Chlorambucil gemcitabine conjugate nanomedicine for cancer therapy

European Journal of Pharmaceutical Sciences

Volumn 79, Issue , 2015, Pages 20-26

  Fan, Mingliang ^a   Liang, Xiaofei ^a   Li, Zonghai ^a   Wang, Hongyang ^a   Yang, Danbo ^a   Shi, Bizhi ^a  

^a School of Medicine   (China)

Author keywords

Chlorambucil; Conjugate; Gemcitabine; Nanodrug; Nanoparticle

Indexed keywords

ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CHLORAMBUCIL GEMCITABINE CONJUGATE; ESTER; GEMCITABINE; NANOCARRIER; NANOPARTICLE; PRODRUG; UNCLASSIFIED DRUG; ALKYLATING AGENT; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; NANOCONJUGATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CANCER MODEL; CANCER THERAPY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHILICITY; HYDROPHOBICITY; IC50; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NANOMEDICINE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TREATMENT DURATION; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; DRUG EFFECTS; LIVER NEOPLASMS; NEOPLASMS; PROCEDURES; TUMOR CELL LINE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CHLORAMBUCIL; DEOXYCYTIDINE; FEMALE; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; NANOCONJUGATES; NANOMEDICINE; NEOPLASM TRANSPLANTATION; NEOPLASMS;

EID: 84943263126     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.08.013     Document Type: Article

References (33)

