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Volumn 13, Issue 12, 2015, Pages 2048-2061

Covert and Overt Hepatic Encephalopathy: Diagnosis and Management

Author keywords

Ammonia; Cirrhosis; Covert Hepatic Encephalopathy; Hepatic Encephalopathy; Lactulose; Overt Hepatic Encephalopathy; Rifaximin

Indexed keywords

ACARBOSE; ALBUMIN; AMMONIA; ANTIBIOTIC AGENT; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZOIC ACID; CARNITINE; DISACCHARIDE; GLUCOSE; GLYCEROL PHENYLBUTYRATE; LACTITOL; LACTULOSE; METRONIDAZOLE; NEOMYCIN; ORNITHINE ASPARTATE; ORNITHINE PHENYLACETATE; OVERT HEPATIC ENCEPHALOPATHY; PAROMOMYCIN; PLACEBO; PROBIOTIC AGENT; RIFAXIMIN; SORBITOL; VANCOMYCIN; VSL3; ZINC;

EID: 84944412381     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2015.06.039     Document Type: Review
Times cited : (163)

References (89)
  • 1
    • 0033034892 scopus 로고    scopus 로고
    • Prognostic significance of hepatic encephalopathy in patients with cirrhosis
    • Bustamante J., Rimola A., Ventura P.J., et al. Prognostic significance of hepatic encephalopathy in patients with cirrhosis. J Hepatol 1999, 30:890-895.
    • (1999) J Hepatol , vol.30 , pp. 890-895
    • Bustamante, J.1    Rimola, A.2    Ventura, P.J.3
  • 2
    • 0036191173 scopus 로고    scopus 로고
    • Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998
    • Ferenci P., Lockwood A., Mullen K., et al. Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002, 35:716-721.
    • (2002) Hepatology , vol.35 , pp. 716-721
    • Ferenci, P.1    Lockwood, A.2    Mullen, K.3
  • 3
    • 84904749223 scopus 로고    scopus 로고
    • Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver
    • Vilstrup H., Amodio P., Bajaj J., et al. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology 2014, 60:715-735.
    • (2014) Hepatology , vol.60 , pp. 715-735
    • Vilstrup, H.1    Amodio, P.2    Bajaj, J.3
  • 4
    • 79952255608 scopus 로고    scopus 로고
    • Review article: the design of clinical trials in hepatic encephalopathy-an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement
    • Bajaj J.S., Cordoba J., Mullen K.D., et al. Review article: the design of clinical trials in hepatic encephalopathy-an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement. Aliment Pharmacol Ther 2011, 33:739-747.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 739-747
    • Bajaj, J.S.1    Cordoba, J.2    Mullen, K.D.3
  • 5
    • 73149120513 scopus 로고    scopus 로고
    • Spectrum of neurocognitive impairment in cirrhosis: implications for the assessment of hepatic encephalopathy
    • Bajaj J.S., Wade J.B., Sanyal A.J. Spectrum of neurocognitive impairment in cirrhosis: implications for the assessment of hepatic encephalopathy. Hepatology 2009, 50:2014-2021.
    • (2009) Hepatology , vol.50 , pp. 2014-2021
    • Bajaj, J.S.1    Wade, J.B.2    Sanyal, A.J.3
  • 6
    • 0035720629 scopus 로고    scopus 로고
    • Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis
    • Das A., Dhiman R.K., Saraswat V.A., et al. Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis. J Gastroenterol Hepatol 2001, 16:531-535.
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 531-535
    • Das, A.1    Dhiman, R.K.2    Saraswat, V.A.3
  • 7
    • 14944382711 scopus 로고    scopus 로고
    • Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations
    • Ortiz M., Jacas C., Cordoba J. Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol 2005, 42(Suppl):S45-S53.
    • (2005) J Hepatol , vol.42 , pp. S45-S53
    • Ortiz, M.1    Jacas, C.2    Cordoba, J.3
  • 8
    • 75749105423 scopus 로고    scopus 로고
    • Review article: the modern management of hepatic encephalopathy
    • Bajaj J.S. Review article: the modern management of hepatic encephalopathy. Aliment Pharmacol Ther 2010, 31:537-547.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 537-547
    • Bajaj, J.S.1
  • 9
    • 84865320804 scopus 로고    scopus 로고
    • In-hospital mortality and economic burden associated with hepatic encephalopathy in the United States from 2005 to 2009
    • Stepanova M., Mishra A., Venkatesan C., et al. In-hospital mortality and economic burden associated with hepatic encephalopathy in the United States from 2005 to 2009. Clin Gastroenterol Hepatol 2012, 10:1034-1041.e1.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 1034-1041.e1
    • Stepanova, M.1    Mishra, A.2    Venkatesan, C.3
  • 10
    • 33846446011 scopus 로고    scopus 로고
    • Review article: the burden of hepatic encephalopathy
    • Poordad F.F. Review article: the burden of hepatic encephalopathy. Aliment Pharmacol Ther 2007, 25(Suppl 1):3-9.
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 3-9
    • Poordad, F.F.1
  • 11
    • 0043202662 scopus 로고    scopus 로고
    • Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis
    • Arguedas M.R., DeLawrence T.G., McGuire B.M. Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis. Dig Dis Sci 2003, 48:1622-1626.
