sorg BL, Schmeiser HH, Phillips DH (2002) Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase. Carcinogenesis 23:1937–1945
    • (2002) Carcinogenesis , vol.23 , pp. 1937-1945
    • Arlt, V.M.1    Glatt, H.2    Muckel, E.3    Pabel, U.4    Sorg, B.L.5    Schmeiser, H.H.6    Phillips, D.H.7
  • 5
    • 0037939783 scopus 로고    scopus 로고
    • Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase
    • COI: 1:CAS:528:DC%2BD3sXkt1aju7s%3D, PID: 12782579
    • Arlt VM, Stiborova M, Hewer A, Schmeiser HH, Phillips DH (2003) Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase. Cancer Res 63:2752–2761
    • (2003) Cancer Res , vol.63 , pp. 2752-2761
    • Arlt, V.M.1    Stiborova, M.2    Hewer, A.3    Schmeiser, H.H.4    Phillips, D.H.5
  • 6
    • 20144388221 scopus 로고    scopus 로고
    • Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols
    • COI: 1:CAS:528:DC%2BD2MXjtVeqsLw%3D, PID: 15805261
    • Arlt VM, Stiborova M, Henderson CJ, Osborne MR, Bieler CA, Frei E, Martinek V, Sopko B, Wolf CR, Schmeiser HH, Phillips DH (2005) Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols. Cancer Res 65:2644–2652
    • (2005) Cancer Res , vol.65 , pp. 2644-2652
    • Arlt, V.M.1    Stiborova, M.2    Henderson, C.J.3    Osborne, M.R.4    Bieler, C.A.5    Frei, E.6    Martinek, V.7    Sopko, B.8    Wolf, C.R.9    Schmeiser, H.H.10    Phillips, D.H.11
  • 7
    • 33645659234 scopus 로고    scopus 로고
    • Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine
    • COI: 1:CAS:528:DC%2BD28XjsVCgtr4%3D, PID: 16331602
    • Arlt VM, Schmeiser HH, Osborne MR, Kawanishi M, Kanno T, Yagi T, Phillips DH, Takamura-Enya T (2006) Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine. Int J Cancer 118:2139–2146
    • (2006) Int J Cancer , vol.118 , pp. 2139-2146
    • Arlt, V.M.1    Schmeiser, H.H.2    Osborne, M.R.3    Kawanishi, M.4    Kanno, T.5    Yagi, T.6    Phillips, D.H.7    Takamura-Enya, T.8
  • 9
    • 84864487999 scopus 로고    scopus 로고
    • Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling
    • COI: 1:CAS:528:DC%2BC38Xht1SktbfE, PID: 22759596
    • Arlt VM, Poirier MC, Sykes SE, John K, Moserova M, Stiborova M, Wolf CR, Henderson CJ, Phillips DH (2012) Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling. Toxicol Lett 213:160–166
    • (2012) Toxicol Lett , vol.213 , pp. 160-166
    • Arlt, V.M.1    Poirier, M.C.2    Sykes, S.E.3    John, K.4    Moserova, M.5    Stiborova, M.6    Wolf, C.R.7    Henderson, C.J.8    Phillips, D.H.9
  • 10
    • 0028797624 scopus 로고
    • Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes
    • COI: 1:CAS:528:DyaK2MXivVertr4%3D, PID: 7703357
    • Bauer E, Guo Z, Ueng YF, Bell LC, Zeldin D, Guengerich FP (1995) Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes. Chem Res Toxicol 8:136–142
    • (1995) Chem Res Toxicol , vol.8 , pp. 136-142
    • Bauer, E.1    Guo, Z.2    Ueng, Y.F.3    Bell, L.C.4    Zeldin, D.5    Guengerich, F.P.6
  • 11
    • 78650027929 scopus 로고    scopus 로고
    • Haplo-insufficiency: a driving force in cancer
    • COI: 1:CAS:528:DC%2BC3MXltlehsw%3D%3D, PID: 21125671
    • Berger AH, Pandolfi PP (2011) Haplo-insufficiency: a driving force in cancer. J Pathol 223(2):137–146
    • (2011) J Pathol , vol.223 , Issue.2 , pp. 137-146
    • Berger, A.H.1    Pandolfi, P.P.2
  • 12
    • 80051680291 scopus 로고    scopus 로고
    • A continuum model for tumour suppression
    • COI: 1:CAS:528:DC%2BC3MXhtVOku7zM, PID: 21833082