1. A.C. Anselmo, and S. Mitragotri An overview of clinical and commercial impact of drug delivery systems J. Control. Release 190 2014 15 28
2. C.E. Ashley, E.C. Carnes, G.K. Phillips, D. Padilla, P.N. Durfee, P.A. Brown, T.N. Hanna, J. Liu, B. Phillips, M.B. Carter, N.J. Carroll, X. Jiang, D.R. Dunphy, C.L. Willman, D.N. Petsev, D.G. Evans, A.N. Parikh, B. Chackerian, W. Wharton, D.S. Peabody, and C.J. Brinker The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers Nat. Mater. 10 2011 389 397
3. F. Bai, C. Wang, Q. Lu, M. Zhao, F.Q. Ban, D.H. Yu, Y.Y. Guan, X. Luan, Y.R. Liu, H.Z. Chen, and C. Fang Nanoparticle-mediated drug delivery to tumor neovasculature to combat P-gp expressing multidrug resistant cancer Biomaterials 34 2013 6163 6174
4. L. Brannon-Peppas, and J.O. Blanchette Nanoparticle and targeted systems for cancer therapy Adv. Drug Deliv. Rev. 56 2004 1649 1659
5. A.G. Cheetham, P. Zhang, Y.A. Lin, L.L. Lock, and H. Cui Supramolecular nanostructures formed by anticancer drug assembly J. Am. Chem. Soc. 135 2013 2907 2910
6. L.Y. Chou, K. Zagorovsky, and W.C. Chan DNA assembly of nanoparticle superstructures for controlled biological delivery and elimination Nat. Nanotechnol. 9 2014 148 155
7. K.E. Coan, and B.K. Shoichet Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors J. Am. Chem. Soc. 130 2008 9606 9612
8. P. Couvreur, B. Stella, L.H. Reddy, H. Hillaireau, C. Dubernet, D. Desmaele, S. Lepetre-Mouelhi, F. Rocco, N. Dereuddre-Bosquet, P. Clayette, V. Rosilio, V. Marsaud, J.M. Renoir, and L. Cattel Squalenoyl nanomedicines as potential therapeutics Nano Lett. 6 2006 2544 2548
9. C.M. Dawidczyk, C. Kim, J.H. Park, L.M. Russell, K.H. Lee, M.G. Pomper, and P.C. Searson State-of-the-art in design rules for drug delivery platforms: lessons learned from FDA-approved nanomedicines J. Control. Release 187 2014 133 144
10. D. Desmaele, R. Gref, and P. Couvreur Squalenoylation: a generic platform for nanoparticular drug delivery J. Control. Release 161 2012 609 618
11. R. Duncan Polymer conjugates as anticancer nanomedicines Nat. Rev. Cancer 6 2006 688 701
12. B.Y. Feng, B.H. Toyama, H. Wille, D.W. Colby, S.R. Collins, B.C. May, S.B. Prusiner, J. Weissman, and B.K. Shoichet Small-molecule aggregates inhibit amyloid polymerization Nat. Chem. Biol. 4 2008 197 199
13. S. Ganta, J.W. Paxton, B.C. Baguley, and S. Garg Pharmacokinetics and pharmacodynamics of chlorambucil delivered in parenteral emulsion Int. J. Pharm. 360 2008 115 121
14. Z.W. Guo, and J.M. Gallo Selective protection of 2′,2′-difluorodeoxycytidine (gemcitabine) J. Org. Chem. 64 1999 8319 8322
15. E. Hertlein, G. Triantafillou, E.J. Sass, J.D. Hessler, X. Zhang, D. Jarjoura, D.M. Lucas, N. Muthusamy, D.M. Goldenberg, R.J. Lee, and J.C. Byrd Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells Blood 116 2010 2554 2558
16. P. Huang, D. Wang, Y. Su, W. Huang, Y. Zhou, D. Cui, X. Zhu, and D. Yan Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug-drug conjugate for cancer therapy J. Am. Chem. Soc. 136 2014 11748 11756
17. A.H. Hung, R.J. Holbrook, M.W. Rotz, C.J. Glasscock, N.D. Mansukhani, K.W. MacRenaris, L.M. Manus, M.C. Duch, K.T. Dam, M.C. Hersam, and T.J. Meade Graphene oxide enhances cellular delivery of hydrophilic small molecules by co-incubation ACS Nano 8 2014 10168 10177
18. A. Jana, K.T. Nguyen, X. Li, P. Zhu, N.S. Tan, H. Agren, and Y. Zhao Perylene-derived single-component organic nanoparticles with tunable emission: efficient anticancer drug carriers with real-time monitoring of drug release ACS Nano 8 2014 5939 5952
19. L.L. Lock, M. LaComb, K. Schwarz, A.G. Cheetham, Y.A. Lin, P. Zhang, and H. Cui Self-assembly of natural and synthetic drug amphiphiles into discrete supramolecular nanostructures Faraday Discuss. 166 2013 285 301
20. J.A. MacKay, M. Chen, J.R. McDaniel, W. Liu, A.J. Simnick, and A. Chilkoti Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection Nat. Mater. 8 2009 993 999
21. A. Maksimenko, M. Alami, F. Zouhiri, J.D. Brion, A. Pruvost, J. Mougin, A. Hamze, T. Boissenot, O. Provot, D. Desmaele, and P. Couvreur Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy ACS Nano 8 2014 2018 2032
22. A. Maksimenko, F. Dosio, J. Mougin, A. Ferrero, S. Wack, L.H. Reddy, A.A. Weyn, E. Lepeltier, C. Bourgaux, B. Stella, L. Cattel, and P. Couvreur A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity Proc. Natl. Acad. Sci. U. S. A. 111 2014 E217 226
23. S.L. McGovern, E. Caselli, N. Grigorieff, and B.K. Shoichet A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening J. Mater. Chem. 45 2002 1712 1722
24. S.L. McGovern, B.T. Helfand, B. Feng, and B.K. Shoichet A specific mechanism of nonspecific inhibition J. Mater. Chem. 46 2003 4265 4272
25. A.E. Nel, L. Madler, D. Velegol, T. Xia, E.M. Hoek, P. Somasundaran, F. Klaessig, V. Castranova, and M. Thompson Understanding biophysicochemical interactions at the nano-bio interface Nat. Mater. 8 2009 543 557
26. B. Pili, L.H. Reddy, C. Bourgaux, S. Lepetre-Mouelhi, D. Desmaele, and P. Couvreur Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation Nanoscale 2 2010 1521 1526
27. A. Roth, D.C. Drummond, F. Conrad, M.E. Hayes, D.B. Kirpotin, C.C. Benz, J.D. Marks, and B. Liu Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells Mol. Cancer Ther. 6 2007 2737 2746
28. J. Seidler, S.L. McGovern, T.N. Doman, and B.K. Shoichet Identification and prediction of promiscuous aggregating inhibitors among known drugs J. Mater. Chem. 46 2003 4477 4486
29. Y. Shen, E. Jin, B. Zhang, C.J. Murphy, M. Sui, J. Zhao, J. Wang, J. Tang, M. Fan, E. Van Kirk, and W.J. Murdoch Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery J. Am. Chem. Soc. 132 2010 4259 4265
30. J.L. Wang, G.P. Tang, J. Shen, Q.L. Hu, F.J. Xu, Q.Q. Wang, Z.H. Li, and W.T. Yang A gene nanocomplex conjugated with monoclonal antibodies for targeted therapy of hepatocellular carcinoma Biomaterials 33 2012 4597 4607
31. D. Wang, T. Zhao, X. Zhu, D. Yan, and W. Wang Bioapplications of hyperbranched polymers Chem. Soc. Rev. 44 2015 4023 4071
32. W. Wu, W. Driessen, and X. Jiang Oligo(ethylene glycol)-based thermosensitive dendrimers and their tumor accumulation and penetration J. Am. Chem. Soc. 136 2014 3145 3155
33. J.F. Xu, L.Y. Niu, Y.Z. Chen, L.Z. Wu, C.H. Tung, and Q.Z. Yang Hydrogen bonding directed self-assembly of small-molecule amphiphiles in water Org. Lett. 16 2014 4016 4019