Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 191, Issue , 2015, Pages 15-22

  Hyderali, Barkath Nisha ^a   Mala, Kanchana ^a  

^a SRM INSTITUTE OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

Antioxidant; Asymmetric dimethyl arginine; Homocysteine; Oxidative stress; Polycystic ovarian syndrome

Indexed keywords

ANTIOXIDANT; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ATHEROSCLEROSIS; CELL DAMAGE; DISEASE SEVERITY; DNA DAMAGE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; HUMAN; HYPERANDROGENISM; HYPERGLYCEMIA; INSULIN RESISTANCE; OBESITY; OVARY POLYCYSTIC DISEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; THROMBOSIS; BIOLOGICAL MODEL; CARDIOVASCULAR DISEASES; FEMALE; METABOLISM; PATHOPHYSIOLOGY; RISK FACTOR; SEVERITY OF ILLNESS INDEX; VASCULAR ENDOTHELIUM;

CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INSULIN RESISTANCE; MODELS, BIOLOGICAL; NITRIC OXIDE; OXIDATIVE STRESS; POLYCYSTIC OVARY SYNDROME; REACTIVE OXYGEN SPECIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84943613298     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2015.05.005     Document Type: Review

References (133)

1. E.S. Knochenhauer, T.J. Key, M. Kahsar-Miller, and et al. Prevalence of the polycystic ovary syndrome in unselected black and white women of the south eastern United States: a prospective study J Clin Endocrinol Metab 83 1998 3078 3082
2. R.A. Wild, B. Grubb, A. Hartz, and et al. Clinical signs of androgen excess as risk factors for coronary artery disease Fertil Steril 54 1990 255 259
3. M. McKittrick Diet and polycystic ovary syndrome Nutr Today 37 2002 63 69
4. E. Dahlgren, P.O. Janson, S. Johansson, and et al. Polycystic ovary syndrome and risk for myocardial infarction: evaluated from a risk factor model based on a prospective study of women Acta Obstet Gynecol Scand 71 1992 599 604
5. G. Paradisi, H.O. Steinberg, A. Hempfling, and et al. Polycystic ovary syndrome is associated with endothelial dysfunction Circulation 103 2001 1410 1415
6. A. Agarwal, A. Aponte-Mellado, B.J. Premkumar, and et al. The effects of oxidative stress on female reproduction: a review Reprod Biol Endocrinol 10 2012 49 80
7. H. Cai, and D.G. Harrison Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress Circ Res 87 2000 840 844
8. M. Rosselli, P.J. Keller, and R.K. Dubey Role of nitric oxide in the biology, physiology and pathophysiology of reproduction Hum Reprod Update 4 1998 3 24
9. W. Dröge Free radicals in the physiological control of cell function Physiol Rev 82 2001 47 95
10. N.R. Madamanchi, and M.S. Runge Redox signaling in cardiovascular health and disease Free Radic Biol Med 61C 2013 473 501
11. K.H. Al-Gubory, P.A. Fowler, and C. Garrel The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes Int J Biochem Cell Biol 42 2010 1634 1650
12. T. Sabuncu, H. Vural, M. Harma, and et al. Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease Clin Biochem 34 2001 407 413
13. A. Agarwal, S. Gupta, and R.K. Sharma Role of oxidative stress in female reproduction Reprod Biol Endocrinol 3 2005 28 49
14. F.F. Verit, and O. Erel Oxidative stress in nonobese women with polycystic ovary syndrome: correlations with endocrine and screening parameters Gynecol Obstet Invest 65 2008 233 239
15. A.S. Bickerton, N. Clark, D. Meeking, and et al. Cardiovascular risk in women with polycystic ovarian syndrome (PCOS) J Clin Pathol 58 2005 151 154
16. F.T. Ruschitzka, G. Noll, and T.F. Luscher The endothelium in coronary artery disease Cardiology 88 1997 3 19
17. E. Carmina, F. Orio, S. Palomba, and et al. Endothelial dysfunction in PCOS: role of obesity and adipose hormones Am J Med 119 2006 356.e1-6
18. E. Diamanti-Kandarakis, K. Alexandraki, C. Piperi, and et al. Inflammatory and endothelial markers in women with polycystic ovary syndrome Eur J Clin Invest 36 2006 691 697