    • Berger AH, Knudson AG, Pandolfi PP (2011) A continuum model for tumour suppression. Nature 476:163–169
    • (2011) Nature , vol.476 , pp. 163-169
    • Berger, A.H.1    Knudson, A.G.2    Pandolfi, P.P.3
  • 13
    • 0034751259 scopus 로고    scopus 로고
    • Mechanisms of hormonal carcinogenesis in the p53 +/- hemizygous knockout mouse: studies with diethylstilbestrol
    • COI: 1:CAS:528:DC%2BD3MXotl2ms7w%3D, PID: 11695552
    • Carmichael PL, Mills JJ, Campbell M, Basu M, Caldwell J (2001) Mechanisms of hormonal carcinogenesis in the p53 +/- hemizygous knockout mouse: studies with diethylstilbestrol. Toxicol Pathol 29(Suppl):155–160
    • (2001) Toxicol Pathol , vol.29 , pp. 155-160
    • Carmichael, P.L.1    Mills, J.J.2    Campbell, M.3    Basu, M.4    Caldwell, J.5
  • 14
    • 84901235131 scopus 로고    scopus 로고
    • Insights into wild-type and mutant p53 functions provided by genetically engineered mice
    • COI: 1:CAS:528:DC%2BC2cXosVOnsbY%3D
    • Donehower LA (2014) Insights into wild-type and mutant p53 functions provided by genetically engineered mice. Human Mutat 35:715–727
    • (2014) Human Mutat , vol.35 , pp. 715-727
    • Donehower, L.A.1
  • 15
    • 24044506283 scopus 로고    scopus 로고
    • Regulation of DNA damage recognition and nucleotide excision repair: another role for p53
    • COI: 1:CAS:528:DC%2BD2MXosVehu7k%3D, PID: 15927209
    • Ford JM (2005) Regulation of DNA damage recognition and nucleotide excision repair: another role for p53. Mutat Res 577:195–202
    • (2005) Mutat Res , vol.577 , pp. 195-202
    • Ford, J.M.1
  • 16
    • 84872160824 scopus 로고    scopus 로고
    • Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53
    • COI: 1:CAS:528:DC%2BC3sXktV2qtw%3D%3D, PID: 23054612
    • Goldstein I, Rivlin N, Shoshana OY, Ezra O, Madar S, Goldfinger N, Rotter V (2013) Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53. Carcinogenesis 34:190–198
    • (2013) Carcinogenesis , vol.34 , pp. 190-198
    • Goldstein, I.1    Rivlin, N.2    Shoshana, O.Y.3    Ezra, O.4    Madar, S.5    Goldfinger, N.6    Rotter, V.7
  • 18
    • 0032574332 scopus 로고    scopus 로고
    • Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta Mouse)
    • COI: 1:CAS:528:DyaK1cXitFKnt7k%3D, PID: 9626972
    • Hakura A, Tsutsui Y, Sonoda J, Kai J, Imade T, Shimada M, Sugihara Y, Mikami T (1998) Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta Mouse). Mutat Res 398:123–130
    • (1998) Mutat Res , vol.398 , pp. 123-130
    • Hakura, A.1    Tsutsui, Y.2    Sonoda, J.3    Kai, J.4    Imade, T.5    Shimada, M.6    Sugihara, Y.7    Mikami, T.8
  • 19
    • 33750595636 scopus 로고    scopus 로고
    • Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2
    • Hockley SL, Arlt VM, Brewer D, Giddings I, Phillips DH (2006) Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2. BMC Genom 7:260
    • (2006) BMC Genom , vol.7 , pp. 260
    • Hockley, S.L.1    Arlt, V.M.2    Brewer, D.3    Giddings, I.4    Phillips, D.H.5
  • 20
    • 38849094467 scopus 로고    scopus 로고
    • Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53
    • COI: 1:CAS:528:DC%2BD1cXhs1aitbs%3D, PID: 17942461
    • Hockley SL, Arlt VM, Jahnke G, Hartwig A, Giddings I, Phillips DH (2008) Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. Carcinogenesis 29:202–210
    • (2008) Carcinogenesis , vol.29 , pp. 202-210
    • Hockley, S.L.1    Arlt, V.M.2    Jahnke, G.3    Hartwig, A.4    Giddings, I.5    Phillips, D.H.6
