메뉴 건너뛰기




Volumn 27, Issue 1, 2005, Pages 69-76

Effects of p21ciP1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells

Author keywords

Adenomatous polyps; Apoptosis; Cell growth; Colorectal cancer; Differentiation; Gene therapy; p21; p53

Indexed keywords

AGAR; ALKALINE PHOSPHATASE; BUTYRIC ACID DERIVATIVE; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; FLUOROURACIL; ISOBUTYRIC ACID; PROTEIN P53;

EID: 24644524555     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.27.1.69     Document Type: Article
Times cited : (13)

References (49)
  • 1
    • 0027938209 scopus 로고
    • Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
    • Hunter T and Pines J: Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79: 573-582, 1994.
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 3
    • 0028988585 scopus 로고
    • Inhibitors of mammalian Gl cyclindependent kinases
    • Sherr CJ and Roberts JM: Inhibitors of mammalian Gl cyclindependent kinases. Genes Dev 9: 1149-1163, 1995.
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 4
    • 0030057835 scopus 로고    scopus 로고
    • Early alterations of cell-cycle-regulated gene expression in colorectal neoplasia
    • Polyak K, Hamilton SR, Vogelstein B and Kinzler KW: Early alterations of cell-cycle-regulated gene expression in colorectal neoplasia. Am J Pathol 149: 381-387, 1996.
    • (1996) Am J Pathol , vol.149 , pp. 381-387
    • Polyak, K.1    Hamilton, S.R.2    Vogelstein, B.3    Kinzler, K.W.4
  • 5
    • 0029791681 scopus 로고    scopus 로고
    • P21/WAFl/CIPl expression in normal mucosa and in adenomas and adenocarcinomas of the colon: Its relationship with differentiation
    • Doglioni C, Pelosio P, Laurino L, Macri E, Meggiolaro E, Favretti F and Barbareschi M: p21/WAFl/CIPl expression in normal mucosa and in adenomas and adenocarcinomas of the colon: its relationship with differentiation. J Pathol 179: 248-253, 1996.
    • (1996) J Pathol , vol.179 , pp. 248-253
    • Doglioni, C.1    Pelosio, P.2    Laurino, L.3    Macri, E.4    Meggiolaro, E.5    Favretti, F.6    Barbareschi, M.7
  • 7
    • 0029802296 scopus 로고    scopus 로고
    • Reduced messenger RNA expression level of p21CIPl in human colorectal carcinoma tissues and its association with p53 gene mutation
    • Matsushita K, Kobayashi S, Kato M, Itoh Y, Okuyama K, Sakiyama S and Isono K: Reduced messenger RNA expression level of p21CIPl in human colorectal carcinoma tissues and its association with p53 gene mutation. Int J Cancer 69: 259-264, 1996.
    • (1996) Int J Cancer , vol.69 , pp. 259-264
    • Matsushita, K.1    Kobayashi, S.2    Kato, M.3    Itoh, Y.4    Okuyama, K.5    Sakiyama, S.6    Isono, K.7
  • 8
    • 0028973212 scopus 로고
    • Overexpression of p21WAFl/CIPl induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines
    • Sheikh MS, Rochefort H and Garcia M: Overexpression of p21WAFl/CIPl induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene 11 : 1899-1905, 1995.
    • (1995) Oncogene , vol.11 , pp. 1899-1905
    • Sheikh, M.S.1    Rochefort, H.2    Garcia, M.3
  • 9
    • 0030610390 scopus 로고    scopus 로고
    • Overexpression of p21(wafl) leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells
    • Li WW, Fan JG, Hochhauser D and Bertino JR: Overexpression of p21(wafl) leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. Cancer Res 57: 2193-2199, 1997.
    • (1997) Cancer Res , vol.57 , pp. 2193-2199
    • Li, W.W.1    Fan, J.G.2    Hochhauser, D.3    Bertino, J.R.4
  • 10
    • 0031575927 scopus 로고    scopus 로고
    • Functional expression of human p21(WAFl/CIPl) gene in rat glioma cells suppresses tumor growth in vivo and induces radiosensitivity
    • Hsiao M, Tse V, Carmel J, Costanzi E, Strauss B, Haas M and Silverberg GD: Functional expression of human p21(WAFl/CIPl) gene in rat glioma cells suppresses tumor growth in vivo and induces radiosensitivity. Biochem Biophys Res Commun 233: 329-335, 1997.
