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Volumn 17, Issue 12, 2015, Pages

Cardiovascular Benefits of Dark Chocolate?

Author keywords

Cocoa; Dark chocolate; Epicatechin; Flavanols; Mitochondria; Skeletal muscle

Indexed keywords

ADENOSINE TRIPHOSPHATE; EPICATECHIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

EID: 84944316805     PISSN: 10928464     EISSN: 15343189     Source Type: Journal    
DOI: 10.1007/s11936-015-0419-5     Document Type: Review
Times cited : (10)

References (41)
  • 1
    • 37649008913 scopus 로고    scopus 로고
    • Chemical and archeological evidence for the earliest cacao beverages
    • COI: 1:CAS:528:DC%2BD2sXhsVSru7nM, PID: 18024588
    • Henderson JS, Joyce RA, Hall GR, Hurst WJ, McGoven PE. Chemical and archeological evidence for the earliest cacao beverages. Proc Natl Acad Sci. 2007;104(48):18937–40.
    • (2007) Proc Natl Acad Sci , vol.104 , Issue.48 , pp. 18937-18940
    • Henderson, J.S.1    Joyce, R.A.2    Hall, G.R.3    Hurst, W.J.4    McGoven, P.E.5
  • 4
    • 0012845499 scopus 로고
    • The blood pressure of the Kuna Indians
    • Kean BH. The blood pressure of the Kuna Indians. Am J Trop Med Hyg. 1944;24:341–3.
    • (1944) Am J Trop Med Hyg , vol.24 , pp. 341-343
    • Kean, B.H.1
  • 7
    • 33846661267 scopus 로고    scopus 로고
    • Does flavanol intake influence mortality from nitric-oxide dependent process? Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama
    • COI: 1:CAS:528:DC%2BD2sXhvFCisbg%3D, PID: 17299579
    • Bayard V, Chamorro F, Motta J, Hollenberg NK. Does flavanol intake influence mortality from nitric-oxide dependent process? Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama. Int J Med Sci. 2007;4(1):53–8.
    • (2007) Int J Med Sci , vol.4 , Issue.1 , pp. 53-58
    • Bayard, V.1    Chamorro, F.2    Motta, J.3    Hollenberg, N.K.4
  • 8
    • 27744449813 scopus 로고    scopus 로고
    • Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers
    • COI: 1:CAS:528:DC%2BD2MXhtlarsr%2FN, PID: 16198843
    • Heiss C, Kleinbongard P, Dejam A, Perre S, Schroeter H, Sies H, et al. Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers. J Am Coll Cardiol. 2005;46(7):1276–83.
    • (2005) J Am Coll Cardiol , vol.46 , Issue.7 , pp. 1276-1283
    • Heiss, C.1    Kleinbongard, P.2    Dejam, A.3    Perre, S.4    Schroeter, H.5    Sies, H.6
  • 9
    • 3042707713 scopus 로고    scopus 로고
    • Markers of malign across the cardiovascular continuum: interpretation and application
    • Cohn JN, Quyyumi AA, Hollengerg NK, Jamerson KA. Markers of malign across the cardiovascular continuum: interpretation and application. Circulation. 2004;109:IV-31–6.
    • (2004) Circulation , vol.109 , pp. 31-36
    • Cohn, J.N.1    Quyyumi, A.A.2    Hollengerg, N.K.3    Jamerson, K.A.4
  • 10
    • 44049096970 scopus 로고    scopus 로고
    • Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial
    • COI: 1:CAS:528:DC%2BD1cXms1Wktb4%3D, PID: 18510961
    • Balzer J, Rassaf T, Heiss C, Kleinbongard P, Lauer T, Merx M, et al. Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol. 2008;51(22):2141–9.
    • (2008) J Am Coll Cardiol , vol.51 , Issue.22 , pp. 2141-2149
    • Balzer, J.1    Rassaf, T.2    Heiss, C.3    Kleinbongard, P.4    Lauer, T.5    Merx, M.6
  • 11
    • 36348953898 scopus 로고    scopus 로고
    • Dark chocolate improves coronary vasomotion and reduces platelet reactivity
    • PID: 17984375
    • Flammer AJ, Hermann F, Sudano I, Spieker L, Hermann M, Cooper KA, et al. Dark chocolate improves coronary vasomotion and reduces platelet reactivity. Circulation. 2007;116(21):2376–82.
