Erratum to Biology of childhood germ cell tumours, focussing on the significance of microRNAs. [Andrology 3(1), 129-139. doi: 10.1111/andr.277];Biology of childhood germ cell tumours, focussing on the significance of microRNAs

Andrology

Volumn 3, Issue 1, 2015, Pages 129-139

  Murray, Matthew J ^a,b   Nicholson, J C ^b   Coleman, N ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

373; Biomarker; Germ cell tumour; Let 7; LIN28; MicroRNA; MiR 302 367; MiR 371; Serum

Indexed keywords

MICRORNA; TUMOR MARKER;

ADOLESCENT; CHILD; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; HUMAN; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; ONSET AGE; OVARIAN NEOPLASMS; PATHOLOGY; PHENOTYPE; PRESCHOOL CHILD; PROGNOSIS; RISK FACTOR; TESTICULAR NEOPLASMS;

ADOLESCENT; AGE OF ONSET; BIOMARKERS, TUMOR; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; MALE; MICRORNAS; NEOPLASMS, GERM CELL AND EMBRYONAL; OVARIAN NEOPLASMS; PHENOTYPE; PROGNOSIS; RISK FACTORS; TESTICULAR NEOPLASMS;

EID: 84943655280     PISSN: 20472919     EISSN: 20472927     Source Type: Journal    
DOI: 10.1111/andr.12038     Document Type: Erratum

References (102)

1. Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA & Skotheim RI. (2011) The testicular germ cell tumour transcriptome. Int J Androl 34, e133– e150; discussion e150-131.
2. Atkin NB & Baker MC. (1982) Specific chromosome change, i(12p), in testicular tumours? Lancet 2, 1349.
3. Barroso-del Jesus A, Romero-Lopez C, Lucena-Aguilar G, Melen GJ, Sanchez L, Ligero G, Berzal-Herranz A & Menendez P. (2008) Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter. Mol Cell Biol 28, 6609–6619.
4. Belge G, Dieckmann KP, Spiekermann M, Balks T & Bullerdiek J. (2012) Serum levels of microRNAs miR-371-3: a novel class of serum biomarkers for testicular germ cell tumors? Eur Urol 61, 1068–1069.
5. Biermann K, Heukamp LC, Steger K, Zhou H, Franke FE, Sonnack V, Brehm R, Berg J, Bastian PJ, Muller SC, Wang-Eckert L & Buettner R. (2007) Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors. Cancer Genomics Proteomics 4, 359–367.
6. Bokemeyer C, Berger CC, Kuczyk MA & Schmoll HJ. (1996a) Evaluation of long-term toxicity after chemotherapy for testicular cancer. J Clin Oncol 14, 2923–2932.
7. Bokemeyer C, Kohrmann O, Tischler J, Weissbach L, Rath U, Haupt A, Schoffski P, Harstrick A & Schmoll HJ. (1996b) A randomized trial of cisplatin, etoposide and bleomycin (PEB) versus carboplatin, etoposide and bleomycin (CEB) for patients with ‘good-risk’ metastatic non-seminomatous germ cell tumors. Ann Oncol 7, 1015– 1021.
8. Bokemeyer C, Kuczyk MA, Dunn T, Serth J, Hartmann K, Jonasson J, Pietsch T, Jonas U & Schmoll HJ. (1996c) Expression of stem-cell factor and its receptor c-kit protein in normal testicular tissue and malignant germ-cell tumours. J Cancer Res Clin Oncol 122, 301–306.
9. Bosl GJ, Leitner SP, Atlas SA, Sealey JE, Preibisz JJ & Scheiner E. (1986) Increased plasma renin and aldosterone in patients treated with cisplatin-based chemotherapy for metastatic germ-cell tumors. J Clin Oncol 4, 1684–1689.
10. Bussey KJ, Lawce HJ, Himoe E, Shu XO, Suijkerbuijk RF, Olson SB & Magenis RE. (2001) Chromosomes 1 and 12 abnormalities in pediatric germ cell tumors by interphase fluorescence in situ hybridization. Cancer Genet Cytogenet 125, 112–118.
11. Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G & Bonnerot C. (2005) Exosomal-like vesicles are present in human blood plasma. Int Immunol 17, 879–887.
12. Calin GA & Croce CM. (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6, 857–866.
13. Cao D, Allan RW, Cheng L, Peng Y, Guo CC, Dahiya N, Akhi S & Li J. (2011a) RNA-binding protein LIN28 is a marker for testicular germ cell tumors. Hum Pathol 42, 710–718.
14. Cao D, Liu A, Wang F, Allan RW, Mei K, Peng Y, Du J, Guo S, Abel TW, Lane Z, Ma J, Rodriguez M, Akhi S, Dehiya N & Li J. (2011b) RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases. Mod Pathol 24, 288–296.
15. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Zhang Y, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J & Zhang CY. (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18, 997–1006.
16. Cheng L, Roth LM, Zhang S, Wang M, Morton MJ, Zheng W, Abdul Karim FW, Montironi R & Lopez-Beltran A. (2011) KIT gene mutation and amplification in dysgerminoma of the ovary. Cancer 117, 2096–2103.
17. Collinson K, Murray MJ, Orsi NM, Cummings M, Shipley J, Joffe JK, Coleman N & Stark D. (2014) Age-related biological features of germ cell tumors. Genes Chromosomes Cancer 53, 215–227.
18. Dieckmann KP, Spiekermann M, Balks T, Flor I, Loning T, Bullerdiek J & Belge G. (2012) MicroRNAs miR-371-3 in serum as diagnostic tools in the management of testicular germ cell tumours. Br J Cancer 107, 1754–1760.
19. van Dongen S, Abreu-Goodger C & Enright AJ. (2008) Detecting microRNA binding and siRNA off-target effects from expression data. Nat Methods 5, 1023–1025.
20. Einhorn LH & Donohue JP. (1977) Improved chemotherapy in disseminated testicular cancer. J Urol 117, 65–69.
21. Einhorn LH, Brames MJ, Heinrich MC, Corless CL & Madani A. (2006) Phase II study of imatinib mesylate in chemotherapy refractory germ cell tumors expressing KIT. Am J Clin Oncol 29, 12–13.