    • (1997) Biochem Biophys Res Commun , vol.233 , pp. 329-335
    • Hsiao, M.1    Tse, V.2    Carmel, J.3    Costanzi, E.4    Strauss, B.5    Haas, M.6    Silverberg, G.D.7
  • 11
    • 0029996726 scopus 로고    scopus 로고
    • Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation
    • Wang J and Walsh K: Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science 273: 359-361, 1996.
    • (1996) Science , vol.273 , pp. 359-361
    • Wang, J.1    Walsh, K.2
  • 12
    • 0029956387 scopus 로고    scopus 로고
    • Protective role of p21 (Waf 1/Cipl) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells
    • Gorospe M, Wang X, Guyton KZ and Holbrook NJ: Protective role of p21 (Waf 1/Cipl) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells. Mol Cell Biol 16:6654-6660, 1996.
    • (1996) Mol Cell Biol , vol.16 , pp. 6654-6660
    • Gorospe, M.1    Wang, X.2    Guyton, K.Z.3    Holbrook, N.J.4
  • 13
    • 0030013337 scopus 로고    scopus 로고
    • Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-medialed apoptosis
    • Attardi LD, Lowe SW, Brugarolas J and Jacks T: Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-medialed apoptosis. EMBO J 15: 3693-3701,1996.
    • (1996) EMBO J , vol.15 , pp. 3693-3701
    • Attardi, L.D.1    Lowe, S.W.2    Brugarolas, J.3    Jacks, T.4
  • 14
    • 0029416970 scopus 로고
    • Activation of p21WAFl/Cipl expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis
    • Kobayashi T, Consoli U, Andreeff M, Shiku H, Deisseroth AB and Zhang W: Activation of p21WAFl/Cipl expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis. Oncogene 11: 2311-2316, 1995.
    • (1995) Oncogene , vol.11 , pp. 2311-2316
    • Kobayashi, T.1    Consoli, U.2    Andreeff, M.3    Shiku, H.4    Deisseroth, A.B.5    Zhang, W.6
  • 16
    • 0029034451 scopus 로고
    • MyoDinduced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation
    • Guo K, Wang J, Andres V, Smith RC and Walsh K: MyoDinduced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation. Mol Cell Biol 15:3823-3829, 1995.
    • (1995) Mol Cell Biol , vol.15 , pp. 3823-3829
    • Guo, K.1    Wang, J.2    Andres, V.3    Smith, R.C.4    Walsh, K.5
  • 17
    • 0028939009 scopus 로고
    • Posttranscriptional stabilization underlies p53-independent induction of p21 WAF1/CIP1/ SDH in differentiating human leukemic cells
    • Schwaller J, Koeffler HP, Niklaus G, Loetscher P, Nagel S, Fey MF and Tobler A: Posttranscriptional stabilization underlies p53-independent induction of p21 WAF1/CIP1/ SDH in differentiating human leukemic cells. J Clin Invest 95: 973-979, 1995.
    • (1995) J Clin Invest , vol.95 , pp. 973-979
    • Schwaller, J.1    Koeffler, H.P.2    Niklaus, G.3    Loetscher, P.4    Nagel, S.5    Fey, M.F.6    Tobler, A.7
  • 18
    • 0029916932 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells
    • Poluha W, Poluha DK, Chang B, Crosbie NE, Schonhoff CM, Kilpatrick DL and Ross AH: The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. Mol Cell Biol 16: 1335-1341, 1996.
    • (1996) Mol Cell Biol , vol.16 , pp. 1335-1341
    • Poluha, W.1    Poluha, D.K.2    Chang, B.3    Crosbie, N.E.4    Schonhoff, C.M.5    Kilpatrick, D.L.6    Ross, A.H.7
  • 19
    • 0030560784 scopus 로고    scopus 로고
    • P53-independent induction of p21(WAFl/CIPl) during differentiation of HL-60 cells by tumor necrosis factor alpha
    • Yoshida K, Murohashi I and Hirashima K: p53-independent induction of p21(WAFl/CIPl) during differentiation of HL-60 cells by tumor necrosis factor alpha. Int J Hematol 65: 41-48, 1996.
