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Volumn 53, Issue 4, 2009, Pages 606-616

Effect of Pentoxifylline on GFR Decline in CKD: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial

Author keywords

Chronic kidney disease; estimated glomerular filtration rate; hypertension; pentoxifylline; proteinuria

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IRBESARTAN; LISINOPRIL; LOSARTAN; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITOR; PLACEBO; RAMIPRIL; VALSARTAN;

EID: 62749098612     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2008.11.026     Document Type: Article
Times cited : (67)

References (30)
  • 1
    • 35848968871 scopus 로고    scopus 로고
    • Prevalence of chronic kidney disease in the United States
    • Coresh J., Selvin E., Stevens L.A., et al. Prevalence of chronic kidney disease in the United States. JAMA 298 (2007) 2038-2047
    • (2007) JAMA , vol.298 , pp. 2038-2047
    • Coresh, J.1    Selvin, E.2    Stevens, L.A.3
  • 2
    • 1942530825 scopus 로고    scopus 로고
    • Unreferred chronic kidney disease: A longitudinal study
    • John R., Webb M., Young A., and Stevens P.E. Unreferred chronic kidney disease: A longitudinal study. Am J Kidney Dis 43 (2004) 823-835
    • (2004) Am J Kidney Dis , vol.43 , pp. 823-835
    • John, R.1    Webb, M.2    Young, A.3    Stevens, P.E.4
  • 3
    • 0038205800 scopus 로고    scopus 로고
    • Risk factors for progressive chronic kidney disease
    • McClellan W., and Flaanders W. Risk factors for progressive chronic kidney disease. J Am Soc Nephrol 14 suppl 2 (2003) S65-S70
    • (2003) J Am Soc Nephrol , vol.14 , Issue.SUPPL. 2
    • McClellan, W.1    Flaanders, W.2
  • 4
    • 0027517659 scopus 로고
    • The effect of angiotensin converting enzyme inhibition on diabetic nephropathy
    • Collaborative Study Group
    • Lewis E., Hunsicker L., Bain R., Rohde R., and Collaborative Study Group. The effect of angiotensin converting enzyme inhibition on diabetic nephropathy. N Engl J Med 329 (1993) 1456-1462
    • (1993) N Engl J Med , vol.329 , pp. 1456-1462
    • Lewis, E.1    Hunsicker, L.2    Bain, R.3    Rohde, R.4
  • 5
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Collaborative Study Group
    • Lewis E.J., Hunsicker L.G., Clarke W.R., et al., Collaborative Study Group. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 345 (2001) 851-860
    • (2001) N Engl J Med , vol.345 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3
  • 6
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • RENAAL Study Investigators
    • Brenner B.M., Cooper M.E., De Zeeuw D., et al., RENAAL Study Investigators. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345 (2001) 861-869
    • (2001) N Engl J Med , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    De Zeeuw, D.3
  • 7
    • 15844368318 scopus 로고    scopus 로고
    • Effect of the angiotensin converting enzyme benazepril on the progression of chronic renal insufficiency
    • Angiotensin Converting Enzyme Inhibition in Progressive Renal Insufficiency Study Group
    • Maschio G., Alberti D., Janin G., et al., Angiotensin Converting Enzyme Inhibition in Progressive Renal Insufficiency Study Group. Effect of the angiotensin converting enzyme benazepril on the progression of chronic renal insufficiency. N Engl J Med 334 (1996) 939-945
    • (1996) N Engl J Med , vol.334 , pp. 939-945
    • Maschio, G.1    Alberti, D.2    Janin, G.3
  • 8
    • 0030604561 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy
    • The GISEN Group
    • The GISEN Group. Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet 349 (1997) 1857-1863
    • (1997) Lancet , vol.349 , pp. 1857-1863
  • 9
    • 0033119248 scopus 로고    scopus 로고
    • Pentoxifylline inhibits PDGF-induced proliferation of and TGF-β-stimulated collagen synthesis by vascular smooth muscle cells
