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Volumn 7, Issue 7, 2012, Pages

Met receptor tyrosine kinase signaling induces secretion of the angiogenic chemokine interleukin-8/CXCL8 in pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; INTERLEUKIN 8; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR;

EID: 84864007949     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040420     Document Type: Article
Times cited : (29)

References (49)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, Jemal A, (2011) Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61: 212-236.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 3
    • 77949264996 scopus 로고    scopus 로고
    • Advanced pancreatic carcinoma: current treatment and future challenges
    • Stathis A, Moore MJ, (2010) Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol 7: 163-172.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 163-172
    • Stathis, A.1    Moore, M.J.2
  • 4
    • 67650924582 scopus 로고    scopus 로고
    • Pancreatic cancer: molecular pathogenesis and new therapeutic targets
    • Wong HH, Lemoine NR, (2009) Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat Rev Gastroenterol Hepatol 6: 412-422.
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 412-422
    • Wong, H.H.1    Lemoine, N.R.2
  • 5
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5
  • 6
    • 79951691421 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations in pancreatic carcinogenesis
    • Delpu Y, Hanoun N, Lulka H, Sicard F, Selves J, et al. (2011) Genetic and epigenetic alterations in pancreatic carcinogenesis. Curr Genomics 12: 15-24.
    • (2011) Curr Genomics , vol.12 , pp. 15-24
    • Delpu, Y.1    Hanoun, N.2    Lulka, H.3    Sicard, F.4    Selves, J.5
  • 8
    • 61349100218 scopus 로고    scopus 로고
    • KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin
    • Shi C, Hong SM, Lim P, Kamiyama H, Khan M, et al. (2009) KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol Cancer Res 7: 230-236.
    • (2009) Mol Cancer Res , vol.7 , pp. 230-236
    • Shi, C.1    Hong, S.M.2    Lim, P.3    Kamiyama, H.4    Khan, M.5
  • 10
    • 0346455774 scopus 로고    scopus 로고
    • Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, et al. (2003) Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 17: 3112-3126.
    • (2003) Genes Dev , vol.17 , pp. 3112-3126
    • Aguirre, A.J.1    Bardeesy, N.2    Sinha, M.3    Lopez, L.4    Tuveson, D.A.5
  • 11
    • 0033842724 scopus 로고    scopus 로고
    • BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications
    • Goggins M, Hruban RH, Kern SE, (2000) BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications. Am J Pathol 156: 1767-1771.
    • (2000) Am J Pathol , vol.156 , pp. 1767-1771
    • Goggins, M.1    Hruban, R.H.2    Kern, S.E.3
  • 12
    • 0034032009 scopus 로고    scopus 로고
    • Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression
    • Wilentz RE, Iacobuzio-Donahue CA, Argani P, McCarthy DM, Parsons JL, et al. (2000) Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res 60: 2002-2006.
    • (2000) Cancer Res , vol.60 , pp. 2002-2006
    • Wilentz, R.E.1    Iacobuzio-Donahue, C.A.2    Argani, P.3    McCarthy, D.M.4    Parsons, J.L.5
  • 13
    • 0028941747 scopus 로고
    • Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer
    • Di Renzo MF, Poulsom R, Olivero M, Comoglio PM, Lemoine NR, (1995) Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res 55: 1129-1138.
    • (1995) Cancer Res , vol.55 , pp. 1129-1138
    • Di Renzo, M.F.1    Poulsom, R.2    Olivero, M.3    Comoglio, P.M.4    Lemoine, N.R.5
  • 15
    • 77957341188 scopus 로고    scopus 로고
    • Cancer cell-derived IL-1alpha promotes HGF secretion by stromal cells and enhances metastatic potential in pancreatic cancer cells
    • Xu D, Matsuo Y, Ma J, Koide S, Ochi N, et al. (2010) Cancer cell-derived IL-1alpha promotes HGF secretion by stromal cells and enhances metastatic potential in pancreatic cancer cells. J Surg Oncol 102: 469-477.
    • (2010) J Surg Oncol , vol.102 , pp. 469-477
    • Xu, D.1    Matsuo, Y.2    Ma, J.3    Koide, S.4    Ochi, N.5
  • 16
    • 78650770246 scopus 로고    scopus 로고
    • Hepatocyte growth factor twenty years on: Much more than a growth factor
    • Nakamura T, Sakai K, Matsumoto K, (2011) Hepatocyte growth factor twenty years on: Much more than a growth factor. J Gastroenterol Hepatol 26: 188-202.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 188-202
    • Nakamura, T.1    Sakai, K.2    Matsumoto, K.3
  • 17
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: principles and functions in development, organ regeneration and cancer
    • Trusolino L, Bertotti A, Comoglio PM, (2010) MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol 11: 834-848.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 18
    • 33745853820 scopus 로고    scopus 로고
    • Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer
    • Yu J, Ohuchida K, Mizumoto K, Ishikawa N, Ogura Y, et al. (2006) Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer. World J Gastroenterol 12: 3878-3882.