    • (1996) Int J Hematol , vol.65 , pp. 41-48
    • Yoshida, K.1    Murohashi, I.2    Hirashima, K.3
  • 20
    • 0030587392 scopus 로고    scopus 로고
    • P21 (WAF1/CIP1) expression is induced in newly non-dividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line
    • Gartel AL, Serfas MS, Gartel M, Goufman E, Wu GS, El-Deiry WS and Tyner AL: p21 (WAF1/CIP1) expression is induced in newly non-dividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line. Exp Cell Res 227: 171-181, 1996.
    • (1996) Exp Cell Res , vol.227 , pp. 171-181
    • Gartel, A.L.1    Serfas, M.S.2    Gartel, M.3    Goufman, E.4    Wu, G.S.5    El-Deiry, W.S.6    Tyner, A.L.7
  • 21
    • 0029914705 scopus 로고    scopus 로고
    • Cell cycle protein suppression and p21 induction in differentiating Caco-2 cells
    • Evers BM, Ko TC, Li J and Thompson EA: Cell cycle protein suppression and p21 induction in differentiating Caco-2 cells. Am J Physiol 271 : G722-G777, 1996.
    • (1996) Am J Physiol , vol.271
    • Evers, B.M.1    Ko, T.C.2    Li, J.3    Thompson, E.A.4
  • 22
    • 0031555861 scopus 로고    scopus 로고
    • Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT29 colonic epithelial cells
    • Siavoshian S, Blottiere HM, Cherbut C and Galmiche JP: Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT29 colonic epithelial cells. Biochem Biophys Res Commun 232: 169-172, 1997.
    • (1997) Biochem Biophys Res Commun , vol.232 , pp. 169-172
    • Siavoshian, S.1    Blottiere, H.M.2    Cherbut, C.3    Galmiche, J.P.4
  • 23
    • 0028066833 scopus 로고
    • A frequent alteration of p53 gene in carcinoma in adenoma of colon
    • Ohue M, Tomita N, Monden T, et al: A frequent alteration of p53 gene in carcinoma in adenoma of colon. Cancer Res 54: 4798-4804, 1994.
    • (1994) Cancer Res , vol.54 , pp. 4798-4804
    • Ohue, M.1    Tomita, N.2    Monden, T.3
  • 25
    • 0030266996 scopus 로고    scopus 로고
    • Regulation of human colonic cell line proliferation and phenotype by sodium butyrate
    • Basson MD, Turowski GA, Rashid Z, Hong F and Madri JA: Regulation of human colonic cell line proliferation and phenotype by sodium butyrate. Dig Dis Sci 41: 1989-1993, 1996.
    • (1996) Dig Dis Sci , vol.41 , pp. 1989-1993
    • Basson, M.D.1    Turowski, G.A.2    Rashid, Z.3    Hong, F.4    Madri, J.A.5
  • 26
    • 0031284667 scopus 로고    scopus 로고
    • Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin Dl
    • Doki Y, Imoto M, Han EK, Sgambato A and Weinstein IB: Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin Dl. Carcinogenesis 18: 1139-1148,1997.
    • (1997) Carcinogenesis , vol.18 , pp. 1139-1148
    • Doki, Y.1    Imoto, M.2    Han, E.K.3    Sgambato, A.4    Weinstein, I.B.5
  • 27
    • 0028859161 scopus 로고
    • Apoptosis in colorectal tumor cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate
    • Hague A, Elder DJ, Hicks DJ and Paraskeva C: Apoptosis in colorectal tumor cells: induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate. Int J Cancer 60: 400-406, 1995.
    • (1995) Int J Cancer , vol.60 , pp. 400-406
    • Hague, A.1    Elder, D.J.2    Hicks, D.J.3    Paraskeva, C.4
  • 28
    • 0030611832 scopus 로고    scopus 로고
    • Expression of p21WAFl/CIPl in colorectal adenomas and adenocarcinomas and its correlation with p53 protein expression
    • Yasui W, Akama Y, Yokozaki H, Semba S, Kudo Y, Shimamoto F and Tahara E: Expression of p21WAFl/CIPl in colorectal adenomas and adenocarcinomas and its correlation with p53 protein expression. Pathol Int 47: 470-477, 1997.
