Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13

Respiratory Research

Volumn 11, Issue , 2010, Pages

  Cho, Jae Youn ^a   Song, Dae Jae ^a   Pham, Alexa ^a   Rosenthal, Peter ^a   Miller, Marina ^a   Dayan, Shanna ^a   Doherty, Taylor A ^a   Varki, Ajit ^a   Broide, David H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; FIBRONECTIN; INTERLEUKIN 13; INTERLEUKIN 4; LECTIN; OVA ALLERGEN; SIALIC ACID BINDUNG IG SUPERFAMILY LECTIN F; UNCLASSIFIED DRUG; DIFFERENTIATION ANTIGEN; LIGAND; OVALBUMIN; SIGLEC F PROTEIN, MOUSE; SIGLEC-F PROTEIN, MOUSE;

ARTICLE; CONTROLLED STUDY; EOSINOPHIL; HISTOPATHOLOGY; INFLAMMATION; MOUSE; MUCUS; NONHUMAN; PROTEIN EXPRESSION; AIRWAY REMODELING; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; EPITHELIUM CELL; LUNG; METABOLISM; PHYSIOLOGY; UPREGULATION;

AIRWAY REMODELING; ANIMALS; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CELLS, CULTURED; EOSINOPHILS; EPITHELIAL CELLS; INTERLEUKIN-13; INTERLEUKIN-4; LIGANDS; LUNG; MICE; MICE, INBRED C57BL; MUCUS; OVALBUMIN; UP-REGULATION;

EID: 77958571341     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-154     Document Type: Article

References (42)

