Covert Hepatic Encephalopathy Is Independently Associated with Poor Survival and Increased Risk of Hospitalization

American Journal of Gastroenterology

Volumn 109, Issue 11, 2014, Pages 1757-1763

  Patidar, Kavish R ^a   Thacker, Leroy R ^a   Wade, James B ^a   Sterling, Richard K ^a   Sanyal, Arun J ^a   Siddiqui, Mohammad S ^a   Matherly, Scott C ^a   Stravitz, R Todd ^a   Puri, Puneet ^a   Luketic, Velimir A ^a   Fuchs, Michael ^a   White, Melanie B ^a   Noble, Nicole A ^a   Unser, Ariel B ^a   Gilles, Hochong ^a   Heuman, Douglas M ^a   Bajaj, Jasmohan S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; COVERT HEPATIC ENCEPHALOPATHY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; EDUCATIONAL STATUS; FEMALE; FOLLOW UP; HEPATIC ENCEPHALOPATHY; HEPATITIS C VIRUS; HOSPITALIZATION; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MODEL FOR END STAGE LIVER DISEASE SCORE; MORTALITY; NONALCOHOLIC FATTY LIVER; OUTPATIENT CARE; OVERT HEPATIC ENCEPHALOPATHY; PROSPECTIVE STUDY; RISK FACTOR; SURVIVAL RATE; ADOLESCENT; COMPLICATION; LIVER TRANSPLANTATION; MIDDLE AGED; RISK; STATISTICS AND NUMERICAL DATA;

ADOLESCENT; ADULT; AGED; FEMALE; HEPATIC ENCEPHALOPATHY; HOSPITALIZATION; HUMANS; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK; SURVIVAL RATE;

EID: 84908893068     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2014.264     Document Type: Article

References (28)

1. Bajaj JS, Wade JB, Sanyal AJ. Spectrum of neurocognitive impairment in cirrhosis: implications for the assessment of hepatic encephalopathy. Hepatology 2009; 50: 2014-21.
2. Das A, Dhiman RK, Saraswat VA et al. Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis. J Gastroenterol Hepatol 2001; 16: 531-5.
3. Ortiz M, Jacas C, Cordoba J. Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol 2005; 42(Suppl 1): S45-S53.
4. Kappus MR, Bajaj JS. Covert hepatic encephalopathy: not as minimal as you might think. Clin Gastroenterol Hepatol 2012; 10: 1208-19.
5. Bajaj JS, Riggio O, Allampati S et al. Cognitive dysfunction is associated with poor socioeconomic status in patients with cirrhosis: an international multicenter study. Clin Gastroenterol Hepatol 2013; 11: 1511-6.
6. Bajaj JS, Hafeezullah M, Hoff mann RG et al. Navigation skill impairment: another dimension of the driving difficulties in minimal hepatic encephalopathy . Hepatology 2008; 47: 596-604
7. Prasad S, Dhiman RK, Duseja A et al. Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology 2007; 45: 549-59.
8. Bajaj JS, Wade JB, Gibson DP et al. The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers. Am J Gastroenterol 2011; 106: 1646-53.
9. Montagnese S, De Rui M, Schiff S et al. Prognostic benefit of the addition of a quantitative index of hepatic encephalopathy to the MELD score: the MELD-EEG. Liver Int; advance online publication, 12 February 2014; doi:10.1111/liv.12490 (e-pub ahead of print).
10. Dhiman RK, Kurmi R, Th umburu KK et al. Diagnosis and prognostic significance of minimal hepatic encephalopathy in patients with cirrhosis of liver. Dig Dis Sci 2010; 55: 2381-90.
11. Hartmann IJ, Groeneweg M, Quero JC et al. The prognostic significance of subclinical hepatic encephalopathy. Am J Gastroenterol 2000; 95: 2029-34.
12. Amodio P, Del Piccolo F, Marchetti P et al. Clinical features and survival of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests. Hepatology 1999; 29: 1662-7.
13. Saxena N, Bhatia M, Joshi YK et al. Auditory P300 event-related potentials and number connection test for evaluation of subclinical hepatic encephalopathy in patients with cirrhosis of the liver: a follow-up study. J Gastroenterol Hepatol 2001; 16: 322-7.
14. Lunia MK, Sharma BC, Sharma P et al. Probiotics prevent hepatic encephalopathy in patients with cirrhosis: a randomized controlled trial. Clin Gastroenterol Hepatol 2014; 12: 1003-1008.e1.
15. Bajaj JS, Heuman DM, Wade JB et al. Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy. Gastroenterology 2011; 140: 478-87. e1.
16. Ferenci P, Lockwood A, Mullen K et al. Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002; 35: 716-21.
17. Bajaj JS, Etemadian A, Hafeezullah M et al. Testing for minimal hepatic encephalopathy in the United States: An AASLD survey. Hepatology 2007; 45: 833-4.
18. Liu Q, Duan ZP, Ha DK et al. Synbiotic modulation of gut flora: eff ect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 2004; 39: 1441-9.
19. Watanabe A, Sakai T, Sato S et al. Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy. Hepatology 1997; 26: 1410-4.
20. Sidhu SS, Goyal O, Mishra BP et al. Rifaximin improves psychometric performance and health-related quality of life in patients with minimal hepatic encephalopathy (the RIME Trial). Am J Gastroenterol 2011; 106: 307-16.
21. Romero-Gomez M, Boza F, Garcia-Valdecasas MS et al. Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy. Am J Gastroenterol 2001; 96: 2718-23.
22. Bajaj JS, Th acker LR, Heuman DM et al. Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study. Liver Transpl 2012; 18: 1179-87.
23. Bass NM, Mullen KD, Sanyal A et al. Rifaximin treatment in hepatic encephalopathy . N Engl J Med 2010; 362: 1071-81.
24. Bajaj JS, Schubert CM, Heuman DM et al. Persistence of cognitive impairment aft er resolution of overt hepatic encephalopathy. Gastroenterology 2010; 138: 2332-40.
25. Riggio O, Ridola L, Pasquale C et al. A simplified psychometric evaluation for the diagnosis of minimal hepatic encephalopathy. Clin Gastroenterol Hepatol 2011; 9: 613-6.e1.
26. Stepanova M, Mishra A, Venkatesan C et al. In-hospital mortality and economic burden associated with hepatic encephalopathy in the United States from 2005 to 2009. Clin Gastroenterol Hepatol 2012; 10: 1034-41.e1.
27. Shawcross DL, Wright G, Olde Damink SW et al. Role of ammonia and inflammation in minimal hepatic encephalopathy. Metab Brain Dis 2007; 22: 125-38.
28. Bajaj JS, Ridlon JM, Hylemon PB et al. Linkage of gut microbiome with cognition in hepatic encephalopathy. Am J Physiol Gastrointest Liver Physiol 2012; 302: G168-G175.