19. C. Meyer, B.P. McGrath, and H.J. Teede Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease J Clin Endocrinol Metab 90 2005 5711 5716
20. M. Karadeniz, M. Erdoʇan, S. Tamsel, and et al. Oxidative stress markers in young patients with polycystic ovary syndrome, the relationship between insulin resistances Exp Clin Endocrinol Diabetes 116 2008 231 235
21. A.B. Karabulut, M. Cakmak, R.T. Kiran, and et al. Oxidative stress status, metabolic profile and cardiovascular risk factors in patients with polycystic ovary syndrome Med Sci 1 2012 27 34
22. C.G. Cochrane Cellular injury by oxidants Am J Med 1991 3C23S-3C30S
23. V.M. Victor, M. Rocha, C. Banuls, and et al. Induction of oxidative stress and human leukocyte/endothelial cell interactions in polycystic ovary syndrome patients with insulin resistance J Clin Endocrinol Metab 96 2001 3115 3122
24. Y. Dincer, T. Akcay, T. Erdem, and et al. DNA damage, DNA susceptibility to oxidation and glutathione level in women with polycystic ovary syndrome Scand J Clin Lab Invest 65 2005 721 728
25. F. Ovalle, and R. Azziz Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus Fertil Steril 77 2002 1095 1105
26. M. Ciampelli, F. Leoni, F. Cucinelli, and et al. Assessment of insulin sensitivity from measurements in the fasting state and during an oral glucose tolerance test in polycystic ovary syndrome and menopausal patients J Clin Endocrinol Metab 90 3 2005 1398 1406
27. C.M. DeUgarte, A.A. Bartolucci, and R. Azziz Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment Fertil Steril 83 5 2005 1454 1460
28. S.E. Kahn, R.L. Prigeon, D.K. McCulloch, and et al. Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function Diabetes 42 1993 1663 1672
29. J. Holte, T. Bergh, C. Berne, and et al. Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance J Clin Endocrinol Metab 78 1994 1052 1058
30. M. Ciampelli, A.M. Fulghesu, F. Cucinelli, and et al. Heterogeneity in β-cell activity, hepatic insulin clearance and peripheral insulin sensitivity in women with polycystic ovary syndrome Hum Reprod 12 1997 1897 1901
31. M. Ciampelli, A.M. Fulghesu, F. Cucinelli, and et al. Impact of insulin and body mass index on metabolic and endocrine variables in polycystic ovary syndrome Metabolism 48 1999 167 172
32. M. Pertynska-Marczewska, and Z. Merhi Relationship of advanced glycation end products with cardiovascular disease in menopausal women Reprod Sci 2014 pii:1933719114549845
33. E. Diamanti-Kandarakis, I. Katsikis, C. Piperi, and et al. Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS) Clin Endocrinol (Oxf) 69 2008 634 641
34. T.M. Paravicini, and R.M. Touyz Redox signaling in hypertension Cardiovasc Res 71 2006 247 258
35. C. Christakou, F. Economou, S. Livadas, and et al. Strong and positive association of endothelin-1 with AGEs in PCOS: a causal relationship or a bystander? Hormones (Athens) 10 2011 292 297
36. C. Kelly, A. Speirs, G. Gould, and et al. Altered vascular function in young women with polycystic ovary syndrome J Clin Endocrinol Metab 87 2002 742 746
37. V.M. Witko-Sarsat, C. Friedlander, T. Capeillère-Blandin, and et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia Kidney Int 49 2002 1304 1313
38. C. Kaya, A.F. Erkan, S.D. Cengiz, and et al. Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome Fertil Steril 92 2009 1372 1377
39. L.H. Sekhon, S. Gupta, Y. Kim, and et al. Female infertility and antioxidants Curr Womens Health Rev 6 2010 84 95
40. A. Agarwal, and S. Allamaneni Role of free radicals in female reproductive diseases and assisted reproduction Reprod Biomed 9 2004 338 347
41. D. Zhang, W.Y. Luo, H. Liao, and et al. The effects of oxidative stress to PCOS Sichuan Da Xue Xue Bao Yi Xue Ban 39 2008 421 423
42. J.R. Palacio, A. Iborra, Z. Ulcova-Gallova, and et al. The presence of antibodies to oxidative modified proteins in serum from polycystic ovary syndrome patients Clin Exp Immunol 144 2006 217 222