22. Esquela-Kerscher A & Slack FJ. (2006) Oncomirs – microRNAs with a role in cancer. Nat Rev Cancer 6, 259–269.
23. Feldman DR, Iyer G, Van Alstine L, Patil S, Al-Ahmadie HA, Reuter VE, Bosl GJ, Chaganti RS & Solit DB. (2014) Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors. Clin Cancer Res 20, 3712–3720.
24. Fritsch MK, Schneider DT, Schuster AE, Murdoch FE & Perlman EJ. (2006) Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors. Pediatr Dev Pathol 9, 115–131.
25. Fustino N, Rakheja D, Ateek CS, Neumann JC & Amatruda JF. (2011) Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours. Int J Androl 34, e218–e233.
26. Gautier L, Cope L, Bolstad BM & Irizarry RA. (2004) affy–analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20, 307– 315.
27. Gilbert D, Rapley E & Shipley J. (2011) Testicular germ cell tumours: predisposition genes and the male germ cell niche. Nat Rev Cancer 11, 278–288.
28. Gillis AJM, Stoop HJ, Hersmus R, Oosterhuis JW, Sun Y, Chen C, Guenther S, Sherlock J, Veltman I, Baeten J, van der Spek PJ, de Alarcon P & Looijenga LHJ. (2007) High-throughput microRNAome analysis in human germ cell tumours. J Pathol 213, 319–328.
29. Gillis AJ, Stoop H, Biermann K, van Gurp RJ, Swartzman E, Cribbes S, Ferlinz A, Shannon M, Oosterhuis JW & Looijenga LH. (2011) Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis. Int J Androl 34, e160–e174.
30. Gillis AJ, Rijlaarsdam MA, Eini R, Dorssers LC, Biermann K, Murray MJ, Nicholson JC, Coleman N, Dieckmann KP, Belge G, Bullerdiek J, Xu T, Bernard N & Looijenga LH. (2013) Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle. Mol Oncol 7, 1083–1092.
31. Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, Inoue K, Enright AJ & Schier AF. (2006) Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312, 75–79.
32. Glendenning JL, Barbachano Y, Norman AR, Dearnaley DP, Horwich A & Huddart RA. (2010) Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicular cancer. Cancer 116, 2322–2331.
33. Honecker F, Wermann H, Mayer F, Gillis AJ, Stoop H, van Gurp RJ, Oechsle K, Steyerberg E, Hartmann JT, Dinjens WN, Oosterhuis JW, Bokemeyer C & Looijenga LH. (2009) Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors. J Clin Oncol 27, 2129–2136.
34. Horwich A, Sleijfer DT, Fossa SD, Kaye SB, Oliver RT, Cullen MH, Mead GM, de Wit R, de Mulder PH, Dearnaley DP, Cook PA, Sylvester RJ & Stenning SP. (1997) Randomized trial of bleomycin, etoposide, and cisplatin compared with bleomycin, etoposide, and carboplatin in good-prognosis metastatic nonseminomatous germ cell cancer: a Multiinstitutional Medical Research Council/European Organization for Research and Treatment of Cancer Trial. J Clin Oncol 15, 1844–1852.
35. Huddart RA, Norman A, Shahidi M, Horwich A, Coward D, Nicholls J & Dearnaley DP. (2003) Cardiovascular disease as a long-term complication of treatment for testicular cancer. J Clin Oncol 21, 1513–1523.
36. International Germ Cell Cancer Collaborative Group (1997) International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. J Clin Oncol 15, 594–603.
37. Jeyapalan JN, Noor DA, Lee SH, Tan CL, Appleby VA, Kilday JP, Palmer RD, Schwalbe EC, Clifford SC, Walker DA, Murray MJ, Coleman N, Nicholson JC & Scotting PJ. (2011) Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance. Br J Cancer 105, 575–585.
38. Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, Chin L, Brown D & Slack FJ. (2007) The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 67, 7713–7722.
39. Kawakami T, Okamoto K, Ogawa O & Okada Y. (2004) XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. Lancet 363, 40–42.
40. Kemmer K, Corless CL, Fletcher JA, McGreevey L, Haley A, Griffith D, Cummings OW, Wait C, Town A & Heinrich MC. (2004) KIT mutations are common in testicular seminomas. Am J Pathol 164, 305–313.
41. Korkola JE, Houldsworth J, Chadalavada RS, Olshen AB, Dobrzynski D, Reuter VE, Bosl GJ & Chaganti RS. (2006) Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res 66, 820–827.
42. Korkola JE, Houldsworth J, Feldman DR, Olshen AB, Qin LX, Patil S, Reuter VE, Bosl GJ & Chaganti RS. (2009) Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors. J Clin Oncol 27, 5240–5247.