    • Chen Y., Wu K., Tsai T., and Hsieh B. Pentoxifylline inhibits PDGF-induced proliferation of and TGF-β-stimulated collagen synthesis by vascular smooth muscle cells. J Mol Cell Cardiol 31 (1999) 773-783
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 773-783
    • Chen, Y.1    Wu, K.2    Tsai, T.3    Hsieh, B.4
  • 10
    • 0025806127 scopus 로고
    • Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes
    • Rao K., Currie M., McCachren S., and Cohen H. Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes. Cell Immunol 135 (1991) 314-325
    • (1991) Cell Immunol , vol.135 , pp. 314-325
    • Rao, K.1    Currie, M.2    McCachren, S.3    Cohen, H.4
  • 11
    • 0033810053 scopus 로고    scopus 로고
    • Effects of pentoxifylline, pentifylline and gamma-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts
    • Strutz F., Heeg M., Kochsiek T., Siemers G., Zeisberg M., and Muller G. Effects of pentoxifylline, pentifylline and gamma-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts. Nephrol Dial Transplant 15 (2000) 1535-1546
    • (2000) Nephrol Dial Transplant , vol.15 , pp. 1535-1546
    • Strutz, F.1    Heeg, M.2    Kochsiek, T.3    Siemers, G.4    Zeisberg, M.5    Muller, G.6
  • 12
    • 0028831965 scopus 로고
    • In vitro and in vivo effects of pentoxifylline on macrophages and lymphocytes derived from autoimmune MRL-lpr/lpr mice
    • Hecht M., Muller M., Lohmann-Matthes M., and Emmendorffer A. In vitro and in vivo effects of pentoxifylline on macrophages and lymphocytes derived from autoimmune MRL-lpr/lpr mice. J Leukoc Biol 57 (1995) 242-249
    • (1995) J Leukoc Biol , vol.57 , pp. 242-249
    • Hecht, M.1    Muller, M.2    Lohmann-Matthes, M.3    Emmendorffer, A.4
  • 13
    • 0035002214 scopus 로고    scopus 로고
    • Suppression of experimental systemic lupus erythematosus (SLE) in mice via TNF inhibition by an anti-TNF-alpha monoclonal antibody and by pentoxifylline
    • Segal R., Dayan M., Zinger H., and Mozes E. Suppression of experimental systemic lupus erythematosus (SLE) in mice via TNF inhibition by an anti-TNF-alpha monoclonal antibody and by pentoxifylline. Lupus 10 (2001) 23-30
    • (2001) Lupus , vol.10 , pp. 23-30
    • Segal, R.1    Dayan, M.2    Zinger, H.3    Mozes, E.4
  • 14
    • 0036892615 scopus 로고    scopus 로고
    • Pentoxifylline attenuated renal disease progression in rats with remnant kidney
    • Lin S., Chen Y., Chien C., Chiaang W., Tsai C., and Tsai T. Pentoxifylline attenuated renal disease progression in rats with remnant kidney. J Am Soc Nephrol 13 (2002) 2916-2929
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2916-2929
    • Lin, S.1    Chen, Y.2    Chien, C.3    Chiaang, W.4    Tsai, C.5    Tsai, T.6
  • 15
    • 0032972830 scopus 로고    scopus 로고
    • Urinary protein excretion and serum tumor necrosis factor in diabetic patients with advanced renal failure: Effects of pentoxifylline administration
    • Navarro J., Mora C., Rivero A., et al. Urinary protein excretion and serum tumor necrosis factor in diabetic patients with advanced renal failure: Effects of pentoxifylline administration. Am J Kidney Dis 33 (1999) 458-463
    • (1999) Am J Kidney Dis , vol.33 , pp. 458-463
    • Navarro, J.1    Mora, C.2    Rivero, A.3
  • 16
    • 0022443771 scopus 로고
    • Pentoxifylline, albumin excretion rate, and proteinuria in type I and type II diabetic patients with microproteinuria. Results of a short-term randomized study
    • Solerte S., Fioravanti M., Bozzetti A., et al. Pentoxifylline, albumin excretion rate, and proteinuria in type I and type II diabetic patients with microproteinuria. Results of a short-term randomized study. Acta Diabetol Lat 23 (1986) 171-177
    • (1986) Acta Diabetol Lat , vol.23 , pp. 171-177
