Serum neurotrophins-A study on the time course and influencing factors in a large old age sample

Neurobiology of Aging

Volumn 28, Issue 9, 2007, Pages 1436-1445

  Ziegenhorn, Andreas A ^a   Schulte Herbrüggen, Olaf ^a   Danker Hopfe, Heidi ^a   Malbranc, Monique ^a   Hartung, Heinz Dieter ^a,b   Anders, Dirk ^c   Lang, Undine E ^a,d   Steinhagen Thiessen, Elisabeth ^a   Schaub, Rainer T ^a,e   Hellweg, Rainer ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Jewish Hospital Berlin   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e Klinikum am Weissenhof   (Germany)

Author keywords

Body mass index (BMI); Brain derived neurotrophic factor (BDNF); Dementia; Gender; Late life depression; Nerve growth factor (NGF); Neurotrophins; Old age; Platelet count; Serum

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN;

AGED; AGING; ARTICLE; BLOOD LEVEL; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMENTIA; DEPRESSION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUOROMETRY; HOMEOSTASIS; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVE GROWTH; PARAMETER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SEX DIFFERENCE; THROMBOCYTE COUNT;

AGE FACTORS; AGED; AGED, 80 AND OVER; BLOOD PLATELETS; BRAIN-DERIVED NEUROTROPHIC FACTOR; GERIATRIC ASSESSMENT; HUMANS; NERVE GROWTH FACTOR; SEX CHARACTERISTICS; STATISTICS; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 34447620845     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2006.06.011     Document Type: Article

References (88)

