Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles

Nano Research

Volumn 8, Issue 10, 2015, Pages 3281-3292

  McCully, Mark ^a   Hernandez, Yulan ^b   Conde, João ^c   Baptista, Pedro V ^d   de la Fuente, Jesus M ^b,e   Hursthouse, Andrew ^f   Stirling, David ^f   Berry, Catherine C ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c Massachusetts Institute of Technology   (United States)

^d UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^e Shanghai Jiao Tong University   (China)

^f UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

Author keywords

drug delivery; glutathione; gold; nanoparticles; PEG; siRNA

Indexed keywords

EID: 84943352059     PISSN: 19980124     EISSN: 19980000     Source Type: Journal    
DOI: 10.1007/s12274-015-0828-5     Document Type: Article

References (36)

1. Chiu, Y.-L.; Rana, T. M. siRNA function in RNAi: A chemical modification analysis. RNA2003, 9, 1034–1048.
2. Derfus, A. M.; Chen, A. A.; Min, D.-H.; Ruoslahti, E.; Bhatia, S. N. Targeted quantum dot conjugates for siRNA delivery. Bioconjugate Chem. 2007, 18, 1391–1396.
3. Grigsby, C. L.; Leong, K. W. Balancing protection and release of DNA: Tools to address a bottleneck of non-viral gene delivery. J. R. Soc. Interface2010, 7, S67–S82.
4. Lévy, R.; Shaheen, U.; Cesbron, Y.; Sée, V. Gold nanoparticles delivery in mammalian live cells: A critical review. Nano Rev. 2010, 1, 4889.
5. Karakoti, A. S.; Das, S.; Thevuthasan, S.; Seal, S. PEGylated inorganic nanoparticles. Angew. Chem., Int. Ed. 2011, 50, 1980–1994.
6. Stefanick, J. F.; Ashley, J. D.; Kiziltepe, T.; Bilgicer, B. A systematic analysis of peptide linker length and liposomal polyethylene glycol coating on cellular uptake of peptidetargeted liposomes. ACS Nano2013, 7, 2935–2947.
7. Oishi, M.; Nakaogami, J.; Ishii, T.; Nagasaki, Y. Smart PEGylated gold nanoparticles for the cytoplasmic delivery of siRNA to induce enhanced gene silencing. Chem. Lett. 2001, 35, 1046–1047.
8. Lushchak, V. I. Glutathione homeostasis and functions: Potential targets for medical interventions. J. Amino Acids2012, 2012, 736837.
9. Conde, J.; Tian, F. R.; Hernández, Y.; Bao, C. C.; Cui, D. X.; Janssen, K.-P.; Ibarra, M. R.; Baptista, P. V.; Stoeger, T.; de la Fuente, J. M. In vivo tumor targeting via nanoparticlemediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models. Biomaterials2013, 34, 7744–7753.
10. Cebrián, V.; Martín-Saavedra, F.; Yagüe, C.; Arruebo, M.; Santamaría, J.; Vilaboa, N. Size-dependent transfection efficiency of PEI-coated gold nanoparticles. Acta Biomater. 2011, 7, 3645–3655.
11. Dreaden, E. C.; Mackey, M. A.; Huang, X. H.; Kang, B.; El-Sayed, M. A. Beating cancer in multiple ways using nanogold. Chem. Soc. Rev. 2011, 40, 3391–3404.
12. Conde, J.; Ambrosone, A.; Sanz, V.; Hernandez, Y.; Marchesano, V.; Tian, F. R.; Child, H.; Berry, C. C.; Ibarra, M. R.; Baptista, P. V. et al. Design of multifunctional gold nanoparticles for in vitro and in vivo gene silencing. ACS Nano2012, 6, 8316–8324.
13. Frens, G. Controlled nucleation for regulation of particle-size in monodisperse gold suspensions. Nat. Phys. Sci. 1973, 241, 20–22.
14. Turkevich, J.; Stevenson, P. C.; Hillier, J. A study of the nucleation and growth processes in the synthesis of colloidal gold. Discuss. Faraday Soc. 1951, 55–75.
