Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 1, 2014, Pages 125-130

  Lu, Yuan ^a   Welsh, John P ^a   Swartz, James R ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; INFLUENZA VACCINE; MONOMER; NEUTRALIZING ANTIBODY; POLIDOCANOL; POLYPEPTIDE;

ARTICLE; BACTERIOPHAGE T4; BINDING KINETICS; CELL FREE SYSTEM; CONTROLLED STUDY; DISULFIDE BOND; ESCHERICHIA COLI; HYDROPHOBICITY; IMMUNOGENICITY; INFLUENZA; INFLUENZA VACCINATION; INFLUENZA VIRUS A H1N1; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; BACTERIOPHAGE T4; CELL-FREE SYSTEM; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MODELS, MOLECULAR; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84891912497     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308701110     Document Type: Article

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