    • (2003) Dig Dis Sci , vol.48 , pp. 1622-1626
    • Arguedas, M.R.1    DeLawrence, T.G.2    McGuire, B.M.3
  • 12
    • 35449004862 scopus 로고    scopus 로고
    • Hepatic encephalopathy as a predictor of survival in patients with end-stage liver disease
    • Stewart C.A., Malinchoc M., Kim W.R., et al. Hepatic encephalopathy as a predictor of survival in patients with end-stage liver disease. Liver Transpl 2007, 13:1366-1371.
    • (2007) Liver Transpl , vol.13 , pp. 1366-1371
    • Stewart, C.A.1    Malinchoc, M.2    Kim, W.R.3
  • 13
    • 84912071410 scopus 로고    scopus 로고
    • Hepatic encephalopathy is associated with significantly increased mortality among patients awaiting liver transplantation
    • Wong R.J., Gish R.G., Ahmed A. Hepatic encephalopathy is associated with significantly increased mortality among patients awaiting liver transplantation. Liver Transpl 2014, 20:1454-1461.
    • (2014) Liver Transpl , vol.20 , pp. 1454-1461
    • Wong, R.J.1    Gish, R.G.2    Ahmed, A.3
  • 14
    • 0017744177 scopus 로고
    • Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy. A double blind controlled trial
    • Conn H.O., Leevy C.M., Vlahcevic Z.R., et al. Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy. A double blind controlled trial. Gastroenterology 1977, 72:573-583.
    • (1977) Gastroenterology , vol.72 , pp. 573-583
    • Conn, H.O.1    Leevy, C.M.2    Vlahcevic, Z.R.3
  • 15
    • 0033831202 scopus 로고    scopus 로고
    • Efficacy of lactulose in cirrhotic patients with subclinical hepatic encephalopathy
    • Dhiman R.K., Sawhney M.S., Chawla Y.K., et al. Efficacy of lactulose in cirrhotic patients with subclinical hepatic encephalopathy. Dig Dis Sci 2000, 45:1549-1552.
    • (2000) Dig Dis Sci , vol.45 , pp. 1549-1552
    • Dhiman, R.K.1    Sawhney, M.S.2    Chawla, Y.K.3
  • 16
    • 0031834155 scopus 로고    scopus 로고
    • Subclinical hepatic encephalopathy impairs daily functioning
    • Groeneweg M., Quero J.C., De Bruijn I., et al. Subclinical hepatic encephalopathy impairs daily functioning. Hepatology 1998, 28:45-49.
    • (1998) Hepatology , vol.28 , pp. 45-49
    • Groeneweg, M.1    Quero, J.C.2    De Bruijn, I.3
  • 17
    • 55249108459 scopus 로고    scopus 로고
    • Inhibitory control test for the diagnosis of minimal hepatic encephalopathy
    • Bajaj J.S., Hafeezullah M., Franco J., et al. Inhibitory control test for the diagnosis of minimal hepatic encephalopathy. Gastroenterology 2008, 135:1591-1600.e1.
    • (2008) Gastroenterology , vol.135 , pp. 1591-1600.e1
    • Bajaj, J.S.1    Hafeezullah, M.2    Franco, J.3
  • 18
    • 84908893068 scopus 로고    scopus 로고
    • Covert hepatic encephalopathy is independently associated with poor survival and increased risk of hospitalization
    • Patidar K.R., Thacker L.R., Wade J.B., et al. Covert hepatic encephalopathy is independently associated with poor survival and increased risk of hospitalization. Am J Gastroenterol 2014, 109:1757-1763.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1757-1763
    • Patidar, K.R.1    Thacker, L.R.2    Wade, J.B.3
  • 19
    • 67649388055 scopus 로고    scopus 로고
    • Hepatic encephalopathy: pathophysiology and emerging therapies
    • vii
    • Sundaram V., Shaikh O.S. Hepatic encephalopathy: pathophysiology and emerging therapies. Med Clin North Am 2009, 93:819-836. vii.
    • (2009) Med Clin North Am , vol.93 , pp. 819-836
    • Sundaram, V.1    Shaikh, O.S.2
  • 20
    • 0034522210 scopus 로고    scopus 로고
    • Hepatic encephalopathy in liver cirrhosis: pathogenesis, diagnosis and management
    • Gerber T., Schomerus H. Hepatic encephalopathy in liver cirrhosis: pathogenesis, diagnosis and management. Drugs 2000, 60:1353-1370.
    • (2000) Drugs , vol.60 , pp. 1353-1370
    • Gerber, T.1    Schomerus, H.2
  • 21
    • 0242331238 scopus 로고    scopus 로고
    • Blood-brain barrier permeability to ammonia in liver failure: a critical reappraisal
    • Ott P., Larsen F.S. Blood-brain barrier permeability to ammonia in liver failure: a critical reappraisal. Neurochem Int 2004, 44:185-198.
    • (2004) Neurochem Int , vol.44 , pp. 185-198
    • Ott, P.1    Larsen, F.S.2
  • 22
    • 0343238857 scopus 로고    scopus 로고
    • Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low-grade cerebral edema?
