Polycystic ovary syndrome is associated with severe platelet and endothelial dysfunction in both obese and lean subjects

Atherosclerosis

Volumn 204, Issue 2, 2009, Pages 509-514

  Rajendran, Sharmalar ^a   Willoughby, Scott R ^a   Chan, Wai Ping A ^a   Liberts, Elizabeth A ^a   Heresztyn, Tamila ^a   Saha, Mrinal ^b   Marber, Michael S ^b   Norman, Robert J ^a   Horowitz, John D ^a  

^a QUEEN ELIZABETH HOSPITAL   (Australia)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Endothelial function; Nitric oxide; Platelets; Polycystic ovary syndrome

Indexed keywords

C REACTIVE PROTEIN; GLYCERYL TRINITRATE; MALONALDEHYDE; N(G),N(G) DIMETHYLARGININE; NITROPRUSSIDE SODIUM; SALBUTAMOL;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FEMALE; FOLLOW UP; HOMEOSTASIS; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LEAN BODY WEIGHT; LIPID PEROXIDATION; OBESITY; OVARY POLYCYSTIC DISEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; STEM CELL; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE DYSFUNCTION; VASCULAR ENDOTHELIUM; VASODILATATION; VASOMOTOR REFLEX;

ADENOSINE DIPHOSPHATE; ADULT; ALBUTEROL; ARGININE; BODY COMPOSITION; C-REACTIVE PROTEIN; COHORT STUDIES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INFLAMMATION MEDIATORS; MALONDIALDEHYDE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROGLYCERIN; NITROPRUSSIDE; OBESITY; OXIDATIVE STRESS; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; POLYCYSTIC OVARY SYNDROME; STEM CELLS; TIME FACTORS; VASODILATOR AGENTS;

EID: 67349217369     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.09.010     Document Type: Article

References (39)