    • (2007) Circulation , vol.116 , Issue.21 , pp. 2376-2382
    • Flammer, A.J.1    Hermann, F.2    Sudano, I.3    Spieker, L.4    Hermann, M.5    Cooper, K.A.6
  • 12
    • 33644599022 scopus 로고    scopus 로고
    • Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study
    • PID: 16505260
    • Buijsse B, Feskens EJ, Kok FJ, Kromhout D. Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study. Arch Intern Med. 2006;166(4):411–7.
    • (2006) Arch Intern Med , vol.166 , Issue.4 , pp. 411-417
    • Buijsse, B.1    Feskens, E.J.2    Kok, F.J.3    Kromhout, D.4
  • 13
    • 77954271889 scopus 로고    scopus 로고
    • Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults
    • COI: 1:CAS:528:DC%2BC3cXotlCns70%3D, PID: 20354055
    • Buijsse B, Weikert C, Drogan D, Bergmann M, Boeing H. Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults. Eur Heart J. 2010;31(13):1616–23.
    • (2010) Eur Heart J , vol.31 , Issue.13 , pp. 1616-1623
    • Buijsse, B.1    Weikert, C.2    Drogan, D.3    Bergmann, M.4    Boeing, H.5
  • 14
    • 68949083483 scopus 로고    scopus 로고
    • Chocolate consumption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology Program
    • COI: 1:CAS:528:DC%2BD1MXhtFGmtb%2FN, PID: 19711504
    • Janszky I, Mukamal KJ, Ljung R, Ahnve S, Ahlbom A, Hallqvist J. Chocolate consumption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology Program. J Intern Med. 2009;266(3):248–57.
    • (2009) J Intern Med , vol.266 , Issue.3 , pp. 248-257
    • Janszky, I.1    Mukamal, K.J.2    Ljung, R.3    Ahnve, S.4    Ahlbom, A.5    Hallqvist, J.6
  • 15
    • 79953047286 scopus 로고    scopus 로고
    • Chocolate consumption in inversely associated with prevalent coronary heart disease: the National Heart, Lung, and Blood Institute Family Heart Study
    • PID: 20858571
    • Djousse L, Hopkins PN, North KE, Pankow JS, Arnett DK, Ellison RC. Chocolate consumption in inversely associated with prevalent coronary heart disease: the National Heart, Lung, and Blood Institute Family Heart Study. Clin Nutr. 2011;30(2):182–7.
    • (2011) Clin Nutr , vol.30 , Issue.2 , pp. 182-187
    • Djousse, L.1    Hopkins, P.N.2    North, K.E.3    Pankow, J.S.4    Arnett, D.K.5    Ellison, R.C.6
  • 16
    • 79451473124 scopus 로고    scopus 로고
    • Chocolate consumption is inversely associated with calcified atherosclerotic plaques in coronary arteries: the NHLBI Family Heart Study
    • COI: 1:CAS:528:DC%2BC3MXhslKqu74%3D, PID: 20655129
    • Djousse L, Hopkins PN, Arnett DK, Pankow JS, Borecki I, North KE, et al. Chocolate consumption is inversely associated with calcified atherosclerotic plaques in coronary arteries: the NHLBI Family Heart Study. Clin Nutr. 2011;30(1):38–43.
    • (2011) Clin Nutr , vol.30 , Issue.1 , pp. 38-43
    • Djousse, L.1    Hopkins, P.N.2    Arnett, D.K.3    Pankow, J.S.4    Borecki, I.5    North, K.E.6
  • 17
    • 84941556096 scopus 로고    scopus 로고
    • Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women
    • This large analysis of dark chocolate consumption is the most recent data on the topic and suggests that consumption may be related to lower blood pressure. Their paper also includes a meta-analysis of nine separate studies that found an association with dark chocolate and decreased risk of various cardiovascular conditions
    • Kowk C, Boekholdt SM, Lentjes MA, Loke YK, Luben RN, Yeong JK, et al. Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women. Heart. 2015;101(16):1279–87. This large analysis of dark chocolate consumption is the most recent data on the topic and suggests that consumption may be related to lower blood pressure. Their paper also includes a meta-analysis of nine separate studies that found an association with dark chocolate and decreased risk of various cardiovascular conditions.