43. Kraggerud SM, Szymanska J, Abeler VM, Kaern J, Eknaes M, Heim S, Teixeira MR, Trope CG, Peltomaki P & Lothe RA. (2000) DNA copy number changes in malignant ovarian germ cell tumors. Cancer Res 60, 3025–3030.
44. Kraggerud SM, Skotheim RI, Szymanska J, Eknaes M, Fossa SD, Stenwig AE, Peltomaki P & Lothe RA. (2002) Genome profiles of familial/ bilateral and sporadic testicular germ cell tumors. Genes Chromosom Cancer 34, 168–174.
45. Lakshmipathy U, Love B, Goff LA, Jornsten R, Graichen R, Hart RP & Chesnut JD. (2007) MicroRNA expression pattern of undifferentiated and differentiated human embryonic stem cells. Stem Cells Dev 16, 1003–1016.
46. Laurent LC. (2008) MicroRNAs in embryonic stem cells and early embryonic development. J Cell Mol Med 12, 2181–2188.
47. LeBron C, Pal P, Brait M, Dasgupta S, Guerrero-Preston R, Looijenga LH, Kowalski J, Netto G & Hoque MO. (2011) Genome-wide analysis of genetic alterations in testicular primary seminoma using high resolution single nucleotide polymorphism arrays. Genomics 97, 341– 349.
48. Li X, Zhang J, Gao L, McClellan S, Finan MA, Butler TW, Owen LB, Piazza GA & Xi Y. (2012) MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit. Cell Death Differ 19, 378–386.
49. Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS & Johnson JM. (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433, 769–773.
50. Looijenga LH, de Leeuw H, van Oorschot M, van Gurp RJ, Stoop H, Gillis AJ, de Gouveia Brazao CA, Weber RF, Kirkels WJ, van Dijk T, von Lindern M, Valk P, Lajos G, Olah E, Nesland JM, Fossa SD & Oosterhuis JW. (2003) Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors. Cancer Res 63, 7674–7678.
51. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR & Golub TR. (2005) MicroRNA expression profiles classify human cancers. Nature 435, 834–838.
52. Mann JR, Raafat F, Robinson K, Imeson J, Gornall P, Sokal M, Gray E, McKeever P, Hale J, Bailey S & Oakhill A. (2000) The United Kingdom Children’s Cancer Study Group’s second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 18, 3809–3818.
53. Masque-Soler N, Szczepanowski M, Leuschner I, Vokuhl C, Haag J, Calaminus G & Klapper W. (2012) Absence of BRAF mutation in pediatric and adolescent germ cell tumors indicate biological differences to adult tumors. Pediatr Blood Cancer 59, 732–735.
54. McIntyre A, Summersgill B, Spendlove HE, Huddart R, Houlston R & Shipley J. (2005) Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors. Neoplasia 7, 1047–1052.
55. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O’Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB & Tewari M. (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105, 10513–10518.
56. Murray MJ & Coleman N. (2012) Testicular cancer: a new generation of biomarkers for malignant germ cell tumours. Nat Rev Urol 9, 298–300.
57. Murray MJ & Nicholson JC. (2010) Germ cell tumours in children and adolescents. Paediatrics and Child Health 20, 109–116.
58. Murray MJ & Nicholson JC. (2011) alpha-Fetoprotein. Arch Dis Child Educ Pract Ed 96, 141–147.
59. Murray MJ & Schönberger S. (2014) Biology of germ cell tumors. In: Pediatric Germ Cell Tumors (eds A Frazier & J Amatruda), pp. 1–15. Springer, Berlin, Heidelberg.
60. Murray MJ, Fern LA, Stark DP, Eden TO & Nicholson JC. (2009) Breaking down barriers: improving outcomes for teenagers and young adults with germ cell tumours. Oncol Rev 3, 201–206.
61. Murray MJ, Saini HK, van Dongen S, Palmer RD, Muralidhar B, Pett MR, Piipari M, Thornton CM, Nicholson JC, Enright AJ & Coleman N. (2010) The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression. Mol Cancer 9, 290.
62. Murray MJ, Halsall DJ, Hook CE, Williams DM, Nicholson JC & Coleman N. (2011) Identification of microRNAs from the miR-371~373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors. Am J Clin Pathol 135, 119–125.
63. Murray MJ, Saini HK, Siegler CA, Hanning JE, Barker EM, van Dongen S, Ward DM, Raby KL, Groves IJ, Scarpini CG, Pett MR, Thornton CM, Enright AJ, Nicholson JC & Coleman N. (2013) LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. Cancer Res 73, 4872–4884.
