Identification of a novel lncRNA in gluteal adipose tissue and evidence for its positive effect on preadipocyte differentiation

Obesity

Volumn 22, Issue 8, 2014, Pages 1781-1785

  Divoux, Adeline ^a,b   Karastergiou, Kalypso ^c   Xie, Hui ^a,b   Guo, Weimen ^c   Perera, Ranjan J ^b   Fried, Susan K ^c   Smith, Steven R ^a,b  

^a FLORIDA HOSPITAL   (United States)

^b BURNHAM INSTITUTE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

adipogenic differentiation; gluteal adipose tissue; HOTAIR

Indexed keywords

LONG UNTRANSLATED RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; HOTAIR LONG UNTRANSLATED RNA, HUMAN;

ABDOMINAL SUBCUTANEOUS FAT; ADIPOSE TISSUE; ADULT; ARTICLE; BODY FAT DISTRIBUTION; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION; GLUTEAL ADIPOSE TISSUE; HOTAIR GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LPL GENE; MALE; MICROARRAY ANALYSIS; NORMAL HUMAN; PPARY GENE; PROADIPOCYTE; REAL TIME POLYMERASE CHAIN REACTION; RNA GENE; ADIPOCYTE; BODY MASS; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT;

ADIPOCYTES; ADULT; BODY FAT DISTRIBUTION; BODY MASS INDEX; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; HUMANS; MALE; PPAR GAMMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, LONG NONCODING; SUBCUTANEOUS FAT;

EID: 84904902745     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20793     Document Type: Article

References (14)

1. Yusuf S, Hawken S, Ounpuu S, et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 2005; 366: 1640-1649.
2. Snijder MB, Dekker JM, Visser M, et al. Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study. Am J Clin Nutr 2003; 77: 1192-1197.
3. Karastergiou K, Smith SR, Greenberg AS, Fried SK,. Sex differences in human adipose tissues-the biology of pear shape. Biol Sex Differ 2012; 3: 13. doi: 10.1186/2042-6410-1183-1113.
4. Karastergiou K, Fried SK, Xie H, et al. Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots. J Clin Endocrinol Metab 2013; 98: 362-371.
5. Heid IM, Jackson AU, Randall JC, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010; 42: 949-960
6. Tontonoz P, Spiegelman BM,. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 2008; 77: 289-312.
7. Guttman M, Rinn JL,. Modular regulatory principles of large non-coding RNAs. Nature 2012; 482: 339-346.
8. Rinn JL, Chang HY,. Genome regulation by long noncoding RNAs. Annu Rev Biochem 2012; 81: 145-166.
9. Rinn JL, Kertesz M, Wang JK, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 2007; 129: 1311-1323.
10. Gupta RA, Shah N, Wang KC, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010; 464: 1071-1076.
11. Lee MJ, Wu Y, Fried SK,. A modified protocol to maximize differentiation of human preadipocytes and improve metabolic phenotypes. Obesity 2012; 20: 2334-2340
12. Sun L, Goff LA, Trapnell C, et al. Long noncoding RNAs regulate adipogenesis. Proc Natl Acad Sci USA 2013; 110: 3387-3392
13. Lovejoy JC, Champagne CM, de Jonge L, Xie H, Smith SR,. Increased visceral fat and decreased energy expenditure during the menopausal transition. Int J Obes 2008; 32: 949-958
14. Bhan A, Hussain I, Ansari KI, Kasiri S, Bashyal A, Mandal SS,. Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J Mol Biol 2013; 425: 3707-3722