    • (2015) Heart , vol.101 , Issue.16 , pp. 1279-1287
    • Kowk, C.1    Boekholdt, S.M.2    Lentjes, M.A.3    Loke, Y.K.4    Luben, R.N.5    Yeong, J.K.6
  • 18
    • 84865497143 scopus 로고    scopus 로고
    • Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia
    • COI: 1:CAS:528:DC%2BC38Xht1Siur%2FL, PID: 22851734
    • Grassi D, Desideri G, Necozione S, Ruggieri F, Blumberg JB, Stornello M, et al. Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia. Hypertension. 2012;60(3):827–32.
    • (2012) Hypertension , vol.60 , Issue.3 , pp. 827-832
    • Grassi, D.1    Desideri, G.2    Necozione, S.3    Ruggieri, F.4    Blumberg, J.B.5    Stornello, M.6
  • 19
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications. A unifying mechanism
    • COI: 1:CAS:528:DC%2BD2MXltVaisbk%3D, PID: 15919781
    • Brownlee M. The pathobiology of diabetic complications. A unifying mechanism. Diabetes. 2005;54(6):1615–25.
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1615-1625
    • Brownlee, M.1
  • 20
    • 77953308194 scopus 로고    scopus 로고
    • Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion
    • COI: 1:CAS:528:DC%2BC3cXps1ansbk%3D, PID: 20579545
    • Yamazaki KG, Taub PR, Barraza-Hildalgo M, Rivas MM, Zambon AC, Ceballos G, et al. Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion. J Am Coll Cardiol. 2010;55(25):2869–76.
    • (2010) J Am Coll Cardiol , vol.55 , Issue.25 , pp. 2869-2876
    • Yamazaki, K.G.1    Taub, P.R.2    Barraza-Hildalgo, M.3    Rivas, M.M.4    Zambon, A.C.5    Ceballos, G.6
  • 21
    • 84906790006 scopus 로고    scopus 로고
    • Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BC2cXhtVOntrfE, PID: 24929184
    • Gasper A, Hollands W, Casgrain A, Saha S, Teucher B, Dainty JR, et al. Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: a randomized controlled trial. Arch Biochem Biophys. 2014;559:29–37.
    • (2014) Arch Biochem Biophys , vol.559 , pp. 29-37
    • Gasper, A.1    Hollands, W.2    Casgrain, A.3    Saha, S.4    Teucher, B.5    Dainty, J.R.6
  • 22
    • 32244437985 scopus 로고    scopus 로고
    • (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
    • COI: 1:CAS:528:DC%2BD28XhsVKgtb8%3D, PID: 16418281
    • Schroeter H, Heiss C, Balzer J, Kleinbonard P, Keen CL, Hollenberg NK, et al. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A. 2006;103(4):1024–9.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.4 , pp. 1024-1029
    • Schroeter, H.1    Heiss, C.2    Balzer, J.3    Kleinbonard, P.4    Keen, C.L.5    Hollenberg, N.K.6
  • 23
    • 77952951185 scopus 로고    scopus 로고
    • (-)-Epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways
    • COI: 1:CAS:528:DC%2BC3cXmt1alur4%3D, PID: 20404222
    • Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. (-)-Epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension. 2010;55(6):1398–405.
    • (2010) Hypertension , vol.55 , Issue.6 , pp. 1398-1405
    • Ramirez-Sanchez, I.1    Maya, L.2    Ceballos, G.3    Villarreal, F.4
  • 24
    • 77953308194 scopus 로고    scopus 로고
    • Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion
    • PID: 20579545
    • Ceballos G, Villarreal JL. Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion. J Am Coll Cardiol. 2010;55(25):2869–76.
    • (2010) J Am Coll Cardiol , vol.55 , Issue.25 , pp. 2869-2876
    • Ceballos, G.1    Villarreal, J.L.2
  • 26
    • 48249109117 scopus 로고    scopus 로고
    • Effect of cyclosporine on reperfusion injury in acute myocardial infarction
    • COI: 1:CAS:528:DC%2BD1cXpt1Sgsr4%3D, PID: 18669426
    • Piot C, Croisille P, Staat P, et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med. 2008;359:473–81.
