Brain-derived neurotrophic factor correlates with functional and cognitive impairment in non-disabled older individuals

Experimental Gerontology

Volumn 72, Issue , 2015, Pages 129-137

  Navarro Martínez, Rut ^a   Fernández Garrido, Julio ^a   Buigues, Cristina ^a   Torralba Martínez, Elena ^a   Martinez Martinez, Mary ^b   Verdejo, Yolanda ^b   Mascarós, Mari Carmen ^b   Cauli, Omar ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b GeroResidencias La Saleta   (Spain)

Author keywords

Aging; Barthel index; BDNF; Biomarker; Mini mental test examination

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; BIOLOGICAL MARKER; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

AGED; ARTICLE; BARTHEL INDEX; BASOPHIL; CELL DIFFERENTIATION; CELL SUBPOPULATION; CHOLESTEROL BLOOD LEVEL; COGNITIVE DEFECT; DAILY LIFE ACTIVITY; DISEASE MARKER; EOSINOPHIL; EOSINOPHIL COUNT; FEMALE; FRAIL ELDERLY; FUNCTIONAL DISEASE; GERIATRIC ASSESSMENT; HUMAN; HUMAN CELL; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MONOCYTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; THROMBOCYTE COUNT; VERY ELDERLY; BLOOD; CLINICAL TRIAL; COGNITION; CROSS-SECTIONAL STUDY; MIDDLE AGED; MULTICENTER STUDY; NEUROPSYCHOLOGICAL TEST; PROCEDURES; PSYCHOLOGY; SPAIN; STATISTICAL MODEL;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; BIOMARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SPAIN;

EID: 84944038504     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2015.10.001     Document Type: Article

References (88)

