메뉴 건너뛰기




Volumn 15, Issue 12, 2015, Pages

Therapies on the Horizon for Diabetic Kidney Disease

Author keywords

Bardoxolone; Diabetic nephropathy; JAK STAT; TGF

Indexed keywords

AFLIBERCEPT; AKB 9778; ALANINE AMINOTRANSFERASE; ALLOPURINOL; ANGIOGENESIS INHIBITOR; ATRASENTAN; AVOSENTAN; BARDOXOLONE METHYL; BARICITINIB; BEVACIZUMAB; BINDARIT; GKT 137831; IRBESARTAN; LOSARTAN; OXIDOREDUCTASE INHIBITOR; PARICALCITOL; PENTOXIFYLLINE; PIRFENIDONE; PLACEBO; RANIBIZUMAB; RUBOXISTAURIN; SPIRONOLACTONE; SULODEXIDE; UNCLASSIFIED DRUG; JANUS KINASE; STAT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84944040027     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-015-0685-3     Document Type: Review
Times cited : (31)

References (64)
  • 2
    • 84937787230 scopus 로고    scopus 로고
    • US Renal Data System 2014 annual data report: epidemiology of kidney disease in the United States
    • Saran R, Li Y, Robinson B, et al. US Renal Data System 2014 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis. 2015;66(1 suppl 1):S1–306.
    • (2015) Am J Kidney Dis , vol.66 , pp. 1-306
    • Saran, R.1    Li, Y.2    Robinson, B.3
  • 3
    • 84919448359 scopus 로고    scopus 로고
    • Non-proteinuric Diabetic Nephropathy
    • Chawla V, Bijan R. Non-proteinuric Diabetic Nephropathy. Curr Diab Rep. 2014; 14–529.
    • (2014) Curr Diab Rep , pp. 14-529
    • Chawla, V.1    Bijan, R.2
  • 4
    • 0026530073 scopus 로고
    • Prognostic significance of microalbuminuria in insulin-dependent diabetes mellitus: a twenty-three year follow-up study
    • COI: 1:STN:280:DyaK38zot1Wntg%3D%3D, PID: 1513106
    • Messent JW, Elliot TG, Hill RD, et al. Prognostic significance of microalbuminuria in insulin-dependent diabetes mellitus: a twenty-three year follow-up study. Kidney Int. 1992;41:836–9.
    • (1992) Kidney Int , vol.41 , pp. 836-839
    • Messent, J.W.1    Elliot, T.G.2    Hill, R.D.3
  • 5
    • 84872313601 scopus 로고    scopus 로고
    • Mechanisms of diabetic complications
    • COI: 1:CAS:528:DC%2BC3sXhvFKns7w%3D, PID: 23303908
    • Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013;93(1):137–88.
    • (2013) Physiol Rev , vol.93 , Issue.1 , pp. 137-188
    • Forbes, J.M.1    Cooper, M.E.2
  • 6
    • 79959487586 scopus 로고    scopus 로고
    • Temporal trends in prevalence of diabetic kidney disease in the United States
    • PID: 21693741
    • de Boer IH, Rue TC, Hall YN, et al. Temporal trends in prevalence of diabetic kidney disease in the United States. JAMA. 2011;305(24):2532–9.
    • (2011) JAMA , vol.305 , Issue.24 , pp. 2532-2539
    • de Boer, I.H.1    Rue, T.C.2    Hall, Y.N.3
  • 7
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977–86.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 8
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. (UKPDS 33)
    • UK Propspective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. (UKPDS 33). Lancet. 1998;352:837–53.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 9
    • 84867497463 scopus 로고    scopus 로고
    • KDOQI clinical practice guideline for diabetes and CKD: 2012 update
    • National Kidney Foundation. KDOQI clinical practice guideline for diabetes and CKD: 2012 update. Am J Kidney Dis. 2012;60(5):850–86.
    • (2012) Am J Kidney Dis , vol.60 , Issue.5 , pp. 850-886
  • 10
    • 84874644599 scopus 로고    scopus 로고
    • KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease
    • Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013;3:1–150.