  • 22
    • 77955354374 scopus 로고    scopus 로고
    • In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models
    • COI: 1:CAS:528:DC%2BC3cXpvFWqs7o%3D, PID: 20097732
    • Kenzelmann Broz D, Attardi LD (2010) In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis 31:1311–1318
    • (2010) Carcinogenesis , vol.31 , pp. 1311-1318
    • Kenzelmann Broz, D.1    Attardi, L.D.2
  • 23
    • 0031595916 scopus 로고    scopus 로고
    • Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1
    • COI: 1:CAS:528:DyaK1cXntVWmsb0%3D, PID: 9806168
    • Kim JH, Stansbury KH, Walker NJ, Trush MA, Strickland PT, Sutter TR (1998) Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1. Carcinogenesis 19:1847–1853
    • (1998) Carcinogenesis , vol.19 , pp. 1847-1853
    • Kim, J.H.1    Stansbury, K.H.2    Walker, N.J.3    Trush, M.A.4    Strickland, P.T.5    Sutter, T.R.6
  • 24
    • 0037211539 scopus 로고    scopus 로고
    • Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo
    • COI: 1:CAS:528:DC%2BD38Xptl2hsbs%3D, PID: 12455047
    • Kondraganti SR, Fernandez-Salguero P, Gonzalez FJ, Ramos KS, Jiang W, Moorthy B (2003) Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo. Int J Cancer 103:5–11
    • (2003) Int J Cancer , vol.103 , pp. 5-11
    • Kondraganti, S.R.1    Fernandez-Salguero, P.2    Gonzalez, F.J.3    Ramos, K.S.4    Jiang, W.5    Moorthy, B.6
  • 25
    • 77953219808 scopus 로고    scopus 로고
    • Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model
    • COI: 1:CAS:528:DC%2BC3cXnsFOqt7g%3D, PID: 20553493
    • Kucab JE, Phillips DH, Arlt VM (2010) Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model. FEBS J 277:2567–2583
    • (2010) FEBS J , vol.277 , pp. 2567-2583
    • Kucab, J.E.1    Phillips, D.H.2    Arlt, V.M.3
  • 27
    • 33645871837 scopus 로고    scopus 로고
    • Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair
    • COI: 1:CAS:528:DC%2BD28Xjtlals74%3D, PID: 16556641
    • Langie SA, Knaapen AM, Brauers KJ, van Berlo D, van Schooten FJ, Godschalk RW (2006) Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair. Mutagenesis 21:153–158
    • (2006) Mutagenesis , vol.21 , pp. 153-158
    • Langie, S.A.1    Knaapen, A.M.2    Brauers, K.J.3    van Berlo, D.4    van Schooten, F.J.5    Godschalk, R.W.6
  • 28
    • 77956069027 scopus 로고    scopus 로고
    • Mouse models of p53 functions
    • PID: 20452944
    • Lozano G (2010) Mouse models of p53 functions. Cold Spring Harb Perspect Biol 2:a001115
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , pp. a001115
    • Lozano, G.1
  • 30
    • 79955751752 scopus 로고    scopus 로고
    • Metabolic regulation by p53
    • COI: 1:CAS:528:DC%2BC3MXitlaqt7w%3D, PID: 21340684
    • Maddocks OD, Vousden KH (2011) Metabolic regulation by p53. J Mol Med 89:237–245
    • (2011) J Mol Med , vol.89 , pp. 237-245
    • Maddocks, O.D.1    Vousden, K.H.2
  • 31
    • 79451472958 scopus 로고    scopus 로고
    • Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats
    • COI: 1:CAS:528:DC%2BC3MXhsFOnsrY%3D, PID: 21167309
    • Mizerovska J, Dracinska H, Frei E, Schmeiser HH, Arlt VM, Stiborova M (2011) Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats. Mutat Res 720:34–41
    • (2011) Mutat Res , vol.720 , pp. 34-41
    • Mizerovska, J.1    Dracinska, H.2    Frei, E.3    Schmeiser, H.H.4    Arlt, V.M.5    Stiborova, M.6
  • 32
    • 0034834264 scopus 로고    scopus 로고