    • Haussinger D., Kircheis G., Fischer R., et al. Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low-grade cerebral edema?. J Hepatol 2000, 32:1035-1038.
    • (2000) J Hepatol , vol.32 , pp. 1035-1038
    • Haussinger, D.1    Kircheis, G.2    Fischer, R.3
  • 23
    • 84884786990 scopus 로고    scopus 로고
    • Neurotransmitter receptor alterations in hepatic encephalopathy: a review
    • Palomero-Gallagher N., Zilles K. Neurotransmitter receptor alterations in hepatic encephalopathy: a review. Arch Biochem Biophys 2013, 536:109-121.
    • (2013) Arch Biochem Biophys , vol.536 , pp. 109-121
    • Palomero-Gallagher, N.1    Zilles, K.2
  • 24
    • 84900538213 scopus 로고    scopus 로고
    • The role of microbiota in hepatic encephalopathy
    • Bajaj J.S. The role of microbiota in hepatic encephalopathy. Gut Microbes 2014, 5:397-403.
    • (2014) Gut Microbes , vol.5 , pp. 397-403
    • Bajaj, J.S.1
  • 25
    • 1642491776 scopus 로고    scopus 로고
    • Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis
    • Shawcross D.L., Davies N.A., Williams R., et al. Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 2004, 40:247-254.
    • (2004) J Hepatol , vol.40 , pp. 247-254
    • Shawcross, D.L.1    Davies, N.A.2    Williams, R.3
  • 26
    • 79954832002 scopus 로고    scopus 로고
    • New assessment of hepatic encephalopathy
    • Cordoba J. New assessment of hepatic encephalopathy. J Hepatol 2011, 54:1030-1040.
    • (2011) J Hepatol , vol.54 , pp. 1030-1040
    • Cordoba, J.1
  • 27
    • 64749100701 scopus 로고    scopus 로고
    • Neuropsychological assessment of hepatic encephalopathy: ISHEN practice guidelines
    • Randolph C., Hilsabeck R., Kato A., et al. Neuropsychological assessment of hepatic encephalopathy: ISHEN practice guidelines. Liver Int 2009, 29:629-635.
    • (2009) Liver Int , vol.29 , pp. 629-635
    • Randolph, C.1    Hilsabeck, R.2    Kato, A.3
  • 28
    • 84884280726 scopus 로고    scopus 로고
    • Comparison of the most favoured methods for the diagnosis of hepatic encephalopathy in liver transplantation candidates
    • Goldbecker A., Weissenborn K., Hamidi Shahrezaei G., et al. Comparison of the most favoured methods for the diagnosis of hepatic encephalopathy in liver transplantation candidates. Gut 2013, 62:1497-1504.
    • (2013) Gut , vol.62 , pp. 1497-1504
    • Goldbecker, A.1    Weissenborn, K.2    Hamidi Shahrezaei, G.3
  • 29
    • 84941744396 scopus 로고    scopus 로고
    • Validation of EncephalApp, Smartphone-Based Stroop Test, for the diagnosis of covert hepatic encephalopathy
    • Bajaj J.S., Heuman D.M., Sterling R.K., et al. Validation of EncephalApp, Smartphone-Based Stroop Test, for the diagnosis of covert hepatic encephalopathy. Clin Gastroenterol Hepatol 2015, 13:1828-1835.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 1828-1835
    • Bajaj, J.S.1    Heuman, D.M.2    Sterling, R.K.3
  • 30
    • 55249111140 scopus 로고    scopus 로고
    • Computerized psychometric testing in minimal encephalopathy and modulation by nitrogen challenge and liver transplant
    • Mardini H., Saxby B.K., Record C.O. Computerized psychometric testing in minimal encephalopathy and modulation by nitrogen challenge and liver transplant. Gastroenterology 2008, 135:1582-1590.
    • (2008) Gastroenterology , vol.135 , pp. 1582-1590
    • Mardini, H.1    Saxby, B.K.2    Record, C.O.3
  • 31
    • 84883235783 scopus 로고    scopus 로고
    • The Stroop smartphone application is a short and valid method to screen for minimal hepatic encephalopathy
    • Bajaj J.S., Thacker L.R., Heuman D.M., et al. The Stroop smartphone application is a short and valid method to screen for minimal hepatic encephalopathy. Hepatology 2013, 58:1122-1132.
    • (2013) Hepatology , vol.58 , pp. 1122-1132
    • Bajaj, J.S.1    Thacker, L.R.2    Heuman, D.M.3
  • 32
    • 33748450302 scopus 로고    scopus 로고
    • The EEG assessment of low-grade hepatic encephalopathy: comparison of an artificial neural network-expert system (ANNES) based evaluation with visual EEG readings and EEG spectral analysis
    • Amodio P., Pellegrini A., Ubiali E., et al. The EEG assessment of low-grade hepatic encephalopathy: comparison of an artificial neural network-expert system (ANNES) based evaluation with visual EEG readings and EEG spectral analysis. Clin Neurophysiol 2006, 117:2243-2251.