1. Crocker PR, Paulson JC, Varki A. Siglecs and their roles in the immune system. Nat Rev Immunol 2007, 7:255-266. 10.1038/nri2056, 17380156.
2. Aizawa H, Zimmermann N, Carrigan PE, Lee JJ, Rothenberg ME, Bochner BS. Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G). Genomics 2003, 82:521-530. 10.1016/S0888-7543(03)00171-X, 14559209.
3. Angata T, Hingorani R, Varki NM, Varki A. Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters. J Biol Chem 2001, 276:45128-45136. 10.1074/jbc.M108573200, 11579105.
4. Tateno H, Crocker PR, Paulson JC. Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6'-sulfo-sialyl Lewis × as a preferred glycan ligand. Glycobiology 2005, 15:1125-1135. 10.1093/glycob/cwi097, 15972893.
5. Zhang M, Angata T, Cho JY, Miller M, Broide DH, Varki A. Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood 2007, 109:4280-4287. 10.1182/blood-2006-08-039255, 1885492, 17272508.
6. Bochner BS, Alvarez RA, Mehta P, Bovin NV, Blixt O, White JR, Schnaar RL. Glycan array screening reveals a candidate ligand for Siglec-8. J Biol Chem 2005, 280:4307-4312. 10.1074/jbc.M412378200, 15563466.
7. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Friedman S, Broide DH. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest 2004, 113:551-560. 338264, 14966564.
8. Floyd H, Ni J, Cornish AL, Zeng Z, Liu D, Carter KC, Steel J, Crocker PR. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily. J Biol Chem 2000, 275:861-866. 10.1074/jbc.275.2.861, 10625619.
9. Avril T, Floyd H, Lopez F, Vivier E, Crocker PR. The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related siglecs expressed on human monocytes and NK cells. J Immunol 2004, 173:6841-6849.
10. Ravetch JV, Lanier LL. Immune inhibitory receptors. Science 2000, 290:84-89. 10.1126/science.290.5489.84, 11021804.
11. Nutku E, Aizawa H, Hudson SA, Bochner BS. Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. Blood 2003, 101:5014-5020. 10.1182/blood-2002-10-3058, 12609831.
12. Vitale C, Romagnani C, Falco M, Ponte M, Vitale M, Moretta A, Bacigalupo A, Moretta L, Mingari MC. Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. Proc Natl Acad Sci USA 1999, 96:15091-15096. 10.1073/pnas.96.26.15091, 24778, 10611343.
13. von Gunten S, Yousefi S, Seitz M, Jakob SM, Schaffner T, Seger R, Takala J, Villiger PM, Simon HU. Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment. Blood 2005, 106:1423-1431. 10.1182/blood-2004-10-4112, 15827126.
14. Song DJ, Cho JY, Miller M, Strangman W, Zhang M, Varki A, Broide DH. Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model. Clin Immunol 2009, 131:157-169. 10.1016/j.clim.2008.11.009, 2683248, 19135419.
15. Song DJ, Cho JY, Lee SY, Miller M, Rosenthal P, Soroosh P, Croft M, Zhang M, Varki A, Broide DH. Anti-Siglec-F antibody reduces allergen induced eosinophilic inflammation and airway remodeling. J Immunol 2009, 183:5333-5341. 10.4049/jimmunol.0801421, 2788790, 19783675.
16. Zimmerman N, McBride ML, Yamada Y, Hudson SA, Jones C, Cromie KD, Crocker PR, Rothenberg ME, Bochner BS. Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils. Allergy 2008, 63:1156-1163. 10.1111/j.1398-9995.2008.01709.x, 2726770, 18699932.
17. Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig MS, Barnes N, Robinson D, Kay AB. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 2003, 112:1029-1036. 198522, 14523040.
18. Lim DH, Cho JY, Song DJ, Lee SY, Miller M, Broide DH. PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling. Am J Physiol Lung Cell Mol Physiol 2009, 296:L210-219. 22, 10.1152/ajplung.90275.2008, 2643991, 19028980.
19. Christie PE, Henderson WR. Lipid inflammatory mediators: leukotrienes, prostaglandins, platelet-activating factor. Clin Allergy Immunol 2002, 16:233-254.
20. Henderson WR, Tang LO, Chu SJ, Tsao SM, Chiang GK, Jones F, Jonas M, Pae C, Wang H, Chi EY. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 2002, 165:108-116.
21. Thomas MJ, Smith A, Head DH, Milne L, Nicholls A, Pearce W, Vanhaesebroeck B, Wymann MP, Hirsch E, Trifilieff A, Walker C, Finan P, Westwick J. Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases. Eur J Immunol 2005, 35:1283-1291. 10.1002/eji.200425634, 15739165.
22. Le AV, Cho JY, Miller M, McElwain S, Golgotiu K, Broide DH. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J Immunol 2007, 178:7310-7316.
