메뉴 건너뛰기




Volumn 39, Issue 5, 2015, Pages 398-404

Pancreatic Lipid Content Is Not Associated with Beta Cell Dysfunction in Youth-Onset Type 2 Diabetes

Author keywords

Adolescent; Lipotoxicity; Nuclear magnetic resonance (NMR) spectroscopy; Pancreas; Steatosis; Type 2 diabetes

Indexed keywords

GLYCINE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INSULIN; LIPID; SERINE; TRIACYLGLYCEROL;

EID: 84943363219     PISSN: 14992671     EISSN: 23523840     Source Type: Journal    
DOI: 10.1016/j.jcjd.2015.04.001     Document Type: Article
Times cited : (12)

References (48)
  • 1
    • 45849141304 scopus 로고    scopus 로고
    • Type 2 diabetes: Pathogenesis and treatment
    • Stumvoll M., Goldstein B.J., van Haeften T.W. Type 2 diabetes: Pathogenesis and treatment. Lancet 2008, 371:2153-2156.
    • (2008) Lancet , vol.371 , pp. 2153-2156
    • Stumvoll, M.1    Goldstein, B.J.2    van Haeften, T.W.3
  • 2
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • Prentki M., Nolan C.J. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006, 116:1802-1812.
    • (2006) J Clin Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 3
    • 0842284799 scopus 로고    scopus 로고
    • Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    • Robertson R.P., Harmon J., Tran P.O., et al. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004, 53(Suppl 1):S119-S124.
    • (2004) Diabetes , vol.53 , pp. S119-S124
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3
  • 4
    • 79951716917 scopus 로고    scopus 로고
    • From pre-diabetes to type 2 diabetes in obese youth: Pathophysiological characteristics along the spectrum of glucose dysregulation
    • Bacha F., Lee S., Gungor N., et al. From pre-diabetes to type 2 diabetes in obese youth: Pathophysiological characteristics along the spectrum of glucose dysregulation. Diabetes Care 2010, 33:2225-2231.
    • (2010) Diabetes Care , vol.33 , pp. 2225-2231
    • Bacha, F.1    Lee, S.2    Gungor, N.3
  • 5
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
    • Lee Y., Hirose H., Ohneda M., et al. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships. Proc Nat Acad Sci U S A 1994, 91:10878-10882.
    • (1994) Proc Nat Acad Sci U S A , vol.91 , pp. 10878-10882
    • Lee, Y.1    Hirose, H.2    Ohneda, M.3
  • 6
    • 33846855816 scopus 로고    scopus 로고
    • Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure
    • Goh T.T., Mason T.M., Gupta N., et al. Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure. Am J Physiol Endo Metab 2007, 292:E549-E560.
    • (2007) Am J Physiol Endo Metab , vol.292 , pp. E549-E560
    • Goh, T.T.1    Mason, T.M.2    Gupta, N.3
  • 7
    • 76749169427 scopus 로고    scopus 로고
    • Pancreatic steatosis: Harbinger of type 2 diabetes in obese rodents
    • Lee Y., Lingvay I., Szczepaniak L.S., et al. Pancreatic steatosis: Harbinger of type 2 diabetes in obese rodents. Int J Obes 2010, 34:396-400.
    • (2010) Int J Obes , vol.34 , pp. 396-400
    • Lee, Y.1    Lingvay, I.2    Szczepaniak, L.S.3
  • 8
    • 74249119937 scopus 로고    scopus 로고
    • Review of magnetic resonance spectroscopy in the liver and the pancreas
    • Perman W.H., Balci N.C., Akduman I. Review of magnetic resonance spectroscopy in the liver and the pancreas. Top Magn Reson Imaging 2009, 20:89-97.
    • (2009) Top Magn Reson Imaging , vol.20 , pp. 89-97
    • Perman, W.H.1    Balci, N.C.2    Akduman, I.3
  • 9
    • 75749146712 scopus 로고    scopus 로고
    • Proton HR-MAS NMR spectroscopic characterization of metabolites in various human organ tissues: Pancreas, brain and liver from trauma cases
    • Misra D., Gupta V., Sonkar A.A., et al. Proton HR-MAS NMR spectroscopic characterization of metabolites in various human organ tissues: Pancreas, brain and liver from trauma cases. Physiol Chem Physics Med NMR 2008, 40:67-88.