43. N.K. Kuscu, and A. Var Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome Acta Obstet Gynecol Scand 88 2009 612 617
44. J.Y. Lee, C.K. Baw, S. Gupta, and et al. Role of oxidative stress in polycystic ovary syndrome Curr Womens Health Rev 6 2010 96 107
45. V. Fenkci, S. Fenkci, M. Yilmazer, and et al. Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease Fertil Steril 80 2003 123 127
46. J. Mier-Cabrera, T. Aburto-Soto, S. Burrola-Mendez, and et al. Women with endometriosis improved their peripherals antioxidants markers after the application of a high antioxidant diet Reprod Biol Endocrinol 28 2009 54 65
47. A.M. Fulghesu, M. Ciampelli, G. Muzi, and et al. N-acetyl cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome Fertil Steril 77 2002 1128 1135
48. H.H. Ting, F.K. Timimi, K.S. Boles, and et al. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus J Clin Invest 97 1996 22 28
49. U. Solzbach, B. Hornig, M. Jeserich, and et al. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients Circulation 96 1997 1513 1519
50. A.M. Al-Kataan, M.A. Ibrahim, M.H.H. Al-Jammas, and et al. Serum antioxidant vitamins changes in women with polycystic ovary syndrome J Bahrain Med Soc 22 2010 68 71
51. M. Rafraf, E. Mohammadi, L. Farzadi, and et al. Effects of Omega-3 fatty acid supplement on serum lipid profile and markers of oxidative stress in women with polycystic ovary syndrome Iran J Obstet Gynecol Infertil 15 2012 1 10
52. L. Pal, A. Berry, L. Coraluzzi, and et al. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome Gynecol Endocrinol 28 2012 965 968
53. K. Gayatri, J. Saubhagya Kumar, and B. Basanta Kumar Metformin and N-acetyl cysteine in polycystic ovarian syndrome - a comparative study Indian J Clin Med 1 2010 7 13
54. A. Agarwal, S. Gupta, L. Sekhon, and R. Shah Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications Antioxid Redox Signal 10 2008 1376 1388
55. Nutrition Guide, Human Performance Research Center. http://hprc-online.org/nutrition/warfighter-nutrition-guide-chapter-4-1/FoodSourcesAntioxidants.pdf.
56. A.W.R. Hamad, S.A. Ahmad, and F.A. Rasheed Comparative study of antioxidant levels (vitamin E & selenium) in serum of polycystic ovary syndrome patients and control J Al-Nahrain Univ 14 2011 40 43
57. Mayo Clinic Medical Information Drugs and supplements. Vitamin E 2005 http://www.mayoclinic.com/health/vitamin-e/NS-patientvitamin-e
58. H. Nitta, M. Kinoyama, A. Watanabe, and et al. Effects of nutritional supplementation with antioxidant vitamins and minerals and fish oil on antioxidant status and psychosocial stress in smokers: an open trial Clin Exp Med 7 2007 179 183
59. A. Dunaif Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis Endocr Rev 18 1997 774 800
60. G.S. Conway, H.S. Jacobs, J.M. Holly, and et al. Effects of luteinizing hormone, insulin, insulin-like growth factor-I and insulin-like growth factor small binding protein 1 in the polycystic ovary syndrome Clin Endocrinol (Oxf) 33 1990 593 603
61. D. Macut, M. Pfeifer, B.O. Yildiz, and E. Diamanti-Kandarakis Polycystic ovary syndrome. Novel insights into causes and therapy. Front Horm Res vol. 40 2013 Karger 64 82
62. A. Dunaif, J. Xia, C.B. Book, and et al. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome J Clin Invest 96 1995 801 810
63. S. Kandasamy, R.I. Sivagamasundari, A. Bupathy, and et al. Evaluation of insulin resistance and oxidative stress in obese patients with polycystic ovary syndrome Int J Appl Biol Pharm Technol 1 2010 391 398
64. D. Rosenbaum, R.S. Haber, and A. Dunaif Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes Am J Physiol 264 1993 E197 E202
65. A. Chandra, N. Surti, S. Kesavan, and et al. Significance of oxidative stress in human reproduction Arch Med 5 2009 528 542
66. J. Fujii, Y. Iuchi, and F. Okada Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system Reprod Biol Endocrinol 3 2005 43 53