1. Alleva E., and Santucci D. Psychosocial vs. physical stress situations in rodents and humans-role of neurotrophins. Physiol Behav 73 (2001) 313-320
2. Aloe L., BracciLaudiero L., Bonini S., and Manni L. The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases. Allergy 52 (1997) 883-894
3. Altar C.A. Neurotrophins and depression. Trends Pharmacol Sci 20 (1999) 59-61
4. Angelucci F., Aloe L., Vasquez P.J., and Mathe A.A. Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depression. Neuroreport 11 (2000) 1369-1373
5. Angelucci F., Mathe A.A., and Aloe L. Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia. Prog Brain Res 146 (2004) 151-165
6. Azar S.T., Major S.C., and Safieh-Garabedian B. Altered plasma levels of nerve growth factor and transforming growth factor-beta2 in type-1 diabetes mellitus. Brain Behav Immun 13 (1999) 361-366
7. Blasko I., Lederer W., Oberbauer H., Walch T., Kemmler G., Hinterhuber H., et al. Measurement of thirteen biological markers in CSF of patients with Alzheimer's disease and other dementias. Dement Geriatr Cogn Disord 21 (2006) 9-15
8. Branchi I., Francia N., and Alleva E. Epigenetic control of neurobehavioural plasticity: the role of neurotrophins. Behav Pharmacol 15 (2004) 353-362
9. Braun A., Lommatzsch M., Mannsfeldt A., Neuhaus-Steinmetz U., Fischer A., Schnoy N., et al. Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation. Am J Respir Cell Mol Biol 21 (1999) 537-546
10. Chaldakov G.N., Fiore M., Stankulov I.S., Manni L., Hristova M.G., Antonelli A., et al. Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease?. Prog Brain Res 146 (2004) 279-289
11. Chaudhuri R., McMahon A.D., McSharry C.P., Macleod K.J., Fraser I., Livingston E., et al. Serum and sputum neurotrophin levels in chronic persistent cough. Clin Exp Allergy 35 (2005) 949-953
12. Chiaretti A., Antonelli A., Piastra M., Genovese O., Polidori G., and Aloe L. Expression of neurotrophic factors in cerebrospinal fluid and plasma of children with viral and bacterial meningoencephalitis. Acta Paediatr 93 (2004) 1178-1184
13. Connor B., Young D., Yan Q., Faull R.L.M., Synek B., and Dragunow M. Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res Mol Brain Res 49 (1997) 71-81
14. Crookston K.P., Webb D.J., Wolf B.B., and Gonias S.L. Classification of alpha 2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions. J Biol Chem 269 (1994) 1533-1540
15. Desai P., Nebes R., DeKosky S.T., and Kamboh M.I. Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression. Neurosci Lett 379 (2005) 229-234
16. Edling A.E., Nanavati T., Johnson J.M., and Tuohy V.K. Human and murine lymphocyte neurotrophin expression is confined to B cells. J Neurosci Res 77 (2004) 709-717
17. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 (2003) 257-269
18. Fahnestock M., Garzon D., Holsinger R.M., and Michalski B. Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule?. J Neural Transm Suppl (2002) 241-252
19. Frossard N., Freund W., and Advenier C. Nerve growth factor and its receptors in asthma and inflammation. Eur J Pharmacol 500 (2004) 453-465
20. Fujimura H., Altar C.A., Chen R.Y., Nakamura T., Nakahashi T., Kambayashi J., et al. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 87 (2002) 728-734
21. Gervasoni N., Aubry J.M., Bondolfi G., Osiek C., Schwald M., Bertschy G., et al. Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode. Neuropsychobiology 51 (2005) 234-238
22. Gielen A., Khademi M., Muhallab S., Olsson T., and Piehl F. Increased brain-derived neurotrophic factor expression in white blood cells of relapsing-remitting multiple sclerosis patients. Scand J Immunol 57 (2003) 493-497
23. Gold S.M., Schulz K.H., Hartmann S., Mladek M., Lang U.E., Hellweg R., et al. Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. J Neuroimmunol 138 (2003) 99-105
24. Hariri A.R., Goldberg T.E., Mattay V.S., Kolachana B.S., Callicott J.H., Egan M.F., et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23 (2003) 6690-6694
25. Hellweg R., Hock C., and Hartung H.D. An improved rapid and highly sensitive enzyme immunoassay for nerve growth factor. Technique J Meth Cell Mol Biol 1 (1989) 43-49
26. Hellweg R., von Richthofen S., Anders D., Baethge C., Ropke S., Hartung H.D., et al. The time course of nerve growth factor content in different neuropsychiatric diseases--a unifying hypothesis. J Neural Transm 105 (1998) 871-903
27. Hellweg R., Gericke C.A., Jendroska K., Hartung H.D., and Cervos-Navarro J. NGF content in the cerebral cortex of non-demented patients with amyloid-plaques and in symptomatic Alzheimer's disease. Int J Dev Neurosci 16 (1998) 787-794
28. Hellweg R., von Arnim C.A.F., Buchner M., Huber R., and Riepe M.W. Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation. Exp Neurol 183 (2003) 346-354
29. Hellweg R., Lohmann P., Huber R., Kuhl A., and Riepe M.W. Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment. Learn Mem 13 (2006) 63-71