    • (2006) World J Gastroenterol , vol.12 , pp. 3878-3882
    • Yu, J.1    Ohuchida, K.2    Mizumoto, K.3    Ishikawa, N.4    Ogura, Y.5
  • 19
    • 79955641985 scopus 로고    scopus 로고
    • Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma
    • Zhu GH, Huang C, Qiu ZJ, Liu J, Zhang ZH, et al. (2011) Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma. Dig Dis Sci 56: 1090-1098.
    • (2011) Dig Dis Sci , vol.56 , pp. 1090-1098
    • Zhu, G.H.1    Huang, C.2    Qiu, Z.J.3    Liu, J.4    Zhang, Z.H.5
  • 20
    • 0034441736 scopus 로고    scopus 로고
    • Localization of Hepatocyte Growth Factor and Its Receptor met in Endocrine Cells and Related Tumors of the Gut and Pancreas: An Immunohistochemical Study
    • La Rosa S, Uccella S, Capella C, Erba S, Sessa F, (2000) Localization of Hepatocyte Growth Factor and Its Receptor met in Endocrine Cells and Related Tumors of the Gut and Pancreas: An Immunohistochemical Study. Endocr Pathol 11: 315-329.
    • (2000) Endocr Pathol , vol.11 , pp. 315-329
    • La Rosa, S.1    Uccella, S.2    Capella, C.3    Erba, S.4    Sessa, F.5
  • 21
    • 0028801180 scopus 로고
    • Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis
    • Furukawa T, Duguid WP, Kobari M, Matsuno S, Tsao MS, (1995) Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis. Am J Pathol 147: 889-895.
    • (1995) Am J Pathol , vol.147 , pp. 889-895
    • Furukawa, T.1    Duguid, W.P.2    Kobari, M.3    Matsuno, S.4    Tsao, M.S.5
  • 22
    • 0027939437 scopus 로고
    • Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer
    • Ebert M, Yokoyama M, Friess H, Buchler MW, Korc M, (1994) Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer. Cancer Res 54: 5775-5778.
    • (1994) Cancer Res , vol.54 , pp. 5775-5778
    • Ebert, M.1    Yokoyama, M.2    Friess, H.3    Buchler, M.W.4    Korc, M.5
  • 23
    • 78650160949 scopus 로고    scopus 로고
    • Altered Down Regulation of the Receptor Tyrosine KInase Met in Pancreatic Adenocarcinoma Cells
    • Hill KS, Lorinczi M, Elferink LA, (2010) Altered Down Regulation of the Receptor Tyrosine KInase Met in Pancreatic Adenocarcinoma Cells. J Exp Ther Oncol 8: 297-312.
    • (2010) J Exp Ther Oncol , vol.8 , pp. 297-312
    • Hill, K.S.1    Lorinczi, M.2    Elferink, L.A.3
  • 24
    • 77956296140 scopus 로고    scopus 로고
    • MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth
    • Zhang YW, Staal B, Essenburg C, Su Y, Kang L, et al. (2010) MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth. Cancer Res 70: 6880-6890.
    • (2010) Cancer Res , vol.70 , pp. 6880-6890
    • Zhang, Y.W.1    Staal, B.2    Essenburg, C.3    Su, Y.4    Kang, L.5
  • 25
    • 84864005748 scopus 로고    scopus 로고
    • Recent advances in underlying pathologies provide insight into interleukin-8 expression-mediated inflammation and angiogenesis
    • Qazi BS, Tang K, Qazi A, (2011) Recent advances in underlying pathologies provide insight into interleukin-8 expression-mediated inflammation and angiogenesis. Int J Inflam 2011: 908468.
    • (2011) Int J Inflam , vol.2011 , pp. 908468
    • Qazi, B.S.1    Tang, K.2    Qazi, A.3
  • 27
    • 49249100382 scopus 로고    scopus 로고
    • MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival
    • Jin H, Yang R, Zheng Z, Romero M, Ross J, et al. (2008) MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res 68: 4360-4368.