67. F. Hassani, M. Karami, M.R. Jalali Nadoushan, and et al. Nitric oxide-induced polycystic ovaries in the wistar rat Int J Fertil Steril 6 2012 111 116
68. F. Bayram, D. Kocer, M. Ozsan, and et al. Evaluation of endothelial dysfunction, lipid metabolism in women with polycystic ovary syndrome: relationship of paraoxonase-1 activity, malondialdehyde levels, low-density lipoprotein subfractions, and endothelial dysfunction Gynecol Endocrinol 28 2012 497 501
69. M.Y. Taslipinar, N. Kilic, N. Bayraktar, and et al. Endothelial dysfunction and insulin resistance in young women with polycystic ovarian syndrome Turk J Med Sci 44 2014 787 791
70. A.P. Nácul, C.D. Andrade, P. Schwarz, and et al. Nitric oxide and fibrinogen in polycystic ovary syndrome: associations with insulin resistance and obesity Eur J Obstet Gynecol Reprod Biol 133 2007 191 196
71. M. Erdogan, M. Karadeniz, A. Berdeli, and et al. The relationship of the interleukin-6-174 G>C gene polymorphism with oxidative stress markers in Turkish polycystic ovary syndrome patients J Endocrinol Invest 31 2008 624 629
72. A.J. Pope, K. Karuppiah, and A.J. Cardounel Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production Pharmacol Res 60 2009 461 465
73. C.T.L. Tran, J.M. Leiper, and P. Vallance The DDAH/ADMA/NOS pathway Atheroscler Suppl 4 2003 33 40
74. J.M. Denu, and K.G. Tanner Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation Biochemistry 37 1998 5633 5642
75. M. Kravarti, K.K. Naka, S.N. Kalantaridou, and et al. Predictors of endothelial dysfunction in young women with PCOS J Clin Endocrinol Metab 90 2005 5088 5095
76. V.V. Sprung, D.J. Cuthbertson, C.J.A. Pugh, and et al. Nitric oxide-mediated cutaneous microvascular function is impaired in polycystic ovary syndrome but can be improved by exercise training J Physiol 591 Pt 6 2013 1475 1487
77. E.O. Talbott, J.V. Zborowski, J.R. Rager, and et al. Evidence for an association between metabolic cardiovascular syndrome and coronary and aortic calcification among women with polycystic ovary syndrome J Clin Endocrinol Metab 89 2004 5454 5461
78. R. Calderon-Margalit, D. Siscovick, S.S. Merkin, and et al. Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness: the Coronary Artery Risk Development in Young Adults Women's study Arterioscler Thromb Vasc Biol 34 2014 2688 2694
79. R.C. Christian, D.A. Dumesic, T. Behrenbeck, and et al. Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome J Clin Endocrinol Metab 88 2003 2562 2568
80. E.O. Talbott, D.S. Guzick, K. Sutton-Tyrrell, and et al. Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women Arterioscler Thromb Vasc Biol 20 2000 2414 2422
81. M.W. Elting, J.T. Korsen, P.D. Bezemer, and et al. Prevalence of diabetes mellitus, hypertension and cardiac complaints in a follow-up study of a Dutch PCOS population Hum Reprod 16 2001 556 560
82. E. Talbott, D. Guzick, A. Clerici, and et al. Coronary heart disease risk factors in women with polycystic ovary syndrome Arterioscler Thromb Vasc Biol 15 1995 821 826
83. R.A. De Fronzo, and E. Ferrannini Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease Diabetes Care 14 1991 173 194
84. R.A. Wild Obesity, lipids, cardiovascular risk, and androgen excess Am J Med 98 1995 S27 S32
85. G.S. Conway, R. Agrawal, D.J. Betteridge, and et al. Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome Clin Endocrinol 37 1992 119 125
86. R.A. Wild, P. Alaupovic, and I.J. Parker Lipid and apolipoprotein abnormalities in hirsute women. I. The association with insulin resistance Am J Obstet Gynecol 166 1992 1191 1196
87. T.L. Loucks, E.O. Talbott, K.P. McHugh, and et al. Do polycystic-appearing ovaries affect the risk of cardiovascular disease among women with polycystic ovary syndrome? Fertil Steril 74 2000 547 552
