Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis

Circulation Research

Volumn 117, Issue 9, 2015, Pages 804-816

  Paik, David T ^a,b   Rai, Meena ^a,b   Ryzhov, Sergey ^a,c   Sanders, Lehanna N ^a,b   Aisagbonhi, Omonigho ^a,b,d   Funke, Mitchell J ^a,e   Feoktistov, Igor ^a,b   Hatzopoulos, Antonis K ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Maine Medical Center Research Institute   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e Golden Rule Medical   (United States)

Author keywords

fibrosis; heart failure; myocardial infarction; neovascularization; Wnt signaling pathway

Indexed keywords

ANGIOPOIETIN 1; BETA CATENIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOID ENHANCER FACTOR 1; MYOSIN HEAVY CHAIN ALPHA; PLATELET DERIVED GROWTH FACTOR B; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; WNT10B PROTEIN; WNT11 PROTEIN; ONCOPROTEIN; WNT PROTEIN; WNT10B PROTEIN, HUMAN; WNT10B PROTEIN, MOUSE;

ADULT; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GRANULATION TISSUE; HEART INFARCTION; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; ISCHEMIC CARDIOMYOPATHY; MOUSE; MYOFIBROBLAST; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GAIN OF FUNCTION; SCAR; SIGNAL TRANSDUCTION; TISSUE REPAIR; VASCULAR SMOOTH MUSCLE CELL; WNT SIGNALING PATHWAY; ANIMAL; BLOOD VESSEL; C57BL MOUSE; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CELL CULTURE; CELL LINE; CONFOCAL MICROSCOPY; CYTOLOGY; ENDOTHELIUM CELL; FIBROSIS; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE CELL; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANGIOPOIETIN-1; ANIMALS; ARTERIOLES; BLOOD VESSELS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; FIBROSIS; GENE EXPRESSION; HUMANS; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE; MYOFIBROBLASTS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; WNT PROTEINS;

EID: 84943630704     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.306886     Document Type: Article

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