Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 5, 2015, Pages 1329-1340.e9

  Kiwamoto, Takumi ^a   Katoh, Toshihiko ^b   Evans, Christopher M ^c   Janssen, William J ^c,d   Brummet, Mary E ^a   Hudson, Sherry A ^a   Zhu, Zhou ^a,e   Tiemeyer, Michael ^b   Bochner, Bruce S ^a,f  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d DEPARTMENT OF MEDICINE   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NORTHWESTERN UNIVERSITY   (United States)

Author keywords

airway; apoptosis; asthma; Eosinophil; epithelium; glands; glycan ligands; lung; Muc4; Muc5b; mucin; Siglec F

Indexed keywords

GLYCAN; INTERLEUKIN 5; MUCIN 4; MUCIN 5B; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN F; UNCLASSIFIED DRUG; CARRIER PROTEIN; CYTOKINE; DIFFERENTIATION ANTIGEN; LIGAND; MUCIN; POLYSACCHARIDE; PROTEIN BINDING; SIGLEC5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL DEATH; CONTROLLED STUDY; CYTOCHEMISTRY; EOSINOPHIL; FLOW CYTOMETRY; GLYCOSYLATION; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEOMICS; SIALYLATION; SOLVOLYSIS; SULFATION; TANDEM MASS SPECTROMETRY; TRACHEA MUCOSA; UPREGULATION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; EPITHELIUM CELL; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; LUNG; METABOLISM; PATHOLOGY; PHENOTYPE; PROCEDURES; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; APOPTOSIS; CARRIER PROTEINS; CYTOKINES; EOSINOPHILS; EPITHELIAL CELLS; IMMUNOPHENOTYPING; LIGANDS; LUNG; MICE; MICE, TRANSGENIC; MUCIN-4; MUCIN-5B; MUCINS; PHENOTYPE; POLYSACCHARIDES; PROTEIN BINDING; PROTEOMICS; SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTINS;

EID: 84944096046     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.10.027     Document Type: Article

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