Arkadia enhances BMP signalling through ubiquitylation and degradation of Smad6

Journal of Biochemistry

Volumn 158, Issue 1, 2015, Pages 61-71

  Tsubakihara, Yutaro ^a   Hikita, Atsuhiko ^a,b,c   Yamamoto, Shin ^a,b   Matsushita, Sachi ^d   Matsushita, Natsuki ^d   Oshima, Yusuke ^a,b,c,d   Miyazawa, Keiji ^e   Imamura, Takeshi ^a,b,c,d  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b EHIME UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d EHIME UNIVERSITY HOSPITAL   (Japan)

^e UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Arkadia; BMP; Proteasome dependent degradation; Smad6; Ubiquitylation

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ARKADIA; BONE MORPHOGENETIC PROTEIN; C SKI PROTEIN; PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SNON PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; RNF111 PROTEIN, MOUSE; SMAD6 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MOUSE; MYOBLAST; NONHUMAN; OSTEOBLAST; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION; ANIMAL; CELL CULTURE; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DEFICIENCY; KNOCKOUT MOUSE; METABOLISM;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; SMAD6 PROTEIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84943271865     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvv024     Document Type: Article

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