메뉴 건너뛰기




Volumn 201, Issue 2, 2015, Pages 769-777

Regulatory rewiring in a cross causes extensive genetic heterogeneity

Author keywords

Complex traits; Genetic mapping; Invasive growth; Regulatory networks; Yeast

Indexed keywords

CELL SURFACE PROTEIN; FLO11 PROTEIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; FLO11 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

EID: 84943599867     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.115.180661     Document Type: Article
Times cited : (17)

References (48)
  • 1
    • 83355169645 scopus 로고    scopus 로고
    • Choosing the right lifestyle: Adhesion and development in Saccharomyces cerevisiae
    • Bruckner, S., and H. U. Mosch, 2012 Choosing the right lifestyle: adhesion and development in Saccharomyces cerevisiae. FEMS Microbiol. Rev. 36: 25-58.
    • (2012) FEMS Microbiol. Rev , vol.36 , pp. 25-58
    • Bruckner, S.1    Mosch, H.U.2
  • 2
    • 30044432810 scopus 로고    scopus 로고
    • The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans
    • Cao, F., S. Lane, P. Raniga, Z. Zhou, K. Ramon et al., 2006 The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans. Mol. Biol. Cell 17: 295-307.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 295-307
    • Cao, F.1    Lane, S.2    Raniga, P.3    Zhou, Z.4    Ramon, K.5
  • 3
    • 34547216984 scopus 로고    scopus 로고
    • Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiae
    • Chen, R. E., and J. Thorner, 2007 Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta 1773: 1311-1340.
    • (2007) Biochim. Biophys. Acta , vol.1773 , pp. 1311-1340
    • Chen, R.E.1    Thorner, J.2
  • 4
    • 84870703723 scopus 로고    scopus 로고
    • Genetic variation in Saccharomyces cerevisiae: Circuit diversification in a signal transduction network
    • Chin, B. L., O. Ryan, F. Lewitter, C. Boone, and G. R. Fink, 2012 Genetic variation in Saccharomyces cerevisiae: circuit diversification in a signal transduction network. Genetics 192: 1523-1532.
    • (2012) Genetics , vol.192 , pp. 1523-1532
    • Chin, B.L.1    Ryan, O.2    Lewitter, F.3    Boone, C.4    Fink, G.R.5
  • 5
    • 0034610273 scopus 로고    scopus 로고
    • Glucose depletion causes haploid invasive growth in yeast
    • Cullen, P. J., and G. F. Sprague, Jr.., 2000 Glucose depletion causes haploid invasive growth in yeast. Proc. Natl. Acad. Sci. USA 97: 13619-13624.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13619-13624
    • Cullen, P.J.1    Sprague, G.F.2
  • 7
    • 84859240600 scopus 로고    scopus 로고
    • Genetic architecture of highly complex chemical resistance traits across four yeast strains
    • Ehrenreich, I. M., J. Bloom, N. Torabi, X. Wang, Y. Jia et al., 2012 Genetic architecture of highly complex chemical resistance traits across four yeast strains. PLoS Genet. 8: e1002570.
    • (2012) Plos Genet , vol.8
    • Ehrenreich, I.M.1    Bloom, J.2    Torabi, N.3    Wang, X.4    Jia, Y.5
  • 8
    • 77951143253 scopus 로고    scopus 로고
    • Dissection of genetically complex traits with extremely large pools of yeast segregants
    • Ehrenreich, I. M., N. Torabi, Y. Jia, J. Kent, S. Martis et al., 2010 Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature 464: 1039-1042.
    • (2010) Nature , vol.464 , pp. 1039-1042
    • Ehrenreich, I.M.1    Torabi, N.2    Jia, Y.3    Kent, J.4    Martis, S.5
  • 9
    • 0031464418 scopus 로고    scopus 로고
    • Cloning-free PCR-based allele replacement methods
    • Erdeniz, N., U. H. Mortensen, and R. Rothstein, 1997 Cloning-free PCR-based allele replacement methods. Genome Res. 7: 1174-1183.
