Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Sugawara, Taichi ^a   Kano, Fumi ^a,b   Murata, Masayuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; POLYUBIQUITIN; PROINSULIN; PROTEIN AGGREGATE; RAB PROTEIN; RAB2A PROTEIN, MOUSE; SMALL INTERFERING RNA;

ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; COATED VESICLE; DRUG EFFECTS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; GENETICS; GOLGI COMPLEX; METABOLISM; MOUSE; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; COP-COATED VESICLES; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; GLUCOSE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); GOLGI APPARATUS; INSULIN-SECRETING CELLS; MICE; POLYUBIQUITIN; PROINSULIN; PROTEIN AGGREGATES; RAB GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84944169976     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep06952     Document Type: Article

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