88. M. Sampson, C. Kong, A. Patel, and et al. Ambulatory blood pressure profiles and plasminogen activator inhibitor (PAI-1) activity in lean women with and without the polycystic ovary syndrome Clin Endocrinol 45 1996 623 629
89. D.S. Guzick, E.O. Talbott, K. Sutton-Tyrrell, and et al. Carotid atherosclerosis in women with polycystic ovary syndrome: initial results from a case-control study Am J Obstet Gynecol 174 1996 1224 1229
90. V.T. Goudas, and D.A. Dumesic Polycystic ovary syndrome Endocrinol Metab Clin North Am 26 1997 893 912
91. L.J. Shaw, C.M. Bairey Merz, R. Azziz, and et al. Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health-National Heart, Lung and Blood Institute sponsored Women's Ischemia Syndrome Evaluation J Clin Endocrinol Metab 93 2008 1276 1284
92. P.C. de Groot, O.M. Dekkers, J.A. Romijn, S.W. Dieben, and et al. PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis Hum Reprod Update 17 2011 495 500
93. Z. Allameh, S. Rouholamin, A. Adibi, and et al. Does carotid intima-media thickness have relationship with polycystic ovary syndrome? Int J Prev Med 4 2013 1266 1270
94. R. Korili, J. Fatima, Z. Siddiqi, and et al. Study of early atherosclerotic markers in women with polycystic ovary syndrome Indian J Endocrinol Metab 16 2012 1004 1008
95. E. Talbott, A. Clerici, S.L. Berga, and et al. Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome: results of a case-control study J Clin Epidemiol 51 1998 415 422
96. M.L. Meyer, A.M. Malek, R.A. Wild, and et al. Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis Hum Reprod Update 0 2011 1 15
97. N. Boulman, Y. Levy, R. Leiba, and et al. Increased C-reactive protein levels in the polycystic ovary syndrome: a marker of cardiovascular disease J Clin Endocrinol Metab 89 2004 2160 2165
98. E.O. Talbott, J.V. Zborowski, M.Y. Boudreauz, and et al. The relationship between C-reactive protein and carotid intima-media wall thickness in middle-aged women with polycystic ovary syndrome J Clin Endocrinol Metab 89 2004 6061 6067
99. S.J. Cleland, N. Sattar, J.R. Petrie, and et al. Endothelial dysfunction as a possible link between c-reactive protein levels and cardiovascular disease Clin Sci 98 2000 531 535
100. T.P. Zwaka, V. Hombach, and J. Torzewski C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis Circulation 103 2001 1194 1197
101. C. Kaya, R. Pabuccu, B. Berker, and et al. Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors Fertil Steril 93 2010 1200 1207
102. Y. Aso, K. Okumura, K. Takebayashi, and et al. Relationship of plasma interleukin-18 concentrations to hyperhomocysteinaemia and carotid intimal-media wall thickness in patients with type 2 diabetes Diabetes Care 26 2003 2622 2627
103. T.K. Tso, W.N. Huang, H.Y. Huang, and et al. Relationship of plasma interleukin-18 concentrations to traditional and non-traditional cardiovascular risk factors in patients with systemic lupus erythematosus Rheumatology 45 2006 1148 1153
104. R. Clarke, L. Daly, K. Robinson, and et al. Hyperhomocysteinemia: an independent risk factor for vascular disease N Engl J Med 324 1991 1149 1155
105. Y.F. Zhang, Y.S. Yang, J. Hong, and et al. Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome Endocrine 29 2006 419 423
106. H. Yarali, A. Yildirir, F. Aybar, and et al. Diastolic dysfunction and increased serum homocysteine concentrations may contribute to increased cardiovascular risk in patients with polycystic ovary syndrome Fertil Steril 76 2001 511 516
107. L. Mannerås-Holm, F. Baghaei, G. Holm, and et al. Coagulation and fibrinolytic disturbances in women with polycystic ovary syndrome J Clin Endocrinol Metab 96 2011 1068 1076
108. F. González, J.P. Kirwan, N.S. Rote, and et al. Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome Am J Physiol Endocrinol Metab 304 2013 E375 E383
109. F. Gonzalez, N.S. Rote, J. Minium, and et al. Increased activation of nuclear factor kappa B triggers inflammation and insulin resistance in polycystic ovary syndrome J Clin Endocrinol Metab 91 2006 1508 1512