    • (1997) Pathol Int , vol.47 , pp. 470-477
    • Yasui, W.1    Akama, Y.2    Yokozaki, H.3    Semba, S.4    Kudo, Y.5    Shimamoto, F.6    Tahara, E.7
  • 29
    • 0031009467 scopus 로고    scopus 로고
    • Expression of p21 (wafl/cipl/sdil), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma
    • Gomyo Y, Ikeda M, Osaki M, Tatebe S, Tsujitani S, Ikeguchi M, Kaibara N and Ito H: Expression of p21 (wafl/cipl/sdil), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma. Cancer 79: 2067-2072, 1997.
    • (1997) Cancer , vol.79 , pp. 2067-2072
    • Gomyo, Y.1    Ikeda, M.2    Osaki, M.3    Tatebe, S.4    Tsujitani, S.5    Ikeguchi, M.6    Kaibara, N.7    Ito, H.8
  • 32
    • 0028820762 scopus 로고
    • The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo
    • Yang ZY, Perkins ND, Ohno T, Nabel EG and Nabel GJ: The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo. Nat Med 1: 1052-1056, 1995.
    • (1995) Nat Med , vol.1 , pp. 1052-1056
    • Yang, Z.Y.1    Perkins, N.D.2    Ohno, T.3    Nabel, E.G.4    Nabel, G.J.5
  • 33
    • 0029808931 scopus 로고    scopus 로고
    • Effects of ectopic overexpression of p21(WAFl/CIPl) on aneuploidy and the malignant phenotype of human brain tumor cells
    • Chen J, Willingham T, Shuford M, Bruce D, Rushing E, Smith Y and Nisen PD: Effects of ectopic overexpression of p21(WAFl/CIPl) on aneuploidy and the malignant phenotype of human brain tumor cells. Oncogene 13: 1395-1403, 1996.
    • (1996) Oncogene , vol.13 , pp. 1395-1403
    • Chen, J.1    Willingham, T.2    Shuford, M.3    Bruce, D.4    Rushing, E.5    Smith, Y.6    Nisen, P.D.7
  • 34
    • 0028823416 scopus 로고
    • In vivo gene therapy with p53 or p21 adenovirus for prostate cancer
    • Eastham JA, Hall SJ, Sehgal I, et at In vivo gene therapy with p53 or p21 adenovirus for prostate cancer. Cancer Res 55: 5151-5155, 1995.
    • (1995) Cancer Res , vol.55 , pp. 5151-5155
    • Eastham, J.A.1    Hall, S.J.2    Sehgal, I.3
  • 35
    • 0030832263 scopus 로고    scopus 로고
    • Introduction of p21(Wafl/Cipl) gene into a carcinoma cell line of the uterine cervix with inactivated p53
    • Yokoyama Y, Takahashi Y, Morishita S, Hashimoto M and Tamaya T: Introduction of p21(Wafl/Cipl) gene into a carcinoma cell line of the uterine cervix with inactivated p53. Cancer Lett 116: 233-239, 1997.
    • (1997) Cancer Lett , vol.116 , pp. 233-239
    • Yokoyama, Y.1    Takahashi, Y.2    Morishita, S.3    Hashimoto, M.4    Tamaya, T.5
  • 36
    • 0030998520 scopus 로고    scopus 로고
    • Analysis of IFN-gamma-induced cell cycle arrest and cell death in hepatocytes
    • Kano A, Watanabe Y, Takeda N, Aizawa S and Akaike T: Analysis of IFN-gamma-induced cell cycle arrest and cell death in hepatocytes. J Biochem (Tokyo) 121: 677-683, 1997.
    • (1997) J Biochem (Tokyo) , vol.121 , pp. 677-683
    • Kano, A.1    Watanabe, Y.2    Takeda, N.3    Aizawa, S.4    Akaike, T.5
  • 37
    • 0032529464 scopus 로고    scopus 로고
    • Mechanisms of Taxol-induced cell death are concentration dependent
    • Torres K and Horwitz SB: Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res 58: 3620-3626, 1998.