    • (1997) Genome Res , vol.7 , pp. 1174-1183
    • Erdeniz, N.1    Mortensen, U.H.2    Rothstein, R.3
  • 10
    • 84901309945 scopus 로고    scopus 로고
    • The transcription factors Tec1 and Ste12 interact with coregulators Msa1 and Msa2 to activate adhesion and multicellular development
    • Felden, J., S. Weisser, S. Bruckner, P. Lenz, and H. U. Mosch, 2014 The transcription factors Tec1 and Ste12 interact with coregulators Msa1 and Msa2 to activate adhesion and multicellular development. Mol. Biol. Cell 34: 2283-2293.
    • (2014) Mol. Biol. Cell , vol.34 , pp. 2283-2293
    • Felden, J.1    Weisser, S.2    Bruckner, S.3    Lenz, P.4    Mosch, H.U.5
  • 12
    • 59549099533 scopus 로고    scopus 로고
    • Coding repeat instability in the FLO11 gene of Saccharomyces yeasts
    • Fidalgo, M., R. R. Barrales, and J. Jimenez, 2008 Coding repeat instability in the FLO11 gene of Saccharomyces yeasts. Yeast 25: 879-889.
    • (2008) Yeast , vol.25 , pp. 879-889
    • Fidalgo, M.1    Barrales, R.R.2    Jimenez, J.3
  • 13
    • 0024526152 scopus 로고
    • The yeast G-protein homolog is involved in the mating pheromone signal transduction system
    • Fujimura, H. A., 1989 The yeast G-protein homolog is involved in the mating pheromone signal transduction system. Mol. Cell. Biol. 9: 152-158.
    • (1989) Mol. Cell. Biol , vol.9 , pp. 152-158
    • Fujimura, H.A.1
  • 14
    • 0034710923 scopus 로고    scopus 로고
    • A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating
    • Guo, B., C. A. Styles, Q. Feng, and G. R. Fink, 2000 A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc. Natl. Acad. Sci. USA 97: 12158-12163.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12158-12163
    • Guo, B.1    Styles, C.A.2    Feng, Q.3    Fink, G.R.4
  • 15
    • 1642276329 scopus 로고    scopus 로고
    • Genetic and epigenetic regulation of the FLO gene family generates cellsurface variation in yeast
    • Halme, A., S. Bumgarner, C. Styles, and G. R. Fink, 2004 Genetic and epigenetic regulation of the FLO gene family generates cellsurface variation in yeast. Cell 116: 405-415.
    • (2004) Cell , vol.116 , pp. 405-415
    • Halme, A.1    Bumgarner, S.2    Styles, C.3    Fink, G.R.4
  • 16
    • 0025963054 scopus 로고
    • Putting the HO gene to work: Practical uses for mating-type switching
    • Herskowitz, I., and R. E. Jensen, 1991 Putting the HO gene to work: practical uses for mating-type switching. Methods Enzymol. 194: 132-146.
    • (1991) Methods Enzymol , vol.194 , pp. 132-146
    • Herskowitz, I.1    Jensen, R.E.2
  • 17
    • 13644261913 scopus 로고    scopus 로고
    • Genome-wide survey of nonessential genes required for slowed DNA synthesis-induced filamentous growth in yeast
    • Kang, C. M., and Y. W. Jiang, 2005 Genome-wide survey of nonessential genes required for slowed DNA synthesis-induced filamentous growth in yeast. Yeast 22: 79-90.
    • (2005) Yeast , vol.22 , pp. 79-90
    • Kang, C.M.1    Jiang, Y.W.2
  • 18
    • 84902078118 scopus 로고    scopus 로고
    • Two distinct domains of Flo8 activator mediates its role in transcriptional activation and the physical interaction with Mss11
    • Kim, H. Y., S. B. Lee, H. S. Kang, G. T. Oh, and T. Kim, 2014 Two distinct domains of Flo8 activator mediates its role in transcriptional activation and the physical interaction with Mss11. Biochem. Biophys. Res. Commun. 449: 202-207.