1. Ehrmann D.A. Polycystic ovary syndrome. N Engl J Med 352 (2005) 1223-1236
2. Wang J.X., Davies M.J., and Norman R.J. Polycystic ovarian syndrome and the risk of spontaneous abortion following assisted reproductive technology treatment. Hum Reprod 16 (2001) 2606-2609
3. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 (2004) 41-47
4. Norman R.J., Masters S., and Hague W. Hyperinsulinemia is common in family members of women with polycystic ovary syndrome. Fertil Steril 66 (1996) 942-947
5. Dunaif A., Hoffman A.R., Scully R.E., et al. Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. Obstet Gynecol 66 (1985) 545-552
6. Apridonidze T., Essah P.A., Iuorno M.J., and Nestler J.E. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 90 (2005) 1929-1935
7. Legro R.S., Kunselman A.R., Dodson W.C., and Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84 (1999) 165-169
8. Norman R.J. Obesity, polycystic ovary syndrome and anovulation-how are they interrelated?. Curr Opin Obstet Gynecol 13 (2001) 323-327
9. Paradisi G., Steinberg H.O., Hempfling A., et al. Polycystic ovary syndrome is associated with endothelial dysfunction. Circulation 103 (2001) 1410-1415
10. Orio Jr. F., Palomba S., Cascella T., et al. Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab 89 (2004) 4588-4593
11. Tarkun I., Arslan B.C., Canturk Z., Turemen E., Sahin T., and Duman C. Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation. Obstet Gynecol Surv 60 (2005) 180-181
12. Kravariti M., Naka K.K., Kalantaridou S.N., et al. Predictors of endothelial dysfunction in young women with polycystic ovary. J Clin Endocrinol Metab 90 (2005) 5088-5095
13. Nacul A.P., Andrade C.D., Schwarz P., Homem de Bittencourt Jr. P.I., and Spritzer P.M. Nitric oxide and fibrinogen in polycystic ovary syndrome: associations with insulin resistance and obesity. Eur J Obstet Gynecol Reprod Biol 133 (2007) 191-196
14. Heutling D., Schulz H., Nickel I., et al. Asymmetric dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment. J Clin Endocrinol Metab 93 (2008) 82-90
15. Dereli D., Ozgen G., Buyukkececi F., Guney E., and Yilmaz C. Platelet dysfunction in lean women with polycystic ovary syndrome and association with insulin sensitivity. J Clin Endocrinol Metab 88 (2003) 2263-2268
16. Chirkov Y.Y., and Horowitz J.D. Impaired tissue responsiveness to organic nitrates and nitric oxide: a new therapeutic frontier. Pharmacol Ther 116 (2007) 287-305
17. Schächinger V., Britten M.B., and Zeiher A.M. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101 (2000) 1899-1906
18. Willoughby S.R., Stewart S., Holmes A.S., Chirkov Y.Y., and Horowitz J.D. Platelet nitric oxide responsiveness: a novel prognostic marker in acute coronary syndromes. Arterioscler Thromb Vasc Biol 25 (2005) 2661-2666
19. G'-dimethyl-l-arginine in plasma by liquid chromatography as AccQ-Fluor fluorescent derivatives. J Chromatogr B 805 (2004) 325-329
20. Vasa M., Fichtlscherer S., Aicher A., et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 89 (2001) E1-E7
21. Rahman I., and Biswas S.K. Non-invasive biomarkers of oxidative stress: reproducibility and methodological issues. Redox Rep 9 (2004) 125-143
22. Bird R.P., and Draper H.H. Comparative studies on different methods of malonaldehyde determination. Methods Enzymol 105 (1984) 299-305
23. Chirkov Y.Y., Holmes A.S., Chirkova L.P., and Horowitz J.D. Nitrate resistance in platelets from patients with stable angina pectoris. Circulation 100 (1999) 129-134
24. Wilkinson I.B., Hall I.R., MacCallum H., et al. Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function. Arterioscler Thromb Vasc Biol 22 (2002) 147-152
25. Hayward C.S., Kraidly M., Webb C.M., and Collins P. Assessment of endothelial function using peripheral waveform analysis: a clinical application. J Am Coll Cardiol 40 (2002) 521-528
26. Grundy S.M., et al. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109 (2004) 433-438
27. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
28. Katz A., Nambi S.S., Mather K., et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85 (2000) 2402-2410
29. Chirkov Y.Y., Holmes A.S., Willoughby S.R., et al. Stable angina and acute coronary syndromes are associated with nitric oxide resistance in platelets. J Am Coll Cardiol 37 (2001) 1851-1857
30. Worthley M.I., Holmes A.S., Willoughby S.R., et al. The deleterious effects of hyperglycemia on platelet function in diabetic patients with acute coronary syndromes. Mediation by superoxide production, resolution with intensive insulin administration. J Am Coll Cardiol 49 (2007) 304-310
31. Diamanti-Kandrakis E., Alexandraki K., Piperi C., et al. Inflammatory and endothelial markers in women with polycystic ovary syndrome. Eur J Clin Invest 36 (2006) 691-697
32. Sorensen M.B., Franks S., Robertson C., Pennell D.J., and Collins P. Severe endothelial dysfunction in young women with polycystic ovary syndrome is only partially explained by known cardiovascular risk factors. Clin Endocrinol 65 (2006) 655-659
33. Mather K.J., Verma S., Corenblum D., and Anderson T.J. Normal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome. J Clin Endocrinol Metab 85 (2000) 1851-1856
34. Bickerton A.S., Clark N., Meeking D., et al. Cardiovascular risk in women with polycystic ovary syndrome (PCOS). J Clin Pathol 58 (2005) 151-154
35. Brinkworth G.D., Noakes M., Moran L.J., Norman R., and Clifton P.M. Flow-mediated dilatation in overweight and obese women with polycystic ovary syndrome. BJOG 113 (2006) 1308-1314
36. Sage P.R., de la Lande I.S., Stafford I., et al. Nitroglycerin tolerance in human vessels. Evidence for impaired nitroglycerin bioconversion. Circulation 102 (2000) 2810-2815
37. Thum T., Tsikas D., Stein S., et al. Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine. J Am Coll Cardiol 46 (2005) 1693-1701
38. Werner N., Wassmann S., Ahlers P., et al. Endothelial progenitor cells correlate with endothelial function in patients with coronary artery disease. Basic Res Cardiol 102 (2007) 565-571
39. Legro R.S. Polycystic ovary syndrome and cardiovascular disease: a premature association?. Endocr Rev 24 (2003) 302-312