1. Arancio O., Chao M.V. Neurotrophins, synaptic plasticity and dementia. Curr. Opin. Neurobiol. 2007, 17:325-330.
2. Bird C.M., Burgess N. The hippocampus and memory: insights from spatial processing. Nat. Rev. Neurosci. 2008, 9:182-194.
3. Bonini S., Lambiase A., Angelucci F., Magrini L., Manni L., Aloe L. Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:10955-10960.
4. Brown J., Cooper-Kuhn C.M., Kempermann G., Van Praag H., Winkler J., Gage F.H., Kuhn H.G. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis Eur. J. Neurosci. 2003, 17:2042-2046.
5. Burke S.N., Barnes C.A. Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 2006, 7:30-40.
6. Bus B.A., Arias-Vasquez A., Franke B., Prickaerts J., de Graaf J., Voshaar R.C. Increase in serum brain-derived neurotrophic factor in met allele carriers of the BDNF Val66Met polymorphism is specific to males. Neuropsychobiology 2012, 65:183-187.
7. Bus B.A., Tendolkar I., Franke B., De Graaf J., Den Heijer M., Buitelaar J.K., Voshaar R.C.O. Serum brain-derived neurotrophic factor: determinants and relationship with depressive symptoms in a community population of middle-aged and elderly people. World J. Biol. Psychiatry 2012, 13:39-47.
8. Calero M.D., Navarro E. Cognitive plasticity as a modulating variable on the effects of memory training in elderly persons. Arch. Clin. Neuropsychol. 2007, 22:63-72.
9. Coelho F.M., Pereira D.S., Lustosa L.P., Silva J.P., Dias J.M., Dias R.C., Queiroz B.Z., Teixeira A.L., Teixeira M.M., Pereira L.S. Physical therapy intervention (PTI) increases plasma brain-derived neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly women. Arch. Gerontol. Geriatr. 2012, 54:415-420.
10. Coelho F.G., Gobbi S., Andreatto C.A., Corazza D.I., Pedroso R.V., Santos-Galduróz R.F. Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): a systematic review of experimental studies in the elderly. Arch Gerontol Geriatr 2013, 56(1):10-15.
11. Collard R.M., Boter H., Schoevers R.A., Oude Voshaar R.C. Prevalence of frailty in community-dwelling older persons: a systematic review. J. Am. Geriatr. Soc. 2012, 60:1487-1492.
12. De Foubert G., Carney S.L., Robinson C.S., Destexhe E.J., Tomlinson R., Hicks C.A., Murray T.K., Gaillard J.P., Deville C., Xhenseval V., Thomas C.E., O'Neill M.J., Zetterstrom T.S. Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience 2004, 128:597-604.
13. Donovan M.J., Miranda R.C., Kraemer R., McCaffrey T.A., Tessarollo L., Mahadeo D., Sharif S., Kaplan D.R., Tsoulfas P., Parada L., Toran-Allerand C.D., Hajjar D.P., Hempstead B.L. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells: regulation of expression in response to injury. Am. J. Pathol. 1995, 147:309-324.
14. Elosua R., Garcia M.M., Aguilar A.A., Molina L.L., Covas M.I.M., Marrugat J.J. Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish women. Investigators of the MARATDON Group. Med. Sci. Sports Exerc. 2000, 32:1431-1437.
15. Elosua R., Marrugat J., Molina L., Pons S., Pujol E. Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish men. The MARATHON Investigators. Am. J. Epidemiol. 1994, 139:1197-1209.
16. Evans W.J., Paolisso G., Abbatecola A.M., Corsonello A., Bustacchini S., Strollo F., Lattanzio F. Frailty and muscle metabolism dysregulation in the elderly. Biogerontology 2010, 11(5):527-536.
17. Fernández-Garrido J., Navarro-Martínez R., Buigues-González C., Martínez-Martínez M., Ruiz-Ros V., Cauli O. The value of neutrophil and lymphocytecount in frailolderwomen. Exp. Gerontol. 2014, 54:35-41.
18. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975, 12:189-198.
19. Fried L.P.L., Tangen C.M.C., Walston J.J., Newman A.B.A., Hirsch C.C., Gottdiener J.J., Seeman T.T., Tracy R.R., Kop W.J.W., Burke G.G., Mcburnie M.A.M. Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol. Med. Sci. 2001, 56:M146-M156.
20. Frye C.A., Rhodes M.E. Estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone. Pharmacol. Biochem. Behav. 2005, 81:907-916.
21. Fujimura H., Altar C.A., Chen R., Nakamura T., Nakahashi T., Kambayashi J., Sun B., Tandon N.N. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Haemostasis 2002, 87:728-734.