15. Lee, P. C.; Meisel, D. Adsorption and surface-enhanced Raman of dyes on silver and gold sols. J. Phys. Chem. 1982, 86, 3391–3395.
16. McBeath, R.; Pirone, D. M.; Nelson, C. M.; Bhadriraju, K.; Chen, C. S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell2004, 6, 483–495.
17. Conde, J.; Oliva, N.; Artzi, N. Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance. Proc. Natl. Acad. Sci. USA2015, 112, E1278–E1287.
18. Ackerson, C. J.; Sykes, M. T.; Kornberg, R. D. Defined DNA/nanoparticle conjugates. Proc. Natl. Acad. Sci. USA2005, 102, 13383–13385.
19. ® from PEG cofunctionalized gold nanoparticles. Int. J. Nanomedicine2012, 7, 4007–4022.
20. Chompoosor, A.; Han, G.; Rotello, V. M. Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols. Bioconjugate Chem. 2008, 19, 1342–1345.
21. Hong, R.; Han, G.; Fernández, J. M.; Kim, B.-J.; Forbes, N. S.; Rotello, V. M. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J. Am. Chem. Soc. 2006, 128, 1078–1079.
22. Han, G.; Chari, N. S.; Verma, A.; Hong, R.; Marin, C. T.; Rotello, V. M. Controlled recovery of the transcription of nanoparticle-bound DNA by intracellular concentrations of glutathione. Bioconjugate Chem. 2005, 16, 1356–1359.
23. Zhu, Z.-J.; Yeh, Y.-C.; Tang, R.; Yan, B.; Tamayo, J.; Vachet, R. W.; Rotello, V. M. Stability of quantum dots in live cells. Nat. Chem. 2011, 3, 963–968.
24. Li, D.; Li, G. P.; Guo, W. W.; Li, P. C.; Wang, E. K.; Wang, J. Glutathione-mediated release of functional plasmid DNA from positively charged quantum dots. Biomaterials2008, 29, 2776–2782.
25. Meister, A.; Anderson, M. E. Glutathione. Annu. Rev. Biochem. 1983, 52, 711–760.
26. Wu, G. Y.; Fan, Y.-Z.; Yang, S.; Lupton, J. R.; Turner, N. D. Glutathione metabolism and its implications for health. J. Nutr.2004, 134, 489–492.
27. Lei, X. G. In vivo antioxidant role of glutathione peroxidase: Evidence from knockout mice. Methods Enzymol. 2002, 347, 213–225.
28. Fang, Y.-Z.; Yang, S.; Wu, G. Y. Free radicals, antioxidants, and nutrition. Nutrition2002, 18, 872–879.
29. Meister, A. Glutathione metabolism and its selective modification. J. Biol. Chem.1988, 263, 17205–17208.
30. Kah, J. C. Y.; Wong, K. Y.; Neoh, K. G.; Song, J. H.; Fu, J. W. P.; Mhaisalkar, S.; Olivo, M.; Richard, C. J. Critical parameters in the pegylation of gold nanoshells for biomedical applications: An in vitro macrophage study. J. Drug Target.2009, 17, 181–193.
31. Rana, T. M. Illuminating the silence: Understanding the structure and function of small RNAs. Nat. Rev. Mol. Cell Biol. 2007, 8, 23–36.
32. Li, Z. H.; Rana, T. M. Molecular mechanisms of RNAtriggered gene silencing machineries. Acc. Chem. Res. 2012, 45, 1122–1131.
33. Unsworth, L. D.; Sheardown, H.; Brash, J. L. Protein resistance of surfaces prepared by sorption of end-thiolated poly(ethylene glycol) to gold: Effect of surface chain density. Langmuir2005, 21, 1036–1041.
34. Knop, K.; Hoogenboom, R.; Fischer, D.; Schubert, U. S. Poly(ethylene glycol) in drug delivery: Pros and cons as well as potential alternatives. Angew. Chem., Int. Ed. 2010, 49, 6288–6308.
35. Hinterwirth, H.; Kappel, S.; Waitz, T.; Prohaska, T.; Lindner, W.; Lämmerhofer, M. Quantifying thiol ligand density of self-assembled monolayers on gold nanoparticles by inductively coupled plasma-mass spectrometry. ACS Nano2013, 7, 1129–1136.
36. Häkkinen, H. The gold-sulfur interface at the nanoscale. Nat. Chem. 2012, 4, 443–455.