Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes

Journal of Carcinogenesis

Volumn 11, Issue , 2012, Pages

  Trushin, Neil ^a   Alam, Samina ^a   El Bayoumy, Karam ^a   Krzeminski, Jacek ^a   Amin, Shantu ^a   Gullett, Jenny ^a   Meyers, Craig ^a   Prokopczyk, Bogdan ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

benzo a pyrene; Benzo a pyrene metabolism; cervical cancer; cigarette smoke carcinogen; cytochrome P450 1A1; cytochrome P450 1B1; human papillomavirus

Indexed keywords

BENZO[A]PYRENE; BETA GLUCURONIDASE; CYTOCHROME P450;

ARTICLE; CELL INVASION; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; KERATINOCYTE; PAPILLOMAVIRUS INFECTION; PROTEIN EXPRESSION; SMOKING; UTERINE CERVIX CANCER; VIRUS GENOME; WESTERN BLOTTING;

EID: 84872718113     PISSN: 09746773     EISSN: 14773163     Source Type: Journal    
DOI: 10.4103/1477-3163.92309     Document Type: Article

References (30)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108. (Pubitemid 40372904)
2. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: GLOBOCAN 2000. Int J Cancer 2001;94:153-6. (Pubitemid 32911406)
3. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:518-27. (Pubitemid 36159887)
4. Frattini MG, Lim HB, Laimins LA. In vitro synthesis of oncongenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression. Proc Natl Acad Sci USA 1996;93:3062-7. (Pubitemid 26114363)
5. Doorbar J. Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond) 2006;110:525-41. (Pubitemid 43736116)
6. Woodman CB, Collins SI, Young LS. The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer 2007;7:11-22. (Pubitemid 46020844)
7. Castellsague X, Bosch FX, Munoz N. Environmental co-factors in HPV carcinogenesis. Virus Res 2002;89:191-9. (Pubitemid 35351538)
8. Hoffmann D, Hoffmann I, El-Bayoumy K. The less harmful cigarette: A controversial issue. A tribute to Ernst L. Wynder. Chem Res Toxicol 2001;14:767-90. (Pubitemid 32663874)
9. Hecht SS. Cigarette smoking: cancer risks, carcinogens, and mechanisms. Langenbecks Arch Surg 2006;391:603-13. (Pubitemid 44657742)
10. Koprowska I, Bogacz J. A cyto-pathologic study of tobacco tar-induced lesions of uterine cervix of mouse. J Natl Cancer Inst 1959;23:1-19.
11. Chu EW, Herrold KM, Wood TA Jr. Cytopathological changes of the uterine cervix of Syrian hamsters after painting with DMBA, benzo(a)pyrene, and tobacco tar. Acta Cytol 1962;6:376-84.
12. Alam S, Conway MJ, Chen HS, Meyers C. The cigarette smoke carcinogen benzo[a]pyrene enhances human papillomavirus synthesis. J Virol 2008;82:1053-8.
13. Thakker DR, Yagi H, Levin W, Wood AW, Conney AH, Jerina DM. Polycyclic Aromatic-Hydrocarbons: metabolic activation to ultimate carcinogens. In: Anders MW, editor. Bioactivation of Foreign Compounds. New York: Academic Press; 1985. p. 177-242.
14. Kim JH, Stansbury KH, Walker NJ, Trush MA, Strickland PT, Sutter TR. Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1. Carcinogenesis 1998;19:1847-53. (Pubitemid 28474651)
15. Bauer E, Guo ZY, Ueng YF, Bell LC, Zeldin D, Guengerich FP. Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes. Chem Res Toxicol 1995;8:136-42.
16. Vadlamuri SV, Glover DD, Turner T, Sarkar MA. Regiospecific expression of cytochrome P4501A1 and 1B1 in human uterine tissue. Cancer Lett 1998;122:143-50. (Pubitemid 28058629)
17. Muskhelishvili L, Thompson PA, Kusewitt DF, Wang C, Kadlubar FF. In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues. J Histochem Cytochem 2001;49:229-36. (Pubitemid 32113385)
18. Farin FM, Bigler LG, Oda D, Mcdougall JK, Omiecinski CJ. Expression of cytochrome P450 and microsomal epoxide hydrolase in cervical and oral epithelial cells immortalized by human papillomavirus type 16 E6/E7 genes. Carcinogenesis 1995;16:1391-401.
19. Melikian AA, Sun P, Prokopczyk B, El-Bayoumy K, Hoffmann D, Wang X, et al. Identification of benzo[a]pyrene metabolites in cervical mucus and DNA adducts in cervical tissues in humans by gas chromatography-mass spectrometry. Cancer Lett 1999;146:127-34. (Pubitemid 29492881)
20. Melikian AA, Wang X, Waggoner, S, Hoffmann D, El-Bayoumy K. Comparative response of normal and of human papillomavirus-16 immortalized human epithelial cervical cells to benzo[a]pyrene. Oncol Rep 1999;6:1371-6.
21. Yagi H, Thakker DR, Hernandez O, Koreeda M, Jerina DM. Synthesis and reactions of highly mutagenic 7,8-diol 9,10-epoxides of carcinogen benzo[a]pyrene. J Am Chem Soc 1977;99:1604-11. (Pubitemid 8102965)
22. Whalen DL, Ross AM, Yagi H, Karle JM, Jerina DM. Stereoelectronic factors in solvolysis of bay region diol epoxides of polycyclic aromatic hydrocarbons. J Am Chem Soc 1978;100:5218-21.
23. Ozbun MA, Meyers C. Transforming growth factor beta1 induces differentiation in human papillomavirus-positive keratinocytes. J Virol 1996;70:5437-46. (Pubitemid 26240718)
24. Meyers C, Mayer TJ, Ozbun MA. Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA. J Virol 1997;71:7381-86. (Pubitemid 27391677)
25. Bedell MA, Hudson JB, Golub TR, Turyk ME, Hosken M, Wilbanks GD, et al. Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation. J Virol 1991;65:2254-60.
26. Ruesch MN, Stubenrauch F, Laimins LA. Activation of papillomavirus late gene transcription and genome amplification upon differentiation in semisolid medium is coincident with expression of involucrin and transglutaminase but not keratin-10. J Virol 1998;72:5016-24. (Pubitemid 28219292)
27. Staretz ME, Murphy SE, Patten CJ, Nunes MG, Koehl W, Amin S, et al. Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanol, and N'-nitrosonornicotine in human hepatic microsomes. Drug Metab Dispos 1997;25:154-62. (Pubitemid 27086115)
28. Meyers C, Alam S, Mane M, Hermonatt PL. Altered biology of adeno-associated virus type 2 and human papillomavirus during dual infection of natural host tissue. Virology 2001;287:30-9. (Pubitemid 32778236)
29. Wen X, Walle T. Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols. Carcinogenesis 2005;26:1774-81. (Pubitemid 41487994)
30. Tsuji PA, Walle T. Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids. Carcinogenesis 2006;27:1570-85.