    • Lack of change in the levels of liver and kidney cytochrome P-450 isozymes in p53 +/- knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine
    • COI: 1:CAS:528:DC%2BD3MXntFSqsbo%3D, PID: 11507236
    • Mori Y, Koide A, Fuwa K, Wanibuchi H, Fukushima S (2001) Lack of change in the levels of liver and kidney cytochrome P-450 isozymes in p53 +/- knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Mutagenesis 16:377–383
    • (2001) Mutagenesis , vol.16 , pp. 377-383
    • Mori, Y.1    Koide, A.2    Fuwa, K.3    Wanibuchi, H.4    Fukushima, S.5
  • 33
    • 33644827547 scopus 로고    scopus 로고
    • Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on “development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
    • COI: 1:CAS:528:DC%2BD28XhsVSjtbg%3D, PID: 16338979
    • Nebert DW (2006) Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on “development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes”. Am J Physiol Cell Physiol 290:C37–C41
    • (2006) Am J Physiol Cell Physiol , vol.290 , pp. C37-C41
    • Nebert, D.W.1
  • 34
    • 33845267470 scopus 로고    scopus 로고
    • The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis
    • COI: 1:CAS:528:DC%2BD28Xht1ClsrrN
    • Nebert DW, Dalton TP (2006) The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev 6:947–960
    • (2006) Nat Rev , vol.6 , pp. 947-960
    • Nebert, D.W.1    Dalton, T.P.2
  • 35
    • 84883148290 scopus 로고    scopus 로고
    • Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences–Cyp1 knockout mouse lines as a paradigm
    • COI: 1:CAS:528:DC%2BC3sXhtlCmu7jE, PID: 23761301
    • Nebert DW, Shi Z, Galvez-Peralta M, Uno S, Dragin N (2013) Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences–Cyp1 knockout mouse lines as a paradigm. Mol Pharmacol 84:304–313
    • (2013) Mol Pharmacol , vol.84 , pp. 304-313
    • Nebert, D.W.1    Shi, Z.2    Galvez-Peralta, M.3    Uno, S.4    Dragin, N.5
  • 36
    • 77955363995 scopus 로고    scopus 로고
    • TP53 mutations in human cancers: origins, consequences, and clinical use
    • PID: 20182602
    • Olivier M, Hollstein M, Hainaut P (2010) TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol 2:a001008
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , pp. a001008
    • Olivier, M.1    Hollstein, M.2    Hainaut, P.3
  • 37
    • 39149106168 scopus 로고    scopus 로고
    • The 32P-postlabeling assay for DNA adducts
    • COI: 1:CAS:528:DC%2BD2sXhtlSlsr3L
    • Phillips DH, Arlt VM (2007) The 32P-postlabeling assay for DNA adducts. Nat Protocol 2:2772–2781
    • (2007) Nat Protocol , vol.2 , pp. 2772-2781
    • Phillips, D.H.1    Arlt, V.M.2
  • 38
    • 84908500203 scopus 로고    scopus 로고
    • (32)P-postlabeling analysis of DNA adducts
    • COI: 1:CAS:528:DC%2BC2MXnt1CktLw%3D
    • Phillips DH, Arlt VM (2014) (32)P-postlabeling analysis of DNA adducts. Meth Mol Biol 1105:127–138
    • (2014) Meth Mol Biol , vol.1105 , pp. 127-138
    • Phillips, D.H.1    Arlt, V.M.2
  • 39
    • 0037041278 scopus 로고    scopus 로고
    • The effect of pentachlorophenol on DNA adduct formation in p53 wild-type and knockout mice exposed to benzo[a]pyrene
    • COI: 1:CAS:528:DC%2BD38Xht1ahsbo%3D, PID: 11849736
    • Ress NB, Donnelly KC, George SE (2002) The effect of pentachlorophenol on DNA adduct formation in p53 wild-type and knockout mice exposed to benzo[a]pyrene. Cancer Lett 178:11–17
    • (2002) Cancer Lett , vol.178 , pp. 11-17