22. Gass P., Hellweg R. Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker for affective disorders?. Int. J. Neuropsychopharmacol. 2010, 13(1):1-4.
23. Gervasoni N., Aubry J.M., Bondolfi G., Osiek C., Schwald M., Bertschy G., Karege F. Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode. Neuropsychobiology 2005, 51:234-238.
24. Gibbs R.B. Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain. Brain Res. 1999, 844:20-27.
25. Giovannetti T., Bettcher B.M., Brennan L., Libon D.J., Burke M., Duey K., Nieves C., Wambach D. Characterization of everyday functioning in mild cognitive impairment: a direct assessment approach. Dement Geriatr Cogn Disord 2008, 25(4):359-365.
26. Givalois L., Marmigère F., Rage F., Ixart G., Arancibia S., Tapia-Arancibia L. Immobilization stress rapidly and differentially modulates BDNF and TrkB mRNA expression in the pituitary gland of adult male rats. Neuroendocrinología 2001, 74:148-159.
27. Golden E., Emiliano A., Maudsley S., Windham B.G., Carlson O.D., Egan J.M., Driscoll I., Ferrucci L., Martin B., Mattson M.P. Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging. PLoS One 2010, 5.
28. Guralnik J.M., Simonsick E.M., Ferrucci L., Glynn R.J., Berkman L.F., Blazer D.G., Scherr P.A., Wallace R.B. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J. Gerontol. 1994, 49:M85-M94.
29. Hasselbalch B.J., Knorr U., Hasselbalch S.G., Gade A., Kessing L.V. Cognitive deficits in the remittedstate of unipolardepressive disorder. Neuropsychology 2012, 26:642-651.
30. Henderson C.E. Role of neurotrophic factors in neuronal development. Curr. Opin. Neurobiol. 1996, 6:64-70.
31. Iughetti L., Casarosa E., Predieri B., Patianna V., Luisi S. Plasma brain-derived neurotrophic factor concentrations in children and adolescents. Neuropeptides 2011, 45:205-211.
32. Jacobsen J.P., Mork A. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex of the rat. Brain Res. 2006, 1110:221-225.
33. Jones S., Nyberg L., Sandblom J., Neely A.S., Ingvar M., Petersson K.M., Bäckman L. Cognitive and neural plasticity in aging: general and task-specific limitations. Neurosci. Biobehav. Rev. 2006, 30:864-871.
34. Jung S.H., Kim J., Davis J.M., Blair S.N., Cho H.C. Association among basal serum BDNF, cardiorespiratory fitness and cardiovascular disease risk factors in untrained healthy Korean men. Eur. J. Appl. Physiol. 2011, 111:303-311.
35. Karege F., Perret G., Bondolfi G., Schwald M., Bertschy G., Aubry J.M. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002, 109:143-148.
36. Kerschensteiner M., Gallmeier E., Behrens L., Leal V.V., Misgeld T., Klinkert E.F., Kolbeck R., Hoppe E., Oropeza-Wekerle R.L., Bartke I., Stadelmann C., Lassmann H. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?. J. Exp. Med. 1999, 189:865-870.
37. Kim H.J., Song B.K., So B., Lee O., Song W., Kim Y. Increase of circulating BDNF levels and its relation to improvement of physical fitness following 12weeks of combined exercise in chronic patients with schizophrenia: a pilot study. Psychiatry Res. 2014, 220:792-79.
38. Klein A.B., Williamson R., Santini M.A., Clemmensen C., Ettrup A., Rios M., Knudsen G.M., Aznar S. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol 2011, 14(3):347-353.
39. Komulainen P., Pedersen M., Hänninen T., Bruunsgaard H., Lakka T.A., Kivipelto M., Hassinen M., Rauramaa T.H., Pedersen B.K., Rauramaa R. BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study. Neurobiol. Learn. Mem. 2008, 90:596-603.
40. Krabbe K.S., Mortensen E.L., Avlund K., Pedersen A.N., Pedersen B.K., Jørgensen T., Bruunsgaard H. Brain-derived neurotrophic factor predicts mortality risk in older women. J. Am. Soc. Geriatr. 2009, 57:1447-1452.
41. Lang U.E., Hellweg R., Gallinat J. BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits. Neuropsychopharmacology 2004, 29:795-798.
42. Lawton M.P., Brody E.M. Assessment of older people: self-maintaining and instrumental activities of daily living. The Gerontologist 1969, 9:179-186.