    • Solerte, S.1    Fioravanti, M.2    Bozzetti, A.3
  • 17
    • 33745921200 scopus 로고    scopus 로고
    • Effects of pentoxifylline on the urinary protein excretion profile of type 2 diabetic patients with microproteinuria: A double-blind, placebo-controlled randomized trial
    • Rodriguez-Moran M., Gonzalez-Gonzalez G., Bermudez-Barba M., et al. Effects of pentoxifylline on the urinary protein excretion profile of type 2 diabetic patients with microproteinuria: A double-blind, placebo-controlled randomized trial. Clin Nephrol 66 (2006) 3-10
    • (2006) Clin Nephrol , vol.66 , pp. 3-10
    • Rodriguez-Moran, M.1    Gonzalez-Gonzalez, G.2    Bermudez-Barba, M.3
  • 18
    • 33444465808 scopus 로고    scopus 로고
    • Comparison of the effect of pentoxifylline and captopril on proteinuria in patients with type 2 diabetes mellitus
    • Aminorroaya A., Janghorbani M., Rezvanian H., Aminian T., Gharavi M., and Amini M. Comparison of the effect of pentoxifylline and captopril on proteinuria in patients with type 2 diabetes mellitus. Nephron Clin Pract 99 (2005) c73-c77
    • (2005) Nephron Clin Pract , vol.99
    • Aminorroaya, A.1    Janghorbani, M.2    Rezvanian, H.3    Aminian, T.4    Gharavi, M.5    Amini, M.6
  • 19
    • 23144437575 scopus 로고    scopus 로고
    • Pentoxifylline is as effective as captopril in the reduction of microalbuminuria in non-hypertensive type 2 diabetic patients-A randomized, equivalent trial
    • Rodriguez-Moran M., and Guerrero-Romero F. Pentoxifylline is as effective as captopril in the reduction of microalbuminuria in non-hypertensive type 2 diabetic patients-A randomized, equivalent trial. Clin Nephrol 64 (2005) 91-97
    • (2005) Clin Nephrol , vol.64 , pp. 91-97
    • Rodriguez-Moran, M.1    Guerrero-Romero, F.2
  • 20
    • 33646128029 scopus 로고    scopus 로고
    • Pentoxifylline ameliorates proteinuria through suppression of renal monocyte chemoattractant protein-1 in patients with proteinuric primary glomerular diseases
    • Chen Y., Lin S., Chiang W., Wu K., and Tsai T. Pentoxifylline ameliorates proteinuria through suppression of renal monocyte chemoattractant protein-1 in patients with proteinuric primary glomerular diseases. Kidney Int 69 (2006) 1410-1415
    • (2006) Kidney Int , vol.69 , pp. 1410-1415
    • Chen, Y.1    Lin, S.2    Chiang, W.3    Wu, K.4    Tsai, T.5
  • 21
    • 0043128884 scopus 로고    scopus 로고
    • Effects of pentoxifylline administration on urinary N-acetyl-B-glucosaminidase excretion in type 2 diabetic patients: A short-term, prospective, randomized study
    • Navarro J., Mora C., Muros M., Macia M., and Garcia J. Effects of pentoxifylline administration on urinary N-acetyl-B-glucosaminidase excretion in type 2 diabetic patients: A short-term, prospective, randomized study. Am J Kidney Dis 42 (2003) 264-270
    • (2003) Am J Kidney Dis , vol.42 , pp. 264-270
    • Navarro, J.1    Mora, C.2    Muros, M.3    Macia, M.4    Garcia, J.5
  • 22
    • 0001106451 scopus 로고    scopus 로고
    • A simplified equation to predict glomerular filtration rate from serum creatinine
    • (abstr)
    • Levey A., Greene T., Kusek T., and Beck G. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol 11 (2000) 155A (abstr)
    • (2000) J Am Soc Nephrol , vol.11
    • Levey, A.1    Greene, T.2    Kusek, T.3    Beck, G.4
  • 23
    • 0021998161 scopus 로고
    • A method for estimating nitrogen intake of patients with chronic renal failure
    • Maroni B.J., Steinman T.I., and Mitch W.E. A method for estimating nitrogen intake of patients with chronic renal failure. Kidney Int 27 (1985) 58-65
    • (1985) Kidney Int , vol.27 , pp. 58-65
    • Maroni, B.J.1    Steinman, T.I.2    Mitch, W.E.3
  • 24
    • 0028838569 scopus 로고
    • Blood pressure control, proteinuria, and the progression of renal disease: the modification of diet in renal disease study