    • Ress, N.B.1    Donnelly, K.C.2    George, S.E.3
  • 40
    • 33751168745 scopus 로고    scopus 로고
    • Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice
    • COI: 1:CAS:528:DC%2BD28Xht1eqtrnN, PID: 17049425
    • Sagredo C, Ovrebo S, Haugen A, Fujii-Kuriyama Y, Baera R, Botnen IV, Mollerup S (2006) Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice. Toxicol Lett 167:173–182
    • (2006) Toxicol Lett , vol.167 , pp. 173-182
    • Sagredo, C.1    Ovrebo, S.2    Haugen, A.3    Fujii-Kuriyama, Y.4    Baera, R.5    Botnen, I.V.6    Mollerup, S.7
  • 41
    • 65949086997 scopus 로고    scopus 로고
    • Biotransformation of benzo[a]pyrene in Ahr knockout mice is dependent on time and route of exposure
    • COI: 1:CAS:528:DC%2BD1MXhvFGntrw%3D, PID: 19216581
    • Sagredo C, Mollerup S, Cole KJ, Phillips DH, Uppstad H, Ovrebo S (2009) Biotransformation of benzo[a]pyrene in Ahr knockout mice is dependent on time and route of exposure. Chem Res Toxicol 22:584–591
    • (2009) Chem Res Toxicol , vol.22 , pp. 584-591
    • Sagredo, C.1    Mollerup, S.2    Cole, K.J.3    Phillips, D.H.4    Uppstad, H.5    Ovrebo, S.6
  • 42
    • 0035030550 scopus 로고    scopus 로고
    • Comparative xenobiotic metabolism between Tg.AC and p53 +/- genetically altered mice and their respective wild types
    • COI: 1:CAS:528:DC%2BD3MXjtV2rs7w%3D, PID: 11294974
    • Sanders JM, Burka LT, Chanas B, Matthews HB (2001) Comparative xenobiotic metabolism between Tg.AC and p53 +/- genetically altered mice and their respective wild types. Toxicol Sci 61:54–61
    • (2001) Toxicol Sci , vol.61 , pp. 54-61
    • Sanders, J.M.1    Burka, L.T.2    Chanas, B.3    Matthews, H.B.4
  • 43
    • 11244344381 scopus 로고    scopus 로고
    • p53: traffic cop at the crossroads of DNA repair and recombination
    • COI: 1:CAS:528:DC%2BD2MXlvVWh, PID: 15688066
    • Sengupta S, Harris CC (2005) p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol 6:44–55
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 44-55
    • Sengupta, S.1    Harris, C.C.2
  • 45
    • 51549086000 scopus 로고    scopus 로고
    • Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53
    • COI: 1:CAS:528:DC%2BD1cXhtFCktLvP, PID: 18639569
    • Simoes ML, Hockley SL, Schwerdtle T, da Costa GG, Schmeiser HH, Phillips DH, Arlt VM (2008) Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53. Toxicol Appl Pharmacol 232:86–98
    • (2008) Toxicol Appl Pharmacol , vol.232 , pp. 86-98
    • Simoes, M.L.1    Hockley, S.L.2    Schwerdtle, T.3    da Costa, G.G.4    Schmeiser, H.H.5    Phillips, D.H.6    Arlt, V.M.7
  • 46
    • 33746075616 scopus 로고    scopus 로고
    • The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase
    • COI: 1:CAS:528:DC%2BD28Xnslarsrw%3D, PID: 16714372
    • Stiborova M, Dracinska H, Hajkova J, Kaderabkova P, Frei E, Schmeiser HH, Soucek P, Phillips DH, Arlt VM (2006) The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase. Drug Metab Dispos 34:1398–1405
    • (2006) Drug Metab Dispos , vol.34 , pp. 1398-1405
    • Stiborova, M.1    Dracinska, H.2    Hajkova, J.3    Kaderabkova, P.4    Frei, E.5    Schmeiser, H.H.6    Soucek, P.7    Phillips, D.H.8    Arlt, V.M.9
  • 47
    • 41249085471 scopus 로고    scopus 로고
    • The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity
    • COI: 1:CAS:528:DC%2BD1cXksVagtrk%3D, PID: 18329153