    • (2013) Kidney Int Suppl , vol.3 , pp. 1-150
  • 11
    • 84930465070 scopus 로고    scopus 로고
    • Standards of medical care in diabetes—2015
    • American Diabetes Association. Standards of medical care in diabetes—2015. Diabetes Care. 2015;38 suppl 1:S1–93.
    • (2015) Diabetes Care , vol.38 , pp. 1-93
  • 12
    • 84887467090 scopus 로고    scopus 로고
    • Combined angiotensin inhibition for the treatment of diabetic enphroatphy
    • COI: 1:CAS:528:DC%2BC3sXhvVams73E, PID: 24206457
    • Fried LF, Emanuele N, Zhang JH, et al. Combined angiotensin inhibition for the treatment of diabetic enphroatphy. N Engl J Med. 2013;369:1892–903.
    • (2013) N Engl J Med , vol.369 , pp. 1892-1903
    • Fried, L.F.1    Emanuele, N.2    Zhang, J.H.3
  • 13
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both in people at high vascular risk (the ONTARGET study): a multicenter, randomised, double-blind, controlled trial
    • COI: 1:CAS:528:DC%2BD1cXpvFKgsLs%3D, PID: 18707986
    • Mann JF, Schmieder RE, McQueen M, et al. Renal outcomes with telmisartan, ramipril, or both in people at high vascular risk (the ONTARGET study): a multicenter, randomised, double-blind, controlled trial. Lancet. 2008;372:547–53.
    • (2008) Lancet , vol.372 , pp. 547-553
    • Mann, J.F.1    Schmieder, R.E.2    McQueen, M.3
  • 14
    • 84869492851 scopus 로고    scopus 로고
    • Cardiorenal end points in a trial of aliskiren for type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhvVakt73F, PID: 23121378
    • Parving HH, Brenner BM, McMurray JJ, et al. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med. 2012;367(23):2204–13.
    • (2012) N Engl J Med , vol.367 , Issue.23 , pp. 2204-2213
    • Parving, H.H.1    Brenner, B.M.2    McMurray, J.J.3
  • 15
    • 0037222490 scopus 로고    scopus 로고
    • Effectiveness of aldosterone blockade in patients with diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD38Xps1Ohu74%3D, PID: 12511531
    • Sato A, Hayashi K, Naruse M, et al. Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension. 2003;41:64–8.
    • (2003) Hypertension , vol.41 , pp. 64-68
    • Sato, A.1    Hayashi, K.2    Naruse, M.3
  • 16
    • 24144495285 scopus 로고    scopus 로고
    • Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD2MXhtVGntrzO, PID: 16123474
    • Rossing K, Schoedt K, Smidt U, et al. Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy. Diabetes Care. 2005;28:2106–211.
    • (2005) Diabetes Care , vol.28 , pp. 2106-2211
    • Rossing, K.1    Schoedt, K.2    Smidt, U.3
  • 17
    • 20544465842 scopus 로고    scopus 로고
    • Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study
    • COI: 1:CAS:528:DC%2BD2MXmvVaqurw%3D, PID: 15983956
    • Bianchi S, Bigazzi R, Campese V, et al. Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study. Am J Kidney Dis. 2005;46:45–51.
    • (2005) Am J Kidney Dis , vol.46 , pp. 45-51
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.3
  • 18
    • 84893855713 scopus 로고    scopus 로고
    • The Nrf2 pathway in the progression of renal disease
    • COI: 1:CAS:528:DC%2BC2cXhslyrsrg%3D, PID: 23761459
    • Zoja C, Benigni A, Remuzzi G. The Nrf2 pathway in the progression of renal disease. Nephrol Dial Transplant. 2014;29:i19–24.
    • (2014) Nephrol Dial Transplant , vol.29 , pp. 19-24
    • Zoja, C.1    Benigni, A.2    Remuzzi, G.3
  • 19
    • 84900422389 scopus 로고    scopus 로고
    • The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuate oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease
    • COI: 1:CAS:528:DC%2BC2cXns12htL0%3D, PID: 24195589
    • Aminzadeh MA, Reisman SA, Vziri ND, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuate oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica. 2014;44:570–8.