    • Peterson J.C., Adler S., Burkhart J., et al. Blood pressure control, proteinuria, and the progression of renal disease: the modification of diet in renal disease study. Ann Intern Med 123 (1995) 754-762
    • (1995) Ann Intern Med , vol.123 , pp. 754-762
    • Peterson, J.C.1    Adler, S.2    Burkhart, J.3
  • 25
    • 27744600400 scopus 로고    scopus 로고
    • Additive antiproteinuric effect of pentoxifylline in patients with type 2 diabetes under angiotensin II receptor blockade: A short term, randomized, controlled trial
    • Navarro J., Mora C., Muros M., and Garcia J. Additive antiproteinuric effect of pentoxifylline in patients with type 2 diabetes under angiotensin II receptor blockade: A short term, randomized, controlled trial. J Am Soc Nephrol 16 (2005) 2119-2126
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2119-2126
    • Navarro, J.1    Mora, C.2    Muros, M.3    Garcia, J.4
  • 26
    • 0037978108 scopus 로고    scopus 로고
    • Combination of pentoxifylline with angiotensin converting enzyme inhibitors produces an additional reduction in microalbuminuria in hypertensive type 2 diabetic patients
    • Harmankaya O., Seber S., and Yilmaz M. Combination of pentoxifylline with angiotensin converting enzyme inhibitors produces an additional reduction in microalbuminuria in hypertensive type 2 diabetic patients. Ren Fail 25 (2003) 465-470
    • (2003) Ren Fail , vol.25 , pp. 465-470
    • Harmankaya, O.1    Seber, S.2    Yilmaz, M.3
  • 27
    • 47949128459 scopus 로고    scopus 로고
    • The effect of pentoxifylline on proteinuria in diabetic kidney disease: A meta-analysis
    • McCormick B.B., Sydor A., Akbari A., Fergusson D., Doucette S., and Knoll G. The effect of pentoxifylline on proteinuria in diabetic kidney disease: A meta-analysis. Am J Kidney Dis 52 (2008) 454-463
    • (2008) Am J Kidney Dis , vol.52 , pp. 454-463
    • McCormick, B.B.1    Sydor, A.2    Akbari, A.3    Fergusson, D.4    Doucette, S.5    Knoll, G.6
  • 28
    • 36048950194 scopus 로고    scopus 로고
    • Will the addition of pentoxifylline reduce proteinuria in patients with diabetic glomerulosclerosis refractory to maximal doses of both and angiotensin-converting enzyme inhibitor and an angiotensin receptor blocker?
    • Diskin C., Stokes J., Dansby L., Radcliff L., and Carter T. Will the addition of pentoxifylline reduce proteinuria in patients with diabetic glomerulosclerosis refractory to maximal doses of both and angiotensin-converting enzyme inhibitor and an angiotensin receptor blocker?. J Nephrol 20 (2007) 410-416
    • (2007) J Nephrol , vol.20 , pp. 410-416
    • Diskin, C.1    Stokes, J.2    Dansby, L.3    Radcliff, L.4    Carter, T.5
  • 29
    • 49949102418 scopus 로고    scopus 로고
    • Effect of pentoxifylline in addition to losartan on proteinuria and GFR in CKD: A 12-month randomized trial
    • Lin S.L., Chen Y.M., Chaing W.C., Wu K.W., and Tsai T.J. Effect of pentoxifylline in addition to losartan on proteinuria and GFR in CKD: A 12-month randomized trial. Am J Kidney Dis 52 (2008) 464-474
    • (2008) Am J Kidney Dis , vol.52 , pp. 464-474
    • Lin, S.L.1    Chen, Y.M.2    Chaing, W.C.3    Wu, K.W.4    Tsai, T.J.5
  • 30
    • 34548834734 scopus 로고    scopus 로고
    • Pirfenidone slows renal clearance function decline in patients with focal segmental glomerulosclerosis
    • Cho M.E., Smith D.C., Branton M.H., Penzak S.R., and Kopp J.B. Pirfenidone slows renal clearance function decline in patients with focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 2 (2007) 906-913
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 906-913
    • Cho, M.E.1    Smith, D.C.2    Branton, M.H.3    Penzak, S.R.4    Kopp, J.B.5


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