    • Stiborova M, Dracinska H, Mizerovska J, Frei E, Schmeiser HH, Hudecek J, Hodek P, Phillips DH, Arlt VM (2008) The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity. Toxicology 247:11–22
    • (2008) Toxicology , vol.247 , pp. 11-22
    • Stiborova, M.1    Dracinska, H.2    Mizerovska, J.3    Frei, E.4    Schmeiser, H.H.5    Hudecek, J.6    Hodek, P.7    Phillips, D.H.8    Arlt, V.M.9
  • 49
    • 84896850394 scopus 로고    scopus 로고
    • Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions
    • COI: 1:CAS:528:DC%2BC2cXkslGksL4%3D, PID: 24530354
    • Stiborova M, Moserova M, Cerna V, Indra R, Dracinsky M, Sulc M, Henderson CJ, Wolf CR, Schmeiser HH, Phillips DH, Frei E, Arlt VM (2014) Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions. Toxicology 318:1–12
    • (2014) Toxicology , vol.318 , pp. 1-12
    • Stiborova, M.1    Moserova, M.2    Cerna, V.3    Indra, R.4    Dracinsky, M.5    Sulc, M.6    Henderson, C.J.7    Wolf, C.R.8    Schmeiser, H.H.9    Phillips, D.H.10    Frei, E.11    Arlt, V.M.12
  • 50
    • 84860403811 scopus 로고    scopus 로고
    • Transgenic and knockout mice models to reveal the functions of tumor suppressor genes
    • COI: 1:CAS:528:DC%2BC3MXhtV2mtbbP, PID: 21836819
    • Taneja P, Zhu S, Maglic D, Fry EA, Kendig RD, Inoue K (2011) Transgenic and knockout mice models to reveal the functions of tumor suppressor genes. Clin Med Insights Oncol 5:235–257
    • (2011) Clin Med Insights Oncol , vol.5 , pp. 235-257
    • Taneja, P.1    Zhu, S.2    Maglic, D.3    Fry, E.A.4    Kendig, R.D.5    Inoue, K.6
  • 52
    • 79551475053 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors
    • COI: 1:CAS:528:DC%2BC3MXht1els7k%3D, PID: 20521247
    • Wang T, Gavin HM, Arlt VM, Lawrence BP, Fenton SE, Medina D, Vorderstrasse BA (2011) Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors. Int J Cancer 128:1509–1523
    • (2011) Int J Cancer , vol.128 , pp. 1509-1523
    • Wang, T.1    Gavin, H.M.2    Arlt, V.M.3    Lawrence, B.P.4    Fenton, S.E.5    Medina, D.6    Vorderstrasse, B.A.7
  • 53
    • 58849120883 scopus 로고    scopus 로고
    • p53 polymorphisms: cancer implications
    • COI: 1:CAS:528:DC%2BD1MXpsVCntg%3D%3D
    • Whibley C, Pharoah PD, Hollstein M (2009) p53 polymorphisms: cancer implications. Nature Rev 9:95–107
    • (2009) Nature Rev , vol.9 , pp. 95-107
    • Whibley, C.1    Pharoah, P.D.2    Hollstein, M.3
  • 54
    • 0024289285 scopus 로고
    • Investigation of the bicinchoninic acid protein assay: identification of the groups responsible for color formation
    • COI: 1:CAS:528:DyaL1MXjs1ensQ%3D%3D, PID: 3245570
    • Wiechelman KJ, Braun RD, Fitzpatrick JD (1988) Investigation of the bicinchoninic acid protein assay: identification of the groups responsible for color formation. Anal Biochem 175:231–237
    • (1988) Anal Biochem , vol.175 , pp. 231-237
    • Wiechelman, K.J.1    Braun, R.D.2    Fitzpatrick, J.D.3
  • 55
    • 84958124444 scopus 로고    scopus 로고
    • Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53 dependent mechanism. Arch Toxicol
    • Wohak LE, Krais AM, Kucab JE, Stertmann J, Ovrebo S, Seidel A, Phillips DH, Arlt VM (2014) Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53 dependent mechanism. Arch Toxicol, Nov 15 (Epub ahead of print)
    • (2014) Nov , vol.15 , Issue.Epub ahead of print
    • Wohak, L.E.1    Krais, A.M.2    Kucab, J.E.3    Stertmann, J.4    Ovrebo, S.5    Seidel, A.6    Phillips, D.H.7    Arlt, V.M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.