    • (1998) Cancer Res , vol.58 , pp. 3620-3626
    • Torres, K.1    Horwitz, S.B.2
  • 38
    • 10544250250 scopus 로고    scopus 로고
    • Cell cycle-independent regulation of p21Wafl/Cipl and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells
    • Sheikh MS, Garcia M, Zhan Q, Liu Y and Fornace AJ Jr: Cell cycle-independent regulation of p21Wafl/Cipl and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells. Cell Growth Differ 7: 1599-1607, 1996.
    • (1996) Cell Growth Differ , vol.7 , pp. 1599-1607
    • Sheikh, M.S.1    Garcia, M.2    Zhan, Q.3    Liu, Y.4    Fornace Jr., A.J.5
  • 39
    • 0030694260 scopus 로고    scopus 로고
    • Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide
    • Chen G, Shu J and Stacey DW: Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide. Oncogene 15: 1643-1651, 1997.
    • (1997) Oncogene , vol.15 , pp. 1643-1651
    • Chen, G.1    Shu, J.2    Stacey, D.W.3
  • 40
    • 0029670838 scopus 로고    scopus 로고
    • Inhibition of Gl cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2
    • Gorospe M, Liu Y, Xu Q, Chrest FJ and Holbrook NJ: Inhibition of Gl cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2. Mol Cell Biol 16: 762-770, 1996.
    • (1996) Mol Cell Biol , vol.16 , pp. 762-770
    • Gorospe, M.1    Liu, Y.2    Xu, Q.3    Chrest, F.J.4    Holbrook, N.J.5
  • 42
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • Waldman T, Lengauer C, Kinzler KW and Vogelstein B: Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381: 713-716, 1996.
    • (1996) Nature , vol.381 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3    Vogelstein, B.4
  • 43
    • 0030612714 scopus 로고    scopus 로고
    • Role of p21Wafl/Cipl/Sdil in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells
    • Sheikh MS, Chen YQ, Smith ML and Fornace AJ Jr: Role of p21Wafl/Cipl/Sdil in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene 14: 1875-1882, 1997.
    • (1997) Oncogene , vol.14 , pp. 1875-1882
    • Sheikh, M.S.1    Chen, Y.Q.2    Smith, M.L.3    Fornace Jr., A.J.4
  • 44
    • 0030941675 scopus 로고    scopus 로고
    • Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drugmediated apoptosis in human myeloid leukemia cells (HL-60)
    • Freemerman AJ, Vrana JA, Tombes RM, Jiang H, Chellappan SP, Fisher PB and Grant S: Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drugmediated apoptosis in human myeloid leukemia cells (HL-60). Leukemia 11:504-513, 1997.
    • (1997) Leukemia , vol.11 , pp. 504-513
    • Freemerman, A.J.1    Vrana, J.A.2    Tombes, R.M.3    Jiang, H.4    Chellappan, S.P.5    Fisher, P.B.6    Grant, S.7
  • 45
    • 0029658030 scopus 로고    scopus 로고
    • The absence of p21Cipl/WAFl alters keratinocyte growth and differentiation and promotes ras-tumor progression
    • Missero C, Di Cunto F, Kiyokawa H, Koff A and Dotto GP: The absence of p21Cipl/WAFl alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev 10:3065-3075,1996.
    • (1996) Genes Dev , vol.10 , pp. 3065-3075
    • Missero, C.1    Di Cunto, F.2    Kiyokawa, H.3    Koff, A.4    Dotto, G.P.5
  • 46
    • 0030065422 scopus 로고    scopus 로고
    • Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937
    • Liu M, Lee MH, Cohen M, Bommakanti M and Freedman LP: Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 10: 142-153, 1996.
    • (1996) Genes Dev , vol.10 , pp. 142-153
    • Liu, M.1    Lee, M.H.2    Cohen, M.3    Bommakanti, M.4    Freedman, L.P.5
  • 47
  • 48
    • 0032523239 scopus 로고    scopus 로고
    • Inhibitory function of p21Cipl/WAFl in differentiation of primary mouse keratinocytes independent of cell cycle control
    • Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, Seth PK and Dotto GP: Inhibitory function of p21Cipl/WAFl in differentiation of primary mouse keratinocytes independent of cell cycle control. Science 280: 1069-1072, 1998.
    • (1998) Science , vol.280 , pp. 1069-1072
    • Di Cunto, F.1    Topley, G.2    Calautti, E.3    Hsiao, J.4    Ong, L.5    Seth, P.K.6    Dotto, G.P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.