    • (2006) Clin Neurophysiol , vol.117 , pp. 2243-2251
    • Amodio, P.1    Pellegrini, A.2    Ubiali, E.3
  • 33
    • 5444231954 scopus 로고    scopus 로고
    • Methods for diagnosing hepatic encephalopathy in patients with cirrhosis: a multidimensional approach
    • Montagnese S., Amodio P., Morgan M.Y. Methods for diagnosing hepatic encephalopathy in patients with cirrhosis: a multidimensional approach. Metab Brain Dis 2004, 19:281-312.
    • (2004) Metab Brain Dis , vol.19 , pp. 281-312
    • Montagnese, S.1    Amodio, P.2    Morgan, M.Y.3
  • 34
    • 0036156739 scopus 로고    scopus 로고
    • Critical flicker frequency for quantification of low-grade hepatic encephalopathy
    • Kircheis G., Wettstein M., Timmermann L., et al. Critical flicker frequency for quantification of low-grade hepatic encephalopathy. Hepatology 2002, 35:357-366.
    • (2002) Hepatology , vol.35 , pp. 357-366
    • Kircheis, G.1    Wettstein, M.2    Timmermann, L.3
  • 35
    • 77149136035 scopus 로고    scopus 로고
    • Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosis
    • Sharma P., Sharma B.C., Sarin S.K. Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosis. Hepatobiliary Pancreat Dis Int 2010, 9:27-32.
    • (2010) Hepatobiliary Pancreat Dis Int , vol.9 , pp. 27-32
    • Sharma, P.1    Sharma, B.C.2    Sarin, S.K.3
  • 36
    • 84904397994 scopus 로고    scopus 로고
    • Diagnosis of covert hepatic encephalopathy without specialized tests
    • Nabi E., Thacker L.R., Wade J.B., et al. Diagnosis of covert hepatic encephalopathy without specialized tests. Clin Gastroenterol Hepatol 2014, 12:1384-1389.e2.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 1384-1389.e2
    • Nabi, E.1    Thacker, L.R.2    Wade, J.B.3
  • 37
    • 84905924120 scopus 로고    scopus 로고
    • Serum ammonia level for the evaluation of hepatic encephalopathy
    • Ge P.S., Runyon B.A. Serum ammonia level for the evaluation of hepatic encephalopathy. JAMA 2014, 312:643-644.
    • (2014) JAMA , vol.312 , pp. 643-644
    • Ge, P.S.1    Runyon, B.A.2
  • 38
    • 33744537598 scopus 로고    scopus 로고
    • Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encephalopathy
    • Grover V.P., Dresner M.A., Forton D.M., et al. Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encephalopathy. World J Gastroenterol 2006, 12:2969-2978.
    • (2006) World J Gastroenterol , vol.12 , pp. 2969-2978
    • Grover, V.P.1    Dresner, M.A.2    Forton, D.M.3
  • 39
    • 0027070432 scopus 로고
    • Double-blind randomized clinical trial comparing neomycin and placebo in the treatment of exogenous hepatic encephalopathy
    • Strauss E., Tramote R., Silva E.P., et al. Double-blind randomized clinical trial comparing neomycin and placebo in the treatment of exogenous hepatic encephalopathy. Hepatogastroenterology 1992, 39:542-545.
    • (1992) Hepatogastroenterology , vol.39 , pp. 542-545
    • Strauss, E.1    Tramote, R.2    Silva, E.P.3
  • 40
    • 84878011784 scopus 로고    scopus 로고
    • Antibiotics for the treatment of hepatic encephalopathy
    • Patidar K.R., Bajaj J.S. Antibiotics for the treatment of hepatic encephalopathy. Metab Brain Dis 2013, 28:307-312.
    • (2013) Metab Brain Dis , vol.28 , pp. 307-312
    • Patidar, K.R.1    Bajaj, J.S.2
  • 41
    • 0043124270 scopus 로고    scopus 로고
    • Probiotics can treat hepatic encephalopathy
    • Solga S.F. Probiotics can treat hepatic encephalopathy. Med Hypotheses 2003, 61:307-313.
    • (2003) Med Hypotheses , vol.61 , pp. 307-313
    • Solga, S.F.1
  • 42
    • 0031031819 scopus 로고    scopus 로고
    • Lactulose improves psychometric testing in cirrhotic patients with subclinical encephalopathy
    • Horsmans Y., Solbreux P.M., Daenens C., et al. Lactulose improves psychometric testing in cirrhotic patients with subclinical encephalopathy. Aliment Pharmacol Ther 1997, 11:165-170.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 165-170
    • Horsmans, Y.1    Solbreux, P.M.2    Daenens, C.3
  • 43
    • 0030701641 scopus 로고    scopus 로고
    • Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy
    • Watanabe A., Sakai T., Sato S., et al. Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy. Hepatology 1997, 26:1410-1414.
    • (1997) Hepatology , vol.26 , pp. 1410-1414
    • Watanabe, A.1    Sakai, T.2    Sato, S.3
  • 44
    • 33947392621 scopus 로고    scopus 로고
    • Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy
    • Prasad S., Dhiman R.K., Duseja A., et al. Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology 2007, 45:549-559.