    • (2008) Cancer Res , vol.68 , pp. 4360-4368
    • Jin, H.1    Yang, R.2    Zheng, Z.3    Romero, M.4    Ross, J.5
  • 28
    • 0026722243 scopus 로고
    • Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
    • Bussolino F, Di Renzo MF, Ziche M, Bocchietto E, Olivero M, et al. (1992) Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 119: 629-641.
    • (1992) J Cell Biol , vol.119 , pp. 629-641
    • Bussolino, F.1    Di Renzo, M.F.2    Ziche, M.3    Bocchietto, E.4    Olivero, M.5
  • 29
    • 0026468827 scopus 로고
    • Scatter factor and hepatocyte growth factor: activities, properties, and mechanism
    • Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, et al. (1992) Scatter factor and hepatocyte growth factor: activities, properties, and mechanism. Cell Growth Differ 3: 11-20.
    • (1992) Cell Growth Differ , vol.3 , pp. 11-20
    • Bhargava, M.1    Joseph, A.2    Knesel, J.3    Halaban, R.4    Li, Y.5
  • 30
    • 38849141696 scopus 로고    scopus 로고
    • Cancer-associated stromal fibroblasts promote pancreatic tumor progression
    • Hwang RF, Moore T, Arumugam T, Ramachandran V, Amos KD, et al. (2008) Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res 68: 918-926.
    • (2008) Cancer Res , vol.68 , pp. 918-926
    • Hwang, R.F.1    Moore, T.2    Arumugam, T.3    Ramachandran, V.4    Amos, K.D.5
  • 31
    • 23244462565 scopus 로고    scopus 로고
    • Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice
    • Yokoi K, Kim SJ, Thaker P, Yazici S, Nam DH, et al. (2005) Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice. Neoplasia 7: 696-704.
    • (2005) Neoplasia , vol.7 , pp. 696-704
    • Yokoi, K.1    Kim, S.J.2    Thaker, P.3    Yazici, S.4    Nam, D.H.5
  • 32
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, et al. (2009) Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324: 1457-1461.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3    Gopinathan, A.4    McIntyre, D.5
  • 33
    • 0242331653 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation
    • Zhang YW, Su Y, Volpert OV, Vande Woude GF, (2003) Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc Natl Acad Sci U S A 100: 12718-12723.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12718-12723
    • Zhang, Y.W.1    Su, Y.2    Volpert, O.V.3    Vande Woude, G.F.4
  • 34
    • 0141481285 scopus 로고    scopus 로고
    • A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase
    • Sattler M, Pride YB, Ma P, Gramlich JL, Chu SC, et al. (2003) A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res 63: 5462-5469.
    • (2003) Cancer Res , vol.63 , pp. 5462-5469
    • Sattler, M.1    Pride, Y.B.2    Ma, P.3    Gramlich, J.L.4    Chu, S.C.5
  • 35
    • 34249324494 scopus 로고    scopus 로고
    • An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
    • Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, et al. (2007) An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 67: 4408-4417.
    • (2007) Cancer Res , vol.67 , pp. 4408-4417
    • Zou, H.Y.1    Li, Q.2    Lee, J.H.3    Arango, M.E.4    McDonnell, S.R.5
  • 36
    • 79959817231 scopus 로고    scopus 로고
    • Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer
    • Zeng H, Yu H, Lu L, Jain D, Kidd MS, et al. (2011) Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer. Pancreas 40: 657-663.
    • (2011) Pancreas , vol.40 , pp. 657-663
    • Zeng, H.1    Yu, H.2    Lu, L.3    Jain, D.4    Kidd, M.S.5
  • 37
    • 34548578994 scopus 로고    scopus 로고
    • The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
    • Ide T, Kitajima Y, Miyoshi A, Ohtsuka T, Mitsuno M, et al. (2007) The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ann Surg Oncol 14: 2600-2607.
    • (2007) Ann Surg Oncol , vol.14 , pp. 2600-2607
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3    Ohtsuka, T.4    Mitsuno, M.5
  • 38
    • 79955828776 scopus 로고    scopus 로고
    • Stromal biology and therapy in pancreatic cancer
    • Neesse A, Michl P, Frese KK, Feig C, Cook N, et al. (2011) Stromal biology and therapy in pancreatic cancer. Gut 60: 861-868.
    • (2011) Gut , vol.60 , pp. 861-868
    • Neesse, A.1    Michl, P.2    Frese, K.K.3    Feig, C.4    Cook, N.5
  • 39
    • 80053405625 scopus 로고    scopus 로고
    • Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
    • Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, et al. (2011) Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest 121: 4106-4117.