64. Nakai Y, Nonomura N, Oka D, Shiba M, Arai Y, Nakayama M, Inoue H, Nishimura K, Aozasa K, Mizutani Y, Miki T & Okuyama A. (2005) KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors. Biochem Biophys Res Commun 337, 289–296.
65. Nikolaou M, Valavanis C, Aravantinos G, Fountzilas G, Tamvakis N, Lekka I, Arapantoni-Dadioti P, Zizi A, Ghiconti I, Economopoulos T & Pectasides D. (2007) Kit expression in male germ cell tumors. Anticancer Res 27, 1685–1688.
66. Oosterhuis JW & Looijenga LH. (2005) Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 5, 210–222.
67. Osanto S, Bukman A, Van Hoek F, Sterk PJ, De Laat JA & Hermans J. (1992) Long-term effects of chemotherapy in patients with testicular cancer. J Clin Oncol 10, 574–579.
68. Ottesen AM, Skakkebaek NE, Lundsteen C, Leffers H, Larsen J & Rajpert-De Meyts E. (2003) High-resolution comparative genomic hybridization detects extra chromosome arm 12p material in most cases of carcinoma in situ adjacent to overt germ cell tumors, but not before the invasive tumor development. Genes Chromosom Cancer 38, 117–125.
69. Palmer RD, Foster NA, Vowler SL, Roberts I, Thornton CM, Hale JP, Schneider DT, Nicholson JC & Coleman N. (2007) Malignant germ cell tumours of childhood: new associations of genomic imbalance. Br J Cancer 96, 667–676.
70. Palmer RD, Barbosa-Morais NL, Gooding EL, Muralidhar B, Thornton CM, Pett MR, Roberts I, Schneider DT, Thorne N, Tavare S, Nicholson JC & Coleman N. (2008) Pediatric malignant germ cell tumors show characteristic transcriptome profiles. Cancer Res 68, 4239–4247.
71. Palmer RD, Murray MJ, Saini HK, van Dongen S, Abreu-Goodger C, Muralidhar B, Pett MR, Thornton CM, Nicholson JC, Enright AJ & Coleman N. (2010) Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. Cancer Res 70, 2911–2923.
72. Perlman EJ, Hu J, Ho D, Cushing B, Lauer S & Castleberry RP. (2000) Genetic analysis of childhood endodermal sinus tumors by comparative genomic hybridization. J Pediatr Hematol Oncol 22, 100– 105.
73. Rainen L, Oelmueller U, Jurgensen S, Wyrich R, Ballas C, Schram J, Herdman C, Bankaitis-Davis D, Nicholls N, Trollinger D & Tryon V. (2002) Stabilization of mRNA expression in whole blood samples. Clin Chem 48, 1883–1890.
74. Rosenberg C, Van Gurp RJ, Geelen E, Oosterhuis JW & Looijenga LH. (2000) Overrepresentation of the short arm of chromosome 12 is related to invasive growth of human testicular seminomas and nonseminomas. Oncogene 19, 5858–5862.
75. Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ & Heinrich MC. (2006) Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 66, 473–481.
76. Schneider DT, Schuster AE, Fritsch MK, Calaminus G, Harms D, Gobel U & Perlman EJ. (2001) Genetic analysis of childhood germ cell tumors with comparative genomic hybridization. Klin Padiatr 213, 204–211.
77. Sch€onberger S, Okpanyi V, Alemazkour K, Looijenga LH, Nicholson JC, Borkhardt A & Schneider DT. (2010) Extracellular regulators of the WNT signalling pathway in childhood germ cell tumors: methylation of the SFRP2 promoter leads to WNT activation and b-catenin accumulation. Pediatr Blood Cancer 55, 804.
78. Sommerer F, Hengge UR, Markwarth A, Vomschloss S, Stolzenburg JU, Wittekind C & Tannapfel A. (2005) Mutations of BRAF and RAS are rare events in germ cell tumours. Int J Cancer 113, 329–335.
79. Stadler B, Ivanovska I, Mehta K, Song S, Nelson A, Tan Y, Mathieu J, Darby C, Blau CA, Ware C, Peters G, Miller DG, Shen L, Cleary MA & Ruohola-Baker H. (2010) Characterization of microRNAs involved in embryonic stem cell states. Stem Cells Dev 19, 935–950.
80. Stoneham SJ, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray M, Amatruda JF, Thornton C, Arul GS, Billmire D, Krailo M, Stark D, Covens A, Hurteau J, Stenning S, Nicholson JC, Gershenson D & Frazier AL. (2014) Adolescents and young adults with a “rare” cancer: getting past semantics to optimal care for patients with germ cell tumors. Oncologist 19, 689–692.