    • (2014) Xenobiotica , vol.44 , pp. 570-578
    • Aminzadeh, M.A.1    Reisman, S.A.2    Vziri, N.D.3
  • 20
    • 79960855656 scopus 로고    scopus 로고
    • Bardoxolone methyl and kidney function in CKD with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3MXpslSnsrs%3D, PID: 21699484
    • Pergola P, Raskin P, Toto P, et al. Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med. 2011;365:327–36.
    • (2011) N Engl J Med , vol.365 , pp. 327-336
    • Pergola, P.1    Raskin, P.2    Toto, P.3
  • 21
    • 84901734541 scopus 로고    scopus 로고
    • Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes and stage 4 chronic kidney disease treated with Bardoxolone Methyl
    • COI: 1:CAS:528:DC%2BC2cXhtFemtrjM, PID: 24903467
    • Chin M, Reisman S, Bakris G, et al. Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes and stage 4 chronic kidney disease treated with Bardoxolone Methyl. Am J Nephrol. 2014;39:499–508.
    • (2014) Am J Nephrol , vol.39 , pp. 499-508
    • Chin, M.1    Reisman, S.2    Bakris, G.3
  • 22
    • 47949128459 scopus 로고    scopus 로고
    • The effects of pentoxifylline on proteinuria in diabetic kidney diseaes: a meta-analysis
    • COI: 1:CAS:528:DC%2BD1cXhtFOrt7%2FE, PID: 18433957
    • McCormick B, Sydor A, Akbari A, et al. The effects of pentoxifylline on proteinuria in diabetic kidney diseaes: a meta-analysis. Am J Kidney Dis. 2008;52:454–63.
    • (2008) Am J Kidney Dis , vol.52 , pp. 454-463
    • McCormick, B.1    Sydor, A.2    Akbari, A.3
  • 23
    • 84924173941 scopus 로고    scopus 로고
    • Effect of pentoxifylline on renal function and urinary albumin excretion in patients with diabetic kidney disease: the PREDIAN trial
    • COI: 1:CAS:528:DC%2BC2MXitVCitbY%3D, PID: 24970885, In this study, the addition of pentoxifylline to RAS blockade demonstrated reduction in albuminuria and slowed decreased in eGFR
    • Navarro-Gonzalez J, Mora-Fernandez C, Muros de Fuentes M, et al. Effect of pentoxifylline on renal function and urinary albumin excretion in patients with diabetic kidney disease: the PREDIAN trial. J Am Soc Nephrol. 2015;26:220–9. In this study, the addition of pentoxifylline to RAS blockade demonstrated reduction in albuminuria and slowed decreased in eGFR.
    • (2015) J Am Soc Nephrol , vol.26 , pp. 220-229
    • Navarro-Gonzalez, J.1    Mora-Fernandez, C.2    Muros de Fuentes, M.3
  • 24
    • 62749098612 scopus 로고    scopus 로고
    • Effect of pentoxifylline on GFR decline in CKD: A pilot, double-blind, randomized, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD1MXnslKrsb8%3D, PID: 19216016
    • Perkins RM, Aboudara MC, Uy AL, et al. Effect of pentoxifylline on GFR decline in CKD: A pilot, double-blind, randomized, placebo-controlled trial. Am J Kidney Dis. 2009;53:606–16.
    • (2009) Am J Kidney Dis , vol.53 , pp. 606-616
    • Perkins, R.M.1    Aboudara, M.C.2    Uy, A.L.3
  • 25
    • 34250702110 scopus 로고    scopus 로고
    • The role of protein kinase C activation and the vascular complications of diabetes
    • PID: 17574431
    • Evcimen ND, King GL. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007;55:498–510.
    • (2007) Pharmacol Res , vol.55 , pp. 498-510
    • Evcimen, N.D.1    King, G.L.2
  • 26
    • 0034053336 scopus 로고    scopus 로고
    • Amelioration of accelerated diabetic mesangial expansion by treatment with PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
    • COI: 1:CAS:528:DC%2BD3cXisFyht7g%3D, PID: 10698958
    • Koya D, Haneda M, Nakagawa H, et al. Amelioration of accelerated diabetic mesangial expansion by treatment with PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J. 2000;14(3):439–47.