30. Helmchen H., Linden M., and Wernicke T. Psychiatric morbidity in old age. Results from the Berlin Aging Study. Nervenarzt 67 (1996) 739-750
31. Hohlfeld R., Kerschensteiner M., Stadelmann C., Lassmann H., and Wekerle H. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. J Neuroimmunol 107 (2000) 161-166
32. Horch H.W. Local effects of BDNF on dendritic growth. Rev Neurosci 15 (2004) 117-129
33. Hortnagl H., and Hellweg R. Pathophysiological aspects of human neurodegenerative diseases. Wien Klin Wochenschr 109 (1997) 623-635
34. Howells D.W., Porritt M.J., Wong J.Y.F., Batchelor P.E., Kalnins R., Hughes A.J., et al. Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra. Exp Neurol 166 (2000) 127-135
35. Jockers-Scherubl M.C., Matthies U., Danker-Hopfe H., Lang U.E., Mahlberg R., and Hellweg R. Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naive schizophrenic patients. J Psychopharmacol 17 (2003) 439-445
36. Jockers-Scherubl M.C., Danker-Hopfe H., Mahlberg R., Selig F., Rentzsch J., Schurer F., et al. Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse. Neurosci Lett 371 (2004) 79-83
37. Jockers-Scherubl M.C., Rentzsch J., Danker-Hopfe H., Radzei N., Schurer F., Bahri S., et al. Adequate antipsychotic treatment normalizes serum nerve growth factor concentrations in schizophrenia with and without cannabis or additional substance abuse. Neurosci Lett 400 (2006) 262-266
38. Karege F., Perret G., Bondolfi G., Schwald M., Bertschy G., and Aubry J.M. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 109 (2002) 143-148
39. Karege F., Schwald M., and Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 328 (2002) 261-264
40. Karege F., Bondolfi G., Gervasoni N., Schwald M., Aubry J.M., and Bertschy G. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 57 (2005) 1068-1072
41. Kerschensteiner M., Gallmeier E., Behrens L., Leal V.V., Misgeld T., Klinkert W.E.F., et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?. J Exp Med 189 (1999) 865-870
42. Kim D.J., Roh S., Kim Y., Yoon S.J., Lee H.K., Han C.S., et al. High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. Neurosci Lett 388 (2005) 112-115
43. Kimata H. Kissing reduces allergic skin wheal responses and plasma neurotrophin levels. Physiol Behav 80 (2003) 395-398
44. Lambiase A., Bonini S., Bonini S., Micera A., Magrini L., BracciLaudiero L., et al. Increased plasma-levels of nerve growth-factor in vernal keratoconjuctivitis and relationship to conjunctival mast-cells. Invest Ophthalmol Vis Sci 36 (1995) 2127-2132
45. Lang U.E., Gallinat J., Danker-Hopfe H., Bajbouj M., and Hellweg R. Nerve growth factor serum concentrations in healthy human volunteers: physiological variance and stability. Neurosci Lett 344 (2003) 13-16
46. Lang U.E., Jockers-Scherubl M.C., and Hellweg R. State of the art of the neurotrophin hypothesis in psychiatric disorders: implications and limitations. J Neural Transm 111 (2004) 387-411
47. Lang U.E., Hellweg R., and Gallinat J. BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits. Neuropsychopharmacology 29 (2004) 795-798
48. Lang U.E., Anders D., Danker-Hopfe H., and Hellweg R. Measurement of nerve growth factor serum concentration in a psychologically stressful situation in men. Stress 7 (2004) 39-42
49. Lang U.E., Hellweg R., and Gallinat J. Association of BDNF serum concentrations with central serotonergic activity: evidence from auditory signal processing. Neuropsychopharmacology 30 (2005) 1148-1153
50. Lewin G.R., and Barde Y.A. Physiology of the neurotrophins. Annu Rev Neurosci 19 (1996) 289-317
51. Lommatzsch M., Braun A., and Renz H. Neurotrophins in allergic airway dysfunction what the mouse model is teaching us. Ann NY Acad Sci 992 (2003) 241-249
52. Lommatzsch M., Zingler D., Schuhbaeck K., Schloetcke K., Zingler C., Schuff-Werner P., et al. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 26 (2005) 115-123
53. Lommatzsch M., Schloetcke K., Klotz J., Schuhbaeck K., Zingler D., Zingler C., et al. Brain-derived neurotrophic factor in platelets and airflow limitation in asthma. Am J Respir Crit Care Med 171 (2005) 115-120
54. Manni L., Nikolova V., Vyagova D., Chaldakov G.N., and Aloe L. Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes. Int J Cardiol 102 (2005) 169-171
55. Martocchia A., Sigala S., Proietti A., D'Urso R., Spano P.F., Missale C., et al. Sex-related variations in serum nerve growth factor concentration in humans. Neuropeptides 36 (2002) 391-395
56. McAllister A.K., Lo D.C., and Katz L.C. Neurotrophins regulate dendritic growth in developing visual cortex. Neuron 15 (1995) 791-803
57. Michalski B., and Fahnestock M. Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease. Mol Brain Res 111 (2003) 148-154
58. Miyazaki K., Narita N., Sakuta R., Miyahara T., Naruse H., Okado N., et al. Serum neurotrophin concentrations in autism and mental retardation: a pilot study. Brain Dev 26 (2004) 292-295