    • (2007) Hepatology , vol.45 , pp. 549-559
    • Prasad, S.1    Dhiman, R.K.2    Duseja, A.3
  • 45
    • 43449114798 scopus 로고    scopus 로고
    • An open-label randomized controlled trial of lactulose and probiotics in the treatment of minimal hepatic encephalopathy
    • Sharma P., Sharma B.C., Puri V., et al. An open-label randomized controlled trial of lactulose and probiotics in the treatment of minimal hepatic encephalopathy. Eur J Gastroenterol Hepatol 2008, 20:506-511.
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 506-511
    • Sharma, P.1    Sharma, B.C.2    Puri, V.3
  • 46
    • 80955157383 scopus 로고    scopus 로고
    • Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy: a meta-analysis
    • Luo M., Li L., Lu C.Z., et al. Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy: a meta-analysis. Eur J Gastroenterol Hepatol 2011, 23:1250-1257.
    • (2011) Eur J Gastroenterol Hepatol , vol.23 , pp. 1250-1257
    • Luo, M.1    Li, L.2    Lu, C.Z.3
  • 47
    • 79251535022 scopus 로고    scopus 로고
    • Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    • Bajaj J.S., Heuman D.M., Wade J.B., et al. Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy. Gastroenterology 2011, 140:478-487.e1.
    • (2011) Gastroenterology , vol.140 , pp. 478-487.e1
    • Bajaj, J.S.1    Heuman, D.M.2    Wade, J.B.3
  • 48
    • 79751499077 scopus 로고    scopus 로고
    • Rifaximin improves psychometric performance and health-related quality of life in patients with minimal hepatic encephalopathy (the RIME Trial)
    • Sidhu S.S., Goyal O., Mishra B.P., et al. Rifaximin improves psychometric performance and health-related quality of life in patients with minimal hepatic encephalopathy (the RIME Trial). Am J Gastroenterol 2011, 106:307-316.
    • (2011) Am J Gastroenterol , vol.106 , pp. 307-316
    • Sidhu, S.S.1    Goyal, O.2    Mishra, B.P.3
  • 49
    • 84859133780 scopus 로고    scopus 로고
    • Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis
    • Bajaj J.S., Pinkerton S.D., Sanyal A.J., et al. Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis. Hepatology 2012, 55:1164-1171.
    • (2012) Hepatology , vol.55 , pp. 1164-1171
    • Bajaj, J.S.1    Pinkerton, S.D.2    Sanyal, A.J.3
  • 50
    • 79951678831 scopus 로고    scopus 로고
    • Meta-analysis: the effects of gut flora modulation using prebiotics, probiotics and synbiotics on minimal hepatic encephalopathy
    • Shukla S., Shukla A., Mehboob S., et al. Meta-analysis: the effects of gut flora modulation using prebiotics, probiotics and synbiotics on minimal hepatic encephalopathy. Aliment Pharmacol Ther 2011, 33:662-671.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 662-671
    • Shukla, S.1    Shukla, A.2    Mehboob, S.3
  • 51
    • 84901200252 scopus 로고    scopus 로고
    • Probiotics prevent hepatic encephalopathy in patients with cirrhosis: a randomized controlled trial
    • Lunia M.K., Sharma B.C., Sharma P., et al. Probiotics prevent hepatic encephalopathy in patients with cirrhosis: a randomized controlled trial. Clin Gastroenterol Hepatol 2014, 12:1003-1008.e1.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 1003-1008.e1
    • Lunia, M.K.1    Sharma, B.C.2    Sharma, P.3
  • 52
    • 84937412936 scopus 로고    scopus 로고
    • Effect of probiotic VSL#3 in the treatment of minimal hepatic encephalopathy: a non-inferiority randomized controlled trial
    • Pratap Mouli V., Benjamin J., Bhushan Singh M., et al. Effect of probiotic VSL#3 in the treatment of minimal hepatic encephalopathy: a non-inferiority randomized controlled trial. Hepatol Res 2015, 45:880-889.
    • (2015) Hepatol Res , vol.45 , pp. 880-889
    • Pratap Mouli, V.1    Benjamin, J.2    Bhushan Singh, M.3
  • 53
    • 84899046306 scopus 로고    scopus 로고
    • Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis
    • Bajaj J.S., Heuman D.M., Hylemon P.B., et al. Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. Aliment Pharmacol Ther 2014, 39:1113-1125.
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 1113-1125
    • Bajaj, J.S.1    Heuman, D.M.2    Hylemon, P.B.3
  • 54
    • 0014899607 scopus 로고
    • A controlled clinical trial of lactulose in hepatic encephalopathy
    • Simmons F., Goldstein H., Boyle J.D. A controlled clinical trial of lactulose in hepatic encephalopathy. Gastroenterology 1970, 59:827-832.
    • (1970) Gastroenterology , vol.59 , pp. 827-832
    • Simmons, F.1    Goldstein, H.2    Boyle, J.D.3
  • 55
    • 0015733027 scopus 로고
    • Comparison of results of long-term treatment of chronic hepatic encephalopathy with lactulose and sorbitol
    • Rodgers J.B., Kiley J.E., Balint J.A. Comparison of results of long-term treatment of chronic hepatic encephalopathy with lactulose and sorbitol. Am J Gastroenterol 1973, 60:459-465.