    • (2000) FASEB J , vol.14 , Issue.3 , pp. 439-447
    • Koya, D.1    Haneda, M.2    Nakagawa, H.3
  • 27
    • 28644442122 scopus 로고    scopus 로고
    • The effects of ruboxistaurin on nephropathy in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2MXht1amt7rI, PID: 16249540
    • Tuttle KR, Bakris GL, Toto JB, et al. The effects of ruboxistaurin on nephropathy in type 2 diabetes. Diabetes Care. 2005;28:2686–90.
    • (2005) Diabetes Care , vol.28 , pp. 2686-2690
    • Tuttle, K.R.1    Bakris, G.L.2    Toto, J.B.3
  • 28
    • 34147151265 scopus 로고    scopus 로고
    • Effects of ruboxistuarin on urinary transforming growth factor-b in patients with diabetic nephropathy and type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXkvVOns7o%3D, PID: 17229944
    • Gilbert RE, Kim SA, Tuttle GL, et al. Effects of ruboxistuarin on urinary transforming growth factor-b in patients with diabetic nephropathy and type 2 diabetes. Diabetes Care. 2007;30:995–6.
    • (2007) Diabetes Care , vol.30 , pp. 995-996
    • Gilbert, R.E.1    Kim, S.A.2    Tuttle, G.L.3
  • 29
    • 34548836596 scopus 로고    scopus 로고
    • Kidney outcomes in long-term studies of ruboxistuarin for diabetic eye disease
    • COI: 1:CAS:528:DC%2BD2sXosVejsLY%3D, PID: 17699475
    • Tuttle KR, McGill JB, Haney DJ, et al. Kidney outcomes in long-term studies of ruboxistuarin for diabetic eye disease. Clin J Am Soc Nephrol. 2007;2:631–6.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 631-636
    • Tuttle, K.R.1    McGill, J.B.2    Haney, D.J.3
  • 30
    • 34548836596 scopus 로고    scopus 로고
    • Albuminuria and kidney function in a long-term study of ruboxistaurin for diabetic neuropathy
    • COI: 1:CAS:528:DC%2BD2sXosVejsLY%3D
    • Tuttle KR, Bastyr III JB, McGill CL, et al. Albuminuria and kidney function in a long-term study of ruboxistaurin for diabetic neuropathy. J Am Soc Nephrol. 2007;2(4):631–6.
    • (2007) J Am Soc Nephrol , vol.2 , Issue.4 , pp. 631-636
    • Tuttle, K.R.1    Bastyr, J.B.2    McGill, C.L.3
  • 31
    • 34548834734 scopus 로고    scopus 로고
    • Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis
    • COI: 1:CAS:528:DC%2BD2sXhsVGqt73M, PID: 17702727
    • Cho ME, Smith DC, Branton MH, et al. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2007;2:906–13.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 906-913
    • Cho, M.E.1    Smith, D.C.2    Branton, M.H.3
  • 32
    • 79957670746 scopus 로고    scopus 로고
    • Pirfenidone for diabetic nephropathy
    • COI: 1:CAS:528:DC%2BC3MXot1Ogsrc%3D, PID: 21511828
    • Sharma K, Ix JH, Mathew AV, et al. Pirfenidone for diabetic nephropathy. J Am Soc Nephrol. 2011;22:1144–51.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1144-1151
    • Sharma, K.1    Ix, J.H.2    Mathew, A.V.3
  • 33
    • 34447534187 scopus 로고    scopus 로고
    • Inhibition of MCP-1/CRR2 pathway ameliorates the development of diabetic nephropathy
    • Kanamori H, Matsubara T, Mima A, et al. Inhibition of MCP-1/CRR2 pathway ameliorates the development of diabetic nephropathy. Biochem Biophys Res Commun. 2007;360:727–7.
