Assessing sequence plasticity of a virus-like nanoparticle by evolution toward a versatile scaffold for vaccines and drug delivery

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 40, 2015, Pages 12360-12365

  Lu, Yuan ^a   Chan, Wei ^a   Ko, Benjamin Y ^a   VanLang, Christopher C ^a   Swartz, James R ^a   Tirrell, David A ^a  

^a Stanford University   (United States)

Author keywords

Hepatitis core protein|cell free protein synthesis; Virus like particle|engineered nanoparticles|disulfide stabilization

Indexed keywords

DIMER; FLAGELLIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPATITIS B CORE ANTIGEN; HEPATITIS B VACCINE; MONOMER; NANOPARTICLE; POLYPEPTIDE; VIRUS RNA; CORE PROTEIN; DISULFIDE; VIRUS LIKE PARTICLE VACCINE;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FREE PROTEIN SYNTHESIS; CELL PROLIFERATION ASSAY; CLICK CHEMISTRY; CROSS LINKING; CYTOPLASM; DISULFIDE BOND; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FREEZE THAWING; HYDROPHOBICITY; IMMUNOGENICITY; IMMUNOSTIMULATION; IONIC STRENGTH; LIVER CELL; LYMPHOCYTE PROLIFERATION ASSAY; MOUSE; NONHUMAN; PLASTICITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN ENGINEERING; PROTEIN SYNTHESIS; SIZE EXCLUSION CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; SUCROSE DENSITY GRADIENT CENTRIFUGATION; SURFACE CHARGE; SURFACE PROPERTY; TRANSMISSION ELECTRON MICROSCOPY; VIRION; VIRUS CAPSID; VIRUS CORE; VIRUS GENOME; VIRUS LIKE AGENT; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; GENETICS; HEPATITIS B; HEPATITIS B VIRUS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MOLECULAR MODEL; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROCEDURES; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; VIROLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DISULFIDES; DRUG DELIVERY SYSTEMS; HEPATITIS B; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HOST-PATHOGEN INTERACTIONS; HUMANS; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NANOPARTICLES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; VACCINES, VIRUS-LIKE PARTICLE; VIRAL CORE PROTEINS;

EID: 84943327275     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1510533112     Document Type: Article

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