An antibody-based biomarker discovery method by mass spectrometry sequencing of complementarity determining regions

Analytical and Bioanalytical Chemistry

Volumn 399, Issue 3, 2011, Pages 1081-1091

  Dekker, Lennard J M ^a   Zeneyedpour, Lona ^a   Brouwer, Eric ^a   Van Duijn, Martijn M ^a   Sillevis Smitt, Peter A E ^a   Luider, Theo M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Antibodies; CDRs; de novo sequencing; Mass spectrometry

Indexed keywords

AFFINITY PURIFICATION; ALTERNATIVE APPROACH; ATTOMOLE; AUTOANTIBODIES; AUTOIMMUNE DISORDER; BIO-MARKER DISCOVERY; CDRS; COMPLEMENTARITY-DETERMINING REGIONS; DE NOVO SEQUENCING; DINITROPHENOLS; ENERGY COLLISIONS; LOW LEVEL; NANO-LC; ORBITRAP; ORDERS OF MAGNITUDE; TECHNICAL FEASIBILITY;

ANTIGENS; BIOMARKERS; BODY FLUIDS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; PEPTIDES; PHENOLS; PURIFICATION; SURFACE PLASMON RESONANCE;

CHEMICAL DETECTION;

ADALIMUMAB; BIOLOGICAL MARKER; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PEPTIDE;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; HUMAN; IMMUNOLOGY; MASS SPECTROMETRY; MOUSE; REFERENCE VALUE;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL MARKERS; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; MICE; PEPTIDES; REFERENCE VALUES;

EID: 79251637745     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-4361-9     Document Type: Article

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