Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway

Oncology Reports

Volumn 33, Issue 3, 2015, Pages 1443-1449

  Laothong, Umawadee ^a,b,d   Hiraku, Yusuke ^b   Oikawa, Shinji ^b   Intuyod, Kitti ^a,c   Murata, Mariko ^b   Pinlaor, Somchai ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

^b MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KHON KAEN UNIVERSITY   (Thailand)

^d MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Apoptosis; Cholangiocarcinoma; DNA damage; Melatonin; Mitochondrial pathway; Reactive oxygen species

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CASPASE 3; CASPASE 7; CYTOCHROME C; DNA; MELATONIN; REACTIVE OXYGEN METABOLITE; 8-OXO-7-HYDRODEOXYGUANOSINE; ANTIOXIDANT; DEOXYGUANOSINE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CHOLANGIOCARCINOMA CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; KKU M055 CELL LINE; KKU M214 CELL LINE; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; BILE DUCT TUMOR; BIOSYNTHESIS; CELL SURVIVAL; CHOLANGIOCARCINOMA; DRUG EFFECTS; GENETICS; INTRAHEPATIC BILE DUCT; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY; TUMOR CELL LINE;

ANTIOXIDANTS; APOPTOSIS; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CELL LINE, TUMOR; CELL SURVIVAL; CHOLANGIOCARCINOMA; DEOXYGUANOSINE; DNA DAMAGE; HUMANS; MELATONIN; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84921671445     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.3738     Document Type: Article

References (32)

1. Anderson CD, Pinson CW, Berlin J and Chari RS: Diagnosis and treatment of cholangiocarcinoma. Oncologist 9:43-57, 2004.
2. Tyson GL and El-Serag HB: Risk factors for cholangiocarcinoma. Hepatology 54:173-184, 2011.
3. IARC: A Review of Human Carcinogens: Opisthorchis viverrini and Clonorchis sinensis. IARC Monogr Eval Carcinog Risks Hum 100 B: 341-370, 2012.
4. Gerl R and Vaux DL: Apoptosis in the development and treatment of cancer. Carcinogenesis 26:263-270, 2005.
5. Kaufmann SH and Earnshaw WC: Induction of apoptosis by cancer chemotherapy. Exp Cell Res 256:42-49, 2000.
6. Hannun YA: Apoptosis and the dilemma of cancer chemotherapy. Blood 89:1845-1853, 1997.
7. Hail N Jr and Lotan R: Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state. Mol Nutr Food Res 53:49-67, 2009.
8. Turrens JF: Mitochondrial formation of reactive oxygen species. J Physiol 552:335-344, 2003.
9. Green DR and Reed JC: Mitochondria and apoptosis. Science 281:1309-1312, 1998.
10. Desagher S and Martinou JC: Mitochondria as the central control point of apoptosis. Trends Cell Biol 10:369-377, 2000.
11. Kasibhatla S and Tseng B: Why target apoptosis in cancer treatment? Mol Cancer Ther 2:573-580, 2003.
12. Zhang HM and Zhang Y: Melatonin: a well-documented antioxidant with conditional pro-oxidant actions. J Pineal Res 57:131-146, 2014.
13. Bartsch C, Bartsch H and Karasek M: Melatonin in clinical oncology. Neuro Endocrinol Lett 23:30-38, 2002.
14. Jung B and Ahmad N: Melatonin in cancer management: progress and promise. Cancer Res 66:9789-9793, 2006.
15. Laothong U, Pinlaor P, Boonsiri P, et al: Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters. J Pineal Res 55:257-266, 2013.
16. Sripa B, Leungwattanawanit S, Nitta T, et al: Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100). World J Gastroenterol 11:3392-3397, 2005.
17. Sanchez-Barcelo EJ, Cos S, Fernandez R and Mediavilla MD: Melatonin and mammary cancer: a short review. Endocr Relat Cancer 10:153-159, 2003.
18. Hill SM, Frasch T, Xiang S, Yuan L, Duplessis T and Mao L: Molecular mechanisms of melatonin anticancer effects. Integr Cancer Ther 8:337-346, 2009.
19. Barrenetxe J, Delagrange P and Martinez JA: Physiological and metabolic functions of melatonin. J Physiol Biochem 60:61-72, 2004.
20. Bejarano I, Espino J, Barriga C, Reiter RJ, Pariente JA and Rodriguez AB: Pro-oxidant effect of melatonin in tumour leucocytes: relation with its cytotoxic and pro-apoptotic effects. Basic Clin Pharmacol Toxicol 108:14-20, 2011.
21. Rodriguez C, Martin V, Herrera F, et al: Mechanisms involved in the pro-apoptotic effect of melatonin in cancer cells. Int J Mol Sci 14:6597-6613, 2013.
22. Carbajo-Pescador S, Garcia-Palomo A, Martin-Renedo J, Piva M, Gonzalez-Gallego J and Mauriz JL: Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor. J Pineal Res 51:463-471, 2011.
23. Han Y, Demorrow S, Invernizzi P, et al: Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth. Am J Physiol Gastrointest Liver Physiol 301:G623-G633, 2011.
24. Motilva V, Garcia-Maurino S, Talero E and Illanes M: New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin. J Pineal Res 51:44-60, 2011.
25. Proietti S, Cucina A, Reiter RJ and Bizzarri M: Molecular mechanisms of melatonin's inhibitory actions on breast cancers. Cell Mol Life Sci 70:2139-2157, 2013.
26. Laothong U, Pinlaor P, Hiraku Y, et al: Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters. J Pineal Res 49:271-282, 2010.
27. Buyukavci M, Ozdemir O, Buck S, Stout M, Ravindranath Y and Savasan S: Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect. Fundam Clin Pharmacol 20:73-79, 2006.
28. Bejarano I, Espino J, Marchena AM, et al: Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem 353:167-176, 2011.
29. Lissoni P, Paolorossi F, Tancini G, et al: A phase II study of tamoxifen plus melatonin in metastatic solid tumour patients. Br J Cancer 74:1466-1468, 1996.
30. Martin-Renedo J, Mauriz JL, Jorquera F, Ruiz-Andres O, Gonzalez P and Gonzalez-Gallego J: Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res 45:532-540, 2008.
31. Osseni RA, Rat P, Bogdan A, Warnet JM and Touitou Y: Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2. Life Sci 68:387-399, 2000.
32. Kim W, Jeong JW and Kim JE: CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells. Tumour Biol 135:10919-10929, 2014.