    • (2007) Biochem Biophys Res Commun , vol.360 , pp. 727
    • Kanamori, H.1    Matsubara, T.2    Mima, A.3
  • 34
    • 44949130856 scopus 로고    scopus 로고
    • MCP-1/CLL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD1cXkvVyktrc%3D, PID: 18272603
    • Tesch GH. MCP-1/CLL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy. Am J Physiol Renal Physiol. 2008;294:F697–701.
    • (2008) Am J Physiol Renal Physiol , vol.294 , pp. 697-701
    • Tesch, G.H.1
  • 35
    • 80054934421 scopus 로고    scopus 로고
    • Effects of MCP-1 inhibition by bindarit therapy in type 2 diabetes subjects with micro- or macro- albuminuria
    • Ruggenenti P, Negarim M. Effects of MCP-1 inhibition by bindarit therapy in type 2 diabetes subjects with micro- or macro- albuminuria. J Am Soc Nephrol. 2010: 21.
    • (2010) J Am Soc Nephrol , pp. 21
    • Ruggenenti, P.1    Negarim, M.2
  • 36
    • 80052097156 scopus 로고    scopus 로고
    • Antiproteinuric effect of chemokine C-C motif ligand 2 inhibition in subjects with acute proliferative lupus nephritis
    • COI: 1:CAS:528:DC%2BC3MXhtlKrsrrE, PID: 21876349
    • Ble A, Mosca M, Loretto GD, et al. Antiproteinuric effect of chemokine C-C motif ligand 2 inhibition in subjects with acute proliferative lupus nephritis. Am J Nephrol. 2011;34(4):367–72.
    • (2011) Am J Nephrol , vol.34 , Issue.4 , pp. 367-372
    • Ble, A.1    Mosca, M.2    Loretto, G.D.3
  • 37
    • 0026659040 scopus 로고
    • Glycosasminoglycans prevent morphological renal alterations and albuminuria in diabetic rats
    • COI: 1:CAS:528:DyaK3sXjt1Oqtg%3D%3D, PID: 1328749
    • Gambaro G, Cavazzana AO, Luzi P, et al. Glycosasminoglycans prevent morphological renal alterations and albuminuria in diabetic rats. Kidney Int. 1992;42:285–91.
    • (1992) Kidney Int , vol.42 , pp. 285-291
    • Gambaro, G.1    Cavazzana, A.O.2    Luzi, P.3
  • 38
    • 0028092966 scopus 로고
    • Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy
    • COI: 1:CAS:528:DyaK2cXmvFagsb4%3D, PID: 7527876
    • Gambaro G, Venturini AP, Noonan DM, et al. Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy. Kidney Int. 1994;46:797–806.
    • (1994) Kidney Int , vol.46 , pp. 797-806
    • Gambaro, G.1    Venturini, A.P.2    Noonan, D.M.3
  • 39
    • 0030071528 scopus 로고    scopus 로고
    • Increased glomerular expression α1(IV) collagen expression and deposition in long-term diabetic rats is prevented by chronic glycosaminoglycan treatment
    • COI: 1:CAS:528:DyaK28Xit12lt7s%3D, PID: 8780166, In this study, atrasentan (a selective endothelin A receptor antagonist) with RAS inhibition successfully reduced albuminuria in type 2 diabetic nephropathy and thus may improve renal outcomes
    • Ceol M, Nerlich A, Baggio B, et al. Increased glomerular expression α1(IV) collagen expression and deposition in long-term diabetic rats is prevented by chronic glycosaminoglycan treatment. Lab Investig. 1996;74:484–95. In this study, atrasentan (a selective endothelin A receptor antagonist) with RAS inhibition successfully reduced albuminuria in type 2 diabetic nephropathy and thus may improve renal outcomes.