    • (2011) J Clin Invest , vol.121 , pp. 4106-4117
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3    Aakre, M.E.4    Bierie, B.5
  • 40
    • 0035887435 scopus 로고    scopus 로고
    • Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model
    • Tomioka D, Maehara N, Kuba K, Mizumoto K, Tanaka M, et al. (2001) Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model. Cancer Res 61: 7518-7524.
    • (2001) Cancer Res , vol.61 , pp. 7518-7524
    • Tomioka, D.1    Maehara, N.2    Kuba, K.3    Mizumoto, K.4    Tanaka, M.5
  • 41
    • 2942555478 scopus 로고    scopus 로고
    • Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice
    • Wen J, Matsumoto K, Taniura N, Tomioka D, Nakamura T, (2004) Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice. Cancer Gene Ther 11: 419-430.
    • (2004) Cancer Gene Ther , vol.11 , pp. 419-430
    • Wen, J.1    Matsumoto, K.2    Taniura, N.3    Tomioka, D.4    Nakamura, T.5
  • 42
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y, Baba H, Fukuda T, Takashima M, Sugimachi K, (2000) High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 88: 2239-2245.
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3    Takashima, M.4    Sugimachi, K.5
  • 43
    • 78149406059 scopus 로고    scopus 로고
    • A phase II study of bevacizumab plus erlotinib for gemcitabine-refractory metastatic pancreatic cancer
    • Ko AH, Venook AP, Bergsland EK, Kelley RK, Korn WM, et al. (2010) A phase II study of bevacizumab plus erlotinib for gemcitabine-refractory metastatic pancreatic cancer. Cancer Chemother Pharmacol 66: 1051-1057.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 1051-1057
    • Ko, A.H.1    Venook, A.P.2    Bergsland, E.K.3    Kelley, R.K.4    Korn, W.M.5
  • 44
    • 0032712997 scopus 로고    scopus 로고
    • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic
    • Shi Q, Abbruzzese JL, Huang S, Fidler IJ, Xiong Q, et al. (1999) Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res 5: 3711-3721.
    • (1999) Clin Cancer Res , vol.5 , pp. 3711-3721
    • Shi, Q.1    Abbruzzese, J.L.2    Huang, S.3    Fidler, I.J.4    Xiong, Q.5
  • 45
    • 1842534910 scopus 로고    scopus 로고
    • Enhanced angiogenesis due to inflammatory cytokines from pancreatic cancer cell lines and relation to metastatic potential
    • Matsuo Y, Sawai H, Funahashi H, Takahashi H, Sakamoto M, et al. (2004) Enhanced angiogenesis due to inflammatory cytokines from pancreatic cancer cell lines and relation to metastatic potential. Pancreas 28: 344-352.
    • (2004) Pancreas , vol.28 , pp. 344-352
    • Matsuo, Y.1    Sawai, H.2    Funahashi, H.3    Takahashi, H.4    Sakamoto, M.5
  • 46
    • 58349094537 scopus 로고    scopus 로고
    • Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis
    • Singh S, Varney M, Singh RK, (2009) Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis. Cancer Res 69: 411-415.
    • (2009) Cancer Res , vol.69 , pp. 411-415
    • Singh, S.1    Varney, M.2    Singh, R.K.3
  • 47
    • 0642318010 scopus 로고    scopus 로고
    • Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells
    • Kuwada Y, Sasaki T, Morinaka K, Kitadai Y, Mukaida N, et al. (2003) Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells. Int J Oncol 22: 765-771.
    • (2003) Int J Oncol , vol.22 , pp. 765-771
    • Kuwada, Y.1    Sasaki, T.2    Morinaka, K.3    Kitadai, Y.4    Mukaida, N.5
  • 48
    • 69249148349 scopus 로고    scopus 로고
    • Ras activity levels control the development of pancreatic diseases
    • 1082 e1071-1076
    • Ji B, Tsou L, Wang H, Gaiser S, Chang DZ, et al. (2009) Ras activity levels control the development of pancreatic diseases. Gastroenterology 137: 1072-1082, 1082 e1071-1076.
    • (2009) Gastroenterology , vol.137 , pp. 1072-1082
    • Ji, B.1    Tsou, L.2    Wang, H.3    Gaiser, S.4    Chang, D.Z.5
  • 49
    • 76249113994 scopus 로고    scopus 로고
    • Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers
    • Logan-Collins J, Thomas RM, Yu P, Jaquish D, Mose E, et al. (2010) Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. Cancer Res 70: 1130-1140.
    • (2010) Cancer Res , vol.70 , pp. 1130-1140
    • Logan-Collins, J.1    Thomas, R.M.2    Yu, P.3    Jaquish, D.4    Mose, E.5


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