    • (2014) Biochem. Biophys. Res. Commun , vol.449 , pp. 202-207
    • Kim, H.Y.1    Lee, S.B.2    Kang, H.S.3    Oh, G.T.4    Kim, T.5
  • 19
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows-Wheeler transform
    • Li, H., and R. Durbin, 2009 Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25: 1754-1760.
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 21
    • 84874478803 scopus 로고    scopus 로고
    • Polygenic molecular architecture underlying non-sexual cell aggregation in budding yeast
    • Li, J., L. Wang, X. Wu, O. Fang, L. Wang et al., 2013 Polygenic molecular architecture underlying non-sexual cell aggregation in budding yeast. DNA Res. 20: 55-66.
    • (2013) DNA Res , vol.20 , pp. 55-66
    • Li, J.1    Wang, L.2    Wu, X.3    Fang, O.4    Wang, L.5
  • 22
    • 62649089109 scopus 로고    scopus 로고
    • Population genomics of domestic and wild yeasts
    • Liti, G., D. M. Carter, A. M. Moses, J. Warringer, L. Parts et al., 2009 Population genomics of domestic and wild yeasts. Nature 458: 337-341.
    • (2009) Nature , vol.458 , pp. 337-341
    • Liti, G.1    Carter, D.M.2    Moses, A.M.3    Warringer, J.4    Parts, L.5
  • 23
    • 0029914164 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth
    • Liu, H., C. A. Styles, and G. R. Fink, 1996 Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth. Genetics 144: 967-978.
    • (1996) Genetics , vol.144 , pp. 967-978
    • Liu, H.1    Styles, C.A.2    Fink, G.R.3
  • 24
    • 0031908792 scopus 로고    scopus 로고
    • The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae
    • Lo, W. S., and A. M. Dranginis, 1998 The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae. Mol. Biol. Cell 9: 161-171.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 161-171
    • Lo, W.S.1    Dranginis, A.M.2
  • 25
    • 84927509365 scopus 로고    scopus 로고
    • Dissecting complex traits using the Drosophila Synthetic Population Resource
    • Long, A. D., S. J. Macdonald, and E. G. King, 2014 Dissecting complex traits using the Drosophila Synthetic Population Resource. Trends Genet. 30: 488-495.
    • (2014) Trends Genet , vol.30 , pp. 488-495
    • Long, A.D.1    Macdonald, S.J.2    King, E.G.3
  • 26
    • 84885413003 scopus 로고    scopus 로고
    • The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases
    • Manchia, M., J. Cullis, G. Turecki, G. A. Rouleau, R. Uher et al., 2013 The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases. PLoS One 8: e76295.
    • (2013) Plos One , vol.8
    • Manchia, M.1    Cullis, J.2    Turecki, G.3    Rouleau, G.A.4    Uher, R.5
  • 28
    • 77951702343 scopus 로고    scopus 로고
    • Genetic heterogeneity in human disease
    • McClellan, J., and M. C. King, 2010 Genetic heterogeneity in human disease. Cell 141: 210-217.
    • (2010) Cell , vol.141 , pp. 210-217
    • McClellan, J.1    King, M.C.2
  • 29
    • 0038765187 scopus 로고    scopus 로고
    • Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae
    • Mosch, H. U., and G. R. Fink, 1997 Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics 145: 671-684.
    • (1997) Genetics , vol.145 , pp. 671-684
    • Mosch, H.U.1    Fink, G.R.2
  • 31
    • 0034660559 scopus 로고    scopus 로고
    • Searching for genetic determinants in the new millennium
    • Risch, N. J., 2000 Searching for genetic determinants in the new millennium. Nature 405: 847-856.
    • (2000) Nature , vol.405 , pp. 847-856
    • Risch, N.J.1
  • 32
    • 0033105258 scopus 로고    scopus 로고
    • MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene
    • Rupp, S., E. Summers, H. J. Lo, H. Madhani, and G. Fink, 1999 MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J. 18: 1257-1269.