    • (1973) Am J Gastroenterol , vol.60 , pp. 459-465
    • Rodgers, J.B.1    Kiley, J.E.2    Balint, J.A.3
  • 56
    • 0023184945 scopus 로고
    • Acidifying enemas (lactitol and lactose) vs. nonacidifying enemas (tap water) to treat acute portal-systemic encephalopathy: a double-blind, randomized clinical trial
    • Uribe M., Campollo O., Vargas F., et al. Acidifying enemas (lactitol and lactose) vs. nonacidifying enemas (tap water) to treat acute portal-systemic encephalopathy: a double-blind, randomized clinical trial. Hepatology 1987, 7:639-643.
    • (1987) Hepatology , vol.7 , pp. 639-643
    • Uribe, M.1    Campollo, O.2    Vargas, F.3
  • 57
    • 0014686855 scopus 로고
    • Lactulose in the treatment of chronic portal-systemic encephalopathy. A double-blind clinical trial
    • Elkington S.G., Floch M.H., Conn H.O. Lactulose in the treatment of chronic portal-systemic encephalopathy. A double-blind clinical trial. N Engl J Med 1969, 281:408-412.
    • (1969) N Engl J Med , vol.281 , pp. 408-412
    • Elkington, S.G.1    Floch, M.H.2    Conn, H.O.3
  • 59
    • 0027367525 scopus 로고
    • Rifaximin in the treatment of chronic hepatic encephalopathy: results of a multicenter study of efficacy and safety
    • Festi D., Mazzella G., Orsini M., et al. Rifaximin in the treatment of chronic hepatic encephalopathy: results of a multicenter study of efficacy and safety. Curr Ther Res Clin Exp 1993, 54:598-609.
    • (1993) Curr Ther Res Clin Exp , vol.54 , pp. 598-609
    • Festi, D.1    Mazzella, G.2    Orsini, M.3
  • 60
    • 0027212359 scopus 로고
    • Double-blind, double-dummy comparison between treatment with rifaximin and lactulose in patients with medium to severe degree hepatic encephalopathy
    • Bucci L., Palmieri G.C. Double-blind, double-dummy comparison between treatment with rifaximin and lactulose in patients with medium to severe degree hepatic encephalopathy. Curr Med Res Opin 1993, 13:109-118.
    • (1993) Curr Med Res Opin , vol.13 , pp. 109-118
    • Bucci, L.1    Palmieri, G.C.2
  • 61
    • 0027879387 scopus 로고
    • Treatment of hepatic encephalopathy with rifaximin: double-blind, double-dummy study versus lactulose
    • Massa P., Vallerino E., Dodero M. Treatment of hepatic encephalopathy with rifaximin: double-blind, double-dummy study versus lactulose. Eur J Clin Res 1993, 4:7-18.
    • (1993) Eur J Clin Res , vol.4 , pp. 7-18
    • Massa, P.1    Vallerino, E.2    Dodero, M.3
  • 62
    • 0027815140 scopus 로고
    • Rifaximin in the treatment of hepatic encephalopathy
    • Fera G., Agostinacchio F., Nigro M., et al. Rifaximin in the treatment of hepatic encephalopathy. Eur J Clin Res 1993, 4:57-66.
    • (1993) Eur J Clin Res , vol.4 , pp. 57-66
    • Fera, G.1    Agostinacchio, F.2    Nigro, M.3
  • 63
    • 0037232911 scopus 로고    scopus 로고
    • Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial
    • Mas A., Rodes J., Sunyer L., et al. Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial. J Hepatol 2003, 38:51-58.
    • (2003) J Hepatol , vol.38 , pp. 51-58
    • Mas, A.1    Rodes, J.2    Sunyer, L.3
  • 64
    • 33847213560 scopus 로고    scopus 로고
    • Hospitalizations during the use of rifaximin versus lactulose for the treatment of hepatic encephalopathy
    • Leevy C.B., Phillips J.A. Hospitalizations during the use of rifaximin versus lactulose for the treatment of hepatic encephalopathy. Dig Dis Sci 2007, 52:737-741.
    • (2007) Dig Dis Sci , vol.52 , pp. 737-741
    • Leevy, C.B.1    Phillips, J.A.2
  • 65
    • 21844455251 scopus 로고    scopus 로고
    • Comparison of rifaximin and lactulose for the treatment of hepatic encephalopathy: a prospective randomized study
    • Paik Y.H., Lee K.S., Han K.H., et al. Comparison of rifaximin and lactulose for the treatment of hepatic encephalopathy: a prospective randomized study. Yonsei Med J 2005, 46:399-407.
    • (2005) Yonsei Med J , vol.46 , pp. 399-407
    • Paik, Y.H.1    Lee, K.S.2    Han, K.H.3
  • 66
    • 77950246404 scopus 로고    scopus 로고
    • Rifaximin treatment in hepatic encephalopathy
    • Bass N.M., Mullen K.D., Sanyal A., et al. Rifaximin treatment in hepatic encephalopathy. N Engl J Med 2010, 362:1071-1081.