43. Lee S.W., Clemenson G.D., Gage F.H. New neurons in an aged brain. Behav. Brain Res. 2012, 227:497-507.
44. Lee J., Duan W., Mattson M.P. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J. Neurochem. 2002, 82:1367-1375.
45. Lister J.P., Barnes C.A. Neurobiological changes in the hippocampus during normative aging. Arch. Neurol. 2009, 66:829-833.
46. Lommatzsch M., Braun A., Mannsfeldt A., Botchkarev V.A., Botchkareva N.V., Paus R., Fischer A., Lewin G.R., Renz H. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived Neurotrophic functions. Am. J. Pathol. 1999, 155:1183-1193.
47. Lommatzsch M., Zingler D., Schuhbaeck K., Schloetcke K., Zingler C., Schuff-Werner P., Virchow J.C. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol. Aging 2005, 26:115-123.
48. MacQueen G., Chokka P. Special issues in the management of depression in women. Can. J. Psychiatr. 2004, 49:27S-40S.
49. Mahncke H.W., Bronstone A., Merzenich M.M. Brain plasticity and functional losses in the aged: scientific bases for a novel intervention. Prog. Brain 2006, 157:81-109.
50. Mahoney F.I., Barthel D.W. Functional evaluation: the Barthel Index. Md. State Med. J. 1965, 14:56-61.
51. Matsuki C., To M., Kondo Y., Sugiyama H., Yamamoto Y., Shimizu T., Kamata Y., Saruta J., Tsukinoki K. Associations between brain-derived neurotrophic factor and estradiol in women's saliva. Neuro Endocrinol. Lett. 2014, 35:236-241.
52. Molendijk M.L., Spinhoven P., Polak M., Bus B.A., Penninx B.W., Elzinga B.M. Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484). Mol. Psychiatry 2014, 19:791-800.
53. Mowla S.J., Farhadi H.F., Pareek S., Atwal J.K., Morris S.J., Seidah N.G., Murphy R.A. Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J. Biol. Chem. 2001, 276:12660-12666.
54. Nakahashi T., Fujimura H., Altar C.A., Li J., Kambayashi J., Tandon N.N., Sun B. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett. 2000, 470:113-117.
55. Noga O., Englmann C., Hanf G., Grutzkau A., Seybold J., Kunke G. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin. Exp. Allergy 2003, 33:649-654.
56. Norton D. Norton revised risk scores. Nurs. Times 1987, 83:6.
57. Ottenbacher K.J., Branch L.G., Ray L., Gonzales V.A., Peek M.K., Hinman M.R. The reliability of upper- and lower-extremity strength testing in a community survey of older adults. Arch. Phys. Med. Rehabil. 2002, 83:1423-1427.
58. Pan W., Banks W.A., Fasold M.B., Bluth J., Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998, 37:1553-1561.
59. Papathanassoglou E.D., Miltiadous P., Karanikola M.N. May BDNF be implicated in the exercise-mediated regulation of inflammation? Critical review and synthesis of evidence. Biol. Res. Nurs. 2014, 1-19.
60. Parque H.J., Lee S., Jung J.W., Kim B.C., Ryu J.H., Kim D.H. Glucocorticoid- and long-term stress-induced aberrant synaptic plasticity are mediated by activation of the glucocorticoid receptor. Arc. Pharm. Res. 2015, 38:1204-1212.
61. Peng S., Wuu J., Mufson E.J., Fahnestock M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J. Neurochem. 2005, 93:1412-1421.
62. Pereira D.S., de Queiroz B.Z., Miranda A.S., Rocha N.P., Felício D.C., Mateo E.C., Favero M., Coelho F.M., Jesus-Moraleida F., Gomes Pereira D.A., Teixeira A.L., Máximo Pereira L.S. Effects of physical exercise on plasma levels of brain-derived neurotrophic factor and depressive symptoms in elderly women-a randomized clinical trial. Arch. Phys. Med. Rehabil. 2013, 94:1443-1450.
63. Raap U., Goltz C., Deneka N., Bruder M., Renz H., Kapp A., Wedi B. Brain-derived neurotrophic factor is increased in atopic dermatitis and modulates eosinophil functions compared with that seen in nonatopic subjects. J. Allergy Clin. Immunol. 2005, 115:1268-1275.
64. Radka S.F., Holst P.A., Fritsche M., Altar C.A. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res. 1996, 709:122-301.
65. Radloff L.S. The CES-D Scale: a self-report depression scale for research in the general population. Appl. Psychol. Meas. 1977, 1:385-401.