    • (2008) Physiol Chem Physics Med NMR , vol.40 , pp. 67-88
    • Misra, D.1    Gupta, V.2    Sonkar, A.A.3
  • 10
    • 0028181111 scopus 로고
    • High-resolution 1H NMR study of membrane phospholipids in rat pancreas stimulated by caerulein
    • Esclassan J., Chemin-Thomas C., Creach Y., et al. High-resolution 1H NMR study of membrane phospholipids in rat pancreas stimulated by caerulein. Pancreas 1994, 9:263-269.
    • (1994) Pancreas , vol.9 , pp. 263-269
    • Esclassan, J.1    Chemin-Thomas, C.2    Creach, Y.3
  • 11
    • 0021668111 scopus 로고
    • Magnetic resonance imaging of the pancreas
    • Haaga J.R. Magnetic resonance imaging of the pancreas. Radiol Clin North Am 1984, 22:869-877.
    • (1984) Radiol Clin North Am , vol.22 , pp. 869-877
    • Haaga, J.R.1
  • 12
    • 0020082115 scopus 로고
    • Nuclear magnetic resonance imaging of the pancreas
    • Smith F.W., Reid A., Hutchison J.M., Mallard J.R. Nuclear magnetic resonance imaging of the pancreas. Radiology 1982, 142:677-680.
    • (1982) Radiology , vol.142 , pp. 677-680
    • Smith, F.W.1    Reid, A.2    Hutchison, J.M.3    Mallard, J.R.4
  • 13
    • 38949096076 scopus 로고    scopus 로고
    • Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3
    • Vesterhus M., Raeder H., Johansson S., et al. Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3. Diabetes Care 2008, 31:306-310.
    • (2008) Diabetes Care , vol.31 , pp. 306-310
    • Vesterhus, M.1    Raeder, H.2    Johansson, S.3
  • 14
    • 36049000864 scopus 로고    scopus 로고
    • Pancreatic fat content and beta-cell function in men with and without type 2 diabetes
    • Tushuizen M.E., Bunck M.C., Pouwels P.J., et al. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 2007, 30:2916-2921.
    • (2007) Diabetes Care , vol.30 , pp. 2916-2921
    • Tushuizen, M.E.1    Bunck, M.C.2    Pouwels, P.J.3
  • 15
    • 84868110769 scopus 로고    scopus 로고
    • Pancreatic steatosis and its relationship to beta-cell dysfunction in humans: Racial and ethnic variations
    • Szczepaniak L.S., Victor R.G., Mathur R., et al. Pancreatic steatosis and its relationship to beta-cell dysfunction in humans: Racial and ethnic variations. Diabetes Care 2012, 35:2377-2383.
    • (2012) Diabetes Care , vol.35 , pp. 2377-2383
    • Szczepaniak, L.S.1    Victor, R.G.2    Mathur, R.3
  • 16
    • 79951705814 scopus 로고    scopus 로고
    • Ectopic fat storage in the pancreas, liver, and abdominal fat depots: Impact on beta-cell function in individuals with impaired glucose metabolism
    • van der Zijl N.J., Goossens G.H., Moors C.C., et al. Ectopic fat storage in the pancreas, liver, and abdominal fat depots: Impact on beta-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metab 2011, 96:459-467.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 459-467
    • van der Zijl, N.J.1    Goossens, G.H.2    Moors, C.C.3
  • 17
    • 84860304384 scopus 로고    scopus 로고
    • Hepatic steatosis and low cardiorespiratory fitness in youth with type 2 diabetes
    • Wittmeier K.D., Wicklow B.A., MacIntosh A.C., et al. Hepatic steatosis and low cardiorespiratory fitness in youth with type 2 diabetes. Obesity (Silver Spring, MD) 2012, 20:1034-1040.