    • (1996) Lab Investig , vol.74 , pp. 484-495
    • Ceol, M.1    Nerlich, A.2    Baggio, B.3
  • 40
    • 0033672331 scopus 로고    scopus 로고
    • Glycosaminoglycan therapy prevents TGF- β 1 overexpression and pathologic changes in renal tissue of long-term diabetic rats
    • COI: 1:CAS:528:DC%2BD3cXptVagsbw%3D, PID: 11095655
    • Ceol M, Gambaro G, Sauer U, et al. Glycosaminoglycan therapy prevents TGF- β 1 overexpression and pathologic changes in renal tissue of long-term diabetic rats. J Am Soc Nephrol. 2000;11:2324–36.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 2324-2336
    • Ceol, M.1    Gambaro, G.2    Sauer, U.3
  • 41
    • 33845309464 scopus 로고    scopus 로고
    • Increased expression of heparanase in overt diabetic nephropathy
    • PID: 17051139
    • Van den Hoven MJ, Rops AL, Bakker MA, et al. Increased expression of heparanase in overt diabetic nephropathy. Kidney Int. 2006;70:2100–8.
    • (2006) Kidney Int , vol.70 , pp. 2100-2108
    • Van den Hoven, M.J.1    Rops, A.L.2    Bakker, M.A.3
  • 42
    • 0036014944 scopus 로고    scopus 로고
    • Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric type 1 and type 2 diabetic patients: the Di.N.A.S. randomized trial
    • COI: 1:CAS:528:DC%2BD38XkvFelsbk%3D, PID: 12039991
    • Gambaro G, Kinalska I, Oksa A, et al. Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric type 1 and type 2 diabetic patients: the Di.N.A.S. randomized trial. J Am Soc Nephrol. 2002;13:1615–25.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1615-1625
    • Gambaro, G.1    Kinalska, I.2    Oksa, A.3
  • 43
    • 80055018022 scopus 로고    scopus 로고
    • Sulodexide for kidney protection in type 2 diabetes patients with microalbuminuria: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BC3MXhtlOlsr%2FM, PID: 21872376
    • Lewis EJ, Lewis JB, Greene T, et al. Sulodexide for kidney protection in type 2 diabetes patients with microalbuminuria: a randomized controlled trial. Am J Kidney Dis. 2011;58:729–36.
    • (2011) Am J Kidney Dis , vol.58 , pp. 729-736
    • Lewis, E.J.1    Lewis, J.B.2    Greene, T.3
  • 44
    • 84863393468 scopus 로고    scopus 로고
    • Sulodexide fails to demonstrate renoprotective in overt type 2 diabetic nephropathy
    • COI: 1:CAS:528:DC%2BC38XitFCiu74%3D, PID: 22034636
    • Packham DK, Wolfe R, Reutens AT, et al. Sulodexide fails to demonstrate renoprotective in overt type 2 diabetic nephropathy. J Am Soc Nephrol. 2012;23:123–30.
    • (2012) J Am Soc Nephrol , vol.23 , pp. 123-130
    • Packham, D.K.1    Wolfe, R.2    Reutens, A.T.3
  • 45
    • 62149126622 scopus 로고    scopus 로고
    • Avosentan reduces albumin excretion in diabetics with macroalbuminuria
    • Wenzel R, Littke T, Kuranoff S, et al. Avosentan reduces albumin excretion in diabetics with macroalbuminuria. J Am Soc Neprol. 2009;20:655–64.
    • (2009) J Am Soc Neprol , vol.20 , pp. 655-664
    • Wenzel, R.1    Littke, T.2    Kuranoff, S.3
  • 46
    • 77949877308 scopus 로고    scopus 로고
    • Avosentan for overt diabetic nephropathy
    • COI: 1:CAS:528:DC%2BC3cXjvFClu7k%3D, PID: 20167702
    • Mann JF, Green D, Jamerson K, et al. Avosentan for overt diabetic nephropathy. J Am Soc Nephrol. 2010;21:527–35.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 527-535
    • Mann, J.F.1    Green, D.2    Jamerson, K.3
  • 47
    • 79953295959 scopus 로고    scopus 로고
    • Addition of atrasetan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathy
    • Kohan DE. Addition of atrasetan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathy. J Am Soc Nephrol. 2011;58:763–72.