    • (2008) N Engl J Med , vol.359 , pp. 473-481
    • Piot, C.1    Croisille, P.2    Staat, P.3
  • 27
    • 55549114375 scopus 로고    scopus 로고
    • (-)Epigallocatechingallate protects the mitochondria against the deleterious effects of lipids, calcium, and adenosine triphosphate in isoproterenol induced myocardial infarcted male Wistar rats
    • COI: 1:CAS:528:DC%2BD1cXhsVGmu7bE, PID: 18528854
    • Devika PT, Stanely Mainzen Prince P. (-)Epigallocatechingallate protects the mitochondria against the deleterious effects of lipids, calcium, and adenosine triphosphate in isoproterenol induced myocardial infarcted male Wistar rats. J Appl Toxicol. 2008;28(8):938–44.
    • (2008) J Appl Toxicol , vol.28 , Issue.8 , pp. 938-944
    • Devika, P.T.1    Stanely Mainzen Prince, P.2
  • 28
    • 84918801034 scopus 로고    scopus 로고
    • Co-administration of the flavanol (-)-epicatechin with doxycycline synergistically reduced infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling
    • COI: 1:CAS:528:DC%2BC2cXhslehtLbF, PID: 25281837, An assessment of the potential cardioprotective effects of epicatechin in an in vivo rat model. This was the first study to suggest that epicatechin may confer benefits through inhibition of the mitochondrial permeability transition pore (mPTP), which is now a major focus of research
    • Ortiz-Vilchis P, Yamazaki KG, Rubio-Gayosso I, Ramirez-Sanchez I, Calzada C, Romero-Perez D, et al. Co-administration of the flavanol (-)-epicatechin with doxycycline synergistically reduced infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling. Eur J Pharmacol. 2014;744:76–82. An assessment of the potential cardioprotective effects of epicatechin in an in vivo rat model. This was the first study to suggest that epicatechin may confer benefits through inhibition of the mitochondrial permeability transition pore (mPTP), which is now a major focus of research.
    • (2014) Eur J Pharmacol , vol.744 , pp. 76-82
    • Ortiz-Vilchis, P.1    Yamazaki, K.G.2    Rubio-Gayosso, I.3    Ramirez-Sanchez, I.4    Calzada, C.5    Romero-Perez, D.6
  • 29
    • 80052793189 scopus 로고    scopus 로고
    • (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle
    • COI: 1:CAS:528:DC%2BC3MXht1CgsLnO, PID: 21788351
    • Nogueira L, Ramirez-Sanchez I, Perkins GA, Murphy A, Taub PR, Ceballos G, et al. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011;589(Pt 18):4615–31.
    • (2011) J Physiol , vol.589 , pp. 4615-4631
    • Nogueira, L.1    Ramirez-Sanchez, I.2    Perkins, G.A.3    Murphy, A.4    Taub, P.R.5    Ceballos, G.6
  • 30
    • 84857649267 scopus 로고    scopus 로고
    • Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa
    • PID: 22376256, This was the first study of the role of epicatechin on mitochondria in a population at high risk for cardiovascular events. The analysis suggested the beneficial effects of epicatechin upon mitochondria structure and function, analyzed via assessment of skeletal muscle changes and mitochondrial protein levels
    • Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R, et al. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012;5(1):43–7. This was the first study of the role of epicatechin on mitochondria in a population at high risk for cardiovascular events. The analysis suggested the beneficial effects of epicatechin upon mitochondria structure and function, analyzed via assessment of skeletal muscle changes and mitochondrial protein levels.
    • (2012) Clin Transl Sci , vol.5 , Issue.1 , pp. 43-47
    • Taub, P.R.1    Ramirez-Sanchez, I.2    Ciaraldi, T.P.3    Perkins, G.4    Murphy, A.N.5    Naviaux, R.6
  • 31
    • 84944348992 scopus 로고    scopus 로고
    • Effects of dark chocolate (DC) on exercise capacity in sedentary older adults (a double blind placebo controlled trial)
    • 65(10_S)
    • Taub PR, Patel M, Higginbotham E, Ramon L, Moreno-Ulloa A, Ramirez-Sanchez I, Ceballos G, Villarreal F. Effects of dark chocolate (DC) on exercise capacity in sedentary older adults (a double blind placebo controlled trial). J Am Coll Cardiol. 2015; 65(10_S):. doi:10.1016/S0735-1097(15)61455-3.
    • (2015) J Am Coll Cardiol
  • 32
    • 0037031301 scopus 로고    scopus 로고
    • Prediction of long-term prognosis in 12 169 men referred for cardiac rehabilitation
    • PID: 12163425
    • Kavanagh T, Mertens DJ, Hamm LF, et al. Prediction of long-term prognosis in 12 169 men referred for cardiac rehabilitation. Circulation. 2002;106:666–71.