59. Mohapel P., Frielingsdorf H., Haggblad J., Zachrisson O., and Brundin P. Platelet-derived growth factor (PDGF-BB) and brainderived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience 132 (2005) 767-776
60. Nacmias B., Piccini C., Bagnoli S., Tedde A., Cellini E., Bracco L., et al. Brain-derived neurotrophic factor, apolipoprotein E genetic variants and cognitive performance in Alzheimer's disease. Neurosci Lett 367 (2004) 379-383
61. Nakazato M., Hashimoto K., Shimizu E., Kumakiri C., Koizumi H., Okamura N., et al. Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders. Biol Psychiatry 54 (2003) 485-490
62. Nassenstein C., Schulte-Herbruggen O., Renz H., and Braun A. Nerve growth factor: the central hub in the development of allergic asthma?. Eur J Pharmacol 533 (2006) 195-206
63. Nockher W.A., and Renz H. Neurotrophins in clinical diagnostics: pathophysiology and laboratory investigation. Clin Chim Acta 352 (2005) 49-74
64. Noga O., Hanf G., Schaper C., O'Connor A., and Kunkel G. The influence of inhalative corticosteroids on circulating nerve growth factor brain-derived neurotrophic factor and neurotrophin-3 in allergic asthmatics. Clin Exp Allergy 31 (2001) 1906-1912
65. Pan W.H., Banks W.A., Fasold M.B., Bluth J., and Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37 (1998) 1553-1561
66. Peng S.Y., Wuu J., Mufson E.J., and Fahnestock M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem 93 (2005) 1412-1421
67. Pica F., Volpi A., Barillari G., Fraschetti M., Franzese O., Vullo V., et al. Detection of high nerve growth factor serum levels in AIDS-related and -unrelated Kaposi's sarcoma patients. AIDS 12 (1998) 2025-2029
68. Radka S.F., Holst P.A., Fritsche M., and Altar C.A. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res 709 (1996) 122-301
69. Raychaudhuri S.P., and Raychaudhuri S.K. Role of NGF and neurogenic inflammation in the pathogenesis of psoriasis. Prog Brain Res 146 (2004) 433-437
70. Ronne H., Anundi H., Rask L., and Peterson P.A. Nerve growth factor binds to serum alpha-2-macroglobulin. Biochem Biophys Res Commun 87 (1979) 330-336
71. Schaub R.T., Anders D., Golz G., Gohringer K., and Hellweg R. Serum nerve growth factor concentration and its role in the preclinical stage of dementia. Am J Psychol 159 (2002) 1227-1229
72. Serrano-Sanchez T., Robinson-Agramonte M.A., Lorigados-Pedre L., Diaz-Armesto I., Gonzalez-Fragela M.E., and Dorta-Contreras A.J. Endogenous nerve growth factor in patients with Alzheimer's disease. Rev Neurol 32 (2001) 825-828
73. Serrano T., Lorigados L.C., and Armenteros S. Nerve growth factor levels in normal human sera. Neuroreport 8 (1996) 179-181
74. Shimizu E., Hashimoto K., Okamura N., Koike K., Komatsu N., Kumakiri C., et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 54 (2003) 70-75
75. Shoval G., and Weizman A. The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia. Eur Neuropsychopharmacol 15 (2005) 319-329
76. Siegel G.J., and Chauhan N.B. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Brain Res Rev 33 (2000) 199-227
77. Sigala S., Martocchia A., Missale C., Falaschi P., and Spano P.F. Increased serum concentration of nerve growth factor in patients with microprolactinoma. Neuropeptides 38 (2004) 21-24
78. Stephani U., Sutter A., and Zimmermann A. Nerve growth factor (NGF) in serum: evaluation of serum NGF levels with a sensitive bioassay employing embryonic sensory neurons. J Neurosci Res 17 (1987) 25-35
79. Strauss J., Barr C.L., George C.J., Devlin B., Vetro A., Kiss E., et al. Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample. Mol Psychiatry 10 (2005) 861-867
80. Thoenen H. The Changing Scene of Neurotrophic Factors. Trends Neurosci 14 (1991) 165-170
81. Thomas K., and Davies A. Neurotrophins: a ticket to ride for BDNF. Curr Biol 15 (2005) R262-R264
82. Toyooka K., Asama K., Watanabe Y., Muratake T., Takahashi M., Someya T., et al. Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients. Psychiatry Res 110 (2002) 249-257
83. Tria M.A., Fusco M., Vantini G., and Mariot R. Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats. Exp Neurol 127 (1994) 178-183
84. Tuszynski M.H., Thal L., Pay M., Salmon D.P., Sang U.H., Bakay R., et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 11 (2005) 551-555
85. Unutzer J., Katon W., Callahan C.M., Williams Jr. J.W., Hunkeler E., Harpole L., et al. Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA 288 (2002) 2836-2845
86. Ventriglia M., Bocchio C.L., Benussi L., Binetti G., Zanetti O., Riva M.A., et al. Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Mol Psychiatry 7 (2002) 136-137
87. Weickert C.S., Hyde T.M., Lipska B.K., Herman M.M., Weinberger D.R., and Kleinman J.E. Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol Psychiatry 8 (2003) 592-610
88. Wernicke T.F., Linden M., Gilberg R., and Helmchen H. Ranges of psychiatric morbidity in the old and the very old-results from the Berlin Aging Study (BASE). Eur Arch Psychiatry Clin Neurosci 250 (2000) 111-119