    • (2010) N Engl J Med , vol.362 , pp. 1071-1081
    • Bass, N.M.1    Mullen, K.D.2    Sanyal, A.3
  • 67
    • 84883744232 scopus 로고    scopus 로고
    • A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy
    • Sharma B.C., Sharma P., Lunia M.K., et al. A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy. Am J Gastroenterol 2013, 108:1458-1463.
    • (2013) Am J Gastroenterol , vol.108 , pp. 1458-1463
    • Sharma, B.C.1    Sharma, P.2    Lunia, M.K.3
  • 68
    • 77957971138 scopus 로고    scopus 로고
    • Drug therapy: rifaximin
    • Bajaj J.S., Riggio O. Drug therapy: rifaximin. Hepatology 2010, 52:1484-1488.
    • (2010) Hepatology , vol.52 , pp. 1484-1488
    • Bajaj, J.S.1    Riggio, O.2
  • 69
    • 84860810938 scopus 로고    scopus 로고
    • Probiotics for patients with hepatic encephalopathy
    • McGee R.G., Bakens A., Wiley K., et al. Probiotics for patients with hepatic encephalopathy. Cochrane Database Syst Rev 2011, 11:CD008716.
    • (2011) Cochrane Database Syst Rev , vol.11 , pp. CD008716
    • McGee, R.G.1    Bakens, A.2    Wiley, K.3
  • 70
    • 69249166158 scopus 로고    scopus 로고
    • Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo
    • 891.e1
    • Sharma B.C., Sharma P., Agrawal A., et al. Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo. Gastroenterology 2009, 137:885-891. 891.e1.
    • (2009) Gastroenterology , vol.137 , pp. 885-891
    • Sharma, B.C.1    Sharma, P.2    Agrawal, A.3
  • 71
    • 77950586321 scopus 로고    scopus 로고
    • Predictors of the recurrence of hepatic encephalopathy in lactulose-treated patients
    • Bajaj J.S., Sanyal A.J., Bell D., et al. Predictors of the recurrence of hepatic encephalopathy in lactulose-treated patients. Aliment Pharmacol Ther 2010, 31:1012-1017.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 1012-1017
    • Bajaj, J.S.1    Sanyal, A.J.2    Bell, D.3
  • 72
    • 84904384671 scopus 로고    scopus 로고
    • Rifaximin is safe and well tolerated for long-term maintenance of remission from overt hepatic encephalopathy
    • Mullen K.D., Sanyal A.J., Bass N.M., et al. Rifaximin is safe and well tolerated for long-term maintenance of remission from overt hepatic encephalopathy. Clin Gastroenterol Hepatol 2014, 12:1390-1397.e2.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 1390-1397.e2
    • Mullen, K.D.1    Sanyal, A.J.2    Bass, N.M.3
  • 73
    • 84915746507 scopus 로고    scopus 로고
    • Prolonged remission from hepatic encephalopathy with rifaximin: results of a placebo crossover analysis
    • Bajaj J.S., Barrett A.C., Bortey E., et al. Prolonged remission from hepatic encephalopathy with rifaximin: results of a placebo crossover analysis. Aliment Pharmacol Ther 2015, 41:39-45.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 39-45
    • Bajaj, J.S.1    Barrett, A.C.2    Bortey, E.3
  • 74
    • 84902830462 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: the effects of rifaximin in hepatic encephalopathy
    • Kimer N., Krag A., Moller S., et al. Systematic review with meta-analysis: the effects of rifaximin in hepatic encephalopathy. Aliment Pharmacol Ther 2014, 40:123-132.
    • (2014) Aliment Pharmacol Ther , vol.40 , pp. 123-132
    • Kimer, N.1    Krag, A.2    Moller, S.3
  • 75
    • 84863722812 scopus 로고    scopus 로고
    • Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy
    • Agrawal A., Sharma B.C., Sharma P., et al. Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy. Am J Gastroenterol 2012, 107:1043-1050.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1043-1050
    • Agrawal, A.1    Sharma, B.C.2    Sharma, P.3
  • 76
    • 84913553798 scopus 로고    scopus 로고
    • Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: a randomized, controlled trial
    • Dhiman R.K., Rana B., Agrawal S., et al. Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: a randomized, controlled trial. Gastroenterology 2014, 147:1327-1337.e3.
    • (2014) Gastroenterology , vol.147 , pp. 1327-1337.e3
    • Dhiman, R.K.1    Rana, B.2    Agrawal, S.3
  • 77
    • 0032079801 scopus 로고    scopus 로고
    • Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study
    • Stauch S., Kircheis G., Adler G., et al. Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study. J Hepatol 1998, 28:856-864.
    • (1998) J Hepatol , vol.28 , pp. 856-864
    • Stauch, S.1    Kircheis, G.2    Adler, G.3
  • 78
    • 0031003989 scopus 로고    scopus 로고
    • Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study
    • Kircheis G., Nilius R., Held C., et al. Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study. Hepatology 1997, 25:1351-1360.
    • (1997) Hepatology , vol.25 , pp. 1351-1360
    • Kircheis, G.1    Nilius, R.2    Held, C.3
  • 79
    • 79960698297 scopus 로고    scopus 로고
    • A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy
    • Mittal V.V., Sharma B.C., Sharma P., et al. A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy. Eur J Gastroenterol Hepatol 2011, 23:725-732.