    • (2002) Circulation , vol.106 , pp. 666-671
    • Kavanagh, T.1    Mertens, D.J.2    Hamm, L.F.3
  • 34
    • 84880175168 scopus 로고    scopus 로고
    • Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa
    • COI: 1:CAS:528:DC%2BC3sXpsFChsrg%3D
    • Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Gonzales-Basutro S, Coral-Vazquez R, Perkins G, et al. Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa. Clin Sci (Lond). 2013;125(8):383–9.
    • (2013) Clin Sci (Lond) , vol.125 , Issue.8 , pp. 383-389
    • Taub, P.R.1    Ramirez-Sanchez, I.2    Ciaraldi, T.P.3    Gonzales-Basutro, S.4    Coral-Vazquez, R.5    Perkins, G.6
  • 35
    • 69249110069 scopus 로고    scopus 로고
    • 2+-handling apparatus in diabetes-related muscle weakness
    • COI: 1:CAS:528:DC%2BD1cXltlers70%3D, PID: 21479410
    • 2+-handling apparatus in diabetes-related muscle weakness. Mol Med Rep. 2008;1:297–306.
    • (2008) Mol Med Rep , vol.1 , pp. 297-306
    • Mulvey, C.1    Mullen, E.2    Ohlendieck, K.3
  • 36
    • 84925225912 scopus 로고    scopus 로고
    • Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
    • COI: 1:CAS:528:DC%2BC2cXhvVSqsbnP, PID: 25344629, This illustrates a promising new area of epicatechin research within neurology and cognitive-behavioral sciences. There will likely be more data over the next few years related to epicatechin and effects on cognitive function and other neurological pathways
    • Brickman AM, Khan UA, Provenano FA, Yeung LK, Suzuki W, Schroeter H, et al. Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nat Neurosci. 2014;17(12):1798–803. This illustrates a promising new area of epicatechin research within neurology and cognitive-behavioral sciences. There will likely be more data over the next few years related to epicatechin and effects on cognitive function and other neurological pathways.
    • (2014) Nat Neurosci , vol.17 , Issue.12 , pp. 1798-1803
    • Brickman, A.M.1    Khan, U.A.2    Provenano, F.A.3    Yeung, L.K.4    Suzuki, W.5    Schroeter, H.6
  • 37
    • 84924536187 scopus 로고    scopus 로고
    • Dark chocolate consumption and lower HbA1c in children with diabetes: direct cause or pure happiness?
    • COI: 1:CAS:528:DC%2BC2MXhtFKru7Y%3D, PID: 25620414
    • Scaramuzza AE, Succotti GV. Dark chocolate consumption and lower HbA1c in children with diabetes: direct cause or pure happiness? Clin Nutr. 2015;34(2):333–4.
    • (2015) Clin Nutr , vol.34 , Issue.2 , pp. 333-334
    • Scaramuzza, A.E.1    Succotti, G.V.2
  • 38
    • 84904717733 scopus 로고    scopus 로고
    • The short-term effect of flavonoid-rich dark chocolate on retinal vessel diameter in glaucoma patients and age-matched controls
    • COI: 1:CAS:528:DC%2BC2cXhtF2ltrrP, PID: 24628966
    • Terai N, Gedenk A, Spoerl E, Pillunat LE, Stodmeister R. The short-term effect of flavonoid-rich dark chocolate on retinal vessel diameter in glaucoma patients and age-matched controls. Acta Ophthalmol. 2014;92(5):e341–5.
    • (2014) Acta Ophthalmol , vol.92 , Issue.5 , pp. e341-e345
    • Terai, N.1    Gedenk, A.2    Spoerl, E.3    Pillunat, L.E.4    Stodmeister, R.5
  • 40
    • 84926467838 scopus 로고    scopus 로고
    • (-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice
    • PID: 25821434
    • Lee I, Huttemann M, Kruger A, Bollig-Fischer A, Malek MH. (-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice. Front Pharmacol. 2015;6:43.
    • (2015) Front Pharmacol , vol.6 , pp. 43
    • Lee, I.1    Huttemann, M.2    Kruger, A.3    Bollig-Fischer, A.4    Malek, M.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.