    • (1999) EMBO J , vol.18 , pp. 1257-1269
    • Rupp, S.1    Summers, E.2    Lo, H.J.3    Madhani, H.4    Fink, G.5
  • 33
    • 0036141585 scopus 로고    scopus 로고
    • Yeast formins regulate cell polarity by controlling the assembly of actin cables
    • Sagot, I., S. K. Klee, and D. Pellman, 2002 Yeast formins regulate cell polarity by controlling the assembly of actin cables. Nat. Cell Biol. 4: 42-50.
    • (2002) Nat. Cell Biol , vol.4 , pp. 42-50
    • Sagot, I.1    Klee, S.K.2    Pellman, D.3
  • 34
    • 58149396842 scopus 로고    scopus 로고
    • Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis
    • Shao, H., L. C. Burrage, D. S. Sinasac, A. E. Hill, S. R. Ernest et al., 2008 Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc. Natl. Acad. Sci. USA 105: 19910-19914.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 19910-19914
    • Shao, H.1    Burrage, L.C.2    Sinasac, D.S.3    Hill, A.E.4    Ernest, S.R.5
  • 35
    • 0001083002 scopus 로고
    • Guide to yeast genetics and molecular
    • edited by C. Guthrie, and G. R. Fink. Elsevier Academic Press, San Diego
    • Sherman, F., 1991 Guide to yeast genetics and molecular, pp. 3-21 in Methods in Enzymology, edited by C. Guthrie, and G. R. Fink. Elsevier Academic Press, San Diego.
    • (1991) Methods in Enzymology , pp. 3-21
    • Sherman, F.1
  • 36
    • 84920901742 scopus 로고    scopus 로고
    • Allelic variation, aneuploidy, and nongenetic mechanisms suppress a monogenic trait in yeast
    • Sirr, A., G. A. Cromie, E. W. Jeffery, T. L. Gilbert, C. L. Ludlow et al., 2015 Allelic variation, aneuploidy, and nongenetic mechanisms suppress a monogenic trait in yeast. Genetics 199: 247-262.
    • (2015) Genetics , vol.199 , pp. 247-262
    • Sirr, A.1    Cromie, G.A.2    Jeffery, E.W.3    Gilbert, T.L.4    Ludlow, C.L.5
  • 37
    • 43249129715 scopus 로고    scopus 로고
    • Gene-environment interaction in yeast gene expression
    • Smith, E. N., and L. Kruglyak, 2008 Gene-environment interaction in yeast gene expression. PLoS Biol. 6: e83.
    • (2008) Plos Biol , vol.6
    • Smith, E.N.1    Kruglyak, L.2
  • 38
    • 84924028426 scopus 로고    scopus 로고
    • Pooled segregant sequencing reveals genetic determinants of yeast pseudohyphal growth
    • Song, Q., C. Johnson, T. E. Wilson, and A. Kumar, 2014 Pooled segregant sequencing reveals genetic determinants of yeast pseudohyphal growth. PLoS Genet. 10: e1004570.
    • (2014) Plos Genet , vol.10
    • Song, Q.1    Johnson, C.2    Wilson, T.E.3    Kumar, A.4
  • 39
    • 84861108449 scopus 로고    scopus 로고
    • Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice
    • Spiezio, S. H., T. Takada, T. Shiroishi, and J. H. Nadeau, 2012 Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice. BMC Genet. 13: 38.
    • (2012) BMC Genet , vol.13 , pp. 38
    • Spiezio, S.H.1    Takada, T.2    Shiroishi, T.3    Nadeau, J.H.4
  • 40
    • 0034903337 scopus 로고    scopus 로고
    • In vivo site-directed mutagenesis using oligonucleotides
    • Storici, F., L. K. Lewis, and M. A. Resnick, 2001 In vivo site-directed mutagenesis using oligonucleotides. Nat. Biotechnol. 19: 773-776.