23. Lim DH, Cho JY, Miller M, McElwain K, McElwain S, Broide DH. Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice. Am J Physiol Lung Cell Mol Physiol 2006, 291:L265-271. 10.1152/ajplung.00305.2005, 16825657.
24. Hudson SA, Bovin NV, Schnaar RL, Crocker PR, Bochner BS. Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic siglec-8 ligand, polymeric 6'-sulfated sialyl lewis X. J Pharmacol Exp Ther 2009, 330:608-612. 10.1124/jpet.109.152439, 2713093, 19458105.
25. McMillan SJ, Xanthou G, Lloyd CM. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. J Immunol 2005, 174:5774-5780.
26. Fattouh R, Midence G, Arias K, Johnson J, Walker T, Goncharova S, Souza K, Gregory R, Lonning S, Gauldie J, Jordana M. Transforming growth factor-β regulates house dust mite-induced allergic airway inflammation but not airway remodeling. Am J Repir Crit Care Med 2008, 177:593-603.
27. Alcorn J, Rinaldi L, Jaffe E, van Loon M, Bates J, Janssen-Heininger Y, Irvin C. Transforming growth factor-β1 suppresses airway hyperresponsiveness in allergic airway disease. Am J Respir Crit Care Med 2007, 176:974-982. 10.1164/rccm.200702-334OC, 2078678, 17761617.
28. Deng H, Dokshin GA, Jing L, Goldsmith AM, Bitar KN, Fingar DC, Hershenson MB, Bentley JK. Inhibition of glycogen synthase kinase-3β is sufficient for airway smooth muscle hypertrophy. J Biol Chem 2008, 283:10198-10207. 10.1074/jbc.M800624200, 2442285, 18252708.
29. Lundgren LD, Davey RT, Lundgren B, Mullol J, Marom Z, Logun C, Baraniuk J, Kaliner MA, Shelhamer JH. Eosinophil cationic protein stimulates and major basic protein inhibits airway mucus secretion. J Allergy Clin Immunol 1991, 87:689-698. 10.1016/0091-6749(91)90390-A, 2005321.
30. Ponikau JU, Sherris DA, Kephart GM, Kern EB, Congdon DJ, Adolphson CR, Springett MJ, Gleich GJ, Kita H. Striking deposition of toxic eosinophil major basic protein in mucus: Implications for chronic rhinosinusitis. J Allergy Clin Immunol 2005, 116:362-369. 10.1016/j.jaci.2005.03.049, 16083791.
31. Lai HY, Rogers DF. Mucus hypersecretion in asthma: intracellular signaling pathways as targets for pharmacotherapy. Curr Opin Allergy Clin Immunol 2010, 10:67-76. 10.1097/ACI.0b013e328334643a, 19907312.
32. White ES, Baralle FE, Muro AF. New insights into form and function of fibronectin splice variants. J Pathol 2008, 216:1-14. 10.1002/path.2388, 18680111.
33. Burgess JK. The role of the extracellular matrix and specific growth factors in the regulation of inflammation and remodelling in asthma. Pharmacol Ther 2009, 122:19-29. 10.1016/j.pharmthera.2008.12.002, 19141302.
34. Dolhnikoff M, da Silva LF, de Araujo BB, Gomes HA, Fernezlian S, Mulder A, Lindeman JH, Mauad T. The outer wall of small airways is a major site of remodeling in fatal asthma. J Allergy Clin Immunol 2009, 123:1090-1097. 10.1016/j.jaci.2009.02.032, 19361849.
35. McDonald JA, Kelley DG, Broekelmann T. Role of fibronectin in collagen deposition: Fab' to the gelatin-binding domain of fibronectin inhibits both fibronectin and collagen organization in fibroblast extracellular matrix. J Cell Biol 1982, 92:485-492. 10.1083/jcb.92.2.485, 2112086, 7061591.
36. Kato J, Kohyama T, Okazaki H, Desaki M, Nagase T, Rennard SI, Takizawa H. Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts. Clin Immunol 2005, 117:177-181. 10.1016/j.clim.2005.07.003, 16109507.
37. Hirst SJ, Twort CH, Lee TH. Differential effects of extracellular matrix proteins on human airway smooth muscle cell proliferation and phenotype. Am J Respir Cell Mol Biol 2000, 23:335-344.
38. Chan V, Burgess JK, Ratoff JC, O'Connor BJ, Greenough A, Lee TH, Hirst SJ. Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells. Am J Respir Crit Care Med 2006, 174:379-385. 10.1164/rccm.200509-1420OC, 16709936.
39. James AL, Pare PD, Hogg JC. The mechanics in airway narrowing in asthma. Am Rev Respir Dis 1989, 139:242-246.
40. Niimi A, Matsumoto H, Takemura M, Ueda T, Chin K, Mishima M. Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma. Am J Respir Crit Care Med 2003, 168:983-988. 10.1164/rccm.200211-1268OC, 12829452.
41. Pare PD. Airway hyperresponsiveness in asthma geometry is not everything!. Am J Respir Crit Care Med 2003, 168:913-914. 10.1164/rccm.2307005, 14555455.
42. Kikly KK, Bochner BS, Freeman S, Tan KB, Gallagher KT, D'Alessio K, Holmes SD, Abrahamson J, Hopson CB, Fischer EI, Erickson-Miller CL, Tachimoto H, Schleimer RP, White JR. Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. J Allergy Clin Immunol 2000, 105:1093-1100. 10.1067/mai.2000.107127, 10856141.