    • (2011) J Am Soc Nephrol , vol.58 , pp. 763-772
    • Kohan, D.E.1
  • 48
    • 84859060635 scopus 로고    scopus 로고
    • Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function
    • Zoppini G, Targher G, Chonchol M, et al. Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function. Diabetes Care. 2010;35:99–104.
    • (2010) Diabetes Care , vol.35 , pp. 99-104
    • Zoppini, G.1    Targher, G.2    Chonchol, M.3
  • 49
    • 33645461474 scopus 로고    scopus 로고
    • Uric acid- induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells
    • COI: 1:CAS:528:DC%2BD28XhvFWqtw%3D%3D, PID: 16251237
    • Kang DH, Park SK, Lee IK, et al. Uric acid- induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005;16:3553–62.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3553-3562
    • Kang, D.H.1    Park, S.K.2    Lee, I.K.3
  • 50
    • 29244447160 scopus 로고    scopus 로고
    • Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    • COI: 1:CAS:528:DC%2BD28Xpt1emug%3D%3D, PID: 16377385
    • Siu YP, Leung KT, Tong MK, et al. Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am J Kidney Dis. 2006;47:51–9.
    • (2006) Am J Kidney Dis , vol.47 , pp. 51-59
    • Siu, Y.P.1    Leung, K.T.2    Tong, M.K.3
  • 51
    • 77955729725 scopus 로고    scopus 로고
    • Effects of allopurinol in chronic kidney disease progression and cardiovascular risk
    • COI: 1:CAS:528:DC%2BC3cXhtFCru7nK, PID: 20538833
    • Goicoechea M, de Vinuesa SG, Verdalles U, et al. Effects of allopurinol in chronic kidney disease progression and cardiovascular risk. Clin J Am Soc Nephrol. 2010;5(8):1388–93.
    • (2010) Clin J Am Soc Nephrol , vol.5 , Issue.8 , pp. 1388-1393
    • Goicoechea, M.1    de Vinuesa, S.G.2    Verdalles, U.3
  • 52
    • 84880135111 scopus 로고    scopus 로고
    • Uric acid lowering to prevent kidney function loss in diabetes: the preventing early renal function loss (PERL)
    • COI: 1:CAS:528:DC%2BC3sXhtVyrtLnK, PID: 23649945
    • Maahs DM, Caramori ML, Cherney DZI, et al. Uric acid lowering to prevent kidney function loss in diabetes: the preventing early renal function loss (PERL). Curr Diab Rep. 2013;13(4):550–9.
    • (2013) Curr Diab Rep , vol.13 , Issue.4 , pp. 550-559
    • Maahs, D.M.1    Caramori, M.L.2    Cherney, D.Z.I.3
  • 53
    • 84858234310 scopus 로고    scopus 로고
    • Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy
    • COI: 1:CAS:528:DC%2BC38XkslCiur8%3D, PID: 22169009
    • Sanchez-Nino MD, Bozic M, Cordoba-Lanus E, et al. Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy. Am J Physiol Renal Physiol. 2012;302:F647–57.
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. 647-657
    • Sanchez-Nino, M.D.1    Bozic, M.2    Cordoba-Lanus, E.3
  • 54
    • 78149359262 scopus 로고    scopus 로고
    • Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetic nephropathy (VITAL study): a randomised controlled trial
    • de Zeeuw D, Agrawal R, Amdahl M, et al. Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetic nephropathy (VITAL study): a randomised controlled trial. Lancet. 2010;367:1543–51.
    • (2010) Lancet , vol.367 , pp. 1543-1551
    • de Zeeuw, D.1    Agrawal, R.2    Amdahl, M.3
  • 55
    • 84925423332 scopus 로고    scopus 로고
    • Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema
    • The Diabetic Retinopathy Clinical Research Network. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. N Engl J Med. 2015;372:1193–120.
    • (2015) N Engl J Med , vol.372 , pp. 1120-1193
  • 56
    • 84871719489 scopus 로고    scopus 로고
    • Orchestral actions of angiopoeitin-1 in vascular regeneration
    • COI: 1:CAS:528:DC%2BC3sXhsFOisw%3D%3D, PID: 23182855
    • Koh GY. Orchestral actions of angiopoeitin-1 in vascular regeneration. Trends Mol Med. 2013;19(1):31–9.