    • (2001) Nat. Biotechnol , vol.19 , pp. 773-776
    • Storici, F.1    Lewis, L.K.2    Resnick, M.A.3
  • 41
    • 22544446444 scopus 로고    scopus 로고
    • Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigidcompulsive behaviors
    • Sutcliffe, J. S., R. J. Delahanty, H. C. Prasad, J. L. McCauley, Q. Han et al., 2005 Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigidcompulsive behaviors. Am. J. Hum. Genet. 77: 265-279.
    • (2005) Am. J. Hum. Genet , vol.77 , pp. 265-279
    • Sutcliffe, J.S.1    Delahanty, R.J.2    Prasad, H.C.3    McCauley, J.L.4    Han, Q.5
  • 42
    • 84901599270 scopus 로고    scopus 로고
    • Genetic interactions involving five or more genes contribute to a complex trait in yeast
    • Taylor, M. B., and I. M. Ehrenreich, 2014 Genetic interactions involving five or more genes contribute to a complex trait in yeast. PLoS Genet. 10: e1004324.
    • (2014) Plos Genet , vol.10
    • Taylor, M.B.1    Ehrenreich, I.M.2
  • 43
    • 0035861532 scopus 로고    scopus 로고
    • Systematic genetic analysis with ordered arrays of yeast deletion mutants
    • Tong, A. H., M. Evangelista, A. B. Parsons, H. Xu, G. D. Bader et al., 2001 Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294: 2364-2368.
    • (2001) Science , vol.294 , pp. 2364-2368
    • Tong, A.H.1    Evangelista, M.2    Parsons, A.B.3    Xu, H.4    Bader, G.D.5
  • 44
    • 0037423917 scopus 로고    scopus 로고
    • Exit from exit: Resetting the cell cycle through Amn1 inhibition of G protein signaling
    • Wang, Y., T. Shirogane, D. Liu, J. W. Harper, and S. J. Elledge, 2003 Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell 112: 697-709.
    • (2003) Cell , vol.112 , pp. 697-709
    • Wang, Y.1    Shirogane, T.2    Liu, D.3    Harper, J.W.4    Elledge, S.J.5
  • 45
    • 77952332278 scopus 로고    scopus 로고
    • Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisiae populations
    • Will, J. L., H. S. Kim, J. Clarke, J. C. Painter, J. C. Fay et al., 2010 Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisiae populations. PLoS Genet. 6: e1000893.
    • (2010) Plos Genet , vol.6
    • Will, J.L.1    Kim, H.S.2    Clarke, J.3    Painter, J.C.4    Fay, J.C.5
  • 46
    • 84973395781 scopus 로고    scopus 로고
    • Genetic basis of complex geneticdisease: The contribution of disease heterogeneity to missing heritability
    • Wray, N. R., and R. Maier, 2014 Genetic basis of complex geneticdisease: the contribution of disease heterogeneity to missing heritability. Curr. Epidemiol. Rep. 1: 220-227.
    • (2014) Curr. Epidemiol. Rep , vol.1 , pp. 220-227
    • Wray, N.R.1    Maier, R.2
  • 47
    • 0042856391 scopus 로고    scopus 로고
    • Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
    • Yvert, G., R. B. Brem, J. Whittle, J. M. Akey, E. Foss et al., 2003 Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat. Genet. 35: 57-64.
    • (2003) Nat. Genet , vol.35 , pp. 57-64
    • Yvert, G.1    Brem, R.B.2    Whittle, J.3    Akey, J.M.4    Foss, E.5
  • 48
    • 77951610155 scopus 로고    scopus 로고
    • Genetic analysis of variation in transcription factor binding in yeast
    • Zheng, W., H. Zhao, E. Mancera, L. M. Steinmetz, and M. Snyder, 2010 Genetic analysis of variation in transcription factor binding in yeast. Nature 464: 1187-1191.
    • (2010) Nature , vol.464 , pp. 1187-1191
    • Zheng, W.1    Zhao, H.2    Mancera, E.3    Steinmetz, L.M.4    Snyder, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.