    • (2011) Eur J Gastroenterol Hepatol , vol.23 , pp. 725-732
    • Mittal, V.V.1    Sharma, B.C.2    Sharma, P.3
  • 80
    • 33845462426 scopus 로고    scopus 로고
    • Efficacy of oral L-ornithine-L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy. Results of a randomized, lactulose-controlled study
    • Poo J.L., Gongora J., Sanchez-Avila F., et al. Efficacy of oral L-ornithine-L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy. Results of a randomized, lactulose-controlled study. Ann Hepatol 2006, 5:281-288.
    • (2006) Ann Hepatol , vol.5 , pp. 281-288
    • Poo, J.L.1    Gongora, J.2    Sanchez-Avila, F.3
  • 81
    • 84905991368 scopus 로고    scopus 로고
    • Effect of rifaximin, probiotics, and l-ornithine l-aspartate on minimal hepatic encephalopathy: a randomized controlled trial
    • Sharma K., Pant S., Misra S., et al. Effect of rifaximin, probiotics, and l-ornithine l-aspartate on minimal hepatic encephalopathy: a randomized controlled trial. Saudi J Gastroenterol 2014, 20:225-232.
    • (2014) Saudi J Gastroenterol , vol.20 , pp. 225-232
    • Sharma, K.1    Pant, S.2    Misra, S.3
  • 82
    • 84907856389 scopus 로고    scopus 로고
    • Oral l-ornithine-l-aspartate in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled trial
    • Alvares-da-Silva M.R., de Araujo A., Vicenzi J.R., et al. Oral l-ornithine-l-aspartate in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled trial. Hepatol Res 2014, 44:956-963.
    • (2014) Hepatol Res , vol.44 , pp. 956-963
    • Alvares-da-Silva, M.R.1    de Araujo, A.2    Vicenzi, J.R.3
  • 83
    • 34548737013 scopus 로고    scopus 로고
    • L-Ornithine phenylacetate (OP): a novel treatment for hyperammonemia and hepatic encephalopathy
    • Jalan R., Wright G., Davies N.A., et al. L-Ornithine phenylacetate (OP): a novel treatment for hyperammonemia and hepatic encephalopathy. Med Hypotheses 2007, 69:1064-1069.
    • (2007) Med Hypotheses , vol.69 , pp. 1064-1069
    • Jalan, R.1    Wright, G.2    Davies, N.A.3
  • 84
    • 84886599635 scopus 로고    scopus 로고
    • Safety of ornithine phenylacetate in cirrhotic decompensated patients: an open-label, dose-escalating, single-cohort study
    • Ventura-Cots M., Arranz J.A., Simon-Talero M., et al. Safety of ornithine phenylacetate in cirrhotic decompensated patients: an open-label, dose-escalating, single-cohort study. J Clin Gastroenterol 2013, 47:881-887.
    • (2013) J Clin Gastroenterol , vol.47 , pp. 881-887
    • Ventura-Cots, M.1    Arranz, J.A.2    Simon-Talero, M.3
  • 85
    • 84878513677 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the use of oral zinc in the treatment of hepatic encephalopathy
    • Chavez-Tapia N.C., Cesar-Arce A., Barrientos-Gutierrez T., et al. A systematic review and meta-analysis of the use of oral zinc in the treatment of hepatic encephalopathy. Nutr J 2013, 12:74.
    • (2013) Nutr J , vol.12 , pp. 74
    • Chavez-Tapia, N.C.1    Cesar-Arce, A.2    Barrientos-Gutierrez, T.3
  • 86
    • 84887990741 scopus 로고    scopus 로고
    • Effects of intravenous albumin in patients with cirrhosis and episodic hepatic encephalopathy: a randomized double-blind study
    • Simon-Talero M., Garcia-Martinez R., Torrens M., et al. Effects of intravenous albumin in patients with cirrhosis and episodic hepatic encephalopathy: a randomized double-blind study. J Hepatol 2013, 59:1184-1192.
    • (2013) J Hepatol , vol.59 , pp. 1184-1192
    • Simon-Talero, M.1    Garcia-Martinez, R.2    Torrens, M.3
  • 87
    • 4544368484 scopus 로고    scopus 로고
    • Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study
    • Sen S., Davies N.A., Mookerjee R.P., et al. Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study. Liver Transpl 2004, 10:1109-1119.
    • (2004) Liver Transpl , vol.10 , pp. 1109-1119
    • Sen, S.1    Davies, N.A.2    Mookerjee, R.P.3
  • 88
    • 37749045276 scopus 로고    scopus 로고
    • Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis
    • Hassanein T.I., Tofteng F., Brown R.S., et al. Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis. Hepatology 2007, 46:1853-1862.
    • (2007) Hepatology , vol.46 , pp. 1853-1862
    • Hassanein, T.I.1    Tofteng, F.2    Brown, R.S.3
  • 89
    • 84879601583 scopus 로고    scopus 로고
    • The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus
    • Amodio P., Bemeur C., Butterworth R., et al. The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus. Hepatology 2013, 58:325-336.
    • (2013) Hepatology , vol.58 , pp. 325-336
    • Amodio, P.1    Bemeur, C.2    Butterworth, R.3


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