66. Raschke S., Eckel J. Adipo-myokines: two sides of the same coin-mediators of inflammation and mediators of exercise 2013, 2013:1-16.
67. Ruiz-Comellas A., Pera G., Baena-Díez J.M., Mundet-Tudurí X., Alzamora-Sas T., Elosua R., Torán-Monserrat P., Heras A., Forés-Raurell R., Fusté G.M. Validación de una versión reducida en español del cuestionario de-actividad física en el tiempo libre de Minnesota (VREM). Rev. Esp. Salud Pública 2012, 86:495-508.
68. Sakuma K., Aoi W., Yamaguchi A. Current understanding of sarcopenia: possible candidates modulating muscle mass. Pflugers Arch. 2015, 467:213-229.
69. Sartorius A., Hellweg R., Litzke J., Vogt M., Dormann C., Vollmayr B., Danker-Hopfe H., Gass P. Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats. Pharmacopsychiatry 2009, 42:270-276.
70. Schinder A.F., Poo M.M. The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci. 2000, 23:639-645.
71. Seroogy K., Lee J., Mattson M.P. Dietary restriction enhances neurotrophin expression and neurogenesis en the hippocampus of adult mice. J. Neurochem. 2002, 80:539-547.
72. Sheikh J.L., Yesavage J.A. Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clin. Gerontol. 1986, 5:165-173.
73. Shimada H., Makizako H., Doi T., Yoshida D., Tsutsumimoto K., Anan Y., Uemura K., Lee S., Park H., Suzuki T. A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly. Front. Aging Neurosci. 2014, 6:69.
74. Shimizu E., Hashimoto K., Okamura N., Koike K., Komatsu N., Kumakiri C., Nakazato M., Watanabe H., Shinoda N., Okada S., Iyo M. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol. Psiquiatría 2003, 54:70-75.
75. Sitjas Molina E.N., San José Laporte A., Armadans Gil L., Mundet Tuduri X., Vilardell Tarrésb M. Factores predictores del deterioro funcional geriátrico. Aten. Primaria 2003, 32:282-287.
76. Sohrabji F., Lewis D.K. Estrogen-BDNF interactions: implications for neurodegenerative diseases. Front. Neuroendocrinol. 2006, 27:404-414.
77. Talarowska M., Zajaczkowska M., Gałecki P. Cognitive functions in first-episode depression and recurrent depressive disorder. Psychiatr. Danub. 2015, 27:38-43.
78. Tanaka J., Horiike Y., Matsuzaki M., Miyazaki T., Ellis-Davies G.C., Kasai H. Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science 2008, 319:1683-1687.
79. Tapia-Arancibia L., Aliaga E., Silhol M., Arancibia S. New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res. Rev. 2008, 59:201-220.
80. Tapia-Arancibia L., Rage F., Givalois L., Arancibia S. Physiology of BDNF: focus on hypothalamic function. Front. Neuroendocrinol. 2004, 25:77-107.
81. Tinetti M.E., Williams T.F., Mayewski R. Fall risk index for elderly patients based on number of chronic disabilities. Am. J. Med. 1986, 80:429-434.
82. Toyooka K., Asama K., Watanabe Y., Muratake T., Takahashi M., Someya T., Nawa H. Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients. Psychiatry Res. 2002, 110:249-257.
83. Trigás-Ferrín M., Ferreira-González L., Meijide-Míguez H. Escalas de valoración funcional en el anciano. Galicia Clin. 2011, 72:11-16.
84. Tsai S.W., Chan Y.C., Liang F., Hsu C.Y., Lee I.T. Brain- derived neurotrophic factor correlated with muscle strength insubjects undergoing stationary bicycle exercise training. J. Diabetes Complicat. 2015, 29:367-371.
85. Van Praag H., Kempermann G., Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 1999, 2:266-270.
86. Weinstein G., Beiser A.S., Choi S.H., Preis S.R., Chen T.C., Vorgas D., Au R., Pikula A., Wolf P.A., DeStefano A.L., Vasan R.S., Seshadri S. Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. JAMA Neurol. 2014, 71:55-61.
87. Yasui-Furukori N., Tsuchimine S., Kaneda A., Sugawara N., Ishioka M., Kaneko S. Association between plasma brain-derived neurotrophic factor levels and personality traits in healthy Japanese subjects. Psychiatry Res. 2013, 210:220-223.
88. Ziegenhorn A.A., Schulte-Herbrüggen O., Danker-Hopfe H., Malbranc M., Hartung H.D., Anders D., Lang U.E., Steinhagen-Thiessen E., Schaub R.T., Hellweg R. Serum neurotrophins-a study on the time course and influencing factors in a large old age simple. Neurobiol. Aging 2007, 28:1436-1445.