Insight into the binding modes of Lassa nucleoprotein complexed with ssRNA by molecular dynamic simulations and free energy calculations

Journal of Biomolecular Structure and Dynamics

Volumn 33, Issue 5, 2015, Pages 946-960

  Zhang, Ying ^a   Chen, Hang ^a   Han, Ju Guang ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Lassa virus; gate mechanism; molecular dynamics simulation; interaction mechanisms; free energy calculation

Indexed keywords

SINGLE STRANDED RNA; VIRUS NUCLEOPROTEIN; NUCLEOPROTEIN; PROTEIN BINDING; VIRUS PROTEIN; VIRUS RNA;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; GENOME ANALYSIS; LASSA VIRUS; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN RNA BINDING; QUANTITATIVE ANALYSIS; RNA STRUCTURE; STRUCTURE ANALYSIS; VIRUS GENOME; ALGORITHM; CHEMISTRY; CONFORMATION; GENETICS; HUMAN; HYDROGEN BOND; METABOLISM; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; LASSA VIRUS; MOLECULAR DYNAMICS SIMULATION; MUTATION; NUCLEIC ACID CONFORMATION; NUCLEOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RNA, VIRAL; THERMODYNAMICS; VIRAL PROTEINS;

EID: 84944451613     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2014.923785     Document Type: Article

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