Effect of new berberine derivatives on colon cancer cells

Acta Biochimica et Biophysica Sinica

Volumn 47, Issue 10, 2015, Pages 824-833

  Guamán Ortiz, Luis Miguel ^a,b   Croce, Anna Leta ^a   Aredia, Francesca ^a,c   Sapienza, Simone ^a   Fiorillo, Gaetano ^d   Syeda, Tanjia Monir ^d   Buzzetti, Franco ^d   Lombardi, Paolo ^d   Scovassi, Anna Ivana ^a  

^a CNR   (Italy)

^b UNIVERSIDAD TÉCNICA PARTICULAR DE LOJA   (Ecuador)

^c UNIVERSITY OF PAVIA   (Italy)

^d Naxospharma Srl   (Italy)

Author keywords

apoptosis; autophagy; berberine; colon cancer; fluorescence

Indexed keywords

ANTINEOPLASTIC AGENT; BERBERINE;

ANALOGS AND DERIVATIVES; APOPTOSIS; CELL PROLIFERATION; COLONIC NEOPLASMS; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; HUMAN; PATHOLOGY; SYNTHESIS; TREATMENT OUTCOME; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BERBERINE; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; TREATMENT OUTCOME;

EID: 84943523619     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmv077     Document Type: Article

References (29)

1. Tillhon M, Guamán-Ortiz LM, Lombardi P, Scovassi AI. Berberine: new perspectives for old remedies. Biochem Pharmacol 2012, 84: 1260-1267.
2. Guamán-Ortiz LM, Tillhon M, Parks M, Dutto I, Prosperi E, Savio M, Arcamone AG, et al. Multiple effects of berberine derivatives on colon cancer cells. Biomed Res Int 2014, 2014: 924585.
3. Lee KH, Lo HL, Tang WC, Hsiao HH, Yang PM. A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine. Sci Rep 2014, 4: 6394.
4. Singh IP, Mahajan S. Berberine and its derivatives: a patent review (2009-2012). Exp Opin Ther Pat 2013, 23: 215-231.
5. Guamán-Ortiz LM, Lombardi P, Tillhon M, Scovassi AI. Berberine, an epiphany against cancer. Molecules 2014, 19: 12349-12367.
6. Pierpaoli E, Arcamone AG, Buzzetti F, Lombardi P, Salvatore C, Provinciali M. Antitumor effect of novel berberine derivatives in breast cancer cells. Bio Factors 2013, 39: 672-679.
7. Waters ML. Aromatic interactions in model systems. Curr Opin Chem Biol 2002, 6: 736-741.
8. Iwasa K, Kamigauchi M, Sugiura M, Namba H. Antimicrobial activityof some 13-alkyl substituted protoberberinium salts. Planta Med 1997, 63: 196-198.
9. Aredia F, Giansanti V, Mazzini G, Savio M, Ortiz LM, Jaadane I, Zaffaroni N, et al. Multiple effects of the Na(+)/H(+) antiporter inhibitor HMA on cancer cells. Apoptosis 2013, 18: 1586-1598.
10. Aredia F, Guamán-Ortiz LM, Giansanti V, Scovassi AI. Autophagy and cancer. Cells 2012, 1: 520-534.
11. Aredia F, Scovassi AI. Manipulation of autophagy in cancer cells: an innovative strategy to fight drug resistance. Future Med Chem 2013, 5: 1009-1021.
12. Giansanti V, Rodriguez GE, Savoldelli M, Gioia R, Forlino A, Mazzini G, Pennati M, et al. Characterization of stress response in human retinal epithelial cells. J Cell Mol Med 2013, 17: 103-115.
13. Donzelli M, Bernardi R, Negri C, Prosperi E, Padovan L, Lavialle C, Brison O, et al. Apoptosis-prone phenotype of human colon carcinoma cells with a high level amplification of the c-myc gene. Oncogene 1999, 18: 439-448.
14. Bottone MG, Soldani C, Tognon G, Gorrini C, Lazzè MC, Brison O, Ciomei M, et al. Multiple effects of paclitaxel are modulated by a high c-myc amplification level. Exp Cell Res 2003, 290: 49-59.
15. Gorrini G, Donzelli M, Torriglia A, Supino R, Brison O, Bernardi R, Negri C, et al. Effect of apoptogenic stimuli on colon carcinoma cell lines with a different c-myc expression level. Int J Mol Med 2003, 11: 737-742.
16. Peng PL, Kuo WH, Tseng HC, Chou FP. Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death. Int J Radiat Oncol Biol Phys 2008, 70: 529-542.
17. Wang N, Feng Y, Zhu M, Tsang CM, Man K, Tong Y, Tsao SW. Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. J Cell Biochem 2010, 111: 1426-1436.
18. Hou Q, Tang X, Liu H, Tang J, Yang Y, Jing X, Xiao Q, et al. Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147. Cancer Sci 2011, 102: 1287-1292.
19. Fan X, Wang J, Hou J, Lin C, Bensoussan A, Chang D, Liu J, et al. Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway. J Transl Med 2015, 13: 92.
20. Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, Han W, et al. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis 2013, 4: e8380.
21. Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, et al. Autophagy in malignant transformation and cancer progression. EMBO J 2015, 34: 856-880.
22. Uzasçi S, Erim FB. Enhancement of native fluorescence intensity of berber-ine by (2-hydroxypropyl)-β-cyclodextrin in capillary electrophoresis coupled by laser-induced fluorescence detection: application to quality control of medicinal plants. J Chromatogr A 2014, 1338: 184-187.
23. Bhowmik D, Hossain M, Buzzetti F, D'Auria R, Lombardi P, Kumar GS. Biophysical studies on the effect of the 13 position substitution of the antic-ancer alkaloid berberine on its DNA binding. J Phys Chem B 2012, 116: 2314-2324.
24. Hu X, Wu X, Huang Y, Tong Q, Takeda S, Qing Y. Berberine induces double-strand DNA breaks in Rev3 deficient cells. Mol Med Rep 2014, 9: 1883-1888.
25. Zh Y, Ma N, Li HX, Tian L, Ba YF, Hao B. Berberine induces apoptosis and DNA damage in MG-63 human osteosarcoma cells. Mol Med Rep 2014, 10: 1734-1738.
26. Wang Y, Liu Q, Liu Z, Li B, Sun Z, Zhou H, Zhang X, et al. Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells. Mutat Res 2012, 734: 20-29.
27. Liu Z, Liu Q, Xu B, Wu J, Guo C, Zhu F, Yang Q, et al. Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res 2009, 662: 75-83.
28. Rubinsztein DC, Codogno P, Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov 2012, 11: 709-730.
29. Fatokun AA, Dawson VL, Dawson TM. Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol 2014, 171: 2000-2016.