Polycystic ovary syndrome is associated with endothelial dysfunction

Circulation

Volumn 103, Issue 10, 2001, Pages 1410-1415

  Paradisi, Giancarlo ^a   Steinberg, Helmut O ^a   Hempfling, Annette ^a   Cronin, Jessica ^a   Hook, Ginger ^a   Shepard, Marguerite K ^a   Baron, Alain D ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b RICHARD L ROUDEBUSH VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Blood flow; Glucose; Hormones; Insulin; Nitric oxide

Indexed keywords

ANDROGEN; METHACHOLINE CHLORIDE; TESTOSTERONE;

ADULT; ANDROGEN BLOOD LEVEL; ARTICLE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTHELIUM LESION; FEMALE; HUMAN; INSULIN RESISTANCE; LEG BLOOD FLOW; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL;

EID: 0035853088     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.10.1410     Document Type: Article

References (34)

1. Kinetics of in vivo muscle insulin mediated glucose uptake in human obesity
2. Obesity/insulin resistance is associated with endothelial dysfunction: Implications for the syndrome of insulin resistance
3. Insulin as a vascular hormone: Implications for the pathophysiology of cardiovascular disease
4. Type II diabetes abrogates sex differences in endothelial function in premenopausal women
5. Patterns of coronary heart disease morbidity and mortality in the sexes: A 26-year follow up of the Framingham Study
6. Menopause and the risk of coronary heart disease in women
7. Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women
8. Cardioprotective effects of individual conjugated equine estrogens through their possible modulation of insulin resistance and oxidation of low-density lipoprotein
9. Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM
10. The relationship of sex hormones to hyperinsulinemia and hyperglycemia
11. Relationship between insulin sensitivity, obesity, body fat distribution and β-endorphinaemia in obese women
12. Polycystic ovary syndrome
13. Insulin resistance and polycystic ovary, syndrome: Mechanism and implication for pathogenesis
14. Clinical signs of androgen excess as risk factors for coronary artery disease
15. Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization
16. Endothelial function, insulin sensitivity, and hypertension
17. Rates and tissue sites of non-insulin and insulin mediated glucose uptake in humans
18. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
19. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
20. Intravenous glucose tolerance test derived insulin sensitivity changes during the menstrual cycle
21. Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle
22. Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans
23. Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men
24. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans
25. The impairment of flow-mediated vasodilation in obese men with visceral fat accumulation
26. Effects of increased availability of endothelium-derived nitric oxide precursor on independent vascular relaxation in normal subjects and in patients with essential hypertension
27. Sex hormone-binding globulin and female reproductive function
28. Pathophysiology of sex hormone binding globulin (SHBG): Relation to insulin
29. Gender differences in improvement of endothelial-dependent vasodilation after estrogen supplementation
30. 17β-Estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary, heart disease
31. The independent effects of hyperandrogenaemia, hyperinsulinaemia, and obesity on lipid and lipoprotein profiles in women
32. Coronary heart disease risk factors in women with polycystic ovary syndrome
33. Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome
34. Weight control and its beneficial effect on fertility in women with obesity and polycystic ovary syndrome