110. F. González, N.S. Rote, J. Minium, and et al. Evidence of proatherogenic inflammation in polycystic ovary syndrome Metabolism 58 2009 954 962
111. P. Libby Inflammation in atherosclerosis Nature 420 2002 868 874
112. M. Romano, M. Sironi, C. Toniatti, and et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment Immunity 6 1997 315 325
113. L. Nainggolan Obesity and hyperandrogenism promote atherogenesis in PCOS Am J Physiol Endocrinol Metab 304 2013 E375 E383
114. B.R. Silva, L. Pernormian, and L.M. Bendhack Contribution of oxidative stress to endothelial dysfunction in hypertension Front Physiol 3 2012 Article 441
115. N. Samy, M. Hashim, M. Sayed, and et al. Clinical significance of inflammatory markers in polycystic ovary syndrome: their relationship to insulin resistance and body mass index Dis Markers 26 2009 163 170
116. M. Yanagisawa, and T. Masaki Molecular biology and biochemistry of the endothelin Trends Pharmacol Sci 10 1989 10374 10378
117. D. Dubin, R.E. Pratt, J.P. Cooke, and et al. Endothelin, a potent vasoconstrictor, is a vascular smooth mitogen J Vasc Med Biol 1 1989 13 16
118. C. Ferri, V. Pittoni, A. Piccoli, and et al. Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo J Clin Endocrinol Metab 80 1995 829 835
119. K. Takahashi, M.A. Ghatei, H.C. Lam, and et al. Elevated plasma endothelin in patients with diabetes mellitus Diabetologia 33 1990 306 310
120. E. Diamanti-Kandarakis, G. Spina, C. Kouli, and et al. Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy J Clin Endocrinol Metab 86 2001 4666 4673
121. F. Orio, S. Palomba, T. Cascella, and et al. Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome J Clin Endocrinol Metab 89 2004 4588 4593
122. P.M. Ridker, C.H. Hennekens, J.E. Buring, and et al. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women N Engl J Med 342 2000 836 843
123. S. Rajendrana, S.R. Willoughby, W.P. Chana, and et al. Polycystic ovary syndrome is associated with severe platelet and endothelial dysfunction in both obese and lean subjects Atherosclerosis 204 2009 509 514
124. T.W. Hein, U. Singh, J. Vasquez-Vivar, and et al. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo Atherosclerosis 206 2009 61 68
125. I. Tarkun, B.C. Arslan, Z. Canturk, and et al. Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation J Clin Endocrinol Metab 89 2004 5592 5596
126. S. Devaraj, P.R. Kumaresan, and I. Jialal Endothelial microparticles and circulating endothelial cells in vitro and in vivo: further evidence of endothelial dysfunction Clin Chem 57 2011 1757 1761
127. S. Verma, C.H. Wang, S.H. Li, and et al. A self-fulfilling prophecy: CRP attenuates nitric oxide production and inhibits angiogenesis Circulation 106 2002 913 919
128. S.K. Venugopal, S. Devaraj, I. Yuhanna, and et al. Demonstration that CRP decreases eNOS expression and bioactivity in human aortic endothelial cells Circulation 106 2002 1439 1441
129. U. Singh, S. Devaraj, J. Vasquez-Vivar, and et al. C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling J Mol Cell Cardiol 43 2007 780 791
130. H.F. Escobar-Morreale, M. Luque-Ramírez, and F. González Serum inflammatory markers in polycystic ovary syndrome: a systematic review and meta-analysis Fertil Steril 95 2011 1048 1058
131. A. Makedos, D.G. Goulis, M. Arvanitidou, and et al. Increased serum C-reactive protein levels in normal weight women with polycystic ovary syndrome Hippokratia 15 2011 323 326
132. F. Gonzalez, N.S. Rote, J. Minium, and et al. Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome J Clin Endocrinol Metab 91 2006 336
133. D. Macut, T. Simic, A. Lissounov, and et al. Insulin resistance in non-obese women with polycystic ovary syndrome: relation to byproducts of oxidative stress Exp Clin Endocrinol Diabetes 119 2011 451