    • (2013) Trends Mol Med , vol.19 , Issue.1 , pp. 31-39
    • Koh, G.Y.1
  • 57
    • 84944131778 scopus 로고    scopus 로고
    • Web. August 3, 2015
    • Aerpio therapeutics initiates phase 2 study of tie2 activator AKB-9778 for the treatment of diabetic macular edema. Aerpio Therapeutics. February 13, 2014. Web. August 3, 2015. .
    • (2014)
  • 58
    • 79957880117 scopus 로고    scopus 로고
    • Angiopoeitin-1 is essential in mouse vasculature during development and in response to injury
    • COI: 1:CAS:528:DC%2BC3MXnsVaisbg%3D, PID: 21606590
    • Jeansson M, Gawlik A, Anderson G, et al. Angiopoeitin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest. 2011;121(6):2278–89.
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2278-2289
    • Jeansson, M.1    Gawlik, A.2    Anderson, G.3
  • 59
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • Giacoo F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010;107(9):1058–70.
    • (2010) Circ Res , vol.107 , Issue.9 , pp. 1058-1070
    • Giacoo, F.1    Brownlee, M.2
  • 60
    • 84877270825 scopus 로고    scopus 로고
    • NADPH oxidase 1 plays a role in diabetes mellitus-accelerated atherosclerosis
    • COI: 1:CAS:528:DC%2BC3sXnt1WmtLg%3D, PID: 23564668
    • Gray SP, Di Marco E, Okabe J, et al. NADPH oxidase 1 plays a role in diabetes mellitus-accelerated atherosclerosis. Circulation. 2013;127(18):1888–902.
    • (2013) Circulation , vol.127 , Issue.18 , pp. 1888-1902
    • Gray, S.P.1    Di Marco, E.2    Okabe, J.3
  • 61
    • 77952556246 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling abrogate diabetic nephropathy
    • PID: 20185635
    • Ortiz-Muñoz, Lopez-Parra V, Lopez-Franco O, et al. Suppressors of cytokine signaling abrogate diabetic nephropathy. J Am Soc Nephrol. 2010;21(5):763–72.
    • (2010) J Am Soc Nephrol , vol.21 , Issue.5 , pp. 763-772
    • Ortiz-Muñoz1    Lopez-Parra, V.2    Lopez-Franco, O.3
  • 62
    • 39149086711 scopus 로고    scopus 로고
    • Co-regulation of Gremlin and Notch signaling in diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD1cXhslGqsrc%3D, PID: 17980714
    • Walsh DW, Roxburgh SA, McGettigan P, et al. Co-regulation of Gremlin and Notch signaling in diabetic nephropathy. Biochim Biophys Acta. 2008;1782(1):10–21.
    • (2008) Biochim Biophys Acta , vol.1782 , Issue.1 , pp. 10-21
    • Walsh, D.W.1    Roxburgh, S.A.2    McGettigan, P.3
  • 63
    • 33645744364 scopus 로고    scopus 로고
    • Role of JAK/STAT signaling pathway in diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD28Xks1SnurY%3D, PID: 16527921
    • Marrero MB, Banes-Berceli AK, Stern DM, et al. Role of JAK/STAT signaling pathway in diabetic nephropathy. Am J Physiol Renal Physiol. 2006;290(4):F762–8.
    • (2006) Am J Physiol Renal Physiol , vol.290 , Issue.4 , pp. 762-768
    • Marrero, M.B.1    Banes-Berceli, A.K.2    Stern, D.M.3
  • 64
    • 0036894194 scopus 로고    scopus 로고
    • Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin synthesis in mesangial cells
    • COI: 1:CAS:528:DC%2BD38Xptl2nu70%3D, PID: 12453907
    • Wang X, Shaw S, Amiri F, et al. Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin synthesis in mesangial cells. Diabetes. 2002;51(12):3505–9.
    • (2002) Diabetes , vol.51 , Issue.12 , pp. 3505-3509
    • Wang, X.1    Shaw, S.2    Amiri, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.