Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Journal of Biological Chemistry

Volumn 290, Issue 41, 2015, Pages 24636-24648

  Chakraborty, Anirban ^a   Wakamiya, Maki ^a   Venkova Canova, Tatiana ^a   Pandita, Raj K ^c   Aguilera Aguirre, Leopoldo ^a   Sarker, Altaf H ^d   Singh, Dharmendra Kumar ^c   Hosoki, Koa ^a   Wood, Thomas G ^b   Sharma, Gulshan ^a   Cardenas, Victor ^a   Sarkar, Partha S ^a   Sur, Sanjiv ^a   Pandita, Tej K ^c   Boldogh, Istvan ^a   Hazra, Tapas K ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHROMOSOMES; DNA SEQUENCES; GENES; NUCLEIC ACIDS; PATHOLOGY; PROTEINS; REPAIR; RNA; TISSUE; TRANSCRIPTION;

BASE EXCISION REPAIRS; CHROMATIN IMMUNOPRECIPITATION ANALYSIS; EMBRYONIC FIBROBLASTS; GENOMIC INSTABILITY; GENOMIC REGIONS; HIGHER FREQUENCIES; RNA POLYMERASE II; TRANSCRIPTIONALLY ACTIVE;

MAMMALS;

COCKAYNE SYNDROME GROUP B PROTEIN; DNA BASE; DNA GLYCOSYLTRANSFERASE; NEI LIKE 2 PROTEIN; NEI LIKE 23 PROTEIN; PROTEIN NTH1; PROTEIN OGG1; RNA POLYMERASE II; TRANSCRIPTION COUPLED BASE EXCISION REPAIR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IIH; UNCLASSIFIED DRUG; DNA; NEIL2 PROTEIN, MOUSE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME DEFICIENCY; FEMALE; FIBROBLAST; GENE SEQUENCE; GENOME; GENOMIC INSTABILITY; GENOTYPE; IMMUNOPRECIPITATION; INFLAMMATION; KNOCKOUT MOUSE; MALE; MIDDLE AGED; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE; AGING; ANIMAL; CELL LINE; DEFICIENCY; DNA DAMAGE; GENE INACTIVATION; GENETIC TRANSCRIPTION; GENETICS; HOMEOSTASIS; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; TELOMERE;

AGING; ANIMALS; CELL LINE; DNA; DNA DAMAGE; DNA GLYCOSYLASES; GENE KNOCKOUT TECHNIQUES; GENOME; GENOMIC INSTABILITY; HOMEOSTASIS; HUMANS; INFLAMMATION; MICE; OXIDATION-REDUCTION; RNA POLYMERASE II; TELOMERE; TRANSCRIPTION, GENETIC;

EID: 84943800916     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.658146     Document Type: Article

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