81. Strumberg D, Brugge S, Korn MW, Koeppen S, Ranft J, Scheiber G, Reiners C, Mockel C, Seeber S & Scheulen ME. (2002) Evaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer. Ann Oncol 13, 229–236.
82. Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN & Kim KS. (2004) Human embryonic stem cells express a unique set of microRNAs. Dev Biol 270, 488–498.
83. Summersgill B, Osin P, Lu YJ, Huddart R & Shipley J. (2001) Chromosomal imbalances associated with carcinoma in situ and associated testicular germ cell tumours of adolescents and adults. Br J Cancer 85, 213–220.
84. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T & Takahashi T. (2004) Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64, 3753–3756.
85. Teilum G. (1965) Classification of endodermal sinus tumour (mesoblatoma vitellinum) and so-called “embryonal carcinoma” of the ovary. Acta Pathol Microbiol Scand 64, 407–429.
86. Terashima K, Shen J, Luan J, Yu A, Yamaguchi S, Suzuki T, Nishikawa R, Matsutani M, Liang Y, Man T-K & Lau C. (2013) MicroRNA 371–373 and 302a in cerebrospinal fluid are potential tumour-derived biomarkers for intracranial germ cell tumours. Br J Neurosurg 27, e1–e25.
87. Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T & Hammond SM. (2006) Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev 20, 2202–2207.
88. Travis LB, Curtis RE, Storm H, Hall P, Holowaty E, Van Leeuwen FE, Kohler BA, Pukkala E, Lynch CF, Andersson M, Bergfeldt K, Clarke EA, Wiklund T, Stoter G, Gospodarowicz M, Sturgeon J, Fraumeni JF Jr & Boice JD Jr. (1997) Risk of second malignant neoplasms among long-term survivors of testicular cancer. J Natl Cancer Inst 89, 1429– 1439.
89. Travis LB, Fossa SD, Schonfeld SJ, McMaster ML, Lynch CF, Storm H, Hall P, Holowaty E, Andersen A, Pukkala E, Andersson M, Kaijser M, Gospodarowicz M, Joensuu T, Cohen RJ, Boice JD Jr, Dores GM & Gilbert ES. (2005) Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 97, 1354– 1365.
90. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ & Lotvall JO. (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9, 654– 659.
91. Viprey VF, Corrias MV, Kagedal B, Oltra S, Swerts K, Vicha A, Ladenstein R & Burchill SA. (2007) Standardisation of operating procedures for the detection of minimal disease by QRT-PCR in children with neuroblastoma: quality assurance on behalf of SIOPEN-R-NET. Eur J Cancer 43, 341–350.
92. Viswanathan SR, Daley GQ & Gregory RI. (2008) Selective blockade of microRNA processing by Lin28. Science 320, 97–100.
93. Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O’Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH & Daley GQ. (2009) Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet 41, 843–848.
94. Voorhoeve PM, le Sage C, Schrier M, Gillis AJM, Stoop H, Nagel R, Liu Y-P, van Duijse J, Drost J, Griekspoor A, Zlotorynski E, Yabuta N, De Vita G, Nojima H, Looijenga LHJ & Agami R. (2006) A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124, 1169–1181.
95. Wang Y & Blelloch R. (2009) Cell cycle regulation by microRNAs in embryonic stem cells. Cancer Res 69, 4093–4096.
96. Wang Y, Baskerville S, Shenoy A, Babiarz JE, Baehner L & Blelloch R. (2008) Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet 40, 1478–1483.
97. West JA, Viswanathan SR, Yabuuchi A, Cunniff K, Takeuchi A, Park IH, Sero JE, Zhu H, Perez-Atayde A, Frazier AL, Surani MA & Daley GQ. (2009) A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 460, 909–913.
98. Williams SD, Birch R, Einhorn LH, Irwin L, Greco FA & Loehrer PJ. (1987) Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 316, 1435–1440.
99. Wu L & Belasco JG. (2005) Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells. Mol Cell Biol 25, 9198–9208.
100. Xue D, Peng Y, Wang F, Allan RW & Cao D. (2011) RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours. Histopathology 59, 452–459.
101. Zhong X, Li N, Liang S, Huang Q, Coukos G & Zhang L. (2010) Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. J Biol Chem 285, 41961– 41971.
102. Zovoilis A, Nolte J, Drusenheimer N, Zechner U, Hada H, Guan K, Hasenfuss G, Nayernia K & Engel W. (2008) Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles. Mol Hum Reprod 14, 521–529.