β-Elemene induces apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase

Pharmacological Reports

Volumn 68, Issue 1, 2016, Pages 7-11

  Zou, Shibo ^a   Wang, Changyin ^a   Cui, Zhengjun ^a   Guo, Pengfei ^a   Meng, Qingnan ^a   Shi, Xun ^a   Gao, Ya ^a   Yang, Gaoyuan ^a   Han, Zhaofeng ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Apoptosis; Oxidative stress; Rheumatoid arthritis; Elemene

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; BETA ELEMENE; CASPASE 3; CASPASE 9; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; BETA-ELEMENE; SESQUITERPENE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MITOCHONDRIAL MEMBRANE POTENTIAL; NORMAL HUMAN; RHEUMATOID ARTHRITIS; RHEUMATOID ARTHRITIS FIBROBLAST LIKE SYNOVIOCYTE; SYNOVIOCYTE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY; SYNOVIUM;

APOPTOSIS; ARTHRITIS, RHEUMATOID; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SESQUITERPENES; SYNOVIAL MEMBRANE;

EID: 84944230060     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2015.06.004     Document Type: Article

References (30)

1. I.B. McInnes, and G. Schett The pathogenesis of rheumatoid arthritis N Engl J Med 365 23 2011 2205 2219
2. N. Bottini, and G.S. Firestein Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors Nat Rev Rheumatol 9 1 2013 24 33
3. B. Bartok, and G.S. Firestein Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis Immunol Rev 233 1 2010 233 255
4. R.M. Pope Apoptosis as a therapeutic tool in rheumatoid arthritis Nat Rev Immunol 2 7 2002 527 535
5. A. Baier, I. Meineckel, S. Gay, and T. Pap Apoptosis in rheumatoid arthritis Curr Opin Rheumatol 15 3 2003 274 279
6. H. Li, and A. Wan Apoptosis of rheumatoid arthritis fibroblast-like synoviocytes: possible roles of nitric oxide and the thioredoxin 1 Mediators Inflamm 2013 2013 953462
7. U. Laothong, Y. Hiraku, S. Oikawa, K. Intuyod, M. Murata, and S. Pinlaor Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway Oncol Rep 2015 10.3892/or.2015.3738
8. B.E. Oyinloye, A.F. Adenowo, and A.P. Kappo Reactive oxygen species, apoptosis, antimicrobial peptides and human inflammatory diseases Pharmaceuticals (Basel) 8 2 2015 151 175
9. G.C. Shin, C. Kim, J.M. Lee, W.S. Cho, S.G. Lee, M. Jeong, and et al. Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes Chem Biol Interact 182 1 2009 29 36
10. V.H. Olavarría, P. Recabarren, F. Fredericksen, M. Villalba, and A. Yáñez ISAV infection promotes apoptosis of SHK-1 cells through a ROS/p38 MAPK/Bad signaling pathway Mol Immunol 64 1 2015 1 8
11. X. Chen, Y. Wang, H. Luo, Z. Luo, T. Zhang, N. Yang, and et al. β-Elemene acts as an antitumor factor and downregulates the expression of survivin, Bcl-xL and Mta-1 Mol Med Rep 6 5 2012 989 995
12. R.X. Lee, Q.Q. Li, and E. Reed β-Elemene effectively suppresses the growth and survival of both platinum-sensitive and -resistant ovarian tumor cells Anticancer Res 32 8 2012 3103 3113
13. Q.Q. Li, G. Wang, F. Huang, M. Banda, and E. Reed Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells J Pharm Pharmacol 62 8 2010 1018 1027
14. C.C. Yao, Y.R. Tu, J. Jiang, S.F. Ye, H.X. Du, and Y. Zhang β-elemene reverses the drug resistance of lung cancer A549/DDP cells via the mitochondrial apoptosis pathway Oncol Rep 31 5 2014 2131 2138
15. Y.Q. Yao, X. Ding, Y.C. Jia, C.X. Huang, Y.Z. Wang, and Y.H. Xu Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation Cancer Lett 264 1 2008 127 134
16. A. Glasow, N. Prodromou, K. Xu, M. von Lindern, and A. Zelent Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways Blood 105 1 2005 341 349
17. L.B. Liu, H. Xie, Y.X. Xue, Y.H. Liu, Z. Li, and P. Wang Endothelial-monocyte-activating polypeptide II induces rat C6 glioma cell apoptosis via the mitochondrial pathway Biochem Biophys Res Commun 457 4 2015 595 601
18. P. Hua, M. Sun, G. Zhang, Y. Zhang, X. Tian, X Li, and et al. Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells Biochem Biophys Res Commun 2015 pii: S0006-291X(15)00378-2
19. C. Guan, W. Liu, Y. Yue, H. Jin, X. Wang, and X.J. Wang Inhibitory effect of β-elemene on human breast cancer cells Int J Clin Exp Pathol 7 7 2014 3948 3956
20. Z. Hu, H. Wu, Y. Li, Q. Hou, Y. Wang, S. Li, and et al. β-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of hTERT expression Anticancer Drugs 26 5 2015 531 539
21. X. Li, G. Wang, J. Zhao, H. Ding, C. Cunningham, F. Chen, and et al. Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase Cell Mol Life Sci 62 7-8 2005 894 904
22. P. Caroppi, F. Sinibaldi, L. Fiorucci, and R. Santucci Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome C as proapoptotic protein Curr Med Chem 16 31 2009 4058 4065
23. L.R. Kong, K.N. Chua, W.J. Sim, H.C. Ng, C. Bi, J. Ho, and et al. MEK inhibition overcomes cisplatin resistance conferred by SOS/MAPK pathway activation in squamous cell carcinoma Mol Cancer Ther 2015 pii: molcanther.0062.2015
24. W. Hao, X. Yuan, L. Yu, C. Gao, X. Sun, D. Wang, and et al. Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways Sci Rep 5 2015 10336
25. B. Liagre, D.Y. Leger, P. Vergne-Salle, and J.L. Beneytout MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production Int J Mol Med 19 1 2007 113 122
26. B. Liagre, P. Vergne-Salle, D.Y. Leger, and J.L. Beneytout Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2 Int J Mol Med 20 4 2007 451 460
27. Q. Zhang, J. Wu, Q. Cao, L. Xiao, L. Wang, D. He, and et al. A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis Arthritis Rheum 60 12 2009 3602 3612
28. H. Zhou, T. Shen, C. Shang, Y. Luo, L. Liu, J. Yan, and et al. Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway Oncotarget 5 20 2014 10140 10150
29. Z. Yu, R. Wang, L. Xu, S. Xie, J. Dong, and Y. Jing β-Elemene piperazine derivatives induce apoptosis in human leukemia cells through downregulation of c-FLIP and generation of ROS PLoS ONE 6 1 2011 e15843
30. F. Hu, S. Yang, D. Zhao, S. Zhu, Y. Wang, and J. Li Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-κB translocation and ROS production in synoviocytes Biochem Biophys Res Commun 424 1 2012 196 200