    • (2012) Obesity (Silver Spring, MD) , vol.20 , pp. 1034-1040
    • Wittmeier, K.D.1    Wicklow, B.A.2    MacIntosh, A.C.3
  • 18
    • 84862082712 scopus 로고    scopus 로고
    • Metabolic consequences of hepatic steatosis in overweight and obese adolescents
    • Wicklow B.A., Wittmeier K.D., MacIntosh A.C., et al. Metabolic consequences of hepatic steatosis in overweight and obese adolescents. Diabetes Care 2012, 35:905-910.
    • (2012) Diabetes Care , vol.35 , pp. 905-910
    • Wicklow, B.A.1    Wittmeier, K.D.2    MacIntosh, A.C.3
  • 19
    • 0013258825 scopus 로고    scopus 로고
    • The prevalence of the HNF-1alpha G319S mutation in Canadian aboriginal youth with type 2 diabetes
    • Sellers E.A., Triggs-Raine B., Rockman-Greenberg C., Dean H.J. The prevalence of the HNF-1alpha G319S mutation in Canadian aboriginal youth with type 2 diabetes. Diabetes Care 2002, 25:2202-2206.
    • (2002) Diabetes Care , vol.25 , pp. 2202-2206
    • Sellers, E.A.1    Triggs-Raine, B.2    Rockman-Greenberg, C.3    Dean, H.J.4
  • 20
    • 18344376912 scopus 로고    scopus 로고
    • HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community
    • Triggs-Raine B.L., Kirkpatrick R.D., Kelly S.L., et al. HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community. Proc Natl Acad Sci U S A 2002, 99:4614-4619.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 4614-4619
    • Triggs-Raine, B.L.1    Kirkpatrick, R.D.2    Kelly, S.L.3
  • 21
    • 48249145862 scopus 로고    scopus 로고
    • Diabetes susceptibility in the Canadian Oji-Cree population is moderated by abnormal mRNA processing of HNF1A G319S transcripts
    • Harries L.W., Sloman M.J., Sellers E.A., et al. Diabetes susceptibility in the Canadian Oji-Cree population is moderated by abnormal mRNA processing of HNF1A G319S transcripts. Diabetes 2008, 57:1978-1982.
    • (2008) Diabetes , vol.57 , pp. 1978-1982
    • Harries, L.W.1    Sloman, M.J.2    Sellers, E.A.3
  • 22
    • 23644445645 scopus 로고    scopus 로고
    • A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population
    • Weedon M.N., Owen K.R., Shields B., et al. A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population. Diabetes 2005, 54:2487-2491.
    • (2005) Diabetes , vol.54 , pp. 2487-2491
    • Weedon, M.N.1    Owen, K.R.2    Shields, B.3
  • 23
    • 84871995815 scopus 로고    scopus 로고
    • Standards of Medical Care in Diabetes-2013
    • American Diabetes Association Standards of Medical Care in Diabetes-2013. Diabetes Care 2013, 36(Suppl 1):S11-S66.
    • (2013) Diabetes Care , vol.36 , pp. S11-S66
  • 24
    • 84876063112 scopus 로고    scopus 로고
    • 2013 Clinical practice guidelines for the prevention and management of diabetes in Canada
    • Committee of the Canadian Diabetes Association 2013 Clinical practice guidelines for the prevention and management of diabetes in Canada. Can J Diabetes 2013, 37(Suppl 1):S1-S212.
    • (2013) Can J Diabetes , vol.37 , pp. S1-S212
  • 25
    • 0034611996 scopus 로고    scopus 로고
    • Establishing a standard definition for child overweight and obesity worldwide: International survey
    • Cole T.J., Bellizzi M.C., Flegal K.M., Dietz W.H. Establishing a standard definition for child overweight and obesity worldwide: International survey. BMJ 2000, 320:1240-1243.
    • (2000) BMJ , vol.320 , pp. 1240-1243
    • Cole, T.J.1    Bellizzi, M.C.2    Flegal, K.M.3    Dietz, W.H.4
  • 26
    • 70349929485 scopus 로고    scopus 로고
    • Noninvasive quantification of pancreatic fat in humans
    • Lingvay I., Esser V., Legendre J.L., et al. Noninvasive quantification of pancreatic fat in humans. J Clin Endocrinol Metab 2009, 94:4070-4076.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4070-4076
    • Lingvay, I.1    Esser, V.2    Legendre, J.L.3
  • 27
    • 0033970816 scopus 로고    scopus 로고
    • Very selective suppression pulses for clinical MRSI studies of brain and prostate cancer
    • Tran T.K., Vigneron D.B., Sailasuta N., et al. Very selective suppression pulses for clinical MRSI studies of brain and prostate cancer. Magn Reson Med 2000, 43:23-33.
    • (2000) Magn Reson Med , vol.43 , pp. 23-33
    • Tran, T.K.1    Vigneron, D.B.2    Sailasuta, N.3
  • 29
    • 0034959727 scopus 로고    scopus 로고
    • Automatic quantitation of localized in vivo 1H spectra with LCModel
    • Provencher S.W. Automatic quantitation of localized in vivo 1H spectra with LCModel. NIB 2001, 14:260-264.
    • (2001) NIB , vol.14 , pp. 260-264
    • Provencher, S.W.1
  • 30
    • 2342640962 scopus 로고    scopus 로고
    • Insulin sensitivity, cardiorespiratory fitness, and physical activity in overweight Hispanic youth
    • Ball G.D., Shaibi G.Q., Cruz M.L., et al. Insulin sensitivity, cardiorespiratory fitness, and physical activity in overweight Hispanic youth. Obes Res 2004, 12:77-85.
    • (2004) Obes Res , vol.12 , pp. 77-85
    • Ball, G.D.1    Shaibi, G.Q.2    Cruz, M.L.3
  • 32
    • 35048878739 scopus 로고    scopus 로고
    • Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes
    • Zib I., Jacob A.N., Lingvay I., et al. Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes. J Invest Med 2007, 55:230-236.
    • (2007) J Invest Med , vol.55 , pp. 230-236
    • Zib, I.1    Jacob, A.N.2    Lingvay, I.3
  • 33
    • 4043137259 scopus 로고    scopus 로고
    • Waist circumference percentiles for Canadian youth 11-18 y of age
    • Katzmarzyk P.T. Waist circumference percentiles for Canadian youth 11-18 y of age. Eur J Clin Nutr 2004, 58:1011-1015.
    • (2004) Eur J Clin Nutr , vol.58 , pp. 1011-1015
    • Katzmarzyk, P.T.1
  • 34
    • 0344019489 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1 alpha G319S: A private mutation in Oji-Cree associated with type 2 diabetes
    • Hegele R.A., Cao H., Harris S.B., et al. Hepatocyte nuclear factor-1 alpha G319S: A private mutation in Oji-Cree associated with type 2 diabetes. Diabetes Care 1999, 22:524.
    • (1999) Diabetes Care , vol.22 , pp. 524
    • Hegele, R.A.1    Cao, H.2    Harris, S.B.3
  • 35
    • 0035130102 scopus 로고    scopus 로고
    • Diseases of liporegulation: New perspective on obesity and related disorders
    • Unger R.H., Orci L. Diseases of liporegulation: New perspective on obesity and related disorders. FASEB 2001, 15:312-321.
    • (2001) FASEB , vol.15 , pp. 312-321
    • Unger, R.H.1    Orci, L.2
  • 36
    • 79951685702 scopus 로고    scopus 로고
    • Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers
    • Le K.A., Ventura E.E., Fisher J.Q., et al. Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers. Diabetes Care 2011, 34:485-490.
    • (2011) Diabetes Care , vol.34 , pp. 485-490
    • Le, K.A.1    Ventura, E.E.2    Fisher, J.Q.3
  • 37
    • 33749167418 scopus 로고    scopus 로고
    • Lifestyle variables, non-traditional cardiovascular risk factors, and the metabolic syndrome in an Aboriginal Canadian population
    • Liu J., Young T.K., Zinman B., et al. Lifestyle variables, non-traditional cardiovascular risk factors, and the metabolic syndrome in an Aboriginal Canadian population. Obesity (Silver Spring, MD) 2006, 14:500-508.
    • (2006) Obesity (Silver Spring, MD) , vol.14 , pp. 500-508
    • Liu, J.1    Young, T.K.2    Zinman, B.3
  • 38
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology (Baltimore, MD) 2004, 40:1387-1395.
    • (2004) Hepatology (Baltimore, MD) , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 39
    • 33845315534 scopus 로고    scopus 로고
    • Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
    • Petersen K.F., Dufour S., Feng J., et al. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci U S A 2006, 103:18273-18277.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 18273-18277
    • Petersen, K.F.1    Dufour, S.2    Feng, J.3
  • 40
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S., Kozlitina J., Xing C., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nature Genet 2008, 40:1461-1465.
    • (2008) Nature Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 41
    • 78650064129 scopus 로고    scopus 로고
    • Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents
    • Goran M.I., Walker R., Le K.A., et al. Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents. Diabetes 2010, 59:3127-3130.
    • (2010) Diabetes , vol.59 , pp. 3127-3130
    • Goran, M.I.1    Walker, R.2    Le, K.A.3
  • 42
    • 84862154709 scopus 로고    scopus 로고
    • Genetic-related and carbohydrate-related factors affecting liver fat accumulation
    • Goran M.I., Walker R., Allayee H. Genetic-related and carbohydrate-related factors affecting liver fat accumulation. Curr Opin Clin Nutr Metab Care 2012, 15:392-396.
    • (2012) Curr Opin Clin Nutr Metab Care , vol.15 , pp. 392-396
    • Goran, M.I.1    Walker, R.2    Allayee, H.3
  • 43
    • 84857668720 scopus 로고    scopus 로고
    • The role of diet and nutrient composition in nonalcoholic Fatty liver disease
    • McCarthy E.M., Rinella M.E. The role of diet and nutrient composition in nonalcoholic Fatty liver disease. J Acad Nutr Dietet 2012, 112:401-409.
    • (2012) J Acad Nutr Dietet , vol.112 , pp. 401-409
    • McCarthy, E.M.1    Rinella, M.E.2
  • 44
    • 84862700268 scopus 로고    scopus 로고
    • Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis
    • Keating S.E., Hackett D.A., George J., Johnson N.A. Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis. J Hepatol 2012, 57:157-166.
    • (2012) J Hepatol , vol.57 , pp. 157-166
    • Keating, S.E.1    Hackett, D.A.2    George, J.3    Johnson, N.A.4
  • 45
    • 84858996746 scopus 로고    scopus 로고
    • Diagnosis and management of maturity-onset diabetes of the young (MODY)
    • Thanabalasingham G., Owen K.R. Diagnosis and management of maturity-onset diabetes of the young (MODY). BMJ 2011, 343:d6044.
    • (2011) BMJ , vol.343 , pp. d6044
    • Thanabalasingham, G.1    Owen, K.R.2
  • 46
    • 79955463614 scopus 로고    scopus 로고
    • Obesity and type 2 diabetes mellitus in a birth cohort of First Nation children born to mothers with pediatric-onset type 2 diabetes
    • Mendelson M., Cloutier J., Spence L., et al. Obesity and type 2 diabetes mellitus in a birth cohort of First Nation children born to mothers with pediatric-onset type 2 diabetes. Pediatr Diabetes 2011, 12:219-228.
    • (2011) Pediatr Diabetes , vol.12 , pp. 219-228
    • Mendelson, M.1    Cloutier, J.2    Spence, L.3
  • 47
    • 80054091845 scopus 로고    scopus 로고
    • Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    • Lim E.L., Hollingsworth K.G., Aribisala B.S., et al. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011, 54:2506-2514.
    • (2011) Diabetologia , vol.54 , pp. 2506-2514
    • Lim, E.L.1    Hollingsworth, K.G.2    Aribisala, B.S.3
  • 48
    • 44649144546 scopus 로고    scopus 로고
    • Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes
    • Mari A., Tura A., Pacini G., et al. Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes. Diabetic Med 2008, 25:671-677.
    • (2008) Diabetic Med , vol.25 , pp. 671-677
    • Mari